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RAT:SHAN3
Contents |
| Species (Taxon ID) | Rattus norvegicus (Rat). ([1]) | |
| Gene Name(s) | Shank3 | |
| Protein Name(s) | SH3 and multiple ankyrin repeat domains protein 3
Shank3 Proline-rich synapse-associated protein 2 ProSAP2 SPANK-2 | |
| External Links | ||
| EMBL | AJ133120 AF133301 AF159047 | |
| IPI | IPI00204088 IPI00231141 IPI00231142 | |
| RefSeq | NP_067708.1 | |
| UniGene | Rn.42876 | |
| PDB | 2F3N 2F44 | |
| PDBsum | 2F3N 2F44 | |
| ProteinModelPortal | Q9JLU4 | |
| SMR | Q9JLU4 | |
| MINT | MINT-1486849 | |
| STRING | Q9JLU4 | |
| PhosphoSite | Q9JLU4 | |
| PRIDE | Q9JLU4 | |
| GeneID | 59312 | |
| KEGG | rno:59312 | |
| CTD | 85358 | |
| RGD | 69264 | |
| eggNOG | maNOG06792 | |
| GeneTree | ENSGT00510000046474 | |
| HOVERGEN | HBG054027 | |
| InParanoid | Q9JLU4 | |
| OrthoDB | EOG48PMJ9 | |
| NextBio | 611861 | |
| ArrayExpress | Q9JLU4 | |
| Genevestigator | Q9JLU4 | |
| GO | GO:0030054 GO:0005737 GO:0005886 GO:0014069 GO:0045211 GO:0030160 GO:0035255 GO:0008022 GO:0043621 GO:0097110 GO:0017124 GO:0008270 GO:0048854 GO:0060997 GO:0035641 GO:0045794 GO:2000969 GO:2000463 GO:0048170 GO:0051835 GO:0051968 GO:0097107 GO:0051259 GO:2000822 GO:0035176 GO:0021773 GO:0071625 | |
| InterPro | IPR002110 IPR020683 IPR001478 IPR001660 IPR013761 IPR021129 IPR011511 IPR001452 | |
| Gene3D | G3DSA:1.25.40.20 G3DSA:1.10.150.50 | |
| KO | K15009 | |
| Pfam | PF12796 PF00595 PF00536 PF07653 | |
| SMART | SM00248 SM00228 SM00454 SM00326 | |
| SUPFAM | SSF48403 SSF50156 SSF47769 SSF50044 | |
| PROSITE | PS50297 PS50088 PS50106 PS50105 PS50002 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001838 |
embryonic epithelial tube formation |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000104932 |
P |
Seeded From UniProt |
|||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
RGD:621714 |
F |
Seeded From UniProt |
|||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0086 |
C |
Seeded From UniProt |
|||
| GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000104932 |
C |
Seeded From UniProt |
|||
| GO:0005886 |
plasma membrane |
ISS: Inferred from Sequence or Structural Similarity |
C |
Seeded From UniProt |
||||
| GO:0008022 |
protein C-terminus binding |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000104932 |
F |
Seeded From UniProt |
|||
| GO:0008022 |
protein C-terminus binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0008022 |
protein C-terminus binding |
IPI: Inferred from Physical Interaction |
RGD:620768 |
F |
Seeded From UniProt |
|||
| GO:0008270 |
zinc ion binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0014069 |
postsynaptic density |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0297 |
C |
Seeded From UniProt |
|||
| GO:0014069 |
postsynaptic density |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0014069 |
postsynaptic density |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0014069 |
postsynaptic density |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0014069 |
postsynaptic density |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0017124 |
SH3 domain binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0017124 |
SH3 domain binding |
IPI: Inferred from Physical Interaction |
RGD:70941 |
F |
Seeded From UniProt |
|||
| GO:0021773 |
striatal medium spiny neuron differentiation |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0030054 |
cell junction |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0030160 |
GKAP/Homer scaffold activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0035176 |
social behavior |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000104932 |
P |
Seeded From UniProt |
|||
| GO:0035176 |
social behavior |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0035255 |
ionotropic glutamate receptor binding |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000104932 |
F |
Seeded From UniProt |
|||
| GO:0035255 |
ionotropic glutamate receptor binding |
ISS: Inferred from Sequence or Structural Similarity |
F |
Seeded From UniProt |
||||
| GO:0035641 |
locomotory exploration behavior |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0043621 |
protein self-association |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0044309 |
neuron spine |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000104932 |
C |
Seeded From UniProt |
|||
| GO:0044309 |
neuron spine |
ISS: Inferred from Sequence or Structural Similarity |
C |
Seeded From UniProt |
||||
| GO:0045202 |
synapse |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0045202 |
synapse |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0258 |
C |
Seeded From UniProt |
|||
| GO:0045202 |
synapse |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0045211 |
postsynaptic membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0045794 |
negative regulation of cell volume |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0048170 |
positive regulation of long-term neuronal synaptic plasticity |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000104932 |
P |
Seeded From UniProt |
|||
| GO:0048170 |
positive regulation of long-term neuronal synaptic plasticity |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0048854 |
brain morphogenesis |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0051259 |
protein oligomerization |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0051835 |
positive regulation of synapse structural plasticity |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000104932 |
P |
Seeded From UniProt |
|||
| GO:0051835 |
positive regulation of synapse structural plasticity |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0051968 |
positive regulation of synaptic transmission, glutamatergic |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0060997 |
dendritic spine morphogenesis |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000104932 |
P |
Seeded From UniProt |
|||
| GO:0060997 |
dendritic spine morphogenesis |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0071625 |
vocalization behavior |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000104932 |
P |
Seeded From UniProt |
|||
| GO:0071625 |
vocalization behavior |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0097107 |
postsynaptic density assembly |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0097110 |
scaffold protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0097110 |
scaffold protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:2000463 |
positive regulation of excitatory postsynaptic membrane potential |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:2000822 |
regulation of behavioral fear response |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:2000969 |
positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0060170 |
cilium membrane |
IDA: Inferred from Direct Assay |
C |
Subcellular fractionation, Figure 4 A and B showed from cilia fraction Shank3 located at the cilia membrane |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Böckers TM et al. (2001) Synaptic scaffolding proteins in rat brain. Ankyrin repeats of the multidomain Shank protein family interact with the cytoskeletal protein alpha-fodrin. J Biol Chem 276: 40104-12 PubMed GONUTS page
- ↑ 2.0 2.1 Wendholt D et al. (2006) ProSAP-interacting protein 1 (ProSAPiP1), a novel protein of the postsynaptic density that links the spine-associated Rap-Gap (SPAR) to the scaffolding protein ProSAP2/Shank3. J Biol Chem 281: 13805-16 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Tu JC et al. (1999) Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron 23: 583-92 PubMed GONUTS page
- ↑ Tobaben S et al. (2000) The G protein-coupled receptor CL1 interacts directly with proteins of the Shank family. J Biol Chem 275: 36204-10 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Baron MK et al. (2006) An architectural framework that may lie at the core of the postsynaptic density. Science 311: 531-5 PubMed GONUTS page
- ↑ 6.0 6.1 Qualmann B et al. (2004) Linkage of the actin cytoskeleton to the postsynaptic density via direct interactions of Abp1 with the ProSAP/Shank family. J Neurosci 24: 2481-95 PubMed GONUTS page
- ↑ Saavedra MV et al. (2008) Scaffolding proteins in highly purified rat olfactory cilia membranes. Neuroreport 19: 1123-6 PubMed GONUTS page
