The Spring 2012 season of CACAO has started!
PMID:12408809
From GONUTS
De Gregorio, E, Han, SJ, Lee, WJ, Baek, MJ, Osaki, T, Kawabata, S, Lee, BL, Iwanaga, S, Lemaitre, B and Brey, PT (2002) An immune-responsive Serpin regulates the melanization cascade in Drosophila.Dev. Cell 3:581-92
| Abstract | In arthropods, the melanization reaction is associated with multiple host defense mechanisms leading to the sequestration and killing of invading microorganisms. Arthropod melanization is controlled by a cascade of serine proteases that ultimately activates the enzyme prophenoloxidase (PPO), which, in turn, catalyzes the synthesis of melanin. Here we report the biochemical and genetic characterization of a Drosophila serine protease inhibitor protein, Serpin-27A, which regulates the melanization cascade through the specific inhibition of the terminal protease prophenoloxidase-activating enzyme. Our data demonstrate that Serpin-27A is required to restrict the phenoloxidase activity to the site of injury or infection, preventing the insect from excessive melanization. |
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