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MOUSE:VLDLR
Contents |
| Species (Taxon ID) | Mus musculus (Mouse). ([1]) | |
| Gene Name(s) | Vldlr | |
| Protein Name(s) | Very low-density lipoprotein receptor
VLDL receptor VLDL-R | |
| External Links | ||
| EMBL | L33417 U06670 S73732 | |
| IPI | IPI00323114 | |
| PIR | I48952 | |
| RefSeq | NP_001154892.1 NP_038731.2 | |
| UniGene | Mm.4141 | |
| ProteinModelPortal | P98156 | |
| SMR | P98156 | |
| IntAct | P98156 | |
| STRING | P98156 | |
| PRIDE | P98156 | |
| Ensembl | ENSMUST00000167487 | |
| GeneID | 22359 | |
| KEGG | mmu:22359 | |
| UCSC | uc008hbt.2 | |
| CTD | 7436 | |
| MGI | MGI:98935 | |
| eggNOG | roNOG10081 | |
| HOGENOM | HBG358235 | |
| HOVERGEN | HBG006250 | |
| InParanoid | P98156 | |
| OMA | QDDCNDG | |
| PhylomeDB | P98156 | |
| NextBio | 302661 | |
| ArrayExpress | P98156 | |
| Bgee | P98156 | |
| CleanEx | MM_VLDLR | |
| Genevestigator | P98156 | |
| GermOnline | ENSMUSG00000024924 | |
| GO | GO:0005905 GO:0016021 GO:0034361 GO:0005509 GO:0005515 GO:0030229 GO:0008203 GO:0006897 GO:0006869 GO:0021517 GO:0034447 | |
| InterPro | IPR011042 IPR006210 IPR001881 IPR013032 IPR000152 IPR000742 IPR018097 IPR009030 IPR023415 IPR000033 IPR002172 | |
| Gene3D | G3DSA:2.120.10.30 G3DSA:4.10.400.10 | |
| Pfam | PF07645 PF00057 PF00058 | |
| SMART | SM00181 SM00179 SM00192 SM00135 | |
| SUPFAM | SSF57184 SSF57424 | |
| PROSITE | PS00010 PS00022 PS01186 PS50026 PS01187 PS01209 PS50068 PS51120 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001666 |
response to hypoxia |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000036229 |
P |
Seeded From UniProt |
|||
| GO:0004872 |
receptor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005509 |
calcium ion binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005509 |
calcium ion binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005615 |
extracellular space |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005624 |
membrane fraction |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000371532 |
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000036229 |
C |
Seeded From UniProt |
|||
| GO:0005905 |
coated pit |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005905 |
coated pit |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0069 |
C |
Seeded From UniProt |
|||
| GO:0006629 |
lipid metabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006810 |
transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006869 |
lipid transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006897 |
endocytosis |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007507 |
heart development |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000036229 |
P |
Seeded From UniProt |
|||
| GO:0007584 |
response to nutrient |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000036229 |
P |
Seeded From UniProt |
|||
| GO:0008202 |
steroid metabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0008203 |
cholesterol metabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0009725 |
response to hormone stimulus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000036229 |
P |
Seeded From UniProt |
|||
| GO:0009986 |
cell surface |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000036229 |
C |
Seeded From UniProt |
|||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0162 |
C |
Seeded From UniProt |
|||
| GO:0016021 |
integral to membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0021517 |
ventral spinal cord development |
IEP: Inferred from Expression Pattern |
|
P |
Seeded From UniProt |
|||
| GO:0021987 |
cerebral cortex development |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000036229 |
P |
Seeded From UniProt |
|||
| GO:0030229 |
very-low-density lipoprotein particle receptor activity |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000371532 |
F |
Seeded From UniProt |
|||
| GO:0030229 |
very-low-density lipoprotein particle receptor activity |
ISS: Inferred from Sequence or Structural Similarity |
F |
Seeded From UniProt |
||||
| GO:0032496 |
response to lipopolysaccharide |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000036229 |
P |
Seeded From UniProt |
|||
| GO:0032869 |
cellular response to insulin stimulus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000036229 |
P |
Seeded From UniProt |
|||
| GO:0034361 |
very-low-density lipoprotein particle |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0034447 |
very-low-density lipoprotein particle clearance |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000371532 |
P |
Seeded From UniProt |
|||
| GO:0034447 |
very-low-density lipoprotein particle clearance |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0042149 |
cellular response to glucose starvation |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000036229 |
P |
Seeded From UniProt |
|||
| GO:0042493 |
response to drug |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000036229 |
P |
Seeded From UniProt |
|||
| GO:0045177 |
apical part of cell |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000036229 |
C |
Seeded From UniProt |
|||
| GO:0048471 |
perinuclear region of cytoplasm |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000036229 |
C |
Seeded From UniProt |
|||
| GO:0071222 |
cellular response to lipopolysaccharide |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000036229 |
P |
Seeded From UniProt |
|||
| GO:0071347 |
cellular response to interleukin-1 |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000036229 |
P |
Seeded From UniProt |
|||
| GO:0071456 |
cellular response to hypoxia |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000036229 |
P |
Seeded From UniProt |
|||
| GO:0038025 |
reelin receptor activity |
IMP: Inferred from Mutant Phenotype |
F |
Reelin signal was measured in Vldlr knockout mice by measuring Dab1 expression to examine neuron’s ability to transmit Reelin signal across plasma membrane. Quantitative immunofluorescence microscopy was used to determine levels of Dab1 expression. If neurons respond to Reelin, Dab1 expression is decreased whereas neurons that do not respond to Reelin, Dab1 expression is increased. Therefore knockout mice showed higher expression of Dab1 than wild type (five times)when mice reached maturity, meaning knockout mice did not respond to Reelin signaling. (supplemental figure 2) |
complete | |||
| GO:0048813 |
dendrite morphogenesis |
IMP: Inferred from Mutant Phenotype |
P |
Supplemental figure 3B: significant difference in primary and secondary dendritic branch length at early development of 4 DIV knockout Vldlr mice. Also figure 2C shows shorter dendrites in knockout than wild type |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Herrick TM & Cooper JA (2004) High affinity binding of Dab1 to Reelin receptors promotes normal positioning of upper layer cortical plate neurons. Brain Res Mol Brain Res 126: 121-8 PubMed GONUTS page
- ↑ Hoe HS & Rebeck GW (2005) Regulation of ApoE receptor proteolysis by ligand binding. Brain Res Mol Brain Res 137: 31-9 PubMed GONUTS page
- ↑ Palmesino E et al. (2010) Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling. PLoS Biol 8: e1000446 PubMed GONUTS page
- ↑ 4.0 4.1 Fish KN & Krucker T (2008) Functional consequences of hippocampal neuronal ectopia in the apolipoprotein E receptor-2 knockout mouse. Neurobiol Dis 32: 391-401 PubMed GONUTS page
