RAT:LIF

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005615	extracellular space		IDA: Inferred from Direct Assay		C	Source: RGD
	GO:0005125	cytokine activity	PMCID: PMC2756042	IDA: Inferred from Direct Assay		F	Figure 2: LIF alters both astrocyte cell numbers and type in hippocampal cell cultures. Immunocytochemistry showed strong LIF receptor (LIF-R) expression on NG2+-OPC and GFAP+-astrocytes in hippocampal cell cultures.	complete
	GO:0008083	growth factor activity	PMCID: PMC2782399	EXP: Inferred from Experiment		F	Figure 2. The population of cells in the oligodendrocyte lineage is reduced and displays a pronounced chiasm-to-retinal gradient in P10 optic nerve of LIF-/- mice. Without LIF the optic nerves are slower to develop during the first 14 postnatal days.	complete
	GO:0005146	leukemia inhibitory factor receptor binding		IMP: Inferred from Mutant Phenotype		F	Source: RGD
	GO:0048708	astrocyte differentiation		IMP: Inferred from Mutant Phenotype		P	Source: RGD
	GO:0006955	immune response	PMCID: PMC2782399	IMP: Inferred from Mutant Phenotype		P	Figure 1. MBP and PLP immunoreactivity are markedly reduced in optic nerve of P10 LIF-/- mice. Optic nerves of LIF-/- mice compared to those of LIF+/+, had weak MBP immunoreactivity.	complete
	GO:0016525	negative regulation of angiogenesis		IDA: Inferred from Direct Assay		P	Source: RGD
	GO:0031100	organ regeneration		IMP: Inferred from Mutant Phenotype		P	Source: RGD
	GO:0051461	positive regulation of adrenocorticotropin secretion		IDA: Inferred from Direct Assay		P	Source: RGD
	GO:0010976	positive regulation of neuron projection development		IDA: Inferred from Direct Assay		P	Source: RGD
	GO:0060041	retina development in camera-type eye		IDA: Inferred from Direct Assay		P	Source: RGD
	GO:0060290	transdifferentiation		IMP: Inferred from Mutant Phenotype		P	Source: RGD
	GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein	PMID:20624457^[1]	IDA: Inferred from Direct Assay		P	B-C. LIF activates STAT1 in MM.	complete
	GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein	PMID:20624457^[1]	IDA: Inferred from Direct Assay		P	LIF activates STAT3 in MM	complete
Contributes to	GO:0072162	metanephric mesenchymal cell differentiation	PMID:20624457^[1]	IDA: Inferred from Direct Assay		P	"...indicating that STAT1 is also activated in early renal development". (Since LIF is upstream of STAT1, it contributes to metanephric mesenchymal cell differentiation by activating STAT1).	complete
	GO:0051091	positive regulation of transcription factor activity	PMID:20624457^[1]	IDA: Inferred from Direct Assay		P	As shown in Fig.3A, LIF ...induced the expression of LIM-1. "The Lim-1 gene encodes a LIM-homeodomain transcription factor that is highly conserved among vertebrates". definition from PMID:12454922^[2].	complete
	GO:0046587	positive regulation of calcium-dependent cell-cell adhesion	PMID:20624457^[1]	IDA: Inferred from Direct Assay		P	..we also evaluated expression of lim-1 and E-cadherin by immunoblotting. Expression of both markers was induced with LIF treatment. E-cadherin - definition from UniProt Cadherins are calcium-dependent cell adhesion proteins	complete
	GO:0005125	cytokine activity	PMCID: PMC2756042	IEA: Inferred from Electronic Annotation	UniProtKB:P17777	F	Figure 2: LIF alters both astrocyte cell numbers and type in hippocampal cell cultures. Immunocytochemistry showed strong LIF receptor (LIF-R) expression on NG2+-OPC and GFAP+-astrocytes in hippocampal cell cultures.	complete
	GO:0001974	blood vessel remodeling	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000067066	P
	GO:0005102	receptor binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000249075	F
	GO:0005125	cytokine activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001581	F
	GO:0005125	cytokine activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019827	F
	GO:0005125	cytokine activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0202	F
	GO:0005125	cytokine activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000067066	F
	GO:0005125	cytokine activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000249075	F
	GO:0005146	leukemia inhibitory factor receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003624	F
	GO:0005146	leukemia inhibitory factor receptor binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000249075	F
	GO:0005146	leukemia inhibitory factor receptor binding	PMID:14638908^[3]	IMP: Inferred from Mutant Phenotype		F
	GO:0005576	extracellular region	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001581	C
	GO:0005576	extracellular region	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003624	C
	GO:0005576	extracellular region	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019827	C
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C
	GO:0005615	extracellular space	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0202	C
	GO:0005615	extracellular space	PMID:20160138^[4]	IDA: Inferred from Direct Assay		C
	GO:0006955	immune response	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001581	P
	GO:0006955	immune response	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019827	P
	GO:0007566	embryo implantation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000067066	P
	GO:0008083	growth factor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0339	F
	GO:0008083	growth factor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000067066	F
	GO:0008083	growth factor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000249075	F
