MOUSE:TRPV4

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Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Trpv4 ( synonyms: Trp12, Vrl2, Vroac )
Protein Name(s)	Transient receptor potential cation channel subfamily V member 4 TrpV4 Osm-9-like TRP channel 4 OTRPC4 Transient receptor potential protein 12 TRP12 Vanilloid receptor-like channel 2 Vanilloid receptor-like protein 2 Vanilloid receptor-related osmotically-activated channel VR-OAC
External Links
UniProt Identifier	TRPV4_MOUSE
UniProt Accessions	Q9EPK8, A0JNY0, Q91XR5, Q9EQZ4, Q9ERZ7, Q9ES76,
EMBL	AF263522, AJ296078, AF208026, AB021875, AF279672, BC127052,
RefSeq	NP_071300.2,
Ensembl	ENSMUST00000071968, ENSMUST00000112225,
Pfam	PF00023, PF00520,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0005912	adherens junction	PMID:20413591^[1]	IDA: Inferred from Direct Assay		C
	GO:0005262	calcium channel activity	PMID:12538589^[2]	IDA: Inferred from Direct Assay		F
	GO:0005034	osmosensor activity	PMID:12777254^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2667379	F
	GO:0042538	hyperosmotic salinity response	PMID:12777254^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2667379	P
	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000261740	P
	GO:0005912	adherens junction	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0009	C
	GO:0005516	calmodulin binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9HBA0	F
	GO:0005261	cation channel activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000261740	F
	GO:0005216	ion channel activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0407	F
	GO:0005886	plasma membrane	PMID:12538589^[2]	IDA: Inferred from Direct Assay		C
	GO:0042802	identical protein binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000261740	F
	GO:0007231	osmosensory signaling pathway	PMID:11025659^[4]	IDA: Inferred from Direct Assay		P
	GO:0042169	SH2 domain binding	PMID:12538589^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P39688	F
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000261740	C
	GO:0005216	ion channel activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004729	F
	GO:0005262	calcium channel activity	PMID:14517216^[5]	IDA: Inferred from Direct Assay		F
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004729	C
	GO:0005216	ion channel activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005821	F
	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9HBA0	P
	GO:0005262	calcium channel activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000261740	F
	GO:0005262	calcium channel activity	PMID:11025659^[4]	IDA: Inferred from Direct Assay		F
	GO:0005516	calmodulin binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000261740	F
	GO:0005886	plasma membrane	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9HBA0	C
	GO:0005886	plasma membrane	PMID:20413591^[1]	IDA: Inferred from Direct Assay		C
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0006971	hypotonic response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001586	P
	GO:0047484	regulation of response to osmotic stress	PMID:12777254^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2667379	P
	GO:0005515	protein binding	PMID:20413591^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q02248	F
	GO:0007043	cell-cell junction assembly	PMID:20413591^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0006810	transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0813	P
	GO:0030054	cell junction	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0965	C
	GO:0006811	ion transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005821	P
	GO:0055085	transmembrane transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005821	P
	GO:0005886	plasma membrane	PMID:14517216^[5]	IDA: Inferred from Direct Assay		C
	GO:0005034	osmosensor activity	PMID:11025659^[4]	IDA: Inferred from Direct Assay		F
	GO:0070509	calcium ion import	PMID:12538589^[2]	IDA: Inferred from Direct Assay		P
	GO:0005929	cilium	PMID:15858826^[6]	IDA: Inferred from Direct Assay		C
	GO:0006811	ion transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004729	P
	GO:0071476	cellular hypotonic response	PMID:12538589^[2]	IDA: Inferred from Direct Assay		P
	GO:0019901	protein kinase binding	PMID:12538589^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P07948	F
	GO:0006816	calcium ion transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0109	P
	GO:0030103	vasopressin secretion	PMID:12777254^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2667379	P
	GO:0005261	cation channel activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9HBA0	F
	GO:0005262	calcium channel activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0107	F
	GO:0006811	ion transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0406	P
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0070588	calcium ion transmembrane transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0107	P
	GO:0006816	calcium ion transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000261740	P
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0007231	osmosensory signaling pathway	PMID:12777254^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2667379	P
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0007204	elevation of cytosolic calcium ion concentration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000261740	P
	GO:0007231	osmosensory signaling pathway	PMID:12538589^[2]	IDA: Inferred from Direct Assay		P
	GO:0005516	calmodulin binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0112	F
	GO:0006970	response to osmotic stress	PMID:11025659^[4]	IDA: Inferred from Direct Assay		P
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005821	C
	GO:0003779	actin binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001586	F
	GO:0005034	osmosensor activity	PMID:11025659^[4]	IDA: Inferred from Direct Assay		F
	GO:0005034	osmosensor activity	PMID:12777254^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2667379	F
	GO:0005080	protein kinase C binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001586	F
	GO:0005216	ion channel activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004729	F
	GO:0005216	ion channel activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005821	F
	GO:0005216	ion channel activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0407	F
	GO:0005261	cation channel activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000406191	F
	GO:0005261	cation channel activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001586	F
	GO:0005261	cation channel activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9HBA0	F
	GO:0005262	calcium channel activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0107	F
	GO:0005262	calcium channel activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000406191	F
	GO:0005262	calcium channel activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001586	F
	GO:0005262	calcium channel activity	PMID:11025659^[4]	IDA: Inferred from Direct Assay		F
	GO:0005262	calcium channel activity	PMID:12538589^[2]	IDA: Inferred from Direct Assay		F
	GO:0005262	calcium channel activity	PMID:14517216^[5]	IDA: Inferred from Direct Assay		F
	GO:0005515	protein binding	PMID:14517216^[5]	IPI: Inferred from Physical Interaction	UniProtKB:O88735	F
	GO:0005515	protein binding	PMID:20413591^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q02248	F
	GO:0005516	calmodulin binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0112	F
	GO:0005516	calmodulin binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000406191	F
	GO:0005516	calmodulin binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9HBA0	F
