RAT:KPCD

From GONUTS

Jump to: navigation, search

Species (Taxon ID)	Rattus norvegicus (Rat). ([1])
Gene Name(s)	Prkcd (synonyms: Pkcd)
Protein Name(s)	Protein kinase C delta type nPKC-delta
External Links
EMBL	M18330 AJ230617 AJ230618 AJ230619 AJ230620 AJ230621 AJ230622 AJ230623 AJ230624 AJ230625 AJ230626 AJ230627 AJ230628 AJ230629 AJ230630 AJ230631 AJ230632 AJ230633 AF219629 BC076505
IPI	IPI00212816 IPI00231534
PIR	A28163
RefSeq	NP_579841.1
UniGene	Rn.98279
PDB	1BDY
PDBsum	1BDY
ProteinModelPortal	P09215
SMR	P09215
STRING	P09215
PhosphoSite	P09215
PRIDE	P09215
Ensembl	ENSRNOT00000022279 ENSRNOT00000025858
GeneID	170538
KEGG	rno:170538
UCSC	AF219629
CTD	5580
RGD	67383
eggNOG	roNOG14957
GeneTree	ENSGT00590000082973
HOVERGEN	HBG108317
PhylomeDB	P09215
BRENDA	2.7.11.13
NextBio	621024
PMAP-CutDB	P09215
ArrayExpress	P09215
Genevestigator	P09215
GermOnline	ENSRNOG00000016346
GO	GO:0005829 GO:0005624 GO:0005739 GO:0005634 GO:0005886 GO:0005524 GO:0004699 GO:0046872 GO:0019901 GO:0070976 GO:0007568 GO:0015810 GO:0042149 GO:0032869 GO:0032963 GO:0006917 GO:0035556 GO:0046326 GO:0043406 GO:0043410 GO:0046777 GO:0043200 GO:0042493 GO:0045471 GO:0009749 GO:0009408 GO:0042542 GO:0001666 GO:0009612 GO:0014070
InterPro	IPR000961 IPR000008 IPR008973 IPR020454 IPR011009 IPR017892 IPR014376 IPR002219 IPR000719 IPR017441 IPR017442 IPR008271 IPR002290
KO	K06068
Pfam	PF00130 PF00069 PF00433
PIRSF	PIRSF000551
PRINTS	PR00008
SMART	SM00109 SM00239 SM00133 SM00220
SUPFAM	SSF49562 SSF56112
PROSITE	PS51285 PS50004 PS00107 PS50011 PS00108 PS00479 PS50081