	GO:0008284	positive regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000067066	P
	GO:0008284	positive regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000249075	P
	GO:0008285	negative regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000067066	P
	GO:0010976	positive regulation of neuron projection development	PMID:18679704^[5]	IDA: Inferred from Direct Assay		P
	GO:0016525	negative regulation of angiogenesis	PMID:16643897^[6]	IDA: Inferred from Direct Assay		P
	GO:0019827	stem cell maintenance	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000067066	P
	GO:0030324	lung development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000067066	P
	GO:0031100	organ regeneration	PMID:14638908^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0031100	organ regeneration	PMID:16369772^[7]	IEP: Inferred from Expression Pattern		P
	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000249075	P
	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000249075	P
	GO:0042503	tyrosine phosphorylation of Stat3 protein	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000067066	P
	GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000249075	P
	GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000249075	P
	GO:0043410	positive regulation of MAPKKK cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000249075	P
	GO:0045595	regulation of cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000067066	P
	GO:0045651	positive regulation of macrophage differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000249075	P
	GO:0045835	negative regulation of meiosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000067066	P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000249075	P
	GO:0046697	decidualization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000067066	P
	GO:0046888	negative regulation of hormone secretion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000249075	P
	GO:0048286	lung alveolus development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000067066	P
	GO:0048644	muscle organ morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000067066	P
	GO:0048666	neuron development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000067066	P
	GO:0048708	astrocyte differentiation	PMID:17328769^[8]	IMP: Inferred from Mutant Phenotype		P
	GO:0048711	positive regulation of astrocyte differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000067066	P
	GO:0048861	leukemia inhibitory factor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000249075	P
	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000249075	P
	GO:0051461	positive regulation of corticotropin secretion	PMID:20160138^[4]	IDA: Inferred from Direct Assay		P
	GO:0060041	retina development in camera-type eye	PMID:16643897^[6]	IDA: Inferred from Direct Assay		P
	GO:0060135	maternal process involved in female pregnancy	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000067066	P
	GO:0060290	transdifferentiation	PMID:20051627^[9]	IMP: Inferred from Mutant Phenotype		P
	GO:0060426	lung vasculature development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000067066	P
	GO:0060463	lung lobe morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000067066	P
	GO:0060707	trophoblast giant cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000067066	P
	GO:0060708	spongiotrophoblast differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000067066	P
	GO:0070373	negative regulation of ERK1 and ERK2 cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000067066	P
	GO:0072108	positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000249075	P
	GO:0072307	regulation of metanephric nephron tubule epithelial cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000249075	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Wang H et al. (2010) STAT1 activation regulates proliferation and differentiation of renal progenitors. Cell Signal 22: 1717-26 PubMed GONUTS page
↑ Watanabe M et al. (2002) Regulation of the Lim-1 gene is mediated through conserved FAST-1/FoxH1 sites in the first intron. Dev Dyn 225: 448-56 PubMed GONUTS page
↑ ^3.0 ^3.1 Yoshino J et al. (2003) Leukemia inhibitory factor is involved in tubular regeneration after experimental acute renal failure. J Am Soc Nephrol 14: 3090-101 PubMed GONUTS page
↑ ^4.0 ^4.1 Simamura E et al. (2010) Maternal leukemia inhibitory factor (LIF) promotes fetal neurogenesis via a LIF-ACTH-LIF signaling relay pathway. Endocrinology 151: 1853-62 PubMed GONUTS page
↑ Sango K et al. (2008) Neuroprotective properties of ciliary neurotrophic factor for cultured adult rat dorsal root ganglion neurons. Histochem Cell Biol 130: 669-79 PubMed GONUTS page
↑ ^6.0 ^6.1 McColm JR et al. (2006) Exogenous leukemia inhibitory factor (LIF) attenuates retinal vascularization reducing cell proliferation not apoptosis. Exp Eye Res 83: 438-46 PubMed GONUTS page
↑ De Breuck S et al. (2006) Expression and function of leukaemia inhibitory factor and its receptor in normal and regenerating rat pancreas. Diabetologia 49: 108-16 PubMed GONUTS page
↑ Nakanishi M et al. (2007) Microglia-derived interleukin-6 and leukaemia inhibitory factor promote astrocytic differentiation of neural stem/progenitor cells. Eur J Neurosci 25: 649-58 PubMed GONUTS page
↑ Kanazawa H et al. (2010) Heart failure causes cholinergic transdifferentiation of cardiac sympathetic nerves via gp130-signaling cytokines in rodents. J Clin Invest 120: 408-21 PubMed GONUTS page

