RAT:KCMA1

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Kcnma1 (synonyms: Kcnma)
Protein Name(s)	Calcium-activated potassium channel subunit alpha-1 BK channel BKCA alpha Calcium-activated potassium channel, subfamily M subunit alpha-1 K(VCA)alpha KCa1.1 Maxi K channel MaxiK Slo-alpha Slo1 Slowpoke homolog Slo homolog
External Links
UniProt	Q62976
EMBL	U93052 AF135265 U40603 U55995 AF083341 AY330290 AY330291 AY330292 AY330293 AY330294
RefSeq	NP_114016.1
UniGene	Rn.30616
ProteinModelPortal	Q62976
BioGrid	249823
DIP	DIP-40510N
IntAct	Q62976
MINT	MINT-1203282
BindingDB	Q62976
ChEMBL	CHEMBL5505
GuidetoPHARMACOLOGY	380
TCDB	1.A.1.3.2
PhosphoSite	Q62976
PaxDb	Q62976
GeneID	83731
KEGG	rno:83731
CTD	3778
RGD	620715
eggNOG	COG1226
HOVERGEN	HBG052222
InParanoid	Q62976
KO	K04936
PhylomeDB	Q62976
NextBio	616325
PRO	PR:Q62976
Proteomes	UP000002494
Genevestigator	Q62976
GO	GO:0016324 GO:0030425 GO:0005789 GO:0009897 GO:0043025 GO:0048471 GO:0005886 GO:0048787 GO:0043234 GO:0008076 GO:0015269 GO:0060072 GO:0046872 GO:0032403 GO:0042803 GO:0005249 GO:0071805 GO:0051289 GO:0042312 GO:0051592 GO:0031960 GO:0043627 GO:0001666 GO:0009268
Gene3D	3.40.50.720
InterPro	IPR005821 IPR003091 IPR003929 IPR016040 IPR003148
Pfam	PF03493 PF00520 PF02254
PRINTS	PR01449 PR00169