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F	Seeded From UniProt
	GO:0001666	response to hypoxia	PMID:16936002^[1]	IEP: Inferred from Expression Pattern		P	Seeded From UniProt
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F	Seeded From UniProt
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	F	Seeded From UniProt
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000961	F	Seeded From UniProt
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	F	Seeded From UniProt
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008271	F	Seeded From UniProt
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017892	F	Seeded From UniProt
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0723	F	Seeded From UniProt
	GO:0004697	protein kinase C activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014376	F	Seeded From UniProt
	GO:0004697	protein kinase C activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:2.7.11.13	F	Seeded From UniProt
	GO:0004697	protein kinase C activity	PMID:9705215^[2]	IC: Inferred by Curator	GO:0005624	F	Seeded From UniProt
	GO:0004697	protein kinase C activity	PMID:9950866^[3]	IC: Inferred by Curator	GO:0005624	F	Seeded From UniProt
	GO:0004699	calcium-independent protein kinase C activity	PMID:1915352^[4]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0005515	protein binding	PMID:9514928^[5]	IPI: Inferred from Physical Interaction	RGD:708404	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000961	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017441	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017892	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F	Seeded From UniProt
	GO:0005624	membrane fraction	PMID:12388232^[6]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005624	membrane fraction	PMID:9705215^[2]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005624	membrane fraction	PMID:9950866^[3]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005634	nucleus	PMID:12663471^[7]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C	Seeded From UniProt
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C	Seeded From UniProt
	GO:0005737	cytoplasm	PMID:12663471^[7]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005739	mitochondrion	PMID:17008461^[8]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005829	cytosol	PMID:18945317^[9]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005829	cytosol	PMID:9705215^[2]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005829	cytosol	PMID:9950866^[3]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005886	plasma membrane	PMID:18945317^[9]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000961	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008271	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014376	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017892	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	PMID:1915352^[4]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0006468	protein phosphorylation	PMID:9705215^[2]	IC: Inferred by Curator	GO:0005624	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	PMID:9950866^[3]	IC: Inferred by Curator	GO:0005624	P	Seeded From UniProt
	GO:0006917	induction of apoptosis	PMID:12426377^[10]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0006979	response to oxidative stress	PMID:11576956^[11]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0007568	aging	PMID:17008461^[8]	IEP: Inferred from Expression Pattern		P	Seeded From UniProt
	GO:0009408	response to heat	PMID:16990486^[12]	IEP: Inferred from Expression Pattern		P	Seeded From UniProt
	GO:0009612	response to mechanical stimulus	PMID:17487266^[13]	IEP: Inferred from Expression Pattern		P	Seeded From UniProt
	GO:0009749	response to glucose stimulus	PMID:12960081^[14]	IEP: Inferred from Expression Pattern		P	Seeded From UniProt
	GO:0010243	response to organic nitrogen	PMID:17563398^[15]	IEP: Inferred from Expression Pattern		P	Seeded From UniProt
	GO:0014070	response to organic cyclic compound	PMID:11478406^[16]	IEP: Inferred from Expression Pattern		P	Seeded From UniProt
	GO:0015810	aspartate transport	PMID:17364745^[17]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0162	C	Seeded From UniProt
	GO:0016301	kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	F	Seeded From UniProt
	GO:0016310	phosphorylation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	P	Seeded From UniProt
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F	Seeded From UniProt
	GO:0016772	transferase activity, transferring phosphorus-containing groups	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F	Seeded From UniProt
