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RAT:AOFB

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Contents

Species (Taxon ID) Rattus norvegicus (Rat). ([1])
Gene Name(s) Maob
Protein Name(s) Amine oxidase [flavin-containing] B

Monoamine oxidase type B MAO-B

External Links
EMBL M23601
BC089814
IPI IPI00231774
PIR A31870
RefSeq NP_037330.1
UniGene Rn.6656
ProteinModelPortal P19643
SMR P19643
STRING P19643
PRIDE P19643
GeneID 25750
KEGG rno:25750
UCSC NM_013198
CTD 4129
RGD 3041
eggNOG roNOG11531
HOVERGEN HBG004255
InParanoid P19643
OrthoDB EOG412M55
BRENDA 1.4.3.4
NextBio 607939
ArrayExpress P19643
Genevestigator P19643
GermOnline ENSRNOG00000029778
GO GO:0016021
GO:0005741
GO:0050660
GO:0008131
GO:0042803
GO:0014063
GO:0042135
GO:0045964
GO:0010044
GO:0051412
GO:0042493
GO:0045471
GO:0032496
GO:0010269
GO:0009636
InterPro IPR002937
IPR001613
KO K00274
Pfam PF01593
PRINTS PR00757

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005739

mitochondrion

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0496

C

Seeded From UniProt

GO:0005739

mitochondrion

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000040550

C

Seeded From UniProt

GO:0005741

mitochondrial outer membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1000

C

Seeded From UniProt

GO:0005741

mitochondrial outer membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0172

C

Seeded From UniProt

GO:0005741

mitochondrial outer membrane

PMID:12379239[1]

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005741

mitochondrial outer membrane

PMID:18502718[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005743

mitochondrial inner membrane

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000040550

C

Seeded From UniProt

GO:0008131

primary amine oxidase activity

PMID:12379239[1]

TAS: Traceable Author Statement

F

Seeded From UniProt

GO:0008131

primary amine oxidase activity

PMID:18424170[3]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

GO:0009636

response to toxin

PMID:16904659[4]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

GO:0010044

response to aluminum ion

PMID:19526156[5]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

GO:0010269

response to selenium ion

PMID:18304392[6]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

GO:0014063

negative regulation of serotonin secretion

PMID:12175458[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0016020

membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

Seeded From UniProt

GO:0016021

integral to membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded From UniProt

GO:0016491

oxidoreductase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001613

F

Seeded From UniProt

GO:0016491

oxidoreductase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002937

F

Seeded From UniProt

GO:0016491

oxidoreductase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

F

Seeded From UniProt

GO:0032496

response to lipopolysaccharide

PMID:19779138[8]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

GO:0042135

neurotransmitter catabolic process

PMID:12379239[1]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0042135

neurotransmitter catabolic process

PMID:18539264[9]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

GO:0042493

response to drug

PMID:18256746[10]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

GO:0042803

protein homodimerization activity

PMID:18198902[11]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

GO:0045471

response to ethanol

PMID:20022592[12]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

GO:0045964

positive regulation of dopamine metabolic process

PMID:12175458[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0048545

response to steroid hormone stimulus

PMID:18539264[9]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

GO:0050660

flavin adenine dinucleotide binding

PMID:18424170[3]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

GO:0051412

response to corticosterone stimulus

PMID:15919584[13]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

GO:0055114

oxidation-reduction process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001613

P

Seeded From UniProt

GO:0055114

oxidation-reduction process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002937

P

Seeded From UniProt

GO:0055114

oxidation-reduction process

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

P

Seeded From UniProt


Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Arai R et al. (2002) Differential subcellular location of mitochondria in rat serotonergic neurons depends on the presence and the absence of monoamine oxidase type B. Neuroscience 114: 825-35 PubMed GONUTS page
  2. Huang YH et al. (2008) Immunocytochemical localization of monoamine oxidase type B in rat liver. Eur J Histochem 52: 11-8 PubMed GONUTS page
  3. 3.0 3.1 Upadhyay AK & Edmondson DE (2008) Characterization of detergent purified recombinant rat liver monoamine oxidase B expressed in Pichia pastoris. Protein Expr Purif 59: 349-56 PubMed GONUTS page
  4. Castoldi AF et al. (2006) Brain monoaminergic neurotransmission parameters in weanling rats after perinatal exposure to methylmercury and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153). Brain Res 1112: 91-8 PubMed GONUTS page
  5. Zhang J et al. (2009) Berberine and total base from rhizoma coptis chinensis attenuate brain injury in an aluminum-induced rat model of neurodegenerative disease. Saudi Med J 30: 760-6 PubMed GONUTS page
  6. Tang YL et al. (2008) Both inorganic and organic selenium supplements can decrease brain monoamine oxidase B enzyme activity in adult rats. Br J Nutr 100: 660-5 PubMed GONUTS page
  7. 7.0 7.1 Falk EM et al. (2002) An antisense oligonucleotide targeted at MAO-B attenuates rat striatal serotonergic neurotoxicity induced by MDMA. Pharmacol Biochem Behav 72: 617-22 PubMed GONUTS page
  8. Ekuni D et al. (2009) Lipopolysaccharide-induced epithelial monoamine oxidase mediates alveolar bone loss in a rat chronic wound model. Am J Pathol 175: 1398-409 PubMed GONUTS page
  9. 9.0 9.1 Birgner C et al. (2008) Reduced activity of monoamine oxidase in the rat brain following repeated nandrolone decanoate administration. Brain Res 1219: 103-10 PubMed GONUTS page
  10. Khudoerkov RM et al. (2007) Structural, functional, and biochemical changes in the brain during modeling of dopamine system disturbances in rats. Bull Exp Biol Med 144: 36-8 PubMed GONUTS page
  11. Upadhyay AK et al. (2008) Determination of the oligomeric states of human and rat monoamine oxidases in the outer mitochondrial membrane and octyl beta-D-glucopyranoside micelles using pulsed dipolar electron spin resonance spectroscopy. Biochemistry 47: 1554-66 PubMed GONUTS page
  12. Ou XM et al. (2010) A novel role for glyceraldehyde-3-phosphate dehydrogenase and monoamine oxidase B cascade in ethanol-induced cellular damage. Biol Psychiatry 67: 855-63 PubMed GONUTS page
  13. Lindley SE et al. (2005) Monoamine oxidase and catechol-o-methyltransferase enzyme activity and gene expression in response to sustained glucocorticoids. Psychoneuroendocrinology 30: 785-90 PubMed GONUTS page
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