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0099507	ligand-gated ion channel activity involved in regulation of presynaptic membrane potential	PMID:11739569^[1]	ECO:0006054	pharmacological assay evidence used in manual assertion		F	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
enables	GO:0099507	ligand-gated ion channel activity involved in regulation of presynaptic membrane potential	PMID:11739569^[1]	ECO:0006013	patch-clamp recording evidence used in manual assertion		F	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0099059	integral component of presynaptic active zone membrane	PMID:11739569^[1]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:11739569^[1]	ECO:0006054	pharmacological assay evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:11739569^[1]	ECO:0006013	patch-clamp recording evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:11739569^[1]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:1904348	negative regulation of small intestine smooth muscle contraction	PMID:23647678^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097755	positive regulation of blood vessel diameter	PMID:23432816^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097746	regulation of blood vessel diameter	PMID:11157674^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0060072	large conductance calcium-activated potassium channel activity	PMID:17068255^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051592	response to calcium ion	PMID:15111404^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051289	protein homotetramerization	PMID:16045448^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0048787	presynaptic active zone membrane	PMID:11739569^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:10384881^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:15141163^[9]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2060 RGD:620829	F		Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	PMID:16102753^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	PMID:23653329^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:16045448^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:16045448^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:17068255^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031960	response to corticosteroid	PMID:16675526^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:16045448^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0015269	calcium-activated potassium channel activity	PMID:11964233^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:16045448^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0009268	response to pH	PMID:12719228^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	PMID:24051206^[15]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17068255^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:10384881^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0005739	mitochondrion	PMID:23754429^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:15528406^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060087	relaxation of vascular smooth muscle	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99923 PANTHER:PTN000002894 UniProtKB:O18866	P		Seeded From UniProt	complete
enables	GO:0060072	large conductance calcium-activated potassium channel activity	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99923 PANTHER:PTN002224803 RGD:620715 UniProtKB:Q12791	F		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99923 PANTHER:PTN000002875	C		Seeded From UniProt	complete
involved_in	GO:0042391	regulation of membrane potential	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99923 PANTHER:PTN000002872 UniProtKB:Q12791	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99923 PANTHER:PTN000002872 RGD:621106 UniProtKB:Q12791	C		Seeded From UniProt	complete
enables	GO:0015271	outward rectifier potassium channel activity	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000002872 WB:WBGene00004831	F		Seeded From UniProt	complete
enables	GO:0015269	calcium-activated potassium channel activity	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003429 MGI:MGI:99923 PANTHER:PTN002224803 RGD:620715 UniProtKB:Q12791 UniProtKB:Q28204 WB:WBGene00004830	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99923 PANTHER:PTN000002872 RGD:620715	C		Seeded From UniProt	complete
involved_in	GO:0099505	regulation of presynaptic membrane potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099507	P		Seeded From UniProt	complete
involved_in	GO:0099505	regulation of presynaptic membrane potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099507	P		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	F		Seeded From UniProt	complete
enables	GO:0005249	voltage-gated potassium channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028325	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P		Seeded From UniProt	complete
involved_in	GO:0006813	potassium ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003929 InterPro:IPR028325	P		Seeded From UniProt	complete
part_of	GO:0008076	voltage-gated potassium channel complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028325	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003929 InterPro:IPR005821	C		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P		Seeded From UniProt	complete
enables	GO:0060072	large conductance calcium-activated potassium channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR024939	F		Seeded From UniProt	complete
enables	GO:0005267	potassium channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0631	F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
involved_in	GO:0071805	potassium ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0631	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
enables	GO:0005244	voltage-gated ion channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0851	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0034765	regulation of ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0851	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0006813	potassium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0633	P		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Hu, H et al. (2001) Presynaptic Ca2+-activated K+ channels in glutamatergic hippocampal terminals and their role in spike repolarization and regulation of transmitter release. J. Neurosci. 21 9585-97 PubMed GONUTS page
↑ Jing, F et al. (2013) Relaxant effect of chloroquine in rat ileum: possible involvement of nitric oxide and BKCa. J. Pharm. Pharmacol. 65 847-54 PubMed GONUTS page
↑ Iozzi, D et al. (2013) Quercetin relaxes rat tail main artery partly via a PKG-mediated stimulation of KCa 1.1 channels. Acta Physiol (Oxf) 208 329-39 PubMed GONUTS page
↑ Marijic, J et al. (2001) Decreased expression of voltage- and Ca(2+)-activated K(+) channels in coronary smooth muscle during aging. Circ. Res. 88 210-6 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Berkefeld, H et al. (2006) BKCa-Cav channel complexes mediate rapid and localized Ca2+-activated K+ signaling. Science 314 615-20 PubMed GONUTS page
↑ Ha, TS et al. (2004) Functional effects of auxiliary beta4-subunit on rat large-conductance Ca(2+)-activated K(+) channel. Biophys. J. 86 2871-82 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Jo, S et al. (2005) Identification and functional characterization of cereblon as a binding protein for large-conductance calcium-activated potassium channel in rat brain. J. Neurochem. 94 1212-24 PubMed GONUTS page
↑ ^8.0 ^8.1 Mi, H et al. (1999) Identification and localization of Ca(2+)-activated K+ channels in rat sciatic nerve. Glia 26 166-75 PubMed GONUTS page
↑ Liu, G et al. (2004) Assembly of a Ca2+-dependent BK channel signaling complex by binding to beta2 adrenergic receptor. EMBO J. 23 2196-205 PubMed GONUTS page
↑ Zhu, N et al. (2005) Alternative splicing of Slo channel gene programmed by estrogen, progesterone and pregnancy. FEBS Lett. 579 4856-60 PubMed GONUTS page
↑ Chen, M et al. (2013) Activation of BKca channels mediates hippocampal neuronal death after reoxygenation and reperfusion. Mol. Neurobiol. 48 794-807 PubMed GONUTS page
↑ Lai, GJ & McCobb, DP (2006) Regulation of alternative splicing of Slo K+ channels in adrenal and pituitary during the stress-hyporesponsive period of rat development. Endocrinology 147 3961-7 PubMed GONUTS page
↑ Ding, JP & Lingle, CJ (2002) Steady-state and closed-state inactivation properties of inactivating BK channels. Biophys. J. 82 2448-65 PubMed GONUTS page
↑ Avdonin, V et al. (2003) Stimulatory action of internal protons on Slo1 BK channels. Biophys. J. 84 2969-80 PubMed GONUTS page
↑ Shi, L et al. (2013) Aging decreases the contribution of MaxiK channel in regulating vascular tone in mesenteric artery by unparallel downregulation of α- and β1-subunit expression. Mech. Ageing Dev. 134 416-25 PubMed GONUTS page
↑ Singh, H et al. (2013) MitoBK(Ca) is encoded by the Kcnma1 gene, and a splicing sequence defines its mitochondrial location. Proc. Natl. Acad. Sci. U.S.A. 110 10836-41 PubMed GONUTS page
↑ Williams, SE et al. (2004) Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel. Science 306 2093-7 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 ^18.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11739569-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Hu, H et al. (2001) Presynaptic Ca2+-activated K+ channels in glutamatergic hippocampal terminals and their role in spike repolarization and regulation of transmitter release. J. Neurosci. 21 9585-97 PubMed GONUTS page

