RAT:PMP22

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Species (Taxon ID)	Rattus norvegicus (Rat). (taxon:10116)
Gene Name(s)	Pmp22 ( synonyms: Cd25, Pmp-22 )
Protein Name(s)	Peripheral myelin protein 22 PMP-22 Protein CD25 SR13 myelin protein Schwann cell membrane glycoprotein SAG
External Links
UniProt Identifier	PMP22_RAT
UniProt Accessions	P25094,
EMBL	X62431, M69139, S55427,
PIR	A41144,
RefSeq	NP_058733.1,
Ensembl	ENSRNOT00000041606,
Pfam	PF00822,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0043218	compact myelin		IMP: Inferred from Mutant Phenotype		C	Source: RGD
	GO:0016021	integral to membrane		IDA: Inferred from Direct Assay		C	Source: RGD
	GO:0005923	tight junction		IDA: Inferred from Direct Assay		C	Source: RGD
	GO:0007050	cell cycle arrest		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0030154	cell differentiation		IDA: Inferred from Direct Assay		P	Source: RGD
	GO:0030308	negative regulation of cell growth	PMID:11519720^[1]	IDA: Inferred from Direct Assay		P	Figure 3.A. The figure shows a significant inhibition of cell number in the over expressed PMP22 cell lines .However, the other two control (C6 & C6neo) cell lines had a much higher number of cells after a 96 hour incubation.	complete
	GO:0008285	negative regulation of cell proliferation		IMP: Inferred from Mutant Phenotype		P	Source: RGD
	GO:0008285	negative regulation of cell proliferation	PMID:11519720^[1]	IDA: Inferred from Direct Assay		P	Figure 3 A & B. Figure 3.A: The figure shows a significant inhibition of cell number in the over expressed PMP22 cell lines .However, the other two control (C6 & C6neo) cell lines had a much higher number of cells after a 96 hour incubation. Figure 3.B: the figure shows that the PMP22 (which is highly expressed in clone #10 ) strongly inhibits the cell proliferation process when visualized by immunostaining with anti (BrdU) monoclonal antibody; compared to the C6neo (control) cell line after an 8 hour incubation.	complete
	GO:0010977	negative regulation of neuron projection development	PMID:11519720^[1]	IDA: Inferred from Direct Assay		P	Figure 5A.B. The figures show the difference in the growth cone of DRG neurons when co-cultured with PMP22 transfected cells compared to the control. The cell line #10 (which had a high expression of PMP22) and the cell line #26 (which had a moderate expression of PMP22) seemed to have a smaller amount of neurite cell growth compared to the control. Note: a more specific GO term would be negative regulation of DRG neuron neurite outgrowth.	complete
	GO:0007422	peripheral nervous system development	PMID:11519720^[1]	IDA: Inferred from Direct Assay		P	Figure 5A.B. The figures show the difference in the growth cone of DRG neurons when co-cultured with PMP22 transfected cells compared to the control. The cell line #10 (which had a high expression of PMP22) and the cell line #26 (which had a moderate expression of PMP22) seemed to have a smaller amount of neurite cell growth compared to the control.	complete
	GO:0007050	cell cycle arrest	PMID:11519720^[1]	IDA: Inferred from Direct Assay		P	Figure 3.A. The figure shows a significant inhibition of cell number in the over expressed PMP22 cell lines .However, the other two control (C6 & C6neo) cell lines had a much higher number of cells after a 96 hour incubation.	complete
	GO:0005923	tight junction	PMID:11717414^[2]	IDA: Inferred from Direct Assay		C
	GO:0007049	cell cycle	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0131	P
	GO:0007050	cell cycle arrest	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0338	P
	GO:0007422	peripheral nervous system development	PMID:11519720^[1]	IC: Inferred by Curator	GO:0010977	P
	GO:0008285	negative regulation of cell proliferation	PMID:11519720^[1]0	IDA: Inferred from Direct Assay		P
	GO:0008285	negative regulation of cell proliferation	PMID:7720703^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0010977	negative regulation of neuron projection development	PMID:11519720^[1]	IDA: Inferred from Direct Assay		P
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003936	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004031	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016020	membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0162	C
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004032	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0016021	integral to membrane	PMID:11717414^[2]	IDA: Inferred from Direct Assay		C
	GO:0030154	cell differentiation	PMID:11456309^[4]	IDA: Inferred from Direct Assay		P
	GO:0032288	myelin assembly	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000104342	P
	GO:0042552	myelination	PMID:11456309^[4]	IDA: Inferred from Direct Assay		P
	GO:0043218	compact myelin	PMID:1556154^[5]	IDA: Inferred from Direct Assay		C
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Takeda Y et al. (2001) Functional analysis for peripheral myelin protein PASII/PMP22: is it a member of claudin superfamily? Neurochem Res 26: 599-607 PubMed GONUTS page
↑ ^2.0 ^2.1 Notterpek L et al. (2001) Peripheral myelin protein 22 is a constituent of intercellular junctions in epithelia. Proc Natl Acad Sci U S A 98: 14404-9 PubMed GONUTS page
↑ Zoidl G et al. (1995) Retroviral-mediated gene transfer of the peripheral myelin protein PMP22 in Schwann cells: modulation of cell growth. EMBO J 14: 1122-8 PubMed GONUTS page
↑ ^4.0 ^4.1 Nobbio L et al. (2001) PMP22 transgenic dorsal root ganglia cultures show myelin abnormalities similar to those of human CMT1A. Ann Neurol 50: 47-55 PubMed GONUTS page
↑ Snipes GJ et al. (1992) Characterization of a novel peripheral nervous system myelin protein (PMP-22/SR13). J Cell Biol 117: 225-38 PubMed GONUTS page

[PMID:11519720-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Takeda Y et al. (2001) Functional analysis for peripheral myelin protein PASII/PMP22: is it a member of claudin superfamily? Neurochem Res 26: 599-607 PubMed GONUTS page

[PMID:11717414-1] 2.0 ^2.1 Notterpek L et al. (2001) Peripheral myelin protein 22 is a constituent of intercellular junctions in epithelia. Proc Natl Acad Sci U S A 98: 14404-9 PubMed GONUTS page

[PMID:7720703-2] Zoidl G et al. (1995) Retroviral-mediated gene transfer of the peripheral myelin protein PMP22 in Schwann cells: modulation of cell growth. EMBO J 14: 1122-8 PubMed GONUTS page

[PMID:11456309-3] 4.0 ^4.1 Nobbio L et al. (2001) PMP22 transgenic dorsal root ganglia cultures show myelin abnormalities similar to those of human CMT1A. Ann Neurol 50: 47-55 PubMed GONUTS page

[PMID:1556154-4] Snipes GJ et al. (1992) Characterization of a novel peripheral nervous system myelin protein (PMP-22/SR13). J Cell Biol 117: 225-38 PubMed GONUTS page

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RAT:PMP22

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