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RAT:FST
Contents |
| Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
| Gene Name(s) | Fst | |
| Protein Name(s) | Follistatin
FS Activin-binding protein | |
| External Links | ||
| UniProt | P21674 | |
| EMBL | M31591 M31586 M31587 M31588 M31589 M31590 S58913 | |
| IPI | IPI00205317 | |
| PIR | I57698 | |
| RefSeq | NP_036693.1 | |
| UniGene | Rn.162557 | |
| PDB | 1LR7 1LR8 1LR9 2ARP | |
| PDBsum | 1LR7 1LR8 1LR9 2ARP | |
| ProteinModelPortal | P21674 | |
| SMR | P21674 | |
| MINT | MINT-1787002 | |
| STRING | P21674 | |
| MEROPS | I01.966 | |
| Ensembl | ENSRNOT00000015680 | |
| GeneID | 24373 | |
| KEGG | rno:24373 | |
| CTD | 10468 | |
| RGD | 2633 | |
| eggNOG | roNOG06994 | |
| HOVERGEN | HBG051666 | |
| InParanoid | P21674 | |
| OMA | CEDIQCS | |
| OrthoDB | EOG4QRH47 | |
| PhylomeDB | P21674 | |
| NextBio | 603119 | |
| ArrayExpress | P21674 | |
| Genevestigator | P21674 | |
| GermOnline | ENSRNOG00000011631 | |
| GO | GO:0005576 GO:0048185 GO:0043395 GO:0046882 | |
| InterPro | IPR002212 IPR003645 IPR015369 IPR002350 IPR011497 IPR017878 | |
| Gene3D | G3DSA:3.90.290.10 | |
| KO | K04661 | |
| Pfam | PF09289 PF07648 | |
| SMART | SM00274 SM00280 | |
| PROSITE | PS00282 PS51465 PS51364 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000256759 |
P |
Seeded From UniProt |
|||
| GO:0002244 |
hemopoietic progenitor cell differentiation |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000256759 |
P |
Seeded From UniProt |
|||
| GO:0005488 |
binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005575 |
cellular component |
ND: No biological Data available |
|
C |
Seeded From UniProt |
|||
| GO:0005576 |
extracellular region |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005576 |
extracellular region |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0243 |
C |
Seeded From UniProt |
|||
| GO:0032926 |
negative regulation of activin receptor signaling pathway |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000256759 |
P |
Seeded From UniProt |
|||
| GO:0043395 |
heparan sulfate proteoglycan binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0046882 |
negative regulation of follicle-stimulating hormone secretion |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0048185 |
activin binding |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000256759 |
F |
Seeded From UniProt |
|||
| GO:0048185 |
activin binding |
TAS: Traceable Author Statement |
|
F |
Seeded From UniProt |
|||
| GO:0051798 |
positive regulation of hair follicle development |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000256759 |
P |
Seeded From UniProt |
|||
| GO:0014732 |
skeletal muscle atrophy |
IDA: Inferred from Direct Assay |
P |
Findings show follistatin expression increased during recovery phase of post-denervated muscle atrophy. Follistatin/Myostatin ratio can be used to track muscle recovery post nerve injury. Figure 3. |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Innis CA & Hyvönen M (2003) Crystal structures of the heparan sulfate-binding domain of follistatin. Insights into ligand binding. J Biol Chem 278: 39969-77 PubMed GONUTS page
- ↑ Shimasaki S et al. (1989) Follistatin gene expression in the ovary and extragonadal tissues. Mol Endocrinol 3: 651-9 PubMed GONUTS page
- ↑ Rossmanith W et al. (2002) Follistatin overexpression in rodent liver tumors: a possible mechanism to overcome activin growth control. Mol Carcinog 35: 1-5 PubMed GONUTS page
- ↑ Wu RH et al. (2011) A potential indicator of denervated muscle atrophy: the ratio of myostatin to follistatin in peripheral blood. Genet Mol Res 10: 3914-23 PubMed GONUTS page
