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RAT:BAX

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Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) Bax
Protein Name(s) Apoptosis regulator BAX
External Links
UniProt Q63690
EMBL U49729
U59184
U32098
S76511
PIR I53295
UniGene Rn.10668
Rn.232358
ProteinModelPortal Q63690
SMR Q63690
BioGrid 246997
IntAct Q63690
MINT MINT-1541764
PaxDb Q63690
PRIDE Q63690
UCSC RGD:2192
RGD 2192
eggNOG NOG46695
HOGENOM HOG000095178
HOVERGEN HBG003606
InParanoid Q63690
PhylomeDB Q63690
NextBio 13955757
PRO PR:Q63690
Proteomes UP000002494
Genevestigator Q63690
GO GO:0097144
GO:0097136
GO:0005737
GO:0005829
GO:0005789
GO:0031966
GO:0005741
GO:0005757
GO:0005739
GO:0005634
GO:0046930
GO:0051400
GO:0051434
GO:0015267
GO:0051087
GO:0031072
GO:0008289
GO:0032403
GO:0046982
GO:0042803
GO:0006919
GO:0008635
GO:0008637
GO:0006915
GO:0097190
GO:0001783
GO:0007420
GO:0045333
GO:0010248
GO:0097192
GO:0034349
GO:0007007
GO:0097193
GO:0008630
GO:0070059
GO:0043653
GO:0008053
GO:0032091
GO:0007008
GO:0001541
GO:0043065
GO:1900103
GO:2001244
GO:0043525
GO:0032461
GO:0090200
GO:0051881
GO:0043496
GO:0001836
GO:0032976
GO:0042220
GO:0046688
GO:0051412
GO:0042493
GO:0009636
GO:1990009
GO:0006927
InterPro IPR026304
IPR002475
IPR020717
IPR020726
IPR020728
IPR026298
PANTHER PTHR11256
PTHR11256:SF8
Pfam PF00452
PRINTS PR01862
PROSITE PS50062
PS01080
PS01258
PS01259

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0009408

response to heat

PMID:11090436[1]

ECO:0000314

P

Fig. 3) A redistribution of Bax from the cytoplasm to the nuclear periphery was observed in rats that had been exposed once to short-term local testicular heating.

complete

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:9804769[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043525

positive regulation of neuron apoptotic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07813

P

Seeded From UniProt

complete

involved_in

GO:2001244

positive regulation of intrinsic apoptotic signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

involved_in

GO:1900103

positive regulation of endoplasmic reticulum unfolded protein response

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

involved_in

GO:0097193

intrinsic apoptotic signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

involved_in

GO:0097190

apoptotic signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

part_of

GO:0097144

BAX complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

C

Seeded From UniProt

complete

part_of

GO:0097136

Bcl-2 family protein complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

C

Seeded From UniProt

complete

involved_in

GO:0090200

positive regulation of release of cytochrome c from mitochondria

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

involved_in

GO:0070059

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

involved_in

GO:0051881

regulation of mitochondrial membrane potential

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

enables

GO:0051434

BH3 domain binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

F

Seeded From UniProt

complete

part_of

GO:0046930

pore complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

C

Seeded From UniProt

complete

involved_in

GO:0043653

mitochondrial fragmentation involved in apoptotic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

involved_in

GO:0043525

positive regulation of neuron apoptotic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

involved_in

GO:0043496

regulation of protein homodimerization activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

involved_in

GO:0032976

release of matrix enzymes from mitochondria

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

involved_in

GO:0032461

positive regulation of protein oligomerization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

involved_in

GO:0032091

negative regulation of protein binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

enables

GO:0015267

channel activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

F

Seeded From UniProt

complete

involved_in

GO:0010248

establishment or maintenance of transmembrane electrochemical gradient

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

involved_in

GO:0009636

response to toxic substance

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

involved_in

GO:0008637

apoptotic mitochondrial changes

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

involved_in

GO:0008635

activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

enables

GO:0008289

lipid binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

F

Seeded From UniProt

complete

involved_in

GO:0008053

mitochondrial fusion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

involved_in

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

C

Seeded From UniProt

complete

part_of

GO:0005757

mitochondrial permeability transition pore complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

C

Seeded From UniProt

complete

involved_in

GO:0001783

B cell apoptotic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

involved_in

GO:0051412

response to corticosterone

PMID:17562391[3]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0051400

BH domain binding

PMID:9356461[4]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:620717

F

Seeded From UniProt

complete

enables

GO:0051400

BH domain binding

PMID:9356461[4]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:620621

F

Seeded From UniProt

complete

enables

GO:0051400

BH domain binding

PMID:9356461[4]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:620525

F

Seeded From UniProt

complete

enables

GO:0051400

BH domain binding

PMID:9356461[4]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:2200

F

Seeded From UniProt

complete

enables

GO:0051400

BH domain binding

PMID:9356461[4]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:2199

F

Seeded From UniProt

complete

enables

GO:0051087

chaperone binding

PMID:12070120[5]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:621314

F

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

PMID:11299004[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:9356461[4]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:620717

F

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:9356461[4]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:620621

F

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:9356461[4]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:620525

F

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:9356461[4]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:2200

F

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:9356461[4]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:2199

F

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:16579988[7]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:621314

F

Seeded From UniProt

complete

involved_in

GO:0046688

response to copper ion

PMID:18289470[8]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045333

cellular respiration

PMID:12460673[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0044877

protein-containing complex binding

PMID:21561597[10]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:1307794
RGD:628878

