RAT:BAX

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005737	cytoplasm	PMID:16321138^[1]	IDA: Inferred from Direct Assay		C
	GO:0007008	outer mitochondrial membrane organization	PMID:12460673^[2]	IDA: Inferred from Direct Assay		P
	GO:0006915	apoptosis	PMID:18817839^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0005739	mitochondrion	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0496	C
	GO:0005737	cytoplasm	PMID:16084019^[4]	IMP: Inferred from Mutant Phenotype		C
	GO:0006917	induction of apoptosis	PMID:16084019^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0045333	cellular respiration	PMID:12460673^[2]	IDA: Inferred from Direct Assay		P
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0046688	response to copper ion	PMID:18289470^[5]	IEP: Inferred from Expression Pattern		P
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0005739	mitochondrion	PMID:15902200^[6]	IDA: Inferred from Direct Assay		C
	GO:0051412	response to corticosterone stimulus	PMID:17562391^[7]	IEP: Inferred from Expression Pattern		P
	GO:0031072	heat shock protein binding	PMID:16579988^[8]	IPI: Inferred from Physical Interaction		F
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0001541	ovarian follicle development	PMID:17570453^[9]	IEP: Inferred from Expression Pattern		P
	GO:0005739	mitochondrion	PMID:16579988^[8]	IDA: Inferred from Direct Assay		C
	GO:0042981	regulation of apoptosis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002475	P
	GO:0051400	BH domain binding	PMID:9356461^[10]	IPI: Inferred from Physical Interaction		F
	GO:0042981	regulation of apoptosis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020717	P
	GO:0005739	mitochondrion	PMID:16321138^[1]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	PMID:15902200^[6]	IDA: Inferred from Direct Assay		C
	GO:0046982	protein heterodimerization activity	PMID:16579988^[8]	IPI: Inferred from Physical Interaction		F
	GO:0042220	response to cocaine	PMID:17084983^[11]	IEP: Inferred from Expression Pattern		P
	GO:0034349	glial cell apoptosis	PMID:18931364^[12]	IEP: Inferred from Expression Pattern		P
	GO:0042981	regulation of apoptosis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020728	P
	GO:0001836	release of cytochrome c from mitochondria	PMID:16084019^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0005741	mitochondrial outer membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0172	C
	GO:0042981	regulation of apoptosis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000712	P
	GO:0005515	protein binding	PMID:15004018^[13]	IPI: Inferred from Physical Interaction		F
	GO:0005829	cytosol	PMID:16579988^[8]	IDA: Inferred from Direct Assay		C
	GO:0051087	chaperone binding	PMID:12070120^[14]	IPI: Inferred from Physical Interaction		F
	GO:0046982	protein heterodimerization activity	PMID:9356461^[10]	IPI: Inferred from Physical Interaction		F
	GO:0031966	mitochondrial membrane	PMID:16084019^[4]	IMP: Inferred from Mutant Phenotype		C
	GO:0005737	cytoplasm	PMID:15341589^[15]	IDA: Inferred from Direct Assay		C
	GO:0005741	mitochondrial outer membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1000	C
	GO:0006915	apoptosis	PMID:11751624^[16]	IEP: Inferred from Expression Pattern		P
	GO:0031072	heat shock protein binding	PMID:12070120^[14]	IPI: Inferred from Physical Interaction		F
	GO:0008635	activation of caspase activity by cytochrome c	PMID:12460673^[2]	TAS: Traceable Author Statement		P
	GO:0005739	mitochondrion	PMID:15341589^[15]	IDA: Inferred from Direct Assay		C
	GO:0042493	response to drug	PMID:17784886^[17]	IEP: Inferred from Expression Pattern		P
	GO:0006915	apoptosis	PMID:18959742^[18]	IEP: Inferred from Expression Pattern		P
	GO:0042981	regulation of apoptosis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020726	P
	GO:0007007	inner mitochondrial membrane organization	PMID:12460673^[2]	IDA: Inferred from Direct Assay		P
	GO:0006915	apoptosis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0053	P
	GO:0009408	response to heat	PMID:11090436^[19]	IDA: Inferred from Direct Assay		P	Fig. 3) A redistribution of Bax from the cytoplasm to the nuclear periphery was observed in rats that had been exposed once to short-term local testicular heating.	complete
	GO:0001101	response to acid	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0001541	ovarian follicle development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0001541	ovarian follicle development	PMID:17570453^[9]	IEP: Inferred from Expression Pattern		P
	GO:0001764	neuron migration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0001776	leukocyte homeostasis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0001777	T cell homeostatic proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0001782	B cell homeostasis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0001783	B cell apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0001822	kidney development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0001836	release of cytochrome c from mitochondria	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0001836	release of cytochrome c from mitochondria	PMID:16084019^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0001844	protein insertion into mitochondrial membrane involved in induction of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0001974	blood vessel remodeling	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0002262	myeloid cell homeostasis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0002352	B cell negative selection	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0002358	B cell homeostatic proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0002904	positive regulation of B cell apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0005515	protein binding	PMID:15004018^[13]	IPI: Inferred from Physical Interaction	RGD:2199	F
	GO:0005622	intracellular	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	C
	GO:0005625	soluble fraction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005737	cytoplasm	PMID:15341589^[15]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	PMID:16321138^[1]	IDA: Inferred from Direct Assay		C
	GO:0005739	mitochondrion	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0496	C
	GO:0005739	mitochondrion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	C
	GO:0005739	mitochondrion	PMID:15341589^[15]	IDA: Inferred from Direct Assay		C
	GO:0005739	mitochondrion	PMID:15902200^[6]	IDA: Inferred from Direct Assay		C
	GO:0005739	mitochondrion	PMID:16321138^[1]	IDA: Inferred from Direct Assay		C
	GO:0005739	mitochondrion	PMID:16579988^[8]	IDA: Inferred from Direct Assay		C
	GO:0005741	mitochondrial outer membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1000	C
	GO:0005741	mitochondrial outer membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	C
