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This is your chance to challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

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RAT:BAX

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Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) Bax
Protein Name(s) Apoptosis regulator BAX
External Links
UniProt Q63690
EMBL U49729
U59184
U32098
S76511
PIR I53295
UniGene Rn.10668
Rn.232358
ProteinModelPortal Q63690
SMR Q63690
BioGrid 246997
IntAct Q63690
MINT MINT-1541764
PaxDb Q63690
PRIDE Q63690
UCSC RGD:2192
RGD 2192
eggNOG NOG46695
HOGENOM HOG000095178
HOVERGEN HBG003606
InParanoid Q63690
PhylomeDB Q63690
NextBio 13955757
PRO PR:Q63690
Proteomes UP000002494
Genevestigator Q63690
GO GO:0097144
GO:0097136
GO:0005737
GO:0005829
GO:0005789
GO:0031966
GO:0005741
GO:0005757
GO:0005739
GO:0005634
GO:0046930
GO:0051400
GO:0051434
GO:0015267
GO:0051087
GO:0031072
GO:0008289
GO:0032403
GO:0046982
GO:0042803
GO:0006919
GO:0008635
GO:0008637
GO:0006915
GO:0097190
GO:0001783
GO:0007420
GO:0045333
GO:0010248
GO:0097192
GO:0034349
GO:0007007
GO:0097193
GO:0008630
GO:0070059
GO:0043653
GO:0008053
GO:0032091
GO:0007008
GO:0001541
GO:0043065
GO:1900103
GO:2001244
GO:0043525
GO:0032461
GO:0090200
GO:0051881
GO:0043496
GO:0001836
GO:0032976
GO:0042220
GO:0046688
GO:0051412
GO:0042493
GO:0009636
GO:1990009
GO:0006927
InterPro IPR026304
IPR002475
IPR020717
IPR020726
IPR020728
IPR026298
PANTHER PTHR11256
PTHR11256:SF8
Pfam PF00452
PRINTS PR01862
PROSITE PS50062
PS01080
PS01258
PS01259

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0009408

response to heat

PMID:11090436[1]

IDA: Inferred from Direct Assay

P

Fig. 3) A redistribution of Bax from the cytoplasm to the nuclear periphery was observed in rats that had been exposed once to short-term local testicular heating.

complete

GO:0001101

response to acid

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0001541

ovarian follicle development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0001541

ovarian follicle development

PMID:17570453[2]

IEP: Inferred from Expression Pattern

P

complete

GO:0001764

neuron migration

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0001776

leukocyte homeostasis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0001777

T cell homeostatic proliferation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0001782

B cell homeostasis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0001783

B cell apoptosis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0001822

kidney development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0001836

release of cytochrome c from mitochondria

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0001836

release of cytochrome c from mitochondria

PMID:16084019[3]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0001844

protein insertion into mitochondrial membrane involved in induction of apoptosis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0001974

blood vessel remodeling

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0002262

myeloid cell homeostasis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0002352

B cell negative selection

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0002358

B cell homeostatic proliferation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0002904

positive regulation of B cell apoptosis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0005515

protein binding

PMID:15004018[4]

IPI: Inferred from Physical Interaction

RGD:2199

F

complete

GO:0005622

intracellular

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

C

complete

GO:0005625

soluble fraction

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

C

complete

GO:0005737

cytoplasm

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

complete

GO:0005737

cytoplasm

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

C

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

complete

GO:0005737

cytoplasm

PMID:15341589[5]

IDA: Inferred from Direct Assay

C

complete

GO:0005737

cytoplasm

PMID:16321138[6]

IDA: Inferred from Direct Assay

C

complete

GO:0005739

mitochondrion

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0496

C

complete

GO:0005739

mitochondrion

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

C

complete

GO:0005739

mitochondrion

PMID:15341589[5]

IDA: Inferred from Direct Assay

C

complete

GO:0005739

mitochondrion

PMID:15902200[7]

IDA: Inferred from Direct Assay

C

complete

GO:0005739

mitochondrion

PMID:16321138[6]

IDA: Inferred from Direct Assay

C

complete

GO:0005739

mitochondrion

PMID:16579988[8]

IDA: Inferred from Direct Assay

C

complete

GO:0005741

mitochondrial outer membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1000

C

complete

GO:0005741

mitochondrial outer membrane

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

C

complete

GO:0005741

mitochondrial outer membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0172

C

complete

GO:0005783

endoplasmic reticulum

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

C

complete

GO:0005829

cytosol

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

C

complete

GO:0005829

cytosol

PMID:15902200[7]

