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RAT:OXYR

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Contents

Species (Taxon ID) Rattus norvegicus (Rat). ([1])
Gene Name(s) Oxtr (synonyms: Otr)
Protein Name(s) Oxytocin receptor

OT-R

External Links
EMBL U15280
U15169
AY338194
IPI IPI00189655
RefSeq NP_037003.2
UniGene Rn.6841
ProteinModelPortal P70536
STRING P70536
PhosphoSite P70536
PRIDE P70536
Ensembl ENSRNOT00000007724
GeneID 25342
KEGG rno:25342
UCSC L81169
CTD 5021
RGD 3239
eggNOG maNOG08073
HOVERGEN HBG105710
InParanoid P70536
OMA MFASTYL
OrthoDB EOG4VHK6S
PhylomeDB P70536
NextBio 606255
ArrayExpress P70536
Genevestigator P70536
GermOnline ENSRNOG00000005806
GO GO:0016324
GO:0005913
GO:0016021
GO:0005902
GO:0004990
GO:0017046
GO:0005515
GO:0005000
GO:0048565
GO:0042755
GO:0007204
GO:0070371
GO:0060206
GO:0007565
GO:0007507
GO:0042711
GO:0060137
GO:0007613
GO:0060455
GO:0010701
GO:0060406
GO:0051965
GO:0032230
GO:0051968
GO:0070474
GO:0001975
GO:0034059
GO:0042220
GO:0034097
GO:0042493
GO:0032355
GO:0043434
GO:0032570
GO:0030431
GO:0035176
GO:0042713
GO:0001967
GO:0021537
InterPro IPR000276
IPR017452
IPR002062
IPR001817
KO K04229
Pfam PF00001
PRINTS PR00237
PR00665
PR00896
PROSITE PS00237
PS50262

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001967

suckling behavior

PMID:19106214[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0001975

response to amphetamine

PMID:17383105[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0004871

signal transducer activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0807

F

Seeded From UniProt

GO:0004872

receptor activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0675

F

Seeded From UniProt

GO:0004930

G-protein coupled receptor activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0297

F

Seeded From UniProt

GO:0004990

oxytocin receptor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002062

F

Seeded From UniProt

GO:0004990

oxytocin receptor activity

PMID:15821089[3]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

GO:0004990

oxytocin receptor activity

PMID:19560475[4]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

GO:0005000

vasopressin receptor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001817

F

Seeded From UniProt

GO:0005515

protein binding

PMID:9176188[5]

IPI: Inferred from Physical Interaction

RGD:2714

F

Seeded From UniProt

GO:0005886

plasma membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

Seeded From UniProt

GO:0005886

plasma membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0039

C

Seeded From UniProt

GO:0005902

microvillus

PMID:11456414[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005913

cell-cell adherens junction

PMID:19003903[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0006950

response to stress

PMID:17540347[8]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

GO:0007165

signal transduction

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0807

P

Seeded From UniProt

GO:0007186

G-protein coupled receptor signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000276

P

Seeded From UniProt

GO:0007186

G-protein coupled receptor signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001817

P

Seeded From UniProt

GO:0007186

G-protein coupled receptor signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002062

P

Seeded From UniProt

GO:0007186

G-protein coupled receptor signaling pathway

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0297

P

Seeded From UniProt

GO:0007186

G-protein coupled receptor signaling pathway

PMID:9575824[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0007204

elevation of cytosolic calcium ion concentration

PMID:10497238[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0007507

heart development

PMID:15316117[11]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

GO:0007565

female pregnancy

PMID:16832906[12]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

GO:0007613

memory

PMID:18304743[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0010701

positive regulation of norepinephrine secretion

PMID:14656297[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0014070

response to organic cyclic compound

PMID:11264328[15]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

GO:0014070

response to organic cyclic compound

PMID:12504828[16]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

GO:0016020

membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

Seeded From UniProt

GO:0016021

integral to membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000276

C

Seeded From UniProt

GO:0016021

integral to membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001817

C

Seeded From UniProt

GO:0016021

integral to membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002062

C

Seeded From UniProt

GO:0016021

integral to membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded From UniProt

