RAT:RGS2

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Species (Taxon ID)	Rattus norvegicus (Rat). (taxon:10116)
Gene Name(s)	Rgs2
Protein Name(s)	Regulator of G-protein signaling 2 RGS2
External Links
UniProt Identifier	RGS2_RAT
UniProt Accessions	Q9JHX0,
EMBL	AF279918, AF321837, AY043246, BC061969, AJ318489,
RefSeq	NP_445905.1,
Ensembl	ENSRNOT00000005156,
Pfam	PF00615,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0004871	signal transducer activity		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0007049	cell cycle		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0045744	negative regulation of G-protein coupled re...		TAS: Traceable Author Statement		P	Source: RGD
	GO:0009968	negative regulation of signal transduction		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0071878	negative regulation of adrenergic receptor signaling pathway	PMID:20362664^[1]	IMP: Inferred from Mutant Phenotype		P	Figure 6: RGS2 overexpression leads to a reduction in cAMP accumulation in rat neonatal ventricular cardiomyocytes.	complete
	GO:0071875	adrenergic receptor signaling pathway	PMID:20362664^[1]	IDA: Inferred from Direct Assay		P	Figure 1: Activation of B-AR induces RGS expression in cultured cardiomyocytes	complete
	GO:0010614	negative regulation of cardiac muscle hypertrophy	PMID:20362664^[1]	IMP: Inferred from Mutant Phenotype		P	Figure 4+5: RGS2 overexpression attenuates ISO-induced (B-AR) cardiomyoctye hypertrophy and hypertrophic gene expression.	complete
	GO:0043405	regulation of MAP kinase activity	PMID:20362664^[1]	IDA: Inferred from Direct Assay		P	Figurre 7: Immunoblots show that RGS2 decreases ERK phosphorylation (a) and increases JNK phosphorylation (B) - part of MAP kinase pathway.	complete
	GO:0051896	regulation of protein kinase B signaling cascade	PMID:20362664^[1]	IDA: Inferred from Direct Assay		P	Figure 8: Immunoblots show thatRGS2 limits signalling leading to Akt phosphorylation in cardiomyocytes	complete
	GO:0003674	molecular function	GO_REF:0000015	ND: No biological Data available		F
	GO:0004871	signal transducer activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000342	F
	GO:0005096	GTPase activator activity	GO_REF:0000033		PANTHER:PTHR10845_AN0	F
	GO:0005575	cellular component	GO_REF:0000015	ND: No biological Data available		C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005730	nucleolus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0188	C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005737	cytoplasm	GO_REF:0000033		PANTHER:PTHR10845_AN0	C
	GO:0005829	cytosol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115558	C
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115558	C
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0005886	plasma membrane	GO_REF:0000033		PANTHER:PTHR10845_AN0	C
	GO:0006417	regulation of translation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0810	P
	GO:0007049	cell cycle	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0131	P
	GO:0007165	signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000342	P
	GO:0007283	spermatogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115558	P
	GO:0008150	biological process	GO_REF:0000015	ND: No biological Data available		P
	GO:0009898	internal side of plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115558	C
	GO:0009898	internal side of plasma membrane	PMID:21291891^[2]	IDA: Inferred from Direct Assay		C
	GO:0009968	negative regulation of signal transduction	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0734	P
	GO:0010519	negative regulation of phospholipase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115558	P
	GO:0010614	negative regulation of cardiac muscle hypertrophy	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115558	P
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0043407	negative regulation of MAP kinase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115558	P
	GO:0043547	positive regulation of GTPase activity	GO_REF:0000033		PANTHER:PTHR10845_AN0	P
	GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115558	P
	GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway	PMID:11968023^[3]	IEP: Inferred from Expression Pattern		P
	GO:0050873	brown fat cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115558	P
	GO:0055119	relaxation of cardiac muscle	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115558	P
	GO:0060452	positive regulation of cardiac muscle contraction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115558	P
	GO:0071877	regulation of adrenergic receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000115558	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Nunn C et al. (2010) RGS2 inhibits beta-adrenergic receptor-induced cardiomyocyte hypertrophy. Cell Signal 22: 1231-9 PubMed GONUTS page
↑ Chakir K et al. (2011) RGS2 is a primary terminator of β₂-adrenergic receptor-mediated G(i) signaling. J Mol Cell Cardiol 50: 1000-7 PubMed GONUTS page
↑ Thirunavukkarasu K et al. (2002) Analysis of regulator of G-protein signaling-2 (RGS-2) expression and function in osteoblastic cells. J Cell Biochem 85: 837-50 PubMed GONUTS page

[PMID:20362664-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Nunn C et al. (2010) RGS2 inhibits beta-adrenergic receptor-induced cardiomyocyte hypertrophy. Cell Signal 22: 1231-9 PubMed GONUTS page

[PMID:21291891-1] Chakir K et al. (2011) RGS2 is a primary terminator of β₂-adrenergic receptor-mediated G(i) signaling. J Mol Cell Cardiol 50: 1000-7 PubMed GONUTS page

[PMID:11968023-2] Thirunavukkarasu K et al. (2002) Analysis of regulator of G-protein signaling-2 (RGS-2) expression and function in osteoblastic cells. J Cell Biochem 85: 837-50 PubMed GONUTS page

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RAT:RGS2

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