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RAT:GPX1
Contents |
| Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
| Gene Name(s) | Gpx1 | |
| Protein Name(s) | Glutathione peroxidase 1
GPx-1 GSHPx-1 Cellular glutathione peroxidase | |
| External Links | ||
| UniProt | P04041 | |
| EMBL | M21210 X07365 X12367 S50336 S41066 AB004231 | |
| IPI | IPI00192301 | |
| PIR | A30793 | |
| RefSeq | NP_110453.3 | |
| UniGene | Rn.11323 | |
| ProteinModelPortal | P04041 | |
| PeroxiBase | 3730 | |
| PRIDE | P04041 | |
| GeneID | 24404 | |
| KEGG | rno:24404 | |
| UCSC | BC058438 | |
| CTD | 2876 | |
| RGD | 2729 | |
| eggNOG | maNOG16607 | |
| HOVERGEN | HBG004333 | |
| NextBio | 603207 | |
| Genevestigator | P04041 | |
| GO | GO:0005829 GO:0005634 GO:0005625 GO:0043295 GO:0004602 GO:0047066 GO:0008430 GO:0007568 GO:0006749 GO:0042744 GO:0032355 GO:0051593 GO:0009749 GO:0006982 GO:0035094 GO:0010269 | |
| InterPro | IPR000889 IPR012336 | |
| Gene3D | G3DSA:3.40.30.10 | |
| KO | K00432 | |
| PANTHER | PTHR11592 | |
| Pfam | PF00255 | |
| PIRSF | PIRSF000303 | |
| PRINTS | PR01011 | |
| SUPFAM | SSF52833 | |
| PROSITE | PS00460 PS00763 PS51355 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0004601 |
peroxidase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004602 |
glutathione peroxidase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004602 |
glutathione peroxidase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004602 |
glutathione peroxidase activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0004602 |
glutathione peroxidase activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0005625 |
soluble fraction |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005625 |
soluble fraction |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0086 |
C |
Seeded From UniProt |
|||
| GO:0005829 |
cytosol |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0006749 |
glutathione metabolic process |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0006979 |
response to oxidative stress |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006979 |
response to oxidative stress |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0006982 |
response to lipid hydroperoxide |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0007568 |
aging |
IEP: Inferred from Expression Pattern |
|
P |
Seeded From UniProt |
|||
| GO:0008430 |
selenium binding |
IMP: Inferred from Mutant Phenotype |
|
F |
Seeded From UniProt |
|||
| GO:0008430 |
selenium binding |
TAS: Traceable Author Statement |
|
F |
Seeded From UniProt |
|||
| GO:0009749 |
response to glucose stimulus |
IEP: Inferred from Expression Pattern |
|
P |
Seeded From UniProt |
|||
| GO:0010269 |
response to selenium ion |
IEP: Inferred from Expression Pattern |
|
P |
Seeded From UniProt |
|||
| GO:0014070 |
response to organic cyclic compound |
IEP: Inferred from Expression Pattern |
|
P |
Seeded From UniProt |
|||
| GO:0016491 |
oxidoreductase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0032355 |
response to estradiol stimulus |
IEP: Inferred from Expression Pattern |
|
P |
Seeded From UniProt |
|||
| GO:0035094 |
response to nicotine |
IEP: Inferred from Expression Pattern |
|
P |
Seeded From UniProt |
|||
| GO:0042744 |
hydrogen peroxide catabolic process |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0043295 |
glutathione binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0047066 |
phospholipid-hydroperoxide glutathione peroxidase activity |
IMP: Inferred from Mutant Phenotype |
|
F |
Seeded From UniProt |
|||
| GO:0051593 |
response to folic acid |
IEP: Inferred from Expression Pattern |
|
P |
Seeded From UniProt |
|||
| GO:0055114 |
oxidation-reduction process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0055114 |
oxidation-reduction process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
| |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Sunde RA et al. (2005) Dietary selenium requirements based on glutathione peroxidase-1 activity and mRNA levels and other Se-dependent parameters are not increased by pregnancy and lactation in rats. J Nutr 135: 2144-50 PubMed GONUTS page
- ↑ 2.0 2.1 Christensen MJ & Burgener KW (1992) Dietary selenium stabilizes glutathione peroxidase mRNA in rat liver. J Nutr 122: 1620-6 PubMed GONUTS page
- ↑ Lawrence RA & Burk RF (1976) Glutathione peroxidase activity in selenium-deficient rat liver. Biochem Biophys Res Commun 71: 952-8 PubMed GONUTS page
- ↑ Fujii T et al. (2002) Differential expression of glutathione reductase and cytosolic glutathione peroxidase, GPX1, in developing rat lungs and kidneys. Free Radic Res 36: 1041-9 PubMed GONUTS page
- ↑ Ho YS & Howard AJ (1992) Cloning and characterization of the rat glutathione peroxidase gene. FEBS Lett 301: 5-9 PubMed GONUTS page
- ↑ 6.0 6.1 Miyamoto S et al. (2003) Phospholipid hydroperoxides are detoxified by phospholipase A2 and GSH peroxidase in rat gastric mucosa. Lipids 38: 641-9 PubMed GONUTS page
- ↑ Weir CP & Robaire B (2007) Spermatozoa have decreased antioxidant enzymatic capacity and increased reactive oxygen species production during aging in the Brown Norway rat. J Androl 28: 229-40 PubMed GONUTS page
- ↑ Yoshimura S et al. (1988) Determination of nucleotide sequence of cDNA coding rat glutathione peroxidase and diminished expression of the mRNA in selenium deficient rat liver. Biochem Biophys Res Commun 154: 1024-8 PubMed GONUTS page
- ↑ Morrison J et al. (2004) Effect of high glucose on gene expression in mesangial cells: upregulation of the thiol pathway is an adaptational response. Physiol Genomics 17: 271-82 PubMed GONUTS page
- ↑ Schriever SC et al. (2009) Selenium requirements are higher for glutathione peroxidase-1 mRNA than gpx1 activity in rat testis. Exp Biol Med (Maywood) 234: 513-21 PubMed GONUTS page
- ↑ Yeste-Velasco M et al. (2008) DNA low-density array analysis of colchicine neurotoxicity in rat cerebellar granular neurons. Neurotoxicology 29: 309-17 PubMed GONUTS page
- ↑ Zhang L et al. (2007) Effect of oestrogen on reactive oxygen species production in the aortas of ovariectomized Dahl salt-sensitive rats. J Hypertens 25: 407-14 PubMed GONUTS page
- ↑ Bruin JE et al. (2008) Maternal nicotine exposure increases oxidative stress in the offspring. Free Radic Biol Med 44: 1919-25 PubMed GONUTS page
- ↑ Chanson A et al. (2005) Proteomic analysis reveals changes in the liver protein pattern of rats exposed to dietary folate deficiency. J Nutr 135: 2524-9 PubMed GONUTS page