	GO:0019901	protein kinase binding	PMID:15337529^[18]	IPI: Inferred from Physical Interaction	RGD:620795	F	Seeded From UniProt
	GO:0032869	cellular response to insulin stimulus	PMID:17046201^[19]	IEP: Inferred from Expression Pattern		P	Seeded From UniProt
	GO:0032963	collagen metabolic process	PMID:17728702^[20]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0035556	intracellular signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002219	P	Seeded From UniProt
	GO:0035556	intracellular signal transduction	PMID:11562372^[21]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0042149	cellular response to glucose starvation	PMID:17728702^[20]	IEP: Inferred from Expression Pattern		P	Seeded From UniProt
	GO:0042493	response to drug	PMID:17123493^[22]	IEP: Inferred from Expression Pattern		P	Seeded From UniProt
	GO:0042542	response to hydrogen peroxide	PMID:12226102^[23]	IEP: Inferred from Expression Pattern		P	Seeded From UniProt
	GO:0042542	response to hydrogen peroxide	PMID:17397968^[24]	IEP: Inferred from Expression Pattern		P	Seeded From UniProt
	GO:0043065	positive regulation of apoptosis	PMID:12663471^[7]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0043200	response to amino acid stimulus	PMID:17210758^[25]	IEP: Inferred from Expression Pattern		P	Seeded From UniProt
	GO:0043406	positive regulation of MAP kinase activity	PMID:16935468^[26]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0043410	positive regulation of MAPKKK cascade	PMID:12790799^[27]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0045471	response to ethanol	PMID:17728104^[28]	IEP: Inferred from Expression Pattern		P	Seeded From UniProt
	GO:0046326	positive regulation of glucose import	PMID:17098211^[29]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0046777	protein autophosphorylation	PMID:10085132^[30]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F	Seeded From UniProt
	GO:0070976	TIR domain binding	PMID:17161867^[31]	IPI: Inferred from Physical Interaction	UniProtKB:P58753	F	Seeded From UniProt
	GO:0034599	cellular response to oxidative stress	PMID:21696630^[32]	IDA: Inferred from Direct Assay		P	Figure 1 : A, B, C, D, & E.	complete
	GO:0006915	apoptosis	PMID:21696630^[32]	IMP: Inferred from Mutant Phenotype		P	Figure 1: F "PKCδ knockdown by RNAi almost comple- tely blocked the cell death induced by H2O2 at 120 min of treatment, demonstrating the pro-apoptotic function performed by PKCδ in N27 cells" .	complete
	GO:0010468	regulation of gene expression	PMID:21696630^[32]	IMP: Inferred from Mutant Phenotype		P	Figure 3: A, B & C. Show regulation of the activity of PKD1 by PKC delta.	complete
	GO:0006508	proteolysis	PMID:21696630^[32]	IDA: Inferred from Direct Assay		P	Figure 4: A & B	complete
	GO:0042325	regulation of phosphorylation	PMID:21696630^[32]	IDA: Inferred from Direct Assay		P	Fig. 4D	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Kolár F et al. (2007) Role of oxidative stress in PKC-delta upregulation and cardioprotection induced by chronic intermittent hypoxia. Am J Physiol Heart Circ Physiol 292: H224-30 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Mahadev K & Vemuri MC (1998) Selective changes in protein kinase C isoforms and phosphorylation of endogenous substrate proteins in rat cerebral cortex during pre- and postnatal ethanol exposure. Arch Biochem Biophys 356: 249-57 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Albert CJ & Ford DA (1999) Protein kinase C translocation and PKC-dependent protein phosphorylation during myocardial ischemia. Am J Physiol 276: H642-50 PubMed GONUTS page
↑ ^4.0 ^4.1 Olivier AR & Parker PJ (1991) Expression and characterization of protein kinase C-delta. Eur J Biochem 200: 805-10 PubMed GONUTS page
↑ Tokunaga C et al. (1998) Molecular cloning and characterization of a novel protein kinase C-interacting protein with structural motifs related to RBCC family proteins. Biochem Biophys Res Commun 244: 353-9 PubMed GONUTS page
↑ Carter RW & Kanagy NL (2003) Mechanism of enhanced calcium sensitivity and alpha 2-AR vasoreactivity in chronic NOS inhibition hypertension. Am J Physiol Heart Circ Physiol 284: H309-16 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Eitel K et al. (2003) Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells. Diabetes 52: 991-7 PubMed GONUTS page
↑ ^8.0 ^8.1 Hunter JC et al. (2007) Estrogen deficiency decreases ischemic tolerance in the aged rat heart: Roles of PKCdelta, PKCepsilon, Akt, and GSK3beta. Am J Physiol Regul Integr Comp Physiol 292: R800-9 PubMed GONUTS page
