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RAT:NRX1B
Contents |
| Species (Taxon ID) | Rattus norvegicus (Rat). (taxon:10116) | |
| Gene Name(s) | Nrxn1 | |
| Protein Name(s) |
| |
| External Links | ||
| UniProt Identifier | NRX1B_RAT | |
| UniProt Accessions | Q63373, | |
| EMBL | M96375, | |
| PIR | B40228, | |
| PDB | 1C4R, 2R1B, 2R1D, 2WQZ, 2XB6, | |
| IntAct | Q63373, | |
| Pfam | PF02210, | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005102 |
receptor binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005509 |
calcium ion binding |
IDA: Inferred from Direct Assay |
|
F |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
RGD:621117 |
F |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005886 |
plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
||||
| GO:0007155 |
cell adhesion |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0009986 |
cell surface |
IDA: Inferred from Direct Assay |
|
C |
||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0162 |
C |
||||
| GO:0016021 |
integral to membrane |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0030139 |
endocytic vesicle |
IDA: Inferred from Direct Assay |
|
C |
||||
| GO:0050839 |
cell adhesion molecule binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0051290 |
protein heterotetramerization |
IDA: Inferred from Direct Assay |
|
P |
||||
| GO:0042734 |
presynaptic membrane |
IDA: Inferred from Direct Assay |
C |
See Fig 5. Neurexin is largely presynaptic and binds with neuroligin normally to form trans-synaptic complexes and transduce bidirectional signals across the membrane. |
complete | |||
| GO:0001525 |
angiogenesis |
ISS: Inferred from Sequence or Structural Similarity |
P |
|||||
| GO:0005102 |
receptor binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005509 |
calcium ion binding |
IDA: Inferred from Direct Assay |
F |
|||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
RGD:621117 |
F |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005886 |
plasma membrane |
IDA: Inferred from Direct Assay |
C |
|||||
| GO:0007155 |
cell adhesion |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0009986 |
cell surface |
IDA: Inferred from Direct Assay |
C |
|||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0162 |
C |
||||
| GO:0016021 |
integral to membrane |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0030139 |
endocytic vesicle |
IDA: Inferred from Direct Assay |
C |
|||||
| GO:0050839 |
cell adhesion molecule binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0051290 |
protein heterotetramerization |
IDA: Inferred from Direct Assay |
P |
| ||||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Chubykin AA et al. (2005) Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism. J Biol Chem 280: 22365-74 PubMed GONUTS page
- ↑ 2.0 2.1 Koehnke J et al. (2008) Crystal structures of beta-neurexin 1 and beta-neurexin 2 ectodomains and dynamics of splice insertion sequence 4. Structure 16: 410-21 PubMed GONUTS page
- ↑ 3.0 3.1 Fabrichny IP et al. (2007) Structural analysis of the synaptic protein neuroligin and its beta-neurexin complex: determinants for folding and cell adhesion. Neuron 56: 979-91 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Araç D et al. (2007) Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions. Neuron 56: 992-1003 PubMed GONUTS page
- ↑ 5.0 5.1 Mukherjee K et al. (2008) CASK Functions as a Mg2+-independent neurexin kinase. Cell 133: 328-39 PubMed GONUTS page
- ↑ 6.0 6.1 Suckow AT et al. (2008) Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion. Endocrinology 149: 6006-17 PubMed GONUTS page
- ↑ Berninghausen O et al. (2007) Neurexin Ibeta and neuroligin are localized on opposite membranes in mature central synapses. J Neurochem 103: 1855-63 PubMed GONUTS page
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