MOUSE:TNR5

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Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Cd40 ( synonyms: Tnfrsf5 )
Protein Name(s)	Tumor necrosis factor receptor superfamily member 5 B-cell surface antigen CD40 Bp50 CD40L receptor
External Links
UniProt Identifier	TNR5_MOUSE
UniProt Accessions	P27512, Q3TS33, Q3TSL2, Q3U799, Q3U7C9, Q3UBH3, Q542B1, Q8K2X6, Q99NE0, Q99NE1, Q99NE2, Q99NE3,
EMBL	M83312, M94126, M94129, M94128, M94127, AJ401387, AJ401388, AJ401389, AJ401390, AK089861, AK150959, AK152716, AK152756, AK152942, AK156644, AK161978, AK162305, CT010343, AL591495, AL591411, BC029254,
PIR	A46476,
RefSeq	NP_035741.2, NP_733803.2, NP_733804.1, NP_733805.1,
IntAct	P27512,
Ensembl	ENSMUST00000017799, ENSMUST00000073707, ENSMUST00000081310,
Pfam	PF00020,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0009897	external side of plasma membrane		IDA: Inferred from Direct Assay		C	Source: MGI
	GO:0005576	extracellular region		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-SubCell
	GO:0016021	integral to membrane		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-KW
	GO:0043231	intracellular membrane-bounded organelle		IDA: Inferred from Direct Assay		C	Source: MGI
	GO:0004872	receptor activity		IEA: Inferred from Electronic Annotation		F	Source: UniProtKB-KW
	GO:0042113	B cell activation		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0002768	immune response-regulating cell surface rec...		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0030890	positive regulation of B cell proliferation		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0032735	positive regulation of interleukin-12 produ...		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0048304	positive regulation of isotype switching to...		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0051023	regulation of immunoglobulin secretion		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0005515	protein binding	PMID:20614026^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q9JIY5	F	Figures 1 & 2 show co-immunoprecipitation using Western blot verification of mass spectrometry results of hmCD40 and hmCD40D67 ARC ‘‘activated receptor capture’’ samples.	complete
	GO:0005515	protein binding	PMID:20614026^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q924T7	F	Figures 1 & 2 show co-immunoprecipitation using Western blot verification of mass spectrometry results of hmCD40 and hmCD40D67 ARC ‘‘activated receptor capture’’ samples.	complete
	GO:0005515	protein binding	PMID:20614026^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q9JIQ3	F	Figures 1 & 2 show co-immunoprecipitation using Western blot verification of mass spectrometry results of hmCD40 and hmCD40D67 ARC ‘‘activated receptor capture’’ samples.	complete
	GO:0005886	plasma membrane	PMID:20614026^[1]	IDA: Inferred from Direct Assay		C	Figure 2. Western blot verification of mass spectrometry results. hmCD40 and hmCD40D67 ARC ‘‘activated receptor capture’’ samples.	complete
	GO:0002768	immune response-regulating cell surface receptor signaling pathway	PMID:15240714^[2]	IDA: Inferred from Direct Assay		P
	GO:0004872	receptor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0675	F
	GO:0005488	binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001368	F
	GO:0005515	protein binding	PMID:20614026^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P39429	F
	GO:0005515	protein binding	PMID:21441935^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P35991	F
	GO:0005515	protein binding	PMID:8910514^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P70196	F
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000361359	C
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0005886	plasma membrane	PMID:20614026^[1]	IDA: Inferred from Direct Assay		C
	GO:0009897	external side of plasma membrane	PMID:10979977^[5]	IDA: Inferred from Direct Assay		C
	GO:0009897	external side of plasma membrane	PMID:14560001^[6]	IDA: Inferred from Direct Assay		C
	GO:0009897	external side of plasma membrane	PMID:15240714^[2]	IDA: Inferred from Direct Assay		C
	GO:0009897	external side of plasma membrane	PMID:17277142^[7]	IDA: Inferred from Direct Assay		C
	GO:0009897	external side of plasma membrane	PMID:8566034^[8]	IDA: Inferred from Direct Assay		C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0019899	enzyme binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000361359	F