↑ ^9.0 ^9.1 Corsini E et al. (2009) Skin immunosenescence: decreased receptor for activated C kinase-1 expression correlates with defective tumour necrosis factor-alpha production in epidermal cells. Br J Dermatol 160: 16-25 PubMed GONUTS page
↑ DeVries TA et al. (2002) Nuclear import of PKCdelta is required for apoptosis: identification of a novel nuclear import sequence. EMBO J 21: 6050-60 PubMed GONUTS page
↑ Ha H et al. (2001) Activation of protein kinase c-delta and c-epsilon by oxidative stress in early diabetic rat kidney. Am J Kidney Dis 38: S204-7 PubMed GONUTS page
↑ Tan J et al. (2007) Effects of burn injury on myocardial signaling and cytokine secretion: Possible role of PKC. Am J Physiol Regul Integr Comp Physiol 292: R887-96 PubMed GONUTS page
↑ Bullard TA et al. (2007) Altered PKC expression and phosphorylation in response to the nature, direction, and magnitude of mechanical stretch. Can J Physiol Pharmacol 85: 243-50 PubMed GONUTS page
↑ Steiler TL et al. (2003) Effect of hyperglycemia on signal transduction in skeletal muscle from diabetic Goto-Kakizaki rats. Endocrinology 144: 5259-67 PubMed GONUTS page
↑ Clavijo C et al. (2007) Protein kinase Cdelta-dependent and -independent signaling in genotoxic response to treatment of desferroxamine, a hypoxia-mimetic agent. Am J Physiol Cell Physiol 292: C2150-60 PubMed GONUTS page
↑ Morabito D et al. (2001) Obesity is associated with impaired ventricular protein kinase C-MAP kinase signaling and altered ANP mRNA expression in the heart of adult Zucker rats. J Investig Med 49: 310-8 PubMed GONUTS page
↑ Bull ND et al. (2007) Protein kinase C-mediated modulation of glutamate transporter activity in rat retina. Curr Eye Res 32: 123-31 PubMed GONUTS page
↑ Rosenzweig T et al. (2004) Src tyrosine kinase regulates insulin-induced activation of protein kinase C (PKC) delta in skeletal muscle. Cell Signal 16: 1299-308 PubMed GONUTS page
↑ Horovitz-Fried M et al. (2007) Activation of the nuclear transcription factor SP-1 by insulin rapidly increases the expression of protein kinase C delta in skeletal muscle. Cell Signal 19: 556-62 PubMed GONUTS page
↑ ^20.0 ^20.1 Baccora MH et al. (2007) Effects of long-term elevated glucose on collagen formation by mesangial cells. Kidney Int 72: 1216-25 PubMed GONUTS page
↑ Mohammadi K et al. (2001) Role of protein kinase C in the signal pathways that link Na+/K+-ATPase to ERK1/2. J Biol Chem 276: 42050-6 PubMed GONUTS page
↑ Papparella I et al. (2007) Vitamin C prevents zidovudine-induced NAD(P)H oxidase activation and hypertension in the rat. Cardiovasc Res 73: 432-8 PubMed GONUTS page
↑ Saito S et al. (2002) Ligand-independent trans-activation of the platelet-derived growth factor receptor by reactive oxygen species requires protein kinase C-delta and c-Src. J Biol Chem 277: 44695-700 PubMed GONUTS page
↑ Anantharam V et al. (2007) Microarray analysis of oxidative stress regulated genes in mesencephalic dopaminergic neuronal cells: relevance to oxidative damage in Parkinson's disease. Neurochem Int 50: 834-47 PubMed GONUTS page
↑ Gäreskog M & Wentzel P (2007) N-Acetylcysteine and alpha-cyano-4-hydroxycinnamic acid alter protein kinase C (PKC)-delta and PKC-zeta and diminish dysmorphogenesis in rat embryos cultured with high glucose in vitro. J Endocrinol 192: 207-14 PubMed GONUTS page
↑ Hsieh HL et al. (2007) BK-induced COX-2 expression via PKC-delta-dependent activation of p42/p44 MAPK and NF-kappaB in astrocytes. Cell Signal 19: 330-40 PubMed GONUTS page
↑ Wrede CE et al. (2003) Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic beta-cells (INS-1). J Mol Endocrinol 30: 271-86 PubMed GONUTS page
↑ Zhang Y et al. (2007) Ethanol induces apoptosis in hepatocytes by a pathway involving novel protein kinase C isoforms. Cell Signal 19: 2339-50 PubMed GONUTS page
↑ Alpert E et al. (2007) Selective cyclooxygenase-2 inhibitors stimulate glucose transport in L6 myotubes in a protein kinase Cdelta-dependent manner. Biochem Pharmacol 73: 368-77 PubMed GONUTS page
↑ Stempka L et al. (1999) Requirements of protein kinase cdelta for catalytic function. Role of glutamic acid 500 and autophosphorylation on serine 643. J Biol Chem 274: 8886-92 PubMed GONUTS page
↑ Kubo-Murai M et al. (2007) Protein kinase Cdelta binds TIRAP/Mal to participate in TLR signaling. Mol Immunol 44: 2257-64 PubMed GONUTS page
↑ ^32.0 ^32.1 ^32.2 ^32.3 ^32.4 Asaithambi A et al. (2011) Protein kinase D1 (PKD1) activation mediates a compensatory protective response during early stages of oxidative stress-induced neuronal degeneration. Mol Neurodegener 6: 43 PubMed GONUTS page

