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MYCTU:KGD

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Contents

Species (Taxon ID) Mycobacterium tuberculosis. (taxon:1773)
Gene Name(s) kgd
Protein Name(s)
  • 2-oxoglutarate decarboxylase
  • 2-oxoglutarate carboxy-lyase
  • Alpha-ketoglutarate decarboxylase
External Links
UniProt Identifier KGD_MYCTU
UniProt Accessions O50463, Q7D8I9,
EMBL BX842576, AE000516,
PIR G70953,
RefSeq NP_215764.2, NP_335730.1,
Pfam PF00198, PF00676, PF02779,



Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0008683

2-oxoglutarate decarboxylase activity

PMID:16027371[1]

IDA: Inferred from Direct Assay

F

complete

GO:0000287

magnesium ion binding

PMID:16027371[1]

IDA: Inferred from Direct Assay

F

GO:0004591

oxoglutarate dehydrogenase (succinyl-transferring) activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011603

F

GO:0005515

protein binding

PMID:19019160[2]

IPI: Inferred from Physical Interaction

UniProtKB:P64897

F

GO:0005886

plasma membrane

PMID:15525680[3]

IDA: Inferred from Direct Assay

C

GO:0006096

glycolysis

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011603

P

GO:0006099

tricarboxylic acid cycle

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0816

P

GO:0006099

tricarboxylic acid cycle

PMID:16027371[1]

IDA: Inferred from Direct Assay

P

GO:0008152

metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001017

P

GO:0008152

metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001078

P

GO:0008683

2-oxoglutarate decarboxylase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:4.1.1.71

F

GO:0008683

2-oxoglutarate decarboxylase activity

PMID:16027371[1]

IDA: Inferred from Direct Assay

F

GO:0009055

electron carrier activity

PMID:16045627[4]

IDA: Inferred from Direct Assay

F

GO:0016624

oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001017

F

GO:0016829

lyase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0456

F

GO:0016831

carboxy-lyase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0210

F

GO:0030976

thiamine pyrophosphate binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011603

F

GO:0040007

growth

PMID:12657046[5]

IMP: Inferred from Mutant Phenotype

P

GO:0045254

pyruvate dehydrogenase complex

PMID:16045627[4]

IDA: Inferred from Direct Assay

C

GO:0055114

oxidation-reduction process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011603

P

GO:0055114

oxidation-reduction process

PMID:16027371[1]

IDA: Inferred from Direct Assay

P

GO:0055114

oxidation-reduction process

PMID:16045627[4]

IDA: Inferred from Direct Assay

P

NOT

GO:0004591

oxoglutarate dehydrogenase (succinyl-transferring) activity

PMID:16045627[4]

IDA: Inferred from Direct Assay

F


Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Tian J et al. (2005) Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase. Proc Natl Acad Sci U S A 102: 10670-5 PubMed GONUTS page
  2. O'Hare HM et al. (2008) Regulation of glutamate metabolism by protein kinases in mycobacteria. Mol Microbiol 70: 1408-23 PubMed GONUTS page
  3. Mawuenyega KG et al. (2005) Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling. Mol Biol Cell 16: 396-404 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Tian J et al. (2005) Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Mol Microbiol 57: 859-68 PubMed GONUTS page
  5. Sassetti CM et al. (2003) Genes required for mycobacterial growth defined by high density mutagenesis. Mol Microbiol 48: 77-84 PubMed GONUTS page
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