MOUSE:VGLU1

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Species (Taxon ID)	Mus musculus (Mouse). ([1])
Gene Name(s)	Slc17a7 (synonyms: Bnpi, Vglut1)
Protein Name(s)	Vesicular glutamate transporter 1 VGluT1 Brain-specific Na(+)-dependent inorganic phosphate cotransporter Solute carrier family 17 member 7
External Links
EMBL	AK159064 AC149868
IPI	IPI00109153
RefSeq	NP_892038.2
UniGene	Mm.255631
ProteinModelPortal	Q3TXX4
STRING	Q3TXX4
PhosphoSite	Q3TXX4
PRIDE	Q3TXX4
Ensembl	ENSMUST00000085374
GeneID	72961
KEGG	mmu:72961
UCSC	uc009gtx.2
CTD	57030
MGI	MGI:1920211
HOGENOM	HBG561587
HOVERGEN	HBG008834
InParanoid	Q3TXX4
OrthoDB	EOG4XWFXC
PhylomeDB	Q3TXX4
ArrayExpress	Q3TXX4
Bgee	Q3TXX4
Genevestigator	Q3TXX4
GO	GO:0030054 GO:0060076 GO:0016021 GO:0048786 GO:0030672 GO:0019717 GO:0051938 GO:0007616 GO:0006836 GO:0060079 GO:0042137 GO:0035249
InterPro	IPR011701 IPR020846 IPR016196
Pfam	PF07690
SUPFAM	SSF103473
PROSITE	PS50850

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005315	inorganic phosphate transmembrane transporter activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000063604	F	Seeded From UniProt
	GO:0006810	transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0813	P	Seeded From UniProt
	GO:0006811	ion transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0406	P	Seeded From UniProt
	GO:0006814	sodium ion transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0739	P	Seeded From UniProt
	GO:0006817	phosphate ion transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000063604	P	Seeded From UniProt
	GO:0006836	neurotransmitter transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0532	P	Seeded From UniProt
	GO:0007268	synaptic transmission	PMID:17611277^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3617803	P	Seeded From UniProt
	GO:0007616	long-term memory	PMID:17241289^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3051945	P	Seeded From UniProt
	GO:0008021	synaptic vesicle	PMID:15579147^[3]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0015293	symporter activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0769	F	Seeded From UniProt
	GO:0015319	sodium:inorganic phosphate symporter activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000221485	F	Seeded From UniProt
	GO:0015321	sodium-dependent phosphate transmembrane transporter activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000063604	F	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0162	C	Seeded From UniProt
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011701	C	Seeded From UniProt
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C	Seeded From UniProt
	GO:0016021	integral to membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000221485	C	Seeded From UniProt
	GO:0016021	integral to membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000063604	C	Seeded From UniProt
	GO:0019717	synaptosome	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0771	C	Seeded From UniProt
	GO:0019717	synaptosome	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0261	C	Seeded From UniProt
	GO:0030054	cell junction	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0965	C	Seeded From UniProt
	GO:0030672	synaptic vesicle membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0260	C	Seeded From UniProt
	GO:0030672	synaptic vesicle membrane	PMID:15860731^[4]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0031410	cytoplasmic vesicle	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0968	C	Seeded From UniProt
	GO:0035249	synaptic transmission, glutamatergic	PMID:15118123^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3617803	P	Seeded From UniProt
	GO:0042137	sequestering of neurotransmitter	PMID:15103023^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3051945	P	Seeded From UniProt
	GO:0044341	sodium-dependent phosphate transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000063604	P	Seeded From UniProt
	GO:0045202	synapse	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0770	C	Seeded From UniProt
	GO:0045202	synapse	PMID:15118123^[5]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0048786	presynaptic active zone	PMID:18986540^[7]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0050896	response to stimulus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0716	P	Seeded From UniProt
	GO:0051938	L-glutamate import	PMID:15118123^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3617803	P	Seeded From UniProt
	GO:0051938	L-glutamate import	PMID:15860731^[4]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0051938	L-glutamate import	PMID:15860731^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:1345280	P	Seeded From UniProt
	GO:0055085	transmembrane transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011701	P	Seeded From UniProt
	GO:0060076	excitatory synapse	PMID:17823315^[8]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0060079	regulation of excitatory postsynaptic membrane potential	PMID:15118123^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3617803	P	Seeded From UniProt
	GO:0009986	cell surface	PMID:21940441^[9]	IDA: Inferred from Direct Assay		C	After 24hour, staining of VGluT1 was found on the surface of IL1RAPL1 ECD domain coated beads, figure 2G and J.	complete