[PMID:16936002-0] Kolár F et al. (2007) Role of oxidative stress in PKC-delta upregulation and cardioprotection induced by chronic intermittent hypoxia. Am J Physiol Heart Circ Physiol 292: H224-30 PubMed GONUTS page

[PMID:9705215-1] 2.0 ^2.1 ^2.2 ^2.3 Mahadev K & Vemuri MC (1998) Selective changes in protein kinase C isoforms and phosphorylation of endogenous substrate proteins in rat cerebral cortex during pre- and postnatal ethanol exposure. Arch Biochem Biophys 356: 249-57 PubMed GONUTS page

[PMID:9950866-2] 3.0 ^3.1 ^3.2 ^3.3 Albert CJ & Ford DA (1999) Protein kinase C translocation and PKC-dependent protein phosphorylation during myocardial ischemia. Am J Physiol 276: H642-50 PubMed GONUTS page

[PMID:1915352-3] 4.0 ^4.1 Olivier AR & Parker PJ (1991) Expression and characterization of protein kinase C-delta. Eur J Biochem 200: 805-10 PubMed GONUTS page

[PMID:9514928-4] Tokunaga C et al. (1998) Molecular cloning and characterization of a novel protein kinase C-interacting protein with structural motifs related to RBCC family proteins. Biochem Biophys Res Commun 244: 353-9 PubMed GONUTS page

[PMID:12388232-5] Carter RW & Kanagy NL (2003) Mechanism of enhanced calcium sensitivity and alpha 2-AR vasoreactivity in chronic NOS inhibition hypertension. Am J Physiol Heart Circ Physiol 284: H309-16 PubMed GONUTS page

[PMID:12663471-6] 7.0 ^7.1 ^7.2 Eitel K et al. (2003) Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells. Diabetes 52: 991-7 PubMed GONUTS page

[PMID:17008461-7] 8.0 ^8.1 Hunter JC et al. (2007) Estrogen deficiency decreases ischemic tolerance in the aged rat heart: Roles of PKCdelta, PKCepsilon, Akt, and GSK3beta. Am J Physiol Regul Integr Comp Physiol 292: R800-9 PubMed GONUTS page

[PMID:18945317-8] 9.0 ^9.1 Corsini E et al. (2009) Skin immunosenescence: decreased receptor for activated C kinase-1 expression correlates with defective tumour necrosis factor-alpha production in epidermal cells. Br J Dermatol 160: 16-25 PubMed GONUTS page

[PMID:12426377-9] DeVries TA et al. (2002) Nuclear import of PKCdelta is required for apoptosis: identification of a novel nuclear import sequence. EMBO J 21: 6050-60 PubMed GONUTS page

[PMID:11576956-10] Ha H et al. (2001) Activation of protein kinase c-delta and c-epsilon by oxidative stress in early diabetic rat kidney. Am J Kidney Dis 38: S204-7 PubMed GONUTS page

[PMID:16990486-11] Tan J et al. (2007) Effects of burn injury on myocardial signaling and cytokine secretion: Possible role of PKC. Am J Physiol Regul Integr Comp Physiol 292: R887-96 PubMed GONUTS page

[PMID:17487266-12] Bullard TA et al. (2007) Altered PKC expression and phosphorylation in response to the nature, direction, and magnitude of mechanical stretch. Can J Physiol Pharmacol 85: 243-50 PubMed GONUTS page

[PMID:12960081-13] Steiler TL et al. (2003) Effect of hyperglycemia on signal transduction in skeletal muscle from diabetic Goto-Kakizaki rats. Endocrinology 144: 5259-67 PubMed GONUTS page

[PMID:17563398-14] Clavijo C et al. (2007) Protein kinase Cdelta-dependent and -independent signaling in genotoxic response to treatment of desferroxamine, a hypoxia-mimetic agent. Am J Physiol Cell Physiol 292: C2150-60 PubMed GONUTS page

[PMID:11478406-15] Morabito D et al. (2001) Obesity is associated with impaired ventricular protein kinase C-MAP kinase signaling and altered ANP mRNA expression in the heart of adult Zucker rats. J Investig Med 49: 310-8 PubMed GONUTS page

[PMID:17364745-16] Bull ND et al. (2007) Protein kinase C-mediated modulation of glutamate transporter activity in rat retina. Curr Eye Res 32: 123-31 PubMed GONUTS page