IDA: Inferred from Direct Assay

C

complete

GO:0005829

cytosol

PMID:16084019[3]

IDA: Inferred from Direct Assay

C

complete

GO:0005829

cytosol

PMID:16579988[8]

IDA: Inferred from Direct Assay

C

complete

GO:0006687

glycosphingolipid metabolic process

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0006808

regulation of nitrogen utilization

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0006915

apoptosis

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0053

P

complete

GO:0006915

apoptosis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0006915

apoptosis

PMID:11751624[9]

IEP: Inferred from Expression Pattern

P

complete

GO:0006915

apoptosis

PMID:18817839[10]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0006915

apoptosis

PMID:18959742[11]

IEP: Inferred from Expression Pattern

P

complete

GO:0006917

induction of apoptosis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0006917

induction of apoptosis

PMID:16084019[3]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0006919

activation of caspase activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0006974

response to DNA damage stimulus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0007007

inner mitochondrial membrane organization

PMID:12460673[12]

IDA: Inferred from Direct Assay

P

complete

GO:0007008

outer mitochondrial membrane organization

PMID:12460673[12]

IDA: Inferred from Direct Assay

P

complete

GO:0007281

germ cell development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0007283

spermatogenesis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0007399

nervous system development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0007420

brain development

PMID:18058945[13]

IEP: Inferred from Expression Pattern

P

complete

GO:0007548

sex differentiation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0008283

cell proliferation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0008285

negative regulation of cell proliferation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0008584

male gonad development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0008624

induction of apoptosis by extracellular signals

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0008629

induction of apoptosis by intracellular signals

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0008635

activation of caspase activity by cytochrome c

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0008635

activation of caspase activity by cytochrome c

PMID:12460673[12]

TAS: Traceable Author Statement

P

complete

GO:0008637

apoptotic mitochondrial changes

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0009566

fertilization

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0009611

response to wounding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0009636

response to toxin

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0009791

post-embryonic development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0010212

response to ionizing radiation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0010332

response to gamma radiation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0010524

positive regulation of calcium ion transport into cytosol

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0016020

membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

complete

GO:0016021

integral to membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

complete

GO:0019987

negative regulation of anti-apoptosis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0021854

hypothalamus development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0021987

cerebral cortex development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0030264

nuclear fragmentation involved in apoptotic nuclear change

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0031072

heat shock protein binding

PMID:12070120[14]

IPI: Inferred from Physical Interaction

RGD:621314

F

complete

GO:0031072

heat shock protein binding

PMID:16579988[8]

IPI: Inferred from Physical Interaction

RGD:621314

F

complete

GO:0031558

induction of apoptosis in response to chemical stimulus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0031966

mitochondrial membrane

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

C

complete

GO:0031966

mitochondrial membrane

PMID:16084019[3]

IDA: Inferred from Direct Assay

C

complete

GO:0032471

reduction of endoplasmic reticulum calcium ion concentration

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0033137

negative regulation of peptidyl-serine phosphorylation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0033599

regulation of mammary gland epithelial cell proliferation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0034349

glial cell apoptosis

PMID:18931364[15]

IEP: Inferred from Expression Pattern

P

complete

GO:0034644

cellular response to UV

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0035108

limb morphogenesis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0035234

germ cell programmed cell death

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0042220

response to cocaine

PMID:17084983[16]

IEP: Inferred from Expression Pattern

P

complete

GO:0042475

odontogenesis of dentine-containing tooth

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0042493

response to drug

PMID:17784886[17]

IEP: Inferred from Expression Pattern

P

complete

GO:0042803

protein homodimerization activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

F

complete

GO:0042981

regulation of apoptosis

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000712

P

complete

GO:0042981

regulation of apoptosis

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002475

P

complete

GO:0042981

regulation of apoptosis

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020717

P

complete

GO:0042981

regulation of apoptosis

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020726

P

complete

GO:0042981

regulation of apoptosis

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020728

P

complete

GO:0043065

positive regulation of apoptosis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0043281

regulation of caspase activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0043524

negative regulation of neuron apoptosis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0043525

positive regulation of neuron apoptosis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0044445

cytosolic part

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

C

complete

GO:0045136

development of secondary sexual characteristics

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0045333

cellular respiration

PMID:12460673[12]

IDA: Inferred from Direct Assay

P

complete

GO:0046666

retinal cell programmed cell death

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0046688

response to copper ion

PMID:18289470[18]

