GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
MOUSE:UBR1
Contents |
| Species (Taxon ID) | Mus musculus (Mouse). ([1]) | |
| Gene Name(s) | Ubr1 | |
| Protein Name(s) | E3 ubiquitin-protein ligase UBR1
N-recognin-1 Ubiquitin-protein ligase E3-alpha-1 Ubiquitin-protein ligase E3-alpha-I | |
| External Links | ||
| EMBL | AF061555 AF067379 AF067371 AF067372 AF067373 AF067375 AF067377 AF067378 AF067376 AF067374 AL844548 AL935168 AL935168 AL844548 AK078173 AK089616 BC090969 | |
| IPI | IPI00118376 | |
| PIR | T14318 | |
| RefSeq | NP_033487.2 | |
| UniGene | Mm.389330 | |
| ProteinModelPortal | O70481 | |
| IntAct | O70481 | |
| STRING | O70481 | |
| PhosphoSite | O70481 | |
| PRIDE | O70481 | |
| Ensembl | ENSMUST00000028728 | |
| GeneID | 22222 | |
| MGI | MGI:1277977 | |
| HOGENOM | HBG356075 | |
| HOVERGEN | HBG080426 | |
| InParanoid | O70481 | |
| OrthoDB | EOG41G338 | |
| PhylomeDB | O70481 | |
| ArrayExpress | O70481 | |
| Bgee | O70481 | |
| Genevestigator | O70481 | |
| GermOnline | ENSMUSG00000027272 | |
| GO | GO:0005829 GO:0000502 GO:0000151 GO:0005515 GO:0004842 GO:0008270 GO:0071233 GO:0032007 GO:0006511 | |
| InterPro | IPR003769 IPR014719 IPR003126 IPR013993 IPR013083 | |
| Gene3D | G3DSA:3.30.1390.10 G3DSA:3.30.40.10 | |
| Pfam | PF02617 PF02207 | |
| SMART | SM00396 | |
| SUPFAM | SSF54736 | |
| PROSITE | PS00518 PS50089 PS51157 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000151 |
ubiquitin ligase complex |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1861099 |
C |
Seeded From UniProt |
|||
| GO:0000502 |
proteasome complex |
IGI: Inferred from Genetic Interaction |
SGD:S000003416 |
C |
Seeded From UniProt |
|||
| GO:0004842 |
ubiquitin-protein ligase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004842 |
ubiquitin-protein ligase activity |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1861099 |
F |
Seeded From UniProt |
|||
| GO:0004842 |
ubiquitin-protein ligase activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005829 |
cytosol |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0091 |
C |
Seeded From UniProt |
|||
| GO:0006511 |
ubiquitin-dependent protein catabolic process |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2178612 |
P |
Seeded From UniProt |
|||
| GO:0006511 |
ubiquitin-dependent protein catabolic process |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0008270 |
zinc ion binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016567 |
protein ubiquitination |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0016567 |
protein ubiquitination |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1861099 |
P |
Seeded From UniProt |
|||
| GO:0016567 |
protein ubiquitination |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0016874 |
ligase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0030163 |
protein catabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0032007 |
negative regulation of TOR signaling cascade |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000290650 |
P |
Seeded From UniProt |
|||
| GO:0032007 |
negative regulation of TOR signaling cascade |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0046872 |
metal ion binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0070728 |
leucine binding |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000290650 |
F |
Seeded From UniProt |
|||
| GO:0071233 |
cellular response to leucine |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSP00000290650 |
P |
Seeded From UniProt |
|||
| GO:0071233 |
cellular response to leucine |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
| |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Kwon YT et al. (2001) Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway. Mol Cell Biol 21: 8007-21 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Kwon YT et al. (2003) Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway. Mol Cell Biol 23: 8255-71 PubMed GONUTS page
- ↑ 3.0 3.1 Tasaki T et al. (2007) Biochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systems. J Biol Chem 282: 18510-20 PubMed GONUTS page
