MOUSE:TNFL6

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Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Faslg ( synonyms: Apt1lg1, Cd95l, Fasl, gld, Tnfsf6 )
Protein Name(s)	Tumor necrosis factor ligand superfamily member 6 CD95 ligand CD95-L Fas antigen ligand Fas ligand Tumor necrosis factor ligand superfamily member 6, membrane form Tumor necrosis factor ligand superfamily member 6, soluble form
External Links
UniProt Identifier	TNFL6_MOUSE
UniProt Accessions	P41047, Q61217, Q9R1F2,
EMBL	U06948, U10984, S76752, U58995, AF119335,
PIR	A53062,
RefSeq	NP_034307.1,
Ensembl	ENSMUST00000000834,
Pfam	PF00229,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0009897	external side of plasma membrane		IDA: Inferred from Direct Assay		C	Source: MGI
	GO:0005615	extracellular space		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-KW
	GO:0016021	integral to membrane		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-KW
	GO:0005125	cytokine activity		IEA: Inferred from Electronic Annotation		F	Source: UniProtKB-KW
	GO:0006955	immune response		IEA: Inferred from Electronic Annotation		P	Source: InterPro
	GO:0046666	retinal cell programmed cell death		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0007165	signal transduction		IEA: Inferred from Electronic Annotation		P	Source: InterPro
	GO:0043065	positive regulation of apoptosis	PMID:20100735^[1]	IMP: Inferred from Mutant Phenotype		P	fig.1	complete
	GO:0010468	regulation of gene expression	PMID:20100735^[1]	IMP: Inferred from Mutant Phenotype		P	Fig.5A,B	complete
	GO:0005125	cytokine activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0202	F
	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006052	F
	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006053	F
	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008064	F
	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000003998	F
	GO:0005576	extracellular region	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008064	C
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005576	extracellular region	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000356694	C
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C
	GO:0005615	extracellular space	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0202	C
	GO:0005615	extracellular space	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000356694	C
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0005901	caveola	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000003998	C
	GO:0006915	apoptosis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008064	P
	GO:0006915	apoptosis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0053	P
	GO:0006915	apoptosis	PMID:16365167^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:97847	P
	GO:0006919	activation of caspase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000356694	P
	GO:0006925	inflammatory cell apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000003998	P
	GO:0006955	immune response	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006052	P
	GO:0006955	immune response	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006053	P
	GO:0006955	immune response	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008064	P
	GO:0007165	signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008064	P
	GO:0008284	positive regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000003998	P
	GO:0008624	induction of apoptosis by extracellular signals	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000356694	P
	GO:0008624	induction of apoptosis by extracellular signals	PMID:15039234^[3]	IDA: Inferred from Direct Assay		P
	GO:0008624	induction of apoptosis by extracellular signals	PMID:15629131^[4]	IDA: Inferred from Direct Assay		P
	GO:0008624	induction of apoptosis by extracellular signals	PMID:7511063^[5]	IDA: Inferred from Direct Assay		P
	GO:0008625	induction of apoptosis via death domain receptors	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000003998	P
	GO:0008633	activation of pro-apoptotic gene products	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000356694	P
	GO:0009897	external side of plasma membrane	PMID:16973387^[6]	IDA: Inferred from Direct Assay		C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006052	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006053	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008064	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0016023	cytoplasmic membrane-bounded vesicle	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000003998	C
	GO:0016525	negative regulation of angiogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000356694	P
	GO:0030644	cellular chloride ion homeostasis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000003998	