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RAT:NR1H3

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Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) Nr1h3 (synonyms: Lxra)
Protein Name(s) Oxysterols receptor LXR-alpha

Liver X receptor alpha Nuclear receptor subfamily 1 group H member 3 RLD-1

External Links
UniProt Q62685
EMBL U11685
PIR A56043
UniGene Rn.11209
ProteinModelPortal Q62685
SMR Q62685
PhosphoSite Q62685
PRIDE Q62685
UCSC RGD:61909
RGD 61909
eggNOG NOG285805
HOGENOM HOG000220845
HOVERGEN HBG108655
InParanoid Q62685
PhylomeDB Q62685
PRO PR:Q62685
Proteomes UP000002494
Genevestigator Q62685
GO GO:0005737
GO:0005634
GO:0046982
GO:0046965
GO:0043565
GO:0003700
GO:0003707
GO:0008270
GO:0008286
GO:0006629
GO:2000188
GO:0006351
Gene3D 1.10.565.10
3.30.50.10
InterPro IPR023257
IPR008946
IPR000536
IPR001723
IPR001628
IPR013088
Pfam PF00104
PF00105
PRINTS PR02034
PR00398
PR00047
SMART SM00430
SM00399
SUPFAM SSF48508
PROSITE PS00031
PS51030

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0009306

protein secretion

PMID:19229075[1]

IMP: Inferred from Mutant Phenotype

P

Figure 2A and 2b: Inhibition of LXRα by using siRNA (in Fig 2A) or by using arachidonic acid (in Fig 2B) resulted in a decrease in secreted apoE protein, despite the presence of FGF-1, suggesting that LXRα plays a role in apoE secretion.

NOTE: a more specific term could be used if it was available “apolipoprotein secretion”

complete

GO:0010552

positive regulation of gene-specific transcription from RNA polymerase II promoter

PMID:19229075[1]

IMP: Inferred from Mutant Phenotype

P

Figure 2A and 2b: Inhibition of LXRα by using siRNA (in Fig 2A) or by using arachidonic acid (in Fig 2B) resulted in a decrease in cellular apoE protein, despite the presence of FGF-1, suggesting that LXRα regulates apoE gene transcription. Figure 3: suggests that the upregulation of the apoE gene transcription in astrocytes is associated with the increase of LXRα, both being regulated by cellular sterol biosynthesis, as when the cells were treated with compactin, an inhibitor of HMG-CoA reductase (involved in the control of cholesterol biosynthesis), the FGF-1 induced increase of LXRα and apoE mRNA were decreased.

complete

GO:0031490

chromatin DNA binding

PMID:19229075[1]

IDA: Inferred from Direct Assay

F

Figure 5: Chip assay shows that LXRα binds to the apoE promoter

complete

GO:0000790

nuclear chromatin

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000387946

C

complete

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001723

F

complete

GO:0003677

DNA binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0238

F

complete

GO:0003677

DNA binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000106988

F

complete

GO:0003700

sequence-specific DNA binding transcription factor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000536

F

complete

GO:0003700

sequence-specific DNA binding transcription factor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001628

F

complete

GO:0003700

sequence-specific DNA binding transcription factor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008946

F

complete

GO:0003700

sequence-specific DNA binding transcription factor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013088

F

complete

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001723

F

Seeded From UniProt

complete

GO:0003700

sequence-specific DNA binding transcription factor activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000106988

F

complete

GO:0003677

DNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

GO:0003707

steroid hormone receptor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000536

F

complete

GO:0003700

transcription factor activity, sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000536
InterPro:IPR001628
InterPro:IPR008946

F

Seeded From UniProt

complete

GO:0003707

steroid hormone receptor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001723

F

complete

GO:0003707

steroid hormone receptor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000536
InterPro:IPR001723
InterPro:IPR008946

F

Seeded From UniProt

complete

GO:0003707

steroid hormone receptor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008946

F

complete

GO:0003707

steroid hormone receptor activity

PMID:11781314[2]

TAS: Traceable Author Statement

F

Seeded From UniProt

complete

GO:0003707

steroid hormone receptor activity

PMID:11781314[2]

TAS: Traceable Author Statement

F

complete

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000536
InterPro:IPR001628
InterPro:IPR001723

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0004872

receptor activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0675

F

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0004879

ligand-dependent nuclear receptor activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000106988

F

complete

GO:0005634

nucleus

PMID:16773041[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000536

C

complete

GO:0005737

cytoplasm

PMID:16773041[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001628

C

complete

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001723

C

complete

GO:0006351

transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008946

C

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000536
InterPro:IPR001628
InterPro:IPR001723
InterPro:IPR013088

