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PMID:2128175
From GONUTS
Lissemore, JL, Baumgardner, CA, Geer, BW and Sullivan, DT (1990) Effect of dietary carbohydrates and ethanol on expression of genes encoding sn-glycerol-3-phosphate dehydrogenase, aldolase, and phosphoglycerate kinase in Drosophila larvae.Biochem. Genet. 28:615-30
| Abstract | The genes encoding glycolytic enzymes in Drosophila form a group of functionally related genes that may be coordinately regulated and thus controlled by common factors. We have examined the effect of dietary carbohydrates and ethanol on expression of the genes encoding glycerol-3-phosphate dehydrogenase (GPDH), aldolase (ALD), and phosphoglycerate kinase (PGK) in D. melanogaster larvae. GPDH activity and transcript abundance increased in response to ethanol and additional amounts of several different carbohydrates. In addition, the levels of two alternatively processed Gpdh transcripts were differentially regulated by the treatments. The nutritional conditions tested had little or no effect on the activities and transcript levels of ALD and PGK. These results indicate that changes in dietary conditions affect expression of specific genes and do not evoke a general response from genes involved in cellular metabolism. The observation that dietary carbohydrates and ethanol increase Gpdh expression without affecting expression of Ald and Pgk reinforces previous suggestions that dietary carbon can be diverted by GPDH from glycolytic catabolism into lipid biosynthesis. |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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