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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Johnson J et al. (2007) Vesicular glutamate transporter 1 is required for photoreceptor synaptic signaling but not for intrinsic visual functions. J Neurosci 27: 7245-55 PubMed GONUTS page
↑ Tordera RM et al. (2007) Enhanced anxiety, depressive-like behaviour and impaired recognition memory in mice with reduced expression of the vesicular glutamate transporter 1 (VGLUT1). Eur J Neurosci 25: 281-90 PubMed GONUTS page
↑ Nakamura M et al. (2004) Signaling complex formation of phospholipase Cbeta4 with metabotropic glutamate receptor type 1alpha and 1,4,5-trisphosphate receptor at the perisynapse and endoplasmic reticulum in the mouse brain. Eur J Neurosci 20: 2929-44 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Salazar G et al. (2005) Vglut1 and ZnT3 co-targeting mechanisms regulate vesicular zinc stores in PC12 cells. J Cell Sci 118: 1911-21 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Fremeau RT Jr et al. (2004) Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites. Science 304: 1815-9 PubMed GONUTS page
↑ Wojcik SM et al. (2004) An essential role for vesicular glutamate transporter 1 (VGLUT1) in postnatal development and control of quantal size. Proc Natl Acad Sci U S A 101: 7158-63 PubMed GONUTS page
↑ Davis EK et al. (2008) Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation. Neural Dev 3: 32 PubMed GONUTS page
↑ Tabuchi K et al. (2007) A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice. Science 318: 71-6 PubMed GONUTS page
↑ Yoshida T et al. (2011) IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase δ. J Neurosci 31: 13485-99 PubMed GONUTS page

[PMID:17611277-0] Johnson J et al. (2007) Vesicular glutamate transporter 1 is required for photoreceptor synaptic signaling but not for intrinsic visual functions. J Neurosci 27: 7245-55 PubMed GONUTS page

[PMID:17241289-1] Tordera RM et al. (2007) Enhanced anxiety, depressive-like behaviour and impaired recognition memory in mice with reduced expression of the vesicular glutamate transporter 1 (VGLUT1). Eur J Neurosci 25: 281-90 PubMed GONUTS page

[PMID:15579147-2] Nakamura M et al. (2004) Signaling complex formation of phospholipase Cbeta4 with metabotropic glutamate receptor type 1alpha and 1,4,5-trisphosphate receptor at the perisynapse and endoplasmic reticulum in the mouse brain. Eur J Neurosci 20: 2929-44 PubMed GONUTS page

[PMID:15860731-3] 4.0 ^4.1 ^4.2 Salazar G et al. (2005) Vglut1 and ZnT3 co-targeting mechanisms regulate vesicular zinc stores in PC12 cells. J Cell Sci 118: 1911-21 PubMed GONUTS page

[PMID:15118123-4] 5.0 ^5.1 ^5.2 ^5.3 Fremeau RT Jr et al. (2004) Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites. Science 304: 1815-9 PubMed GONUTS page

[PMID:15103023-5] Wojcik SM et al. (2004) An essential role for vesicular glutamate transporter 1 (VGLUT1) in postnatal development and control of quantal size. Proc Natl Acad Sci U S A 101: 7158-63 PubMed GONUTS page

[PMID:18986540-6] Davis EK et al. (2008) Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation. Neural Dev 3: 32 PubMed GONUTS page

[PMID:17823315-7] Tabuchi K et al. (2007) A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice. Science 318: 71-6 PubMed GONUTS page

[PMID:21940441-8] Yoshida T et al. (2011) IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase δ. J Neurosci 31: 13485-99 PubMed GONUTS page

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MOUSE:VGLU1

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