IEP: Inferred from Expression Pattern

P

complete

GO:0046982

protein heterodimerization activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

F

complete

GO:0046982

protein heterodimerization activity

PMID:16579988[8]

IPI: Inferred from Physical Interaction

RGD:621314

F

complete

GO:0046982

protein heterodimerization activity

PMID:9356461[19]

IPI: Inferred from Physical Interaction

RGD:2199

F

complete

GO:0046982

protein heterodimerization activity

PMID:9356461[19]

IPI: Inferred from Physical Interaction

RGD:2200

F

complete

GO:0046982

protein heterodimerization activity

PMID:9356461[19]

IPI: Inferred from Physical Interaction

RGD:620525

F

complete

GO:0046982

protein heterodimerization activity

PMID:9356461[19]

IPI: Inferred from Physical Interaction

RGD:620621

F

complete

GO:0046982

protein heterodimerization activity

PMID:9356461[19]

IPI: Inferred from Physical Interaction

RGD:620717

F

complete

GO:0048087

positive regulation of developmental pigmentation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0048147

negative regulation of fibroblast proliferation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0048515

spermatid differentiation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0048597

post-embryonic camera-type eye morphogenesis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0048678

response to axon injury

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0048872

homeostasis of number of cells

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0048873

homeostasis of number of cells within a tissue

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0051087

chaperone binding

PMID:12070120[14]

IPI: Inferred from Physical Interaction

RGD:621314

F

complete

GO:0051260

protein homooligomerization

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0051281

positive regulation of release of sequestered calcium ion into cytosol

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0051400

BH domain binding

PMID:9356461[19]

IPI: Inferred from Physical Interaction

RGD:2199

F

complete

GO:0051400

BH domain binding

PMID:9356461[19]

IPI: Inferred from Physical Interaction

RGD:2200

F

complete

GO:0051400

BH domain binding

PMID:9356461[19]

IPI: Inferred from Physical Interaction

RGD:620525

F

complete

GO:0051400

BH domain binding

PMID:9356461[19]

IPI: Inferred from Physical Interaction

RGD:620621

F

complete

GO:0051400

BH domain binding

PMID:9356461[19]

IPI: Inferred from Physical Interaction

RGD:620717

F

complete

GO:0001541

ovarian follicle development

PMID:17570453[2]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0051402

neuron apoptosis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0001783

B cell apoptotic process

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q07812

P

Seeded From UniProt

complete

GO:0051412

response to corticosterone stimulus

PMID:17562391[20]

IEP: Inferred from Expression Pattern

P

complete

GO:0001836

release of cytochrome c from mitochondria

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000883418

P

Seeded From UniProt

complete

GO:0051434

BH3 domain binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

F

complete

GO:0005515

protein binding

PMID:15004018[4]

IPI: Inferred from Physical Interaction

RGD:2199

F

Seeded From UniProt

complete

GO:0051726

regulation of cell cycle

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0005515

protein binding

PMID:15004034[21]

IPI: Inferred from Physical Interaction

UniProtKB:O60936

F

Seeded From UniProt

complete

GO:0060041

retina development in camera-type eye

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0005515

protein binding

PMID:15044178[22]

IPI: Inferred from Physical Interaction

RGD:621575

F

Seeded From UniProt

complete

GO:0060058

positive regulation of apoptosis involved in mammary gland involution

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0005515

protein binding

PMID:16579988[8]

IPI: Inferred from Physical Interaction

UniProtKB:P63039

F

Seeded From UniProt

complete

GO:0060068

vagina development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0005515

protein binding

PMID:16639714[23]

IPI: Inferred from Physical Interaction

UniProtKB:Q62881

F

Seeded From UniProt

complete

GO:0070059

apoptosis in response to endoplasmic reticulum stress

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000033093

P

complete

GO:0005634

nucleus

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q07812

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:15341589[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:16321138[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005739

mitochondrion

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

GO:0005739

mitochondrion

PMID:15341589[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005739

mitochondrion

PMID:15902200[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005739

mitochondrion

PMID:16321138[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005739

mitochondrion

PMID:16579988[8]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005741

mitochondrial outer membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-1000

C

Seeded From UniProt

complete

GO:0005741

mitochondrial outer membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0172

