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MYCTU:CP125

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Contents

Species (Taxon ID) Mycobacterium tuberculosis. (taxon:1773)
Gene Name(s) cyp125
Protein Name(s)
  • Steroid C27-monooxygenase
  • Cholest-4-en-3-one monooxygenase
  • Cytochrome P450 125
External Links
UniProt Identifier CP125_MYCTU
UniProt Accessions P63709, P71856,
EMBL BX842583, AE000516,
PIR B70677,
RefSeq NP_218062.1, NP_338194.1,
PDB 2X5L, 2X5W, 2XC3, 2XN8, 3IVY, 3IW0, 3IW1, 3IW2,
Pfam PF00067,

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0009055

electron carrier activity

IEA: Inferred from Electronic Annotation

F

Source: InterPro

GO:0020037

heme binding

IEA: Inferred from Electronic Annotation

F

Source: InterPro

GO:0004497

monooxygenase activity

IEA: Inferred from Electronic Annotation

F

Source: UniProtKB-KW

GO:0055114

oxidation reduction

IEA: Inferred from Electronic Annotation

P

Source: UniProtKB-KW

GO:0004497

monooxygenase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002397

F

GO:0004497

monooxygenase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0503

F

GO:0005506

iron ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001128

F

GO:0005506

iron ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002397

F

GO:0006707

cholesterol catabolic process

PMID:19846551[1]

IDA: Inferred from Direct Assay

P

GO:0008395

steroid hydroxylase activity

PMID:19846551[1]

IDA: Inferred from Direct Assay

F

GO:0009055

electron carrier activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001128

F

GO:0016491

oxidoreductase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

F

GO:0016705

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001128

F

GO:0020037

heme binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001128

F

GO:0020037

heme binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002397

F

GO:0020037

heme binding

PMID:19846551[1]

IDA: Inferred from Direct Assay

F

GO:0031073

cholesterol 26-hydroxylase activity

PMID:19846551[1]

IDA: Inferred from Direct Assay

F

GO:0044117

growth of symbiont in host

PMID:15928073[2]

IMP: Inferred from Mutant Phenotype

P

GO:0046872

metal ion binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0479

F

GO:0055114

oxidation-reduction process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001128

P

GO:0055114

oxidation-reduction process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002397

P

GO:0055114

oxidation-reduction process

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

P


Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Capyk JK et al. (2009) Mycobacterial cytochrome p450 125 (cyp125) catalyzes the terminal hydroxylation of c27 steroids. J Biol Chem 284: 35534-42 PubMed GONUTS page
  2. Rengarajan J et al. (2005) Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages. Proc Natl Acad Sci U S A 102: 8327-32 PubMed GONUTS page
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