MYCTU:MPRB

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Species (Taxon ID)	Mycobacterium tuberculosis. (taxon:1773)
Gene Name(s)	mprB
Protein Name(s)	Signal transduction histidine-protein kinase/phosphatase mprB Mycobacterial persistence regulator B
External Links
UniProt Identifier	MPRB_MYCTU
UniProt Accessions	O53895, Q7D913,
EMBL	BX842575, AE000516,
PIR	B70821,
RefSeq	NP_215497.1, NP_335444.1,
Pfam	PF00672, PF02518, PF00512,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000155	two-component sensor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003661	F
	GO:0000155	two-component sensor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005467	F
	GO:0000160	two-component signal transduction system (phosphorelay)	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0902	P
	GO:0000160	two-component signal transduction system (phosphorelay)	PMID:14638785^[1]	IDA: Inferred from Direct Assay		P
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0004673	protein histidine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005467	F
	GO:0004673	protein histidine kinase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:2.7.13.3	F
	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0904	F
	GO:0004721	phosphoprotein phosphatase activity	PMID:14638785^[1]	IDA: Inferred from Direct Assay		F
	GO:0004871	signal transducer activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003660	F
	GO:0004871	signal transducer activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009082	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003594	F
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F
	GO:0005576	extracellular region	PMID:17443846^[2]	IDA: Inferred from Direct Assay		C
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0005886	plasma membrane	PMID:15525680^[3]	IDA: Inferred from Direct Assay		C
	GO:0006950	response to stress	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0346	P
	GO:0007165	signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003660	P
	GO:0007165	signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003661	P
	GO:0007165	signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005467	P
	GO:0007165	signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009082	P
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003661	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003660	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0016301	kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	F
	GO:0016301	kinase activity	PMID:14638785^[1]	IDA: Inferred from Direct Assay		F
	GO:0016310	phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004358	P
	GO:0016310	phosphorylation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	P
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F
	GO:0016772	transferase activity, transferring phosphorus-containing groups	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004358	F
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F
	GO:0018106	peptidyl-histidine phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005467	P
	GO:0018106	peptidyl-histidine phosphorylation	PMID:14638785^[1]	IDA: Inferred from Direct Assay		P
	GO:0040007	growth	PMID:12657046^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0005886	two-component signal transduction system (phosphorelay)	PMID:21445360^[5]	IDA: Inferred from Direct Assay		P	Figure 1 Schematic depicting the differential centrifugation protocol used to fractionate PepD in M. tuberculosis.	complete
	GO:0000155	two-component sensor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003661	F
	GO:0000155	two-component sensor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005467	F
	GO:0000160	two-component signal transduction system (phosphorelay)	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0902	P
	GO:0000160	two-component signal transduction system (phosphorelay)	PMID:14638785^[1]	IDA: Inferred from Direct Assay		P
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0004673	protein histidine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005467	F
	GO:0004673	protein histidine kinase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:2.7.13.3	F
	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0904	F
	GO:0004721	phosphoprotein phosphatase activity	PMID:14638785^[1]	IDA: Inferred from Direct Assay		F
	GO:0004871	signal transducer activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003660	F
	GO:0004871	signal transducer activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009082	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003594	F
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F
	GO:0005576	extracellular region	PMID:17443846^[2]	IDA: Inferred from Direct Assay		C
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0005886	plasma membrane	PMID:15525680^[3]	IDA: Inferred from Direct Assay		C
	GO:0006950	response to stress	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0346	P
	GO:0007165	signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003660	P
	GO:0007165	signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003661	P
	GO:0007165	signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005467	P
	GO:0007165	signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009082	P
	GO:0009405	pathogenesis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0843	P
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003661	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003660	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0016301	kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	F
	GO:0016301	kinase activity	PMID:14638785^[1]	IDA: Inferred from Direct Assay		F
	GO:0016310	phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004358	P
	GO:0016310	phosphorylation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	P
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F
	GO:0016772	transferase activity, transferring phosphorus-containing groups	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004358	F
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F
	GO:0018106	peptidyl-histidine phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005467	P
	GO:0018106	peptidyl-histidine phosphorylation	PMID:14638785^[1]	IDA: Inferred from Direct Assay		P
	GO:0040007	growth	PMID:12657046^[4]	IMP: Inferred from Mutant Phenotype		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Zahrt TC et al. (2003) Functional analysis of the Mycobacterium tuberculosis MprAB two-component signal transduction system. Infect Immun 71: 6962-70 PubMed GONUTS page
↑ ^2.0 ^2.1 Målen H et al. (2007) Comprehensive analysis of exported proteins from Mycobacterium tuberculosis H37Rv. Proteomics 7: 1702-18 PubMed GONUTS page
↑ ^3.0 ^3.1 Mawuenyega KG et al. (2005) Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling. Mol Biol Cell 16: 396-404 PubMed GONUTS page
↑ ^4.0 ^4.1 Sassetti CM et al. (2003) Genes required for mycobacterial growth defined by high density mutagenesis. Mol Microbiol 48: 77-84 PubMed GONUTS page
↑ White MJ et al. (2011) The HtrA-like serine protease PepD interacts with and modulates the Mycobacterium tuberculosis 35-kDa antigen outer envelope protein. PLoS One 6: e18175 PubMed GONUTS page

[PMID:14638785-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Zahrt TC et al. (2003) Functional analysis of the Mycobacterium tuberculosis MprAB two-component signal transduction system. Infect Immun 71: 6962-70 PubMed GONUTS page

[PMID:17443846-1] 2.0 ^2.1 Målen H et al. (2007) Comprehensive analysis of exported proteins from Mycobacterium tuberculosis H37Rv. Proteomics 7: 1702-18 PubMed GONUTS page

[PMID:15525680-2] 3.0 ^3.1 Mawuenyega KG et al. (2005) Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling. Mol Biol Cell 16: 396-404 PubMed GONUTS page

[PMID:12657046-3] 4.0 ^4.1 Sassetti CM et al. (2003) Genes required for mycobacterial growth defined by high density mutagenesis. Mol Microbiol 48: 77-84 PubMed GONUTS page

[PMID:21445360-4] White MJ et al. (2011) The HtrA-like serine protease PepD interacts with and modulates the Mycobacterium tuberculosis 35-kDa antigen outer envelope protein. PLoS One 6: e18175 PubMed GONUTS page

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MYCTU:MPRB

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