C

Seeded From UniProt

complete

GO:0005741

mitochondrial outer membrane

PMID:15044178[22]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005757

mitochondrial permeability transition pore complex

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q07812

C

Seeded From UniProt

complete

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q07812

C

Seeded From UniProt

complete

GO:0005829

cytosol

PMID:15902200[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005829

cytosol

PMID:16084019[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005829

cytosol

PMID:16579988[8]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006915

apoptotic process

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:11751624[9]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:16084019[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:18817839[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:18959742[11]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q07812

P

Seeded From UniProt

complete

GO:0006927

transformed cell apoptotic process

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q07812

P

Seeded From UniProt

complete

GO:0007007

inner mitochondrial membrane organization

PMID:12460673[12]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0007008

outer mitochondrial membrane organization

PMID:12460673[12]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0007420

brain development

PMID:18058945[13]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0007568

aging

PMID:9813151[24]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0008053

mitochondrial fusion

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q07812

P

Seeded From UniProt

complete

GO:0008053

mitochondrial fusion

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000883418

P

Seeded From UniProt

complete

GO:0008289

lipid binding

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q07812

F

Seeded From UniProt

complete

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000135648

P

Seeded From UniProt

complete

GO:0008635

activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q07812

P

Seeded From UniProt

complete

GO:0008635

activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c

PMID:12460673[12]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008637

apoptotic mitochondrial changes

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q07812

P

Seeded From UniProt

complete

GO:0009636

response to toxic substance

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q07812

P

Seeded From UniProt

complete

GO:0010248

establishment or maintenance of transmembrane electrochemical gradient

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q07812

P

Seeded From UniProt

complete

GO:0015267

channel activity

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q07812

F

Seeded From UniProt

complete

GO:0015267

channel activity

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000883418

F

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

GO:0021987

cerebral cortex development

PMID:9813151[24]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0031072

heat shock protein binding

PMID:12070120[14]

IPI: Inferred from Physical Interaction

RGD:621314

F

Seeded From UniProt

complete

GO:0031072

heat shock protein binding

PMID:16579988[8]

IPI: Inferred from Physical Interaction

RGD:621314

F

Seeded From UniProt

complete

GO:0031966

mitochondrial membrane

PMID:16084019[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0032091

negative regulation of protein binding

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q07812

P

Seeded From UniProt

complete

GO:0032403

protein complex binding

PMID:21561597[25]

IPI: Inferred from Physical Interaction

RGD:1307794
RGD:628878

F

Seeded From UniProt

complete

GO:0032461

positive regulation of protein oligomerization

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q07812

P

Seeded From UniProt

complete

GO:0032976

release of matrix enzymes from mitochondria

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q07812

P

Seeded From UniProt

complete

GO:0034349

glial cell apoptotic process

PMID:18931364[15]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0042220

response to cocaine

PMID:17084983[16]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0042493

response to drug

PMID:17784886[17]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0042803

protein homodimerization activity

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000135648

F

Seeded From UniProt

complete

GO:0042981

regulation of apoptotic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002475
InterPro:IPR020717
InterPro:IPR020726
InterPro:IPR020728
InterPro:IPR026298

P

Seeded From UniProt

complete

GO:0043065

positive regulation of apoptotic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR026304

P

Seeded From UniProt

complete

GO:0043065

positive regulation of apoptotic process

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q07812

P

Seeded From UniProt

complete

GO:0043065

positive regulation of apoptotic process

PMID:11413234[26]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0043496

regulation of protein homodimerization activity

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q07812

P

Seeded From UniProt

complete

GO:0043525

positive regulation of neuron apoptotic process

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q07812

P

Seeded From UniProt

complete

GO:0043653

mitochondrial fragmentation involved in apoptotic process

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q07812

P

Seeded From UniProt

complete

GO:0045333

cellular respiration

PMID:12460673[12]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0046688

response to copper ion

PMID:18289470[18]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0046930

pore complex

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q07812

C

Seeded From UniProt

complete

GO:0046982

protein heterodimerization activity

PMID:16579988[8]

IPI: Inferred from Physical Interaction

RGD:621314

F

Seeded From UniProt

complete

GO:0046982

protein heterodimerization activity

PMID:9356461[19]

IPI: Inferred from Physical Interaction

RGD:2199

F

Seeded From UniProt

complete

GO:0046982

protein heterodimerization activity

PMID:9356461[19]

IPI: Inferred from Physical Interaction

RGD:2200

F

Seeded From UniProt

complete

GO:0046982

protein heterodimerization activity

PMID:9356461[19]

IPI: Inferred from Physical Interaction

RGD:620525

F

Seeded From UniProt

complete

GO:0046982

protein heterodimerization activity

PMID:9356461[19]