[PMID:20624457-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Wang H et al. (2010) STAT1 activation regulates proliferation and differentiation of renal progenitors. Cell Signal 22: 1717-26 PubMed GONUTS page

[PMID:12454922-1] Watanabe M et al. (2002) Regulation of the Lim-1 gene is mediated through conserved FAST-1/FoxH1 sites in the first intron. Dev Dyn 225: 448-56 PubMed GONUTS page

[PMID:14638908-2] 3.0 ^3.1 Yoshino J et al. (2003) Leukemia inhibitory factor is involved in tubular regeneration after experimental acute renal failure. J Am Soc Nephrol 14: 3090-101 PubMed GONUTS page

[PMID:20160138-3] 4.0 ^4.1 Simamura E et al. (2010) Maternal leukemia inhibitory factor (LIF) promotes fetal neurogenesis via a LIF-ACTH-LIF signaling relay pathway. Endocrinology 151: 1853-62 PubMed GONUTS page

[PMID:18679704-4] Sango K et al. (2008) Neuroprotective properties of ciliary neurotrophic factor for cultured adult rat dorsal root ganglion neurons. Histochem Cell Biol 130: 669-79 PubMed GONUTS page

[PMID:16643897-5] 6.0 ^6.1 McColm JR et al. (2006) Exogenous leukemia inhibitory factor (LIF) attenuates retinal vascularization reducing cell proliferation not apoptosis. Exp Eye Res 83: 438-46 PubMed GONUTS page

[PMID:16369772-6] De Breuck S et al. (2006) Expression and function of leukaemia inhibitory factor and its receptor in normal and regenerating rat pancreas. Diabetologia 49: 108-16 PubMed GONUTS page

[PMID:17328769-7] Nakanishi M et al. (2007) Microglia-derived interleukin-6 and leukaemia inhibitory factor promote astrocytic differentiation of neural stem/progenitor cells. Eur J Neurosci 25: 649-58 PubMed GONUTS page

[PMID:20051627-8] Kanazawa H et al. (2010) Heart failure causes cholinergic transdifferentiation of cardiac sympathetic nerves via gp130-signaling cytokines in rodents. J Clin Invest 120: 408-21 PubMed GONUTS page

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Species (Taxon ID)	Rattus norvegicus (Rat). (taxon:10116)
Gene Name(s)	Lif
Protein Name(s)	Leukemia inhibitory factor LIF Cholinergic neuronal differentiation factor
External Links
UniProt Identifier	LIF_RAT
UniProt Accessions	P17777,
EMBL	M32748,
PIR	A40078,
Pfam	PF01291,

RAT:LIF

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