F

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:20385067[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

PMID:17784886[12]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042220

response to cocaine

PMID:17084983[13]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034349

glial cell apoptotic process

PMID:18931364[14]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0031966

mitochondrial membrane

PMID:16084019[15]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0031072

heat shock protein binding

PMID:16579988[7]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:621314

F

Seeded From UniProt

complete

enables

GO:0031072

heat shock protein binding

PMID:12070120[5]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:621314

F

Seeded From UniProt

complete

involved_in

GO:0021987

cerebral cortex development

PMID:9813151[16]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007568

aging

PMID:9813151[16]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007420

brain development

PMID:18058945[17]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007008

outer mitochondrial membrane organization

PMID:12460673[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007007

inner mitochondrial membrane organization

PMID:12460673[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

PMID:18817839[18]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

PMID:16084019[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

PMID:18959742[19]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

PMID:11751624[20]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:16579988[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:16084019[15]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:15902200[21]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

PMID:15044178[22]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:16579988[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:16321138[23]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:15902200[21]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:15341589[24]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:16321138[23]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:15341589[24]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0001541

ovarian follicle development

PMID:17570453[25]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0097192

extrinsic apoptotic signaling pathway in absence of ligand

PMID:21873635[26]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101769
MGI:MGI:108052
MGI:MGI:1097161
MGI:MGI:88138
MGI:MGI:88139
MGI:MGI:99702
PANTHER:PTN000135648
UniProtKB:Q07820

P

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:21873635[26]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88138
MGI:MGI:88139
MGI:MGI:99702
PANTHER:PTN000135648
RGD:2192
RGD:2199
RGD:2200
RGD:620525
RGD:620621
RGD:620717
RGD:621635
RGD:70984
UniProtKB:P10415
UniProtKB:Q07812
UniProtKB:Q07820
UniProtKB:Q16611
UniProtKB:Q92843
ZFIN:ZDB-GENE-000511-7
ZFIN:ZDB-GENE-030825-1
ZFIN:ZDB-GENE-051012-1

F

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:21873635[26]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:99702
PANTHER:PTN000883418
RGD:2192
UniProtKB:Q07812
ZFIN:ZDB-GENE-000511-6

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:21873635[26]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1330841
MGI:MGI:1858494
MGI:MGI:99702
PANTHER:PTN000135648
RGD:621635
UniProtKB:P10415
UniProtKB:Q07812
UniProtKB:Q16611

F

Seeded From UniProt

complete

enables

GO:0015267

channel activity

PMID:21873635[26]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000883418
UniProtKB:Q07812

F

Seeded From UniProt

complete

involved_in

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

PMID:21873635[26]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0029131
MGI:MGI:101769
MGI:MGI:1097161
MGI:MGI:88138
MGI:MGI:88139
MGI:MGI:99702
PANTHER:PTN000135648

P

Seeded From UniProt

complete

involved_in

GO:0008053

mitochondrial fusion

PMID:21873635[26]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:99702
PANTHER:PTN000883418
UniProtKB:Q07812

P

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

PMID:21873635[26]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88139
MGI:MGI:99702
PANTHER:PTN000135648
RGD:2192
RGD:2200
UniProtKB:P10415
UniProtKB:Q07817
WB:WBGene00000423

C

Seeded From UniProt

complete

involved_in

GO:0001836

release of cytochrome c from mitochondria

PMID:21873635[26]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:99702
PANTHER:PTN000883418
UniProtKB:Q07812

P

Seeded From UniProt

complete

involved_in

GO:0042981

regulation of apoptotic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020717
InterPro:IPR020726
InterPro:IPR020728
InterPro:IPR026298
InterPro:IPR036834

P

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR026304

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1000
UniProtKB-SubCell:SL-0172

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Yamamoto, CM et al. (2000) Redistribution of Bax is an early step in an apoptotic pathway leading to germ cell death in rats, triggered by mild testicular hyperthermia. Biol. Reprod. 63 1683-90 PubMed GONUTS page
  2. Hsu, SY & Hsueh, AJ (1998) A splicing variant of the Bcl-2 member Bok with a truncated BH3 domain induces apoptosis but does not dimerize with antiapoptotic Bcl-2 proteins in vitro. J. Biol. Chem. 273 30139-46 PubMed GONUTS page
  3. Yoshimura, A et al. (2007) Influence of age or circadian time on Bcl-2 and Bax mRNA expression in the rat hippocampus after corticosterone exposure. Brain Res. Bull. 73 254-8 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 4.9 Hsu, SY et al. (1997) Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Proc. Natl. Acad. Sci. U.S.A. 94 12401-6 PubMed GONUTS page
  5. 5.0 5.1 Kirchhoff, SR et al. (2002) Cytosolic heat shock protein 60, apoptosis, and myocardial injury. Circulation 105 2899-904 PubMed GONUTS page
  6. Vis, JC et al. (2001) The mitochondrial toxin 3-nitropropionic acid induces differential expression patterns of apoptosis-related markers in rat striatum. Neuropathol. Appl. Neurobiol. 27 68-76 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 Kim, HS et al. (2006) Heat shock protein 60 modified with O-linked N-acetylglucosamine is involved in pancreatic beta-cell death under hyperglycemic conditions. FEBS Lett. 580 2311-6 PubMed GONUTS page
  8. Li, YW et al. (2008) [Excessive copper induces hepatocyte apoptosis and affects Bax and Bcl-2 expression in rat liver]. Zhongguo Dang Dai Er Ke Za Zhi 10 42-6 PubMed GONUTS page
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