GO:0016324

apical plasma membrane

PMID:11456414[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0017046

peptide hormone binding

PMID:15821089[3]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

GO:0021537

telencephalon development

PMID:11021977[17]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

GO:0030431

sleep

PMID:12832103[18]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0032230

positive regulation of synaptic transmission, GABAergic

PMID:11069593[19]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0032355

response to estradiol stimulus

PMID:19258489[20]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

GO:0032570

response to progesterone stimulus

PMID:10856882[21]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

GO:0034059

response to anoxia

PMID:18655887[22]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0034097

response to cytokine stimulus

PMID:10994633[23]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

GO:0035176

social behavior

PMID:17383105[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0042220

response to cocaine

PMID:16677710[24]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

GO:0042493

response to drug

PMID:12834913[25]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

GO:0042493

response to drug

PMID:15380831[26]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

GO:0042711

maternal behavior

PMID:18513132[27]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0042713

sperm ejaculation

PMID:18469843[28]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0042755

eating behavior

PMID:15380376[29]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0043434

response to peptide hormone stimulus

PMID:12700188[30]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

GO:0043434

response to peptide hormone stimulus

PMID:17537544[31]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

GO:0044058

regulation of digestive system process

PMID:12690433[32]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0048545

response to steroid hormone stimulus

PMID:12588901[33]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0048565

digestive tract development

PMID:19003903[7]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

GO:0051965

positive regulation of synapse assembly

PMID:16488155[34]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0051968

positive regulation of synaptic transmission, glutamatergic

PMID:18510735[35]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0060137

maternal process involved in parturition

PMID:18936075[36]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

GO:0060206

estrous cycle phase

PMID:12867731[37]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

GO:0060406

positive regulation of penile erection

PMID:18469843[28]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0060455

negative regulation of gastric acid secretion

PMID:11764003[38]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0070371

ERK1 and ERK2 cascade

PMID:10497238[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0070474

positive regulation of uterine smooth muscle contraction

PMID:19164477[39]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt


edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Kennett JE et al. (2009) Antagonism of oxytocin prevents suckling- and estradiol-induced, but not progesterone-induced, secretion of prolactin. Endocrinology 150: 2292-9 PubMed GONUTS page
  2. ↑ 2.0 2.1 Thompson MR et al. (2007) A role for oxytocin and 5-HT(1A) receptors in the prosocial effects of 3,4 methylenedioxymethamphetamine ("ecstasy"). Neuroscience 146: 509-14 PubMed GONUTS page
  3. ↑ 3.0 3.1 Huber D et al. (2005) Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala. Science 308: 245-8 PubMed GONUTS page
  4. ↑ Lukas M et al. (2010) Maternal separation interferes with developmental changes in brain vasopressin and oxytocin receptor binding in male rats. Neuropharmacology 58: 78-87 PubMed GONUTS page
  5. ↑ Strakova Z & Soloff MS (1997) Coupling of oxytocin receptor to G proteins in rat myometrium during labor: Gi receptor interaction. Am J Physiol 272: E870-6 PubMed GONUTS page
  6. ↑ 6.0 6.1 Morel G et al. (2001) Intrauterine oxytocin system. Compartmental distribution of oxytocin and oxytocin receptors in rat endometrial epithelium. Cell Tissue Res 304: 377-82 PubMed GONUTS page
  7. ↑ 7.0 7.1 Welch MG et al. (2009) Expression and developmental regulation of oxytocin (OT) and oxytocin receptors (OTR) in the enteric nervous system (ENS) and intestinal epithelium. J Comp Neurol 512: 256-70 PubMed GONUTS page
  8. ↑ Lee PR et al. (2007) Prenatal stress generates deficits in rat social behavior: Reversal by oxytocin. Brain Res 1156: 152-67 PubMed GONUTS page
  9. ↑ Strakova Z et al. (1998) ERK2 mediates oxytocin-stimulated PGE2 synthesis. Am J Physiol 274: E634-41 PubMed GONUTS page
  10. ↑ 10.0 10.1 Hoare S et al. (1999) The proximal portion of the COOH terminus of the oxytocin receptor is required for coupling to g(q), but not g(i). Independent mechanisms for elevating intracellular calcium concentrations from intracellular stores. J Biol Chem 274: 28682-9 PubMed GONUTS page
  11. ↑ Jankowski M et al. (2004) Oxytocin in cardiac ontogeny. Proc Natl Acad Sci U S A 101: 13074-9 PubMed GONUTS page
