RAT:CD4

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Species (Taxon ID)	Rattus norvegicus (Rat). (taxon:10116)
Gene Name(s)	Cd4
Protein Name(s)	T-cell surface glycoprotein CD4 T-cell surface antigen T4/Leu-3 W3/25 antigen
External Links
UniProt Identifier	CD4_RAT
UniProt Accessions	P05540,
EMBL	M15768,
PIR	A27449,
RefSeq	NP_036837.1,
PDB	1CID,
Ensembl	ENSRNOT00000021915,
Pfam	PF05790, PF09191, PF00047, PF12104,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0001816	cytokine production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	P
	GO:0001948	glycoprotein binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000011653	F
	GO:0005788	endoplasmic reticulum lumen	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	C
	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	C
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	C
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000011653	C
	GO:0006948	induction by virus of host cell-cell fusion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000011653	P
	GO:0006955	immune response	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000973	P
	GO:0007155	cell adhesion	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008424	P
	GO:0007166	cell surface receptor linked signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	P
	GO:0008270	zinc ion binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000011653	F
	GO:0009897	external side of plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	C
	GO:0009986	cell surface	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000973	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016020	membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0162	C
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008424	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0019901	protein kinase binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000011653	F
	GO:0019901	protein kinase binding	PMID:1372996^[1]	IPI: Inferred from Physical Interaction	RGD:2641	F
	GO:0030217	T cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000011653	P
	GO:0030217	T cell differentiation	PMID:1533274^[2]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P01730	P
	GO:0032507	maintenance of protein location in cell	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000011653	P
	GO:0042110	T cell activation	PMID:10458478^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0042803	protein homodimerization activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000011653	F
	GO:0045058	T cell selection	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000011653	P
	GO:0045058	T cell selection	PMID:9551897^[4]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P01730	P
	GO:0045121	membrane raft	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	C
	GO:0045234	protein palmitoleylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000011653	P
	GO:0045860	positive regulation of protein kinase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000011653	P
	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	P
	GO:0050850	positive regulation of calcium-mediated signaling	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	P
	GO:0050863	regulation of T cell activation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000011653	P
	GO:0050870	positive regulation of T cell activation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	P
	GO:0051789	response to protein stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	P
	GO:0001816	cytokine production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	P
	GO:0001948	glycoprotein binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000011653	F
	GO:0005769	early endosome	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000011653	C
	GO:0005788	endoplasmic reticulum lumen	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	C
	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	C
	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000011653	C
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	C
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000011653	C
	GO:0006948	induction by virus of host cell-cell fusion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000011653	P
	GO:0006955	immune response	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000973	P
	GO:0007155	cell adhesion	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008424	P
	GO:0007166	cell surface receptor linked signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	P
	GO:0008270	zinc ion binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000011653	F
	GO:0009897	external side of plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	C
	GO:0009986	cell surface	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000973	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016020	membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0162	C
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008424	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0019059	initiation of viral infection	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000011653	P
	GO:0019901	protein kinase binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000011653	F
	GO:0019901	protein kinase binding	PMID:1372996^[1]	IPI: Inferred from Physical Interaction	RGD:2641	F
	GO:0030217	T cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000011653	P
	GO:0030217	T cell differentiation	PMID:1533274^[2]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P01730	P
	GO:0032507	maintenance of protein location in cell	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000011653	P
	GO:0042110	T cell activation	PMID:10458478^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0042803	protein homodimerization activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000011653	F
	GO:0045058	T cell selection	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000011653	P
	GO:0045058	T cell selection	PMID:9551897^[4]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P01730	P
	GO:0045121	membrane raft	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	C
	GO:0045234	protein palmitoleylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000011653	P
	GO:0045860	positive regulation of protein kinase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000011653	P
	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	P
	GO:0050850	positive regulation of calcium-mediated signaling	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	P
	GO:0050863	regulation of T cell activation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000011653	P
	GO:0050870	positive regulation of T cell activation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	P
	GO:0051789	response to protein stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Beyers AD et al. (1992) Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5. Proc Natl Acad Sci U S A 89: 2945-9 PubMed GONUTS page
↑ ^2.0 ^2.1 Seong RH et al. (1992) Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail. Nature 356: 718-20 PubMed GONUTS page
↑ ^3.0 ^3.1 Nakatsuji T (1999) Better-surviving liver grafts by the injection of anti-CD2 antibody: the important roles of host CD8+ and CD2+CD28+ T cells in chronic graft rejection and beta type platelet-derived growth factor receptor (PDGFR-beta) expression on apoptotic liver grafts. Tohoku J Exp Med 187: 215-25 PubMed GONUTS page
↑ ^4.0 ^4.1 Frank GD & Parnes JR (1998) The level of CD4 surface protein influences T cell selection in the thymus. J Immunol 160: 634-42 PubMed GONUTS page

[PMID:1372996-0] 1.0 ^1.1 Beyers AD et al. (1992) Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5. Proc Natl Acad Sci U S A 89: 2945-9 PubMed GONUTS page

[PMID:1533274-1] 2.0 ^2.1 Seong RH et al. (1992) Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail. Nature 356: 718-20 PubMed GONUTS page

[PMID:10458478-2] 3.0 ^3.1 Nakatsuji T (1999) Better-surviving liver grafts by the injection of anti-CD2 antibody: the important roles of host CD8+ and CD2+CD28+ T cells in chronic graft rejection and beta type platelet-derived growth factor receptor (PDGFR-beta) expression on apoptotic liver grafts. Tohoku J Exp Med 187: 215-25 PubMed GONUTS page

[PMID:9551897-3] 4.0 ^4.1 Frank GD & Parnes JR (1998) The level of CD4 surface protein influences T cell selection in the thymus. J Immunol 160: 634-42 PubMed GONUTS page

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RAT:CD4

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