	GO:0030890	positive regulation of B cell proliferation	PMID:10979977^[5]	IDA: Inferred from Direct Assay		P
	GO:0030890	positive regulation of B cell proliferation	PMID:11894097^[9]	IDA: Inferred from Direct Assay		P
	GO:0030890	positive regulation of B cell proliferation	PMID:14607964^[10]	IDA: Inferred from Direct Assay		P
	GO:0030890	positive regulation of B cell proliferation	PMID:15963492^[11]	IGI: Inferred from Genetic Interaction	MGI:MGI:87891	P
	GO:0030890	positive regulation of B cell proliferation	PMID:8666928^[12]	IDA: Inferred from Direct Assay		P
	GO:0030890	positive regulation of B cell proliferation	PMID:8920854^[13]	IDA: Inferred from Direct Assay		P
	GO:0032735	positive regulation of interleukin-12 production	PMID:15240714^[2]	IDA: Inferred from Direct Assay		P
	GO:0035631	CD40 receptor complex	PMID:20614026^[1]	IDA: Inferred from Direct Assay		C
	GO:0042113	B cell activation	PMID:14594818^[14]	IDA: Inferred from Direct Assay		P
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000361359	P
	GO:0043231	intracellular membrane-bounded organelle	PMID:16708399^[15]	IDA: Inferred from Direct Assay		C
	GO:0048304	positive regulation of isotype switching to IgG isotypes	PMID:12882831^[16]	IDA: Inferred from Direct Assay		P
	GO:0050776	regulation of immune response	PMID:12882831^[16]	IDA: Inferred from Direct Assay		P
	GO:0051023	regulation of immunoglobulin secretion	PMID:12958312^[17]	IDA: Inferred from Direct Assay		P
	GO:0051607	defense response to virus	PMID:17277142^[7]	IDA: Inferred from Direct Assay		P
	GO:0071260	cellular response to mechanical stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000361359	P
	GO:2000353	positive regulation of endothelial cell apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000361359	P
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Hostager BS et al. (2010) HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex. PLoS One 5: e11380 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 McKee AS & Pearce EJ (2004) CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development. J Immunol 173: 1224-31 PubMed GONUTS page
↑ Liu X et al. (2011) Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk. Nat Immunol 12: 416-24 PubMed GONUTS page
↑ Ishida T et al. (1996) Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region. J Biol Chem 271: 28745-8 PubMed GONUTS page
↑ ^5.0 ^5.1 Sexl V et al. (2000) Stat5a/b contribute to interleukin 7-induced B-cell precursor expansion, but abl- and bcr/abl-induced transformation are independent of stat5. Blood 96: 2277-83 PubMed GONUTS page
↑ Pauleau AL & Murray PJ (2003) Role of nod2 in the response of macrophages to toll-like receptor agonists. Mol Cell Biol 23: 7531-9 PubMed GONUTS page
↑ ^7.0 ^7.1 Hervas-Stubbs S et al. (2007) Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN. J Immunol 178: 2361-9 PubMed GONUTS page
↑ Kong YY et al. (1995) Differential requirements of CD45 for lymphocyte development and function. Eur J Immunol 25: 3431-6 PubMed GONUTS page
↑ Chin AI et al. (2002) Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. Nature 416: 190-4 PubMed GONUTS page
↑ Aldrich MB et al. (2003) Impaired germinal center maturation in adenosine deaminase deficiency. J Immunol 171: 5562-70 PubMed GONUTS page
↑ Skok M et al. (2005) Nicotinic receptors regulate B lymphocyte activation and immune response. Eur J Pharmacol 517: 246-51 PubMed GONUTS page
↑ Byth KF et al. (1996) CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation. J Exp Med 183: 1707-18 PubMed GONUTS page
↑ Chappel MS et al. (1996) Cross-linking the murine heat-stable antigen induces apoptosis in B cell precursors and suppresses the anti-CD40-induced proliferation of mature resting B lymphocytes. J Exp Med 184: 1639-49 PubMed GONUTS page
↑ Merluzzi S et al. (2004) CD40 stimulation induces Pax5/BSAP and EBF activation through a APE/Ref-1-dependent redox mechanism. J Biol Chem 279: 1777-86 PubMed GONUTS page
↑ Chen W et al. (2006) Efficient induction of antitumor T cell immunity by exosomes derived from heat-shocked lymphoma cells. Eur J Immunol 36: 1598-607 PubMed GONUTS page
↑ ^16.0 ^16.1 Gerth AJ et al. (2003) T-bet regulates T-independent IgG2a class switching. Int Immunol 15: 937-44 PubMed GONUTS page
↑ Hostager BS et al. (2003) Tumor necrosis factor receptor-associated factor 2 (TRAF2)-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling. J Biol Chem 278: 45382-90 PubMed GONUTS page

