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PMID:8486153
From GONUTS
Werner-Felmayer, G, Prast, H, Werner, ER, Philippu, A and Wachter, H (1993) Induction of GTP cyclohydrolase I by bacterial lipopolysaccharide in the rat.FEBS Lett. 322:223-6
| Abstract | A 2- to 3-fold increase of GTP cyclohydrolase I (E.C. 3.5.4.16), the key enzyme of tetrahydrobiopterin biosynthesis from GTP, was observed in cerebellum, remaining brain, liver, spleen, and adrenal gland of rats treated with a single dose of lipopolysaccharide (LPS). This led to increased biopterin levels in tissues but not in plasma. Parallel induction of nitric oxide (NO) synthase was indicated by a 10- to 100-fold increase of plasma nitrate levels 6 and 12 hours after injection of LPS. Furthermore, systolic blood pressure was reduced significantly by 23%. Our results demonstrate induction of tetrahydrobiopterin biosynthesis after LPS treatment in vivo. |
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