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PIG:OAS1
Contents
| Species (Taxon ID) | Sus scrofa (Pig). (9823) | |
| Gene Name(s) | OAS1 | |
| Protein Name(s) | 2'-5'-oligoadenylate synthase 1
(2-5')oligo(A) synthase 1 2-5A synthase 1 p42 OAS | |
| External Links | ||
| UniProt | Q29599 | |
| EMBL | AJ225090 F14610 | |
| RefSeq | NP_999468.1 | |
| UniGene | Ssc.1031 | |
| PDB | 1PX5 | |
| PDBsum | 1PX5 | |
| ProteinModelPortal | Q29599 | |
| SMR | Q29599 | |
| PaxDb | Q29599 | |
| GeneID | 397570 | |
| KEGG | ssc:397570 | |
| CTD | 4938 | |
| eggNOG | NOG48070 | |
| HOVERGEN | HBG000994 | |
| InParanoid | Q29599 | |
| KO | K14216 | |
| EvolutionaryTrace | Q29599 | |
| Proteomes | UP000008227 | |
| GO | GO:0005737 GO:0005783 GO:0005576 GO:0005739 GO:0005634 GO:0001730 GO:0005524 GO:0003725 GO:0046872 GO:0051607 GO:0045087 GO:0045071 GO:0006164 | |
| Gene3D | 1.10.1410.20 | |
| InterPro | IPR006117 IPR006116 IPR018952 IPR026774 IPR002934 | |
| PANTHER | PTHR11258 | |
| Pfam | PF01909 PF10421 | |
| PROSITE | PS00832 PS00833 PS50152 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0001730 |
2'-5'-oligoadenylate synthetase activity |
ECO:0000314 |
F |
Figure 4 shows kinetics of formation by purified 2'-5'-oligoadenylate synthetase with ATP binding |
complete | |||||
|
enables |
GO:0001730 |
2'-5'-oligoadenylate synthetase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051607 |
defense response to virus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045071 |
negative regulation of viral genome replication |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006164 |
purine nucleotide biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003725 |
double-stranded RNA binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001730 |
2'-5'-oligoadenylate synthetase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060700 |
regulation of ribonuclease activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000883503 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051607 |
defense response to virus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001344149 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045071 |
negative regulation of viral genome replication |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001344149 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000883503 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000883503 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000883503 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003725 |
double-stranded RNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1344390 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0001730 |
2'-5'-oligoadenylate synthetase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1344390 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003725 |
double-stranded RNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006955 |
immune response |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016779 |
nucleotidyltransferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051607 |
defense response to virus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001730 |
2'-5'-oligoadenylate synthetase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016779 |
nucleotidyltransferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002376 |
immune system process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051607 |
defense response to virus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045087 |
innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Shimizu, N & Sokawa, Y (1983) (2'-5')Oligoadenylate synthetase in pig spleen: isolation and characterization. J. Biochem. 94 1421-8 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Kristiansen, H et al. (2010) Extracellular 2'-5' oligoadenylate synthetase stimulates RNase L-independent antiviral activity: a novel mechanism of virus-induced innate immunity. J. Virol. 84 11898-904 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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