	GO:0005741	mitochondrial outer membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0172	C
	GO:0005783	endoplasmic reticulum	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	C
	GO:0005829	cytosol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	C
	GO:0005829	cytosol	PMID:15902200^[6]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	PMID:16084019^[4]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	PMID:16579988^[8]	IDA: Inferred from Direct Assay		C
	GO:0006687	glycosphingolipid metabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0006808	regulation of nitrogen utilization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0006915	apoptosis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0053	P
	GO:0006915	apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0006915	apoptosis	PMID:11751624^[16]	IEP: Inferred from Expression Pattern		P
	GO:0006915	apoptosis	PMID:18817839^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0006915	apoptosis	PMID:18959742^[18]	IEP: Inferred from Expression Pattern		P
	GO:0006917	induction of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0006917	induction of apoptosis	PMID:16084019^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0006919	activation of caspase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0006974	response to DNA damage stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0007007	inner mitochondrial membrane organization	PMID:12460673^[2]	IDA: Inferred from Direct Assay		P
	GO:0007008	outer mitochondrial membrane organization	PMID:12460673^[2]	IDA: Inferred from Direct Assay		P
	GO:0007281	germ cell development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0007283	spermatogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0007399	nervous system development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0007420	brain development	PMID:18058945^[20]	IEP: Inferred from Expression Pattern		P
	GO:0007548	sex differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0008283	cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0008285	negative regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0008584	male gonad development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0008624	induction of apoptosis by extracellular signals	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0008629	induction of apoptosis by intracellular signals	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0008635	activation of caspase activity by cytochrome c	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0008635	activation of caspase activity by cytochrome c	PMID:12460673^[2]	TAS: Traceable Author Statement		P
	GO:0008637	apoptotic mitochondrial changes	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0009566	fertilization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0009611	response to wounding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0009636	response to toxin	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0009791	post-embryonic development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0010212	response to ionizing radiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0010332	response to gamma radiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0010524	positive regulation of calcium ion transport into cytosol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0019987	negative regulation of anti-apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0021854	hypothalamus development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0021987	cerebral cortex development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0030264	nuclear fragmentation involved in apoptotic nuclear change	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0031072	heat shock protein binding	PMID:12070120^[14]	IPI: Inferred from Physical Interaction	RGD:621314	F
	GO:0031072	heat shock protein binding	PMID:16579988^[8]	IPI: Inferred from Physical Interaction	RGD:621314	F
	GO:0031558	induction of apoptosis in response to chemical stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0031966	mitochondrial membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	C
	GO:0031966	mitochondrial membrane	PMID:16084019^[4]	IDA: Inferred from Direct Assay		C
	GO:0032471	reduction of endoplasmic reticulum calcium ion concentration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0033137	negative regulation of peptidyl-serine phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0033599	regulation of mammary gland epithelial cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0034349	glial cell apoptosis	PMID:18931364^[12]	IEP: Inferred from Expression Pattern		P
	GO:0034644	cellular response to UV	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0035108	limb morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0035234	germ cell programmed cell death	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0042220	response to cocaine	PMID:17084983^[11]	IEP: Inferred from Expression Pattern		P
	GO:0042475	odontogenesis of dentine-containing tooth	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0042493	response to drug	PMID:17784886^[17]	IEP: Inferred from Expression Pattern		P
	GO:0042803	protein homodimerization activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	F
	GO:0042981	regulation of apoptosis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000712	P
	GO:0042981	regulation of apoptosis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002475	P
	GO:0042981	regulation of apoptosis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020717	P
	GO:0042981	regulation of apoptosis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020726	P
	GO:0042981	regulation of apoptosis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020728	P
	GO:0043065	positive regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0043281	regulation of caspase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0043524	negative regulation of neuron apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0043525	positive regulation of neuron apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0044445	cytosolic part	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	C
	GO:0045136	development of secondary sexual characteristics	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0045333	cellular respiration	PMID:12460673^[2]	IDA: Inferred from Direct Assay		P
	GO:0046666	retinal cell programmed cell death	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0046688	response to copper ion	PMID:18289470^[5]	IEP: Inferred from Expression Pattern		P
	GO:0046982	protein heterodimerization activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	F
	GO:0046982	protein heterodimerization activity	PMID:16579988^[8]	IPI: Inferred from Physical Interaction	RGD:621314	F
	GO:0046982	protein heterodimerization activity	PMID:9356461^[10]	IPI: Inferred from Physical Interaction	RGD:2199	F