[PMID:23647678-2] Jing, F et al. (2013) Relaxant effect of chloroquine in rat ileum: possible involvement of nitric oxide and BKCa. J. Pharm. Pharmacol. 65 847-54 PubMed GONUTS page

[PMID:23432816-3] Iozzi, D et al. (2013) Quercetin relaxes rat tail main artery partly via a PKG-mediated stimulation of KCa 1.1 channels. Acta Physiol (Oxf) 208 329-39 PubMed GONUTS page

[PMID:11157674-4] Marijic, J et al. (2001) Decreased expression of voltage- and Ca(2+)-activated K(+) channels in coronary smooth muscle during aging. Circ. Res. 88 210-6 PubMed GONUTS page

[PMID:17068255-5] 5.0 ^5.1 ^5.2 Berkefeld, H et al. (2006) BKCa-Cav channel complexes mediate rapid and localized Ca2+-activated K+ signaling. Science 314 615-20 PubMed GONUTS page

[PMID:15111404-6] Ha, TS et al. (2004) Functional effects of auxiliary beta4-subunit on rat large-conductance Ca(2+)-activated K(+) channel. Biophys. J. 86 2871-82 PubMed GONUTS page

[PMID:16045448-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Jo, S et al. (2005) Identification and functional characterization of cereblon as a binding protein for large-conductance calcium-activated potassium channel in rat brain. J. Neurochem. 94 1212-24 PubMed GONUTS page

[PMID:10384881-8] 8.0 ^8.1 Mi, H et al. (1999) Identification and localization of Ca(2+)-activated K+ channels in rat sciatic nerve. Glia 26 166-75 PubMed GONUTS page

[PMID:15141163-9] Liu, G et al. (2004) Assembly of a Ca2+-dependent BK channel signaling complex by binding to beta2 adrenergic receptor. EMBO J. 23 2196-205 PubMed GONUTS page

[PMID:16102753-10] Zhu, N et al. (2005) Alternative splicing of Slo channel gene programmed by estrogen, progesterone and pregnancy. FEBS Lett. 579 4856-60 PubMed GONUTS page

[PMID:23653329-11] Chen, M et al. (2013) Activation of BKca channels mediates hippocampal neuronal death after reoxygenation and reperfusion. Mol. Neurobiol. 48 794-807 PubMed GONUTS page

[PMID:16675526-12] Lai, GJ & McCobb, DP (2006) Regulation of alternative splicing of Slo K+ channels in adrenal and pituitary during the stress-hyporesponsive period of rat development. Endocrinology 147 3961-7 PubMed GONUTS page

[PMID:11964233-13] Ding, JP & Lingle, CJ (2002) Steady-state and closed-state inactivation properties of inactivating BK channels. Biophys. J. 82 2448-65 PubMed GONUTS page

[PMID:12719228-14] Avdonin, V et al. (2003) Stimulatory action of internal protons on Slo1 BK channels. Biophys. J. 84 2969-80 PubMed GONUTS page

[PMID:24051206-15] Shi, L et al. (2013) Aging decreases the contribution of MaxiK channel in regulating vascular tone in mesenteric artery by unparallel downregulation of α- and β1-subunit expression. Mech. Ageing Dev. 134 416-25 PubMed GONUTS page

[PMID:23754429-16] Singh, H et al. (2013) MitoBK(Ca) is encoded by the Kcnma1 gene, and a splicing sequence defines its mitochondrial location. Proc. Natl. Acad. Sci. U.S.A. 110 10836-41 PubMed GONUTS page

[PMID:15528406-17] Williams, SE et al. (2004) Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel. Science 306 2093-7 PubMed GONUTS page

[PMID:21873635-18] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 ^18.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:KCMA1

Contents

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Notes

References

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