P

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0539

C

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000106988

C

complete

GO:0006629

lipid metabolic process

PMID:11781314[2]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0191

C

complete

GO:0008270

zinc ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001628
InterPro:IPR013088

F

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:16773041[3]

IDA: Inferred from Direct Assay

C

complete

GO:0008286

insulin receptor signaling pathway

PMID:11781314[2]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:16773041[3]

IDA: Inferred from Direct Assay

C

complete

GO:0043401

steroid hormone mediated signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000536

P

Seeded From UniProt

complete

GO:0006351

transcription, DNA-dependent

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0804

P

complete

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001628

F

Seeded From UniProt

complete

GO:0006351

transcription, DNA-dependent

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000106988

P

complete

GO:0043565

sequence-specific DNA binding

PMID:7935418[4]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000536

P

complete

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q13133

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001628

P

complete

GO:0046872

metal ion binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001723

P

complete

GO:0046965

retinoid X receptor binding

PMID:7935418[4]

IPI: Inferred from Physical Interaction

RGD:736929

F

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008946

P

complete

GO:0046982

protein heterodimerization activity

PMID:7935418[4]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013088

P

complete

GO:2000188

regulation of cholesterol homeostasis

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q9Z0Y9

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0805

P

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000106988

P

complete

GO:0006629

lipid metabolic process

PMID:11781314[2]

IEP: Inferred from Expression Pattern

P

complete

GO:0008270

zinc ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001628

F

complete

GO:0008270

zinc ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013088

F

complete

GO:0008286

insulin receptor signaling pathway

PMID:11781314[2]

IEP: Inferred from Expression Pattern

P

complete

GO:0010867

positive regulation of triglyceride biosynthetic process

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000387946

P

complete

GO:0010870

positive regulation of receptor biosynthetic process

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000387946

P

complete

GO:0010875

positive regulation of cholesterol efflux

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000387946

P

complete

GO:0010887

negative regulation of cholesterol storage

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000387946

P

complete

GO:0030522

intracellular receptor mediated signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000106988

P

complete

GO:0032270

positive regulation of cellular protein metabolic process

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000387946

P

complete

GO:0032369

negative regulation of lipid transport

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000387946

P

complete

GO:0032376

positive regulation of cholesterol transport

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000387946

P

complete

GO:0032570

response to progesterone stimulus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000387946

P

complete

GO:0032810

sterol response element binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000387946

F

complete

GO:0034145

positive regulation of toll-like receptor 4 signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000387946

P

complete

GO:0043277

apoptotic cell clearance

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000387946

P

complete

GO:0043401

steroid hormone mediated signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000536

P

complete

GO:0043401

steroid hormone mediated signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008946

P

complete

GO:0043401

steroid hormone mediated signaling pathway

PMID:11781314[2]

TAS: Traceable Author Statement

P

complete

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001628

F

complete

GO:0043565

sequence-specific DNA binding

PMID:7935418[4]

IDA: Inferred from Direct Assay

F

complete

GO:0044255

cellular lipid metabolic process

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000106988

P

complete

GO:0045723

positive regulation of fatty acid biosynthetic process

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000387946

P

complete

GO:0045892

negative regulation of transcription, DNA-dependent

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000106988

P

complete

GO:0046872

metal ion binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0479

F

complete

GO:0046965

retinoid X receptor binding

PMID:7935418[4]

IPI: Inferred from Physical Interaction

RGD:736929

F

complete

GO:0046982

protein heterodimerization activity

PMID:7935418[4]

IDA: Inferred from Direct Assay

F

complete

GO:0048550

negative regulation of pinocytosis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000387946

P

complete

GO:0051006

positive regulation of lipoprotein lipase activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000387946

P

complete

GO:0071222

cellular response to lipopolysaccharide

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000387946

P

complete

GO:2000189

positive regulation of cholesterol homeostasis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000387946

P

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Lu, R et al. (2009) FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes. J. Lipid Res. 50 1156-64 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Tobin, KA et al. (2002) Liver X receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesis. J. Biol. Chem. 277 10691-7 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Helleboid-Chapman, A et al. (2006) Glucose regulates LXRalpha subcellular localization and function in rat pancreatic beta-cells. Cell Res. 16 661-70 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 Apfel, R et al. (1994) A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily. Mol. Cell. Biol. 14 7025-35 PubMed GONUTS page