[PMID:15337529-17] Rosenzweig T et al. (2004) Src tyrosine kinase regulates insulin-induced activation of protein kinase C (PKC) delta in skeletal muscle. Cell Signal 16: 1299-308 PubMed GONUTS page

[PMID:17046201-18] Horovitz-Fried M et al. (2007) Activation of the nuclear transcription factor SP-1 by insulin rapidly increases the expression of protein kinase C delta in skeletal muscle. Cell Signal 19: 556-62 PubMed GONUTS page

[PMID:17728702-19] 20.0 ^20.1 Baccora MH et al. (2007) Effects of long-term elevated glucose on collagen formation by mesangial cells. Kidney Int 72: 1216-25 PubMed GONUTS page

[PMID:11562372-20] Mohammadi K et al. (2001) Role of protein kinase C in the signal pathways that link Na+/K+-ATPase to ERK1/2. J Biol Chem 276: 42050-6 PubMed GONUTS page

[PMID:17123493-21] Papparella I et al. (2007) Vitamin C prevents zidovudine-induced NAD(P)H oxidase activation and hypertension in the rat. Cardiovasc Res 73: 432-8 PubMed GONUTS page

[PMID:12226102-22] Saito S et al. (2002) Ligand-independent trans-activation of the platelet-derived growth factor receptor by reactive oxygen species requires protein kinase C-delta and c-Src. J Biol Chem 277: 44695-700 PubMed GONUTS page

[PMID:17397968-23] Anantharam V et al. (2007) Microarray analysis of oxidative stress regulated genes in mesencephalic dopaminergic neuronal cells: relevance to oxidative damage in Parkinson's disease. Neurochem Int 50: 834-47 PubMed GONUTS page

[PMID:17210758-24] Gäreskog M & Wentzel P (2007) N-Acetylcysteine and alpha-cyano-4-hydroxycinnamic acid alter protein kinase C (PKC)-delta and PKC-zeta and diminish dysmorphogenesis in rat embryos cultured with high glucose in vitro. J Endocrinol 192: 207-14 PubMed GONUTS page

[PMID:16935468-25] Hsieh HL et al. (2007) BK-induced COX-2 expression via PKC-delta-dependent activation of p42/p44 MAPK and NF-kappaB in astrocytes. Cell Signal 19: 330-40 PubMed GONUTS page

[PMID:12790799-26] Wrede CE et al. (2003) Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic beta-cells (INS-1). J Mol Endocrinol 30: 271-86 PubMed GONUTS page

[PMID:17728104-27] Zhang Y et al. (2007) Ethanol induces apoptosis in hepatocytes by a pathway involving novel protein kinase C isoforms. Cell Signal 19: 2339-50 PubMed GONUTS page

[PMID:17098211-28] Alpert E et al. (2007) Selective cyclooxygenase-2 inhibitors stimulate glucose transport in L6 myotubes in a protein kinase Cdelta-dependent manner. Biochem Pharmacol 73: 368-77 PubMed GONUTS page

[PMID:10085132-29] Stempka L et al. (1999) Requirements of protein kinase cdelta for catalytic function. Role of glutamic acid 500 and autophosphorylation on serine 643. J Biol Chem 274: 8886-92 PubMed GONUTS page

[PMID:17161867-30] Kubo-Murai M et al. (2007) Protein kinase Cdelta binds TIRAP/Mal to participate in TLR signaling. Mol Immunol 44: 2257-64 PubMed GONUTS page

[PMID:21696630-31] 32.0 ^32.1 ^32.2 ^32.3 ^32.4 Asaithambi A et al. (2011) Protein kinase D1 (PKD1) activation mediates a compensatory protective response during early stages of oxidative stress-induced neuronal degeneration. Mol Neurodegener 6: 43 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

[26]

[27]

[28]

[29]

[30]

[31]

[32]

RAT:KPCD

Contents

Annotations

Notes

References

a

c

i

k

m

m cont.

n

p

r

t

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Cacao

Journal Clubs

page contributors

Toolbox