	GO:0046982	protein heterodimerization activity	PMID:9356461^[10]	IPI: Inferred from Physical Interaction	RGD:2200	F
	GO:0046982	protein heterodimerization activity	PMID:9356461^[10]	IPI: Inferred from Physical Interaction	RGD:620525	F
	GO:0046982	protein heterodimerization activity	PMID:9356461^[10]	IPI: Inferred from Physical Interaction	RGD:620621	F
	GO:0046982	protein heterodimerization activity	PMID:9356461^[10]	IPI: Inferred from Physical Interaction	RGD:620717	F
	GO:0048087	positive regulation of developmental pigmentation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0048147	negative regulation of fibroblast proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0048515	spermatid differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0048597	post-embryonic camera-type eye morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0048678	response to axon injury	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0048872	homeostasis of number of cells	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0048873	homeostasis of number of cells within a tissue	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0051087	chaperone binding	PMID:12070120^[14]	IPI: Inferred from Physical Interaction	RGD:621314	F
	GO:0051260	protein homooligomerization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0051400	BH domain binding	PMID:9356461^[10]	IPI: Inferred from Physical Interaction	RGD:2199	F
	GO:0051400	BH domain binding	PMID:9356461^[10]	IPI: Inferred from Physical Interaction	RGD:2200	F
	GO:0051400	BH domain binding	PMID:9356461^[10]	IPI: Inferred from Physical Interaction	RGD:620525	F
	GO:0051400	BH domain binding	PMID:9356461^[10]	IPI: Inferred from Physical Interaction	RGD:620621	F
	GO:0051400	BH domain binding	PMID:9356461^[10]	IPI: Inferred from Physical Interaction	RGD:620717	F
	GO:0051402	neuron apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0051412	response to corticosterone stimulus	PMID:17562391^[7]	IEP: Inferred from Expression Pattern		P
	GO:0051434	BH3 domain binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	F
	GO:0051726	regulation of cell cycle	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0060041	retina development in camera-type eye	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0060058	positive regulation of apoptosis involved in mammary gland involution	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0060068	vagina development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
	GO:0070059	apoptosis in response to endoplasmic reticulum stress	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033093	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Capano M & Crompton M (2006) Bax translocates to mitochondria of heart cells during simulated ischaemia: involvement of AMP-activated and p38 mitogen-activated protein kinases. Biochem J 395: 57-64 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Appaix F et al. (2002) Bax and heart mitochondria: uncoupling and inhibition of respiration without permeability transition. Biochim Biophys Acta 1556: 155-67 PubMed GONUTS page
↑ ^3.0 ^3.1 Song Y et al. (2008) p,p'-DDE induces mitochondria-mediated apoptosis of cultured rat Sertoli cells. Toxicology 253: 53-61 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Lin CH et al. (2005) Bax-regulated mitochondria-mediated apoptosis is responsible for the in vitro ischemia induced neuronal cell death of Sprague Dawley rat. Neurosci Lett 387: 22-7 PubMed GONUTS page
↑ ^5.0 ^5.1 Li YW et al. (2008) [Excessive copper induces hepatocyte apoptosis and affects Bax and Bcl-2 expression in rat liver]. Zhongguo Dang Dai Er Ke Za Zhi 10: 42-6 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Birse-Archbold JL et al. (2005) Differential profile of Nix upregulation and translocation during hypoxia/ischaemia in vivo versus in vitro. J Cereb Blood Flow Metab 25: 1356-65 PubMed GONUTS page
↑ ^7.0 ^7.1 Yoshimura A et al. (2007) Influence of age or circadian time on Bcl-2 and Bax mRNA expression in the rat hippocampus after corticosterone exposure. Brain Res Bull 73: 254-8 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 Kim HS et al. (2006) Heat shock protein 60 modified with O-linked N-acetylglucosamine is involved in pancreatic beta-cell death under hyperglycemic conditions. FEBS Lett 580: 2311-6 PubMed GONUTS page
↑ ^9.0 ^9.1 Gürsoy E et al. (2008) Expression and localisation of Bcl-2 and Bax proteins in developing rat ovary. Res Vet Sci 84: 56-61 PubMed GONUTS page
↑ ^10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 Hsu SY et al. (1997) Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Proc Natl Acad Sci U S A 94: 12401-6 PubMed GONUTS page
↑ ^11.0 ^11.1 Dey S et al. (2007) Cocaine exposure in vitro induces apoptosis in fetal locus coeruleus neurons by altering the Bax/Bcl-2 ratio and through caspase-3 apoptotic signaling. Neuroscience 144: 509-21 PubMed GONUTS page
↑ ^12.0 ^12.1 Bhattacharjee M et al. (2008) Bax and Bid act in synergy to bring about T11TS-mediated glioma apoptosis via the release of mitochondrial cytochrome c and subsequent caspase activation. Int Immunol 20: 1489-505 PubMed GONUTS page
↑ ^13.0 ^13.1 Wang J et al. (2004) Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria. J Biol Chem 279: 19948-54 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Kirchhoff SR et al. (2002) Cytosolic heat shock protein 60, apoptosis, and myocardial injury. Circulation 105: 2899-904 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 Hu XL et al. (2004) Dynamic changes of the anti- and pro-apoptotic proteins Bcl-w, Bcl-2, and Bax with Smac/Diablo mitochondrial release after photothrombotic ring stroke in rats. Eur J Neurosci 20: 1177-88 PubMed GONUTS page
↑ ^16.0 ^16.1 Van de Casteele M et al. (2002) Specific expression of Bax-omega in pancreatic beta-cells is down-regulated by cytokines before the onset of apoptosis. Endocrinology 143: 320-6 PubMed GONUTS page
↑ ^17.0 ^17.1 Yu W et al. (2007) Angiotension II receptor 1 blocker modifies the expression of apoptosis-related proteins and transforming growth factor-beta1 in prostate tissue of spontaneously hypertensive rats. BJU Int 100: 1161-5 PubMed GONUTS page
↑ ^18.0 ^18.1 Onoue S et al. (2008) Pituitary adenylate cyclase-activating polypeptide attenuates streptozotocin-induced apoptotic death of RIN-m5F cells through regulation of Bcl-2 family protein mRNA expression. FEBS J 275: 5542-51 PubMed GONUTS page
↑ Yamamoto CM et al. (2000) Redistribution of Bax is an early step in an apoptotic pathway leading to germ cell death in rats, triggered by mild testicular hyperthermia. Biol Reprod 63: 1683-90 PubMed GONUTS page
↑ Soane L et al. (2008) Postnatal developmental regulation of Bcl-2 family proteins in brain mitochondria. J Neurosci Res 86: 1267-76 PubMed GONUTS page