IPI: Inferred from Physical Interaction

RGD:620621

F

Seeded From UniProt

complete

GO:0046982

protein heterodimerization activity

PMID:9356461[19]

IPI: Inferred from Physical Interaction

RGD:620717

F

Seeded From UniProt

complete

GO:0051087

chaperone binding

PMID:12070120[14]

IPI: Inferred from Physical Interaction

RGD:621314

F

Seeded From UniProt

complete

GO:0051400

BH domain binding

PMID:9356461[19]

IPI: Inferred from Physical Interaction

RGD:2199

F

Seeded From UniProt

complete

GO:0051400

BH domain binding

PMID:9356461[19]

IPI: Inferred from Physical Interaction

RGD:2200

F

Seeded From UniProt

complete

GO:0051400

BH domain binding

PMID:9356461[19]

IPI: Inferred from Physical Interaction

RGD:620525

F

Seeded From UniProt

complete

GO:0051400

BH domain binding

PMID:9356461[19]

IPI: Inferred from Physical Interaction

RGD:620621

F

Seeded From UniProt

complete

GO:0051400

BH domain binding

PMID:9356461[19]

IPI: Inferred from Physical Interaction

RGD:620717

F

Seeded From UniProt

complete

GO:0051412

response to corticosterone

PMID:17562391[20]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0051434

BH3 domain binding

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q07812

F

Seeded From UniProt

complete

GO:0051881

regulation of mitochondrial membrane potential

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q07812

P

Seeded From UniProt

complete

GO:0070059

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q07812

P

Seeded From UniProt

complete

GO:0090200

positive regulation of release of cytochrome c from mitochondria

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q07812

P

Seeded From UniProt

complete

GO:0097136

Bcl-2 family protein complex

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q07812

C

Seeded From UniProt

complete

GO:0097144

BAX complex

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q07812

C

Seeded From UniProt

complete

GO:0097190

apoptotic signaling pathway

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q07812

P

Seeded From UniProt

complete

GO:0097192

extrinsic apoptotic signaling pathway in absence of ligand

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000135648

P

Seeded From UniProt

complete

GO:0097193

intrinsic apoptotic signaling pathway

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q07812

P

Seeded From UniProt

complete

GO:1900103

positive regulation of endoplasmic reticulum unfolded protein response

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q07812

P

Seeded From UniProt

complete

GO:1990009

retinal cell apoptotic process

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q07812

P

Seeded From UniProt

complete

GO:2001244

positive regulation of intrinsic apoptotic signaling pathway

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q07812

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Yamamoto, CM et al. (2000) Redistribution of Bax is an early step in an apoptotic pathway leading to germ cell death in rats, triggered by mild testicular hyperthermia. Biol. Reprod. 63 1683-90 PubMed GONUTS page
  2. 2.0 2.1 Gürsoy, E et al. (2008) Expression and localisation of Bcl-2 and Bax proteins in developing rat ovary. Res. Vet. Sci. 84 56-61 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Lin, CH et al. (2005) Bax-regulated mitochondria-mediated apoptosis is responsible for the in vitro ischemia induced neuronal cell death of Sprague Dawley rat. Neurosci. Lett. 387 22-7 PubMed GONUTS page
  4. 4.0 4.1 Wang, J et al. (2004) Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria. J. Biol. Chem. 279 19948-54 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Hu, XL et al. (2004) Dynamic changes of the anti- and pro-apoptotic proteins Bcl-w, Bcl-2, and Bax with Smac/Diablo mitochondrial release after photothrombotic ring stroke in rats. Eur. J. Neurosci. 20 1177-88 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 Capano, M & Crompton, M (2006) Bax translocates to mitochondria of heart cells during simulated ischaemia: involvement of AMP-activated and p38 mitogen-activated protein kinases. Biochem. J. 395 57-64 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 Birse-Archbold, JL et al. (2005) Differential profile of Nix upregulation and translocation during hypoxia/ischaemia in vivo versus in vitro. J. Cereb. Blood Flow Metab. 25 1356-65 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 8.4 8.5 8.6 8.7 8.8 Kim, HS et al. (2006) Heat shock protein 60 modified with O-linked N-acetylglucosamine is involved in pancreatic beta-cell death under hyperglycemic conditions. FEBS Lett. 580 2311-6 PubMed GONUTS page
