GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

RAT:ACACA

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) Acaca (synonyms: Acac)
Protein Name(s) Acetyl-CoA carboxylase 1

ACC1 ACC-alpha Biotin carboxylase

External Links
UniProt P11497
EMBL J03808
M26731
EF121986
EF121987
M26195
M26196
M26197
M55315
PIR A35578
RefSeq NP_071529.1
UniGene Rn.163753
Rn.217177
Rn.44372
ProteinModelPortal P11497
SMR P11497
BioGrid 248868
STRING 10116.ENSRNOP00000050703
BindingDB P11497
ChEMBL CHEMBL2397
PhosphoSite P11497
PaxDb P11497
PRIDE P11497
GeneID 60581
KEGG rno:60581
CTD 31
RGD 621248
eggNOG COG0511
HOGENOM HOG000214115
HOVERGEN HBG005371
InParanoid P11497
KO K11262
PhylomeDB P11497
BRENDA 6.4.1.2
UniPathway UPA00655
NextBio 612298
PRO PR:P11497
Proteomes UP000002494
Genevestigator P11497
GO GO:0005829
GO:0003989
GO:0005524
GO:0009374
GO:0004075
GO:0019900
GO:0046872
GO:0006084
GO:0006633
GO:2001295
GO:0051289
GO:0042493
GO:0014070
Gene3D 3.30.1490.20
3.30.470.20
3.40.50.20
3.90.226.10
InterPro IPR013537
IPR011761
IPR013815
IPR013816
IPR001882
IPR011764
IPR005482
IPR000089
IPR005481
IPR000022
IPR005479
IPR029045
IPR011763
IPR011762
IPR016185
IPR011054
IPR011053
Pfam PF08326
PF02785
PF00364
PF01039
PF00289
PF02786
SMART SM00878
SUPFAM SSF51230
SSF51246
SSF52096
SSF52440
PROSITE PS50975
PS50979
PS00188
PS50968
PS50989
PS50980
PS00866
PS00867

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0003989

acetyl-CoA carboxylase activity

PMID:21569266[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0051289

protein homotetramerization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5SWU9

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5SWU9

C

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

PMID:16979414[2]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0014070

response to organic cyclic compound

PMID:12842871[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0009374

biotin binding

PMID:12949377[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006633

fatty acid biosynthetic process

PMID:11735100[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003989

acetyl-CoA carboxylase activity

PMID:11735100[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003989

acetyl-CoA carboxylase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013537

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005479
InterPro:IPR011761
InterPro:IPR013537
InterPro:IPR013815

F

Seeded From UniProt

complete

involved_in

GO:0006633

fatty acid biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013537

P

Seeded From UniProt

complete

enables

GO:0016874

ligase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011763

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011761

F

Seeded From UniProt

complete

enables

GO:0003989

acetyl-CoA carboxylase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:6.4.1.2

F

Seeded From UniProt

complete

enables

GO:0004075

biotin carboxylase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:6.3.4.14

F

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000037
GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0511
UniProtKB-KW:KW-0021

F

Seeded From UniProt

complete

enables

GO:0016874

ligase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0436

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

involved_in

GO:0006629

lipid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0443

P

Seeded From UniProt

complete

GO:0003989

acetyl-CoA carboxylase activity

PMID:21569266[1]

ECO:0000314

F

Figure 4

complete
CACAO 3560

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0008152

metabolic process

GO_REF:0000037
GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0511
UniProtKB-KW:KW-0021

P

Seeded From UniProt

complete

involved_in

GO:0006633

fatty acid biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0275

P

Seeded From UniProt

complete

involved_in

GO:0006631

fatty acid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0276

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:2001295

malonyl-CoA biosynthetic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00655

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Alberdi, G et al. (2011) Changes in white adipose tissue metabolism induced by resveratrol in rats. Nutr Metab (Lond) 8 29 PubMed GONUTS page
  2. Liang, Y et al. (2006) The messenger RNA profiles in liver, hypothalamus, white adipose tissue, and skeletal muscle of female Zucker diabetic fatty rats after topiramate treatment. Metab. Clin. Exp. 55 1411-9 PubMed GONUTS page
  3. Harwood, HJ Jr et al. (2003) Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals. J. Biol. Chem. 278 37099-111 PubMed GONUTS page
  4. Rathman, SC et al. (2003) Pharmacological biotin supplementation maintains biotin status and function in rats administered dietary carbamazepine. J. Nutr. 133 2857-62 PubMed GONUTS page
  5. 5.0 5.1 Moura, MA et al. (2001) Effect of cold acclimation on brown adipose tissue fatty acid synthesis in rats adapted to a high-protein, carbohydrate-free diet. Metab. Clin. Exp. 50 1493-8 PubMed GONUTS page