[PMID:16321138-0] 1.0 ^1.1 ^1.2 ^1.3 Capano M & Crompton M (2006) Bax translocates to mitochondria of heart cells during simulated ischaemia: involvement of AMP-activated and p38 mitogen-activated protein kinases. Biochem J 395: 57-64 PubMed GONUTS page

[PMID:12460673-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Appaix F et al. (2002) Bax and heart mitochondria: uncoupling and inhibition of respiration without permeability transition. Biochim Biophys Acta 1556: 155-67 PubMed GONUTS page

[PMID:18817839-2] 3.0 ^3.1 Song Y et al. (2008) p,p'-DDE induces mitochondria-mediated apoptosis of cultured rat Sertoli cells. Toxicology 253: 53-61 PubMed GONUTS page

[PMID:16084019-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Lin CH et al. (2005) Bax-regulated mitochondria-mediated apoptosis is responsible for the in vitro ischemia induced neuronal cell death of Sprague Dawley rat. Neurosci Lett 387: 22-7 PubMed GONUTS page

[PMID:18289470-4] 5.0 ^5.1 Li YW et al. (2008) [Excessive copper induces hepatocyte apoptosis and affects Bax and Bcl-2 expression in rat liver]. Zhongguo Dang Dai Er Ke Za Zhi 10: 42-6 PubMed GONUTS page

