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RAT:ALDH2
Contents |
| Species (Taxon ID) | Rattus norvegicus (Rat). ([1]) | |
| Gene Name(s) | Aldh2 | |
| Protein Name(s) | Aldehyde dehydrogenase, mitochondrial
ALDH class 2 ALDH-E2 ALDH1 | |
| External Links | ||
| EMBL | X14977 BC062081 M19030 AY566467 AY566468 AY566469 AF529165 AY034137 | |
| IPI | IPI00197770 | |
| PIR | S03564 | |
| RefSeq | NP_115792.1 | |
| UniGene | Rn.101781 | |
| PDB | 1OM2 2V1S 2V1T 3AWR 3AX2 3AX3 3AX5 | |
| PDBsum | 1OM2 2V1S 2V1T 3AWR 3AX2 3AX3 3AX5 | |
| ProteinModelPortal | P11884 | |
| SMR | P11884 | |
| IntAct | P11884 | |
| STRING | P11884 | |
| PhosphoSite | P11884 | |
| World-2DPAGE | 0004:P11884 | |
| PRIDE | P11884 | |
| GeneID | 29539 | |
| KEGG | rno:29539 | |
| CTD | 217 | |
| RGD | 69219 | |
| eggNOG | maNOG06439 | |
| HOVERGEN | HBG000097 | |
| InParanoid | P11884 | |
| OrthoDB | EOG41ZF9P | |
| PhylomeDB | P11884 | |
| NextBio | 609531 | |
| ArrayExpress | P11884 | |
| Genevestigator | P11884 | |
| GermOnline | ENSRNOG00000001344 | |
| GO | GO:0005759 GO:0004029 GO:0042802 GO:0071398 GO:0032870 GO:0001889 GO:0055093 GO:0032496 GO:0035094 GO:0032570 GO:0033574 | |
| InterPro | IPR016161 IPR016163 IPR016160 IPR016162 IPR015590 | |
| Gene3D | G3DSA:3.40.309.10 G3DSA:3.40.605.10 | |
| Pfam | PF00171 | |
| SUPFAM | SSF53720 | |
| PROSITE | PS00070 PS00687 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001889 |
liver development |
IEP: Inferred from Expression Pattern |
|
P |
Seeded From UniProt |
|||
| GO:0004029 |
aldehyde dehydrogenase (NAD) activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004029 |
aldehyde dehydrogenase (NAD) activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0005739 |
mitochondrion |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005739 |
mitochondrion |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000031411 |
C |
Seeded From UniProt |
|||
| GO:0005739 |
mitochondrion |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005759 |
mitochondrial matrix |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0170 |
C |
Seeded From UniProt |
|||
| GO:0008152 |
metabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0008152 |
metabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0008152 |
metabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0008152 |
metabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0008152 |
metabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0016491 |
oxidoreductase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016491 |
oxidoreductase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016491 |
oxidoreductase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016491 |
oxidoreductase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016491 |
oxidoreductase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016491 |
oxidoreductase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016620 |
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0032496 |
response to lipopolysaccharide |
IEP: Inferred from Expression Pattern |
|
P |
Seeded From UniProt |
|||
| GO:0032570 |
response to progesterone stimulus |
IEP: Inferred from Expression Pattern |
|
P |
Seeded From UniProt |
|||
| GO:0032870 |
cellular response to hormone stimulus |
IEP: Inferred from Expression Pattern |
|
P |
Seeded From UniProt |
|||
| GO:0033574 |
response to testosterone stimulus |
IEP: Inferred from Expression Pattern |
|
P |
Seeded From UniProt |
|||
| GO:0035094 |
response to nicotine |
IEP: Inferred from Expression Pattern |
|
P |
Seeded From UniProt |
|||
| GO:0042802 |
identical protein binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0055093 |
response to hyperoxia |
IEP: Inferred from Expression Pattern |
|
P |
Seeded From UniProt |
|||
| GO:0055114 |
oxidation-reduction process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0055114 |
oxidation-reduction process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0055114 |
oxidation-reduction process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0055114 |
oxidation-reduction process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0055114 |
oxidation-reduction process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0055114 |
oxidation-reduction process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0071398 |
cellular response to fatty acid |
IEP: Inferred from Expression Pattern |
|
P |
Seeded From UniProt |
|||
| GO:0004029 |
aldehyde dehydrogenase (NAD) activity |
IMP: Inferred from Mutant Phenotype |
F |
Figure 2 shows that ALDH2 activity increases in the presence of AldA-1 |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Yoon M et al. (2006) Developmental expression of aldehyde dehydrogenase in rat: a comparison of liver and lung development. Toxicol Sci 89: 386-98 PubMed GONUTS page
- ↑ Tottmar SO et al. (1973) The subcellular distribution and properties of aldehyde dehydrogenases in rat liver. Biochem J 135: 577-86 PubMed GONUTS page
- ↑ 3.0 3.1 Jeng JJ & Weiner H (1991) Purification and characterization of catalytically active precursor of rat liver mitochondrial aldehyde dehydrogenase expressed in Escherichia coli. Arch Biochem Biophys 289: 214-22 PubMed GONUTS page
- ↑ Pang Y et al. (2001) Analysis of genes differentially expressed in astrocytes stimulated with lipopolysaccharide using cDNA arrays. Brain Res 914: 15-22 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Crabb DW et al. (1995) Hormonal and chemical influences on the expression of class 2 aldehyde dehydrogenases in rat H4IIEC3 and human HuH7 hepatoma cells. Alcohol Clin Exp Res 19: 1414-9 PubMed GONUTS page
- ↑ Hu D et al. (2002) Altered profile of gene expression in rat hearts induced by chronic nicotine consumption. Biochem Biophys Res Commun 297: 729-36 PubMed GONUTS page
- ↑ Xu D et al. (2006) Mitochondrial aldehyde dehydrogenase attenuates hyperoxia-induced cell death through activation of ERK/MAPK and PI3K-Akt pathways in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 291: L966-75 PubMed GONUTS page
- ↑ Canuto RA et al. (2001) Increase in class 2 aldehyde dehydrogenase expression by arachidonic acid in rat hepatoma cells. Biochem J 357: 811-8 PubMed GONUTS page
- ↑ Chen CH et al. (2008) Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Science 321: 1493-5 PubMed GONUTS page