  12. ↑ Bealer SL et al. (2006) Oxytocin receptor binding in the hypothalamus during gestation in rats. Am J Physiol Regul Integr Comp Physiol 291: R53-8 PubMed GONUTS page
  13. ↑ Larrazolo-López A et al. (2008) Vaginocervical stimulation enhances social recognition memory in rats via oxytocin release in the olfactory bulb. Neuroscience 152: 585-93 PubMed GONUTS page
  14. ↑ Onaka T et al. (2003) Facilitative role of endogenous oxytocin in noradrenaline release in the rat supraoptic nucleus. Eur J Neurosci 18: 3018-26 PubMed GONUTS page
  15. ↑ Bale TL et al. (2001) CNS region-specific oxytocin receptor expression: importance in regulation of anxiety and sex behavior. J Neurosci 21: 2546-52 PubMed GONUTS page
  16. ↑ Wang D et al. (2003) Genistein supplementation stimulates the oxytocin system in the aorta of ovariectomized rats. Cardiovasc Res 57: 186-94 PubMed GONUTS page
  17. ↑ Chen Q et al. (2000) Vasopressin and oxytocin receptor mRNA expression during rat telencephalon development. Neuropeptides 34: 173-80 PubMed GONUTS page
  18. ↑ Lancel M et al. (2003) Intracerebral oxytocin modulates sleep-wake behaviour in male rats. Regul Pept 114: 145-52 PubMed GONUTS page
  19. ↑ Zaninetti M & Raggenbass M (2000) Oxytocin receptor agonists enhance inhibitory synaptic transmission in the rat hippocampus by activating interneurons in stratum pyramidale. Eur J Neurosci 12: 3975-84 PubMed GONUTS page
  20. ↑ Feng M et al. (2009) Estradiol upregulates the expression of oxytocin receptor in colon in rats. Am J Physiol Endocrinol Metab 296: E1059-66 PubMed GONUTS page
  21. ↑ Murata T et al. (2000) Oxytocin receptor gene expression in rat uterus: regulation by ovarian steroids. J Endocrinol 166: 45-52 PubMed GONUTS page
  22. ↑ Khazipov R et al. (2008) Effects of oxytocin on GABA signalling in the foetal brain during delivery. Prog Brain Res 170: 243-57 PubMed GONUTS page
  23. ↑ Fang X et al. (2000) Effects of LPS and IL-6 on oxytocin receptor in non-pregnant and pregnant rat uterus. Am J Reprod Immunol 44: 65-72 PubMed GONUTS page
  24. ↑ Jarrett TM et al. (2006) Cocaine treatment alters oxytocin receptor binding but not mRNA production in postpartum rat dams. Neuropeptides 40: 161-7 PubMed GONUTS page
  25. ↑ Patisaul HB et al. (2003) Immediate and residual effects of tamoxifen and ethynylestradiol in the female rat hypothalamus. Brain Res 978: 185-93 PubMed GONUTS page
  26. ↑ Johns JM et al. (2004) Gestational treatment with cocaine and fluoxetine alters oxytocin receptor number and binding affinity in lactating rat dams. Int J Dev Neurosci 22: 321-8 PubMed GONUTS page
  27. ↑ Figueira RJ et al. (2008) Oxytocin receptor activity in the ventrocaudal periaqueductal gray modulates anxiety-related behavior in postpartum rats. Behav Neurosci 122: 618-28 PubMed GONUTS page
  28. ↑ 28.0 28.1 Clément P et al. (2008) Brain oxytocin receptors mediate ejaculation elicited by 7-hydroxy-2-(di-N-propylamino) tetralin (7-OH-DPAT) in anaesthetized rats. Br J Pharmacol 154: 1150-9 PubMed GONUTS page
  29. ↑ Verty AN et al. (2004) Evidence for an interaction between CB1 cannabinoid and oxytocin receptors in food and water intake. Neuropharmacology 47: 593-603 PubMed GONUTS page
  30. ↑ Mitchell JA et al. (2003) Parathyroid hormone-related protein treatment of pregnant rats delays the increase in connexin 43 and oxytocin receptor expression in the myometrium. Biol Reprod 69: 556-62 PubMed GONUTS page
  31. ↑ Pournajafi-Nazarloo H et al. (2007) Neonatal oxytocin treatment modulates oxytocin receptor, atrial natriuretic peptide, nitric oxide synthase and estrogen receptor mRNAs expression in rat heart. Peptides 28: 1170-7 PubMed GONUTS page
  32. ↑ Wu CL et al. (2003) Pharmacological effects of oxytocin on gastric emptying and intestinal transit of a non-nutritive liquid meal in female rats. Naunyn Schmiedebergs Arch Pharmacol 367: 406-13 PubMed GONUTS page
  33. ↑ Widmer H et al. (2003) Neurosteroid regulation of oxytocin and vasopressin release from the rat supraoptic nucleus. J Physiol 548: 233-44 PubMed GONUTS page
  34. ↑ Theodosis DT et al. (2006) Oxytocin and estrogen promote rapid formation of functional GABA synapses in the adult supraoptic nucleus. Mol Cell Neurosci 31: 785-94 PubMed GONUTS page
  35. ↑ Breton JD et al. (2008) Oxytocin-induced antinociception in the spinal cord is mediated by a subpopulation of glutamatergic neurons in lamina I-II which amplify GABAergic inhibition. Mol Pain 4: 19 PubMed GONUTS page
  36. ↑ Arthur P et al. (2008) Relationship between gene expression and function of uterotonic systems in the rat during gestation, uterine activation and both term and preterm labour. J Physiol 586: 6063-76 PubMed GONUTS page
  37. ↑ Murata T et al. (2003) Changes of receptor mRNAs for oxytocin and estrogen during the estrous cycle in rat uterus. J Vet Med Sci 65: 707-12 PubMed GONUTS page
  38. ↑ Asad M et al. (2001) Gastric antisecretory and antiulcer activity of oxytocin in rats and guinea pigs. Life Sci 70: 17-24 PubMed GONUTS page
  39. ↑ Magalhaes JK et al. (2009) Oxytocin pretreatment decreases oxytocin-induced myometrial contractions in pregnant rats in a concentration-dependent but not time-dependent manner. Reprod Sci 16: 501-8 PubMed GONUTS page
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