[PMID:15902200-5] 6.0 ^6.1 ^6.2 ^6.3 Birse-Archbold JL et al. (2005) Differential profile of Nix upregulation and translocation during hypoxia/ischaemia in vivo versus in vitro. J Cereb Blood Flow Metab 25: 1356-65 PubMed GONUTS page

[PMID:17562391-6] 7.0 ^7.1 Yoshimura A et al. (2007) Influence of age or circadian time on Bcl-2 and Bax mRNA expression in the rat hippocampus after corticosterone exposure. Brain Res Bull 73: 254-8 PubMed GONUTS page

[PMID:16579988-7] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 Kim HS et al. (2006) Heat shock protein 60 modified with O-linked N-acetylglucosamine is involved in pancreatic beta-cell death under hyperglycemic conditions. FEBS Lett 580: 2311-6 PubMed GONUTS page

[PMID:17570453-8] 9.0 ^9.1 Gürsoy E et al. (2008) Expression and localisation of Bcl-2 and Bax proteins in developing rat ovary. Res Vet Sci 84: 56-61 PubMed GONUTS page

[PMID:9356461-9] 10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 Hsu SY et al. (1997) Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Proc Natl Acad Sci U S A 94: 12401-6 PubMed GONUTS page

[PMID:17084983-10] 11.0 ^11.1 Dey S et al. (2007) Cocaine exposure in vitro induces apoptosis in fetal locus coeruleus neurons by altering the Bax/Bcl-2 ratio and through caspase-3 apoptotic signaling. Neuroscience 144: 509-21 PubMed GONUTS page

[PMID:18931364-11] 12.0 ^12.1 Bhattacharjee M et al. (2008) Bax and Bid act in synergy to bring about T11TS-mediated glioma apoptosis via the release of mitochondrial cytochrome c and subsequent caspase activation. Int Immunol 20: 1489-505 PubMed GONUTS page

[PMID:15004018-12] 13.0 ^13.1 Wang J et al. (2004) Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria. J Biol Chem 279: 19948-54 PubMed GONUTS page

[PMID:12070120-13] 14.0 ^14.1 ^14.2 ^14.3 Kirchhoff SR et al. (2002) Cytosolic heat shock protein 60, apoptosis, and myocardial injury. Circulation 105: 2899-904 PubMed GONUTS page

[PMID:15341589-14] 15.0 ^15.1 ^15.2 ^15.3 Hu XL et al. (2004) Dynamic changes of the anti- and pro-apoptotic proteins Bcl-w, Bcl-2, and Bax with Smac/Diablo mitochondrial release after photothrombotic ring stroke in rats. Eur J Neurosci 20: 1177-88 PubMed GONUTS page

[PMID:11751624-15] 16.0 ^16.1 Van de Casteele M et al. (2002) Specific expression of Bax-omega in pancreatic beta-cells is down-regulated by cytokines before the onset of apoptosis. Endocrinology 143: 320-6 PubMed GONUTS page

[PMID:17784886-16] 17.0 ^17.1 Yu W et al. (2007) Angiotension II receptor 1 blocker modifies the expression of apoptosis-related proteins and transforming growth factor-beta1 in prostate tissue of spontaneously hypertensive rats. BJU Int 100: 1161-5 PubMed GONUTS page

[PMID:18959742-17] 18.0 ^18.1 Onoue S et al. (2008) Pituitary adenylate cyclase-activating polypeptide attenuates streptozotocin-induced apoptotic death of RIN-m5F cells through regulation of Bcl-2 family protein mRNA expression. FEBS J 275: 5542-51 PubMed GONUTS page

[PMID:11090436-18] Yamamoto CM et al. (2000) Redistribution of Bax is an early step in an apoptotic pathway leading to germ cell death in rats, triggered by mild testicular hyperthermia. Biol Reprod 63: 1683-90 PubMed GONUTS page

[PMID:18058945-19] Soane L et al. (2008) Postnatal developmental regulation of Bcl-2 family proteins in brain mitochondria. J Neurosci Res 86: 1267-76 PubMed GONUTS page

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Species (Taxon ID)	Rattus norvegicus (Rat). (taxon:10116)
Gene Name(s)	Bax
Protein Name(s)	Apoptosis regulator BAX
External Links
UniProt Identifier	BAX_RAT
UniProt Accessions	Q63690, Q62995, Q64383,
EMBL	U49729, U59184, U32098, S76511,
PIR	I53295,
RefSeq	NP_058755.1,
Pfam	PF00452,

RAT:BAX

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