  9. 9.0 9.1 Van de Casteele, M et al. (2002) Specific expression of Bax-omega in pancreatic beta-cells is down-regulated by cytokines before the onset of apoptosis. Endocrinology 143 320-6 PubMed GONUTS page
  10. 10.0 10.1 Song, Y et al. (2008) p,p'-DDE induces mitochondria-mediated apoptosis of cultured rat Sertoli cells. Toxicology 253 53-61 PubMed GONUTS page
  11. 11.0 11.1 Onoue, S et al. (2008) Pituitary adenylate cyclase-activating polypeptide attenuates streptozotocin-induced apoptotic death of RIN-m5F cells through regulation of Bcl-2 family protein mRNA expression. FEBS J. 275 5542-51 PubMed GONUTS page
  12. 12.0 12.1 12.2 12.3 12.4 12.5 12.6 12.7 Appaix, F et al. (2002) Bax and heart mitochondria: uncoupling and inhibition of respiration without permeability transition. Biochim. Biophys. Acta 1556 155-67 PubMed GONUTS page
  13. 13.0 13.1 Soane, L et al. (2008) Postnatal developmental regulation of Bcl-2 family proteins in brain mitochondria. J. Neurosci. Res. 86 1267-76 PubMed GONUTS page
  14. 14.0 14.1 14.2 14.3 Kirchhoff, SR et al. (2002) Cytosolic heat shock protein 60, apoptosis, and myocardial injury. Circulation 105 2899-904 PubMed GONUTS page
  15. 15.0 15.1 Bhattacharjee, M et al. (2008) Bax and Bid act in synergy to bring about T11TS-mediated glioma apoptosis via the release of mitochondrial cytochrome c and subsequent caspase activation. Int. Immunol. 20 1489-505 PubMed GONUTS page
  16. 16.0 16.1 Dey, S et al. (2007) Cocaine exposure in vitro induces apoptosis in fetal locus coeruleus neurons by altering the Bax/Bcl-2 ratio and through caspase-3 apoptotic signaling. Neuroscience 144 509-21 PubMed GONUTS page
  17. 17.0 17.1 Yu, W et al. (2007) Angiotension II receptor 1 blocker modifies the expression of apoptosis-related proteins and transforming growth factor-beta1 in prostate tissue of spontaneously hypertensive rats. BJU Int. 100 1161-5 PubMed GONUTS page
  18. 18.0 18.1 Li, YW et al. (2008) [Excessive copper induces hepatocyte apoptosis and affects Bax and Bcl-2 expression in rat liver]. Zhongguo Dang Dai Er Ke Za Zhi 10 42-6 PubMed GONUTS page
  19. 19.00 19.01 19.02 19.03 19.04 19.05 19.06 19.07 19.08 19.09 19.10 19.11 19.12 19.13 19.14 19.15 19.16 19.17 19.18 19.19 Hsu, SY et al. (1997) Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Proc. Natl. Acad. Sci. U.S.A. 94 12401-6 PubMed GONUTS page
  20. 20.0 20.1 Yoshimura, A et al. (2007) Influence of age or circadian time on Bcl-2 and Bax mRNA expression in the rat hippocampus after corticosterone exposure. Brain Res. Bull. 73 254-8 PubMed GONUTS page
  21. Gustafsson, AB et al. (2004) Apoptosis repressor with caspase recruitment domain protects against cell death by interfering with Bax activation. J. Biol. Chem. 279 21233-8 PubMed GONUTS page
  22. 22.0 22.1 Adachi, M et al. (2004) Bax interacts with the voltage-dependent anion channel and mediates ethanol-induced apoptosis in rat hepatocytes. Am. J. Physiol. Gastrointest. Liver Physiol. 287 G695-705 PubMed GONUTS page
  23. Zhang, YQ & Herman, B (2006) ARC protects rat cardiomyocytes against oxidative stress through inhibition of caspase-2 mediated mitochondrial pathway. J. Cell. Biochem. 99 575-88 PubMed GONUTS page
  24. 24.0 24.1 Shimohama, S et al. (1998) Differential expression of rat brain bcl-2 family proteins in development and aging. Biochem. Biophys. Res. Commun. 252 92-6 PubMed GONUTS page
  25. Festa, M et al. (2011) BAG3 protein is overexpressed in human glioblastoma and is a potential target for therapy. Am. J. Pathol. 178 2504-12 PubMed GONUTS page
  26. Jin, KL et al. (2001) Bax kappa, a novel Bax splice variant from ischemic rat brain lacking an ART domain, promotes neuronal cell death. J. Neurochem. 77 1508-19 PubMed GONUTS page