	GO:0005881	cytoplasmic microtubule	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001586	C
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000406191	C
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0005886	plasma membrane	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9HBA0	C
	GO:0005886	plasma membrane	PMID:12538589^[2]	IDA: Inferred from Direct Assay		C
	GO:0005886	plasma membrane	PMID:14517216^[5]	IDA: Inferred from Direct Assay		C
	GO:0005886	plasma membrane	PMID:20413591^[1]	IDA: Inferred from Direct Assay		C
	GO:0005912	adherens junction	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0009	C
	GO:0005912	adherens junction	PMID:20413591^[1]	IDA: Inferred from Direct Assay		C
	GO:0005925	focal adhesion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001586	C
	GO:0005929	cilium	PMID:15858826^[6]	IDA: Inferred from Direct Assay		C
	GO:0006810	transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0813	P
	GO:0006811	ion transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004729	P
	GO:0006811	ion transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005821	P
	GO:0006811	ion transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0406	P
	GO:0006816	calcium ion transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0109	P
	GO:0006816	calcium ion transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000406191	P
	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000406191	P
	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9HBA0	P
	GO:0006970	response to osmotic stress	PMID:11025659^[4]	IDA: Inferred from Direct Assay		P
	GO:0006971	hypotonic response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001586	P
	GO:0007015	actin filament organization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001586	P
	GO:0007043	cell-cell junction assembly	PMID:20413591^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0007204	elevation of cytosolic calcium ion concentration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000406191	P
	GO:0007231	osmosensory signaling pathway	PMID:11025659^[4]	IDA: Inferred from Direct Assay		P
	GO:0007231	osmosensory signaling pathway	PMID:12538589^[2]	IDA: Inferred from Direct Assay		P
	GO:0007231	osmosensory signaling pathway	PMID:12777254^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2667379	P
	GO:0008017	microtubule binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001586	F
	GO:0010977	negative regulation of neuron projection development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001586	P
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005821	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004729	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0019901	protein kinase binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000406191	F
	GO:0019901	protein kinase binding	PMID:12538589^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P07948	F
	GO:0030027	lamellipodium	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001586	C
	GO:0030054	cell junction	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0965	C
	GO:0030103	vasopressin secretion	PMID:12777254^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2667379	P
	GO:0030175	filopodium	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001586	C
	GO:0030426	growth cone	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001586	C
	GO:0030864	cortical actin cytoskeleton	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001586	C
	GO:0031117	positive regulation of microtubule depolymerization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001586	P
	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001586	P
	GO:0032587	ruffle membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001586	C
	GO:0042169	SH2 domain binding	PMID:12538589^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P39688	F
	GO:0042538	hyperosmotic salinity response	PMID:12777254^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2667379	P
	GO:0043014	alpha-tubulin binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001586	F
	GO:0043622	cortical microtubule organization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001586	P
	GO:0046785	microtubule polymerization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001586	P
	GO:0047484	regulation of response to osmotic stress	PMID:12777254^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2667379	P
	GO:0048487	beta-tubulin binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001586	F
	GO:0051015	actin filament binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001586	F
	GO:0055085	transmembrane transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005821	P
	GO:0070509	calcium ion import	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001586	P
	GO:0070509	calcium ion import	PMID:12538589^[2]	IDA: Inferred from Direct Assay		P
	GO:0070588	calcium ion transmembrane transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0107	P
	GO:0070588	calcium ion transmembrane transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000406191	P
	GO:0071476	cellular hypotonic response	PMID:12538589^[2]	IDA: Inferred from Direct Assay		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Sokabe T et al. (2010) The TRPV4 channel contributes to intercellular junction formation in keratinocytes. J Biol Chem 285: 18749-58 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 Xu H et al. (2003) Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress. J Biol Chem 278: 11520-7 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 ^3.9 Mizuno A et al. (2003) Impaired osmotic sensation in mice lacking TRPV4. Am J Physiol Cell Physiol 285: C96-101 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Strotmann R et al. (2000) OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nat Cell Biol 2: 695-702 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Suzuki M et al. (2003) Microtubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4). J Biol Chem 278: 51448-53 PubMed GONUTS page
↑ ^6.0 ^6.1 Teilmann SC et al. (2005) Localization of transient receptor potential ion channels in primary and motile cilia of the female murine reproductive organs. Mol Reprod Dev 71: 444-52 PubMed GONUTS page

[PMID:20413591-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Sokabe T et al. (2010) The TRPV4 channel contributes to intercellular junction formation in keratinocytes. J Biol Chem 285: 18749-58 PubMed GONUTS page

[PMID:12538589-1] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 Xu H et al. (2003) Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress. J Biol Chem 278: 11520-7 PubMed GONUTS page

[PMID:12777254-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 ^3.9 Mizuno A et al. (2003) Impaired osmotic sensation in mice lacking TRPV4. Am J Physiol Cell Physiol 285: C96-101 PubMed GONUTS page

[PMID:11025659-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Strotmann R et al. (2000) OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nat Cell Biol 2: 695-702 PubMed GONUTS page

[PMID:14517216-4] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Suzuki M et al. (2003) Microtubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4). J Biol Chem 278: 51448-53 PubMed GONUTS page

[PMID:15858826-5] 6.0 ^6.1 Teilmann SC et al. (2005) Localization of transient receptor potential ion channels in primary and motile cilia of the female murine reproductive organs. Mol Reprod Dev 71: 444-52 PubMed GONUTS page

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MOUSE:TRPV4

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