[PMID:20614026-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Hostager BS et al. (2010) HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex. PLoS One 5: e11380 PubMed GONUTS page

[PMID:15240714-1] 2.0 ^2.1 ^2.2 McKee AS & Pearce EJ (2004) CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development. J Immunol 173: 1224-31 PubMed GONUTS page

[PMID:21441935-2] Liu X et al. (2011) Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk. Nat Immunol 12: 416-24 PubMed GONUTS page

[PMID:8910514-3] Ishida T et al. (1996) Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region. J Biol Chem 271: 28745-8 PubMed GONUTS page

[PMID:10979977-4] 5.0 ^5.1 Sexl V et al. (2000) Stat5a/b contribute to interleukin 7-induced B-cell precursor expansion, but abl- and bcr/abl-induced transformation are independent of stat5. Blood 96: 2277-83 PubMed GONUTS page

[PMID:14560001-5] Pauleau AL & Murray PJ (2003) Role of nod2 in the response of macrophages to toll-like receptor agonists. Mol Cell Biol 23: 7531-9 PubMed GONUTS page

[PMID:17277142-6] 7.0 ^7.1 Hervas-Stubbs S et al. (2007) Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN. J Immunol 178: 2361-9 PubMed GONUTS page

[PMID:8566034-7] Kong YY et al. (1995) Differential requirements of CD45 for lymphocyte development and function. Eur J Immunol 25: 3431-6 PubMed GONUTS page

[PMID:11894097-8] Chin AI et al. (2002) Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. Nature 416: 190-4 PubMed GONUTS page

[PMID:14607964-9] Aldrich MB et al. (2003) Impaired germinal center maturation in adenosine deaminase deficiency. J Immunol 171: 5562-70 PubMed GONUTS page

[PMID:15963492-10] Skok M et al. (2005) Nicotinic receptors regulate B lymphocyte activation and immune response. Eur J Pharmacol 517: 246-51 PubMed GONUTS page

[PMID:8666928-11] Byth KF et al. (1996) CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation. J Exp Med 183: 1707-18 PubMed GONUTS page

[PMID:8920854-12] Chappel MS et al. (1996) Cross-linking the murine heat-stable antigen induces apoptosis in B cell precursors and suppresses the anti-CD40-induced proliferation of mature resting B lymphocytes. J Exp Med 184: 1639-49 PubMed GONUTS page

[PMID:14594818-13] Merluzzi S et al. (2004) CD40 stimulation induces Pax5/BSAP and EBF activation through a APE/Ref-1-dependent redox mechanism. J Biol Chem 279: 1777-86 PubMed GONUTS page

[PMID:16708399-14] Chen W et al. (2006) Efficient induction of antitumor T cell immunity by exosomes derived from heat-shocked lymphoma cells. Eur J Immunol 36: 1598-607 PubMed GONUTS page

[PMID:12882831-15] 16.0 ^16.1 Gerth AJ et al. (2003) T-bet regulates T-independent IgG2a class switching. Int Immunol 15: 937-44 PubMed GONUTS page

[PMID:12958312-16] Hostager BS et al. (2003) Tumor necrosis factor receptor-associated factor 2 (TRAF2)-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling. J Biol Chem 278: 45382-90 PubMed GONUTS page

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MOUSE:TNR5

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