The Spring 2012 season of CACAO has started!
PMID:19187040
From GONUTS
Dean, PJ, Siwiec, T, Waterworth, WM, Schlögelhofer, P, Armstrong, SJ and West, CE (2009) A novel ATM dependant X-ray inducible gene is essential for both plant meiosis and gametogenesis.Plant J.
| Abstract | Summary DNA damage in Arabidopsis thaliana seedlings results in the up-regulation of hundreds of genes. One of the earliest and highest levels of induction is displayed by a previously uncharacterised gene that we have termed X-ray induced 1 (XRI1). Analysis of plants carrying a null xri1 allele revealed two distinct requirements for this gene in plant fertility; XRI1 was important for the post-meiotic stages of pollen development, leading to inviability of xri(-) pollen and abnormal segregation of the mutant allele in heterozygous xri1(+/-) plants. In addition, XRI1 was essential for male and female meiosis, indicated by the complete sterility of homozygous xri1 mutants due to extensive chromosome fragmentation visible in meiocytes. Abolition of programmed DNA double strand breaks (DSBs) in a spo11-1 mutant background failed to rescue the DNA fragmentation of xri1 mutants suggesting that XRI1 functions at an earlier stage than SPO11-1. Yeast two-hybrid studies identified interaction between XRI1 and a novel component of the Arabidopsis MND1/AHP2 complex, indicating possible requirements for XRI1 in meiotic DNA repair. |
| Links | PubMed Online version:10.1111/j.1365-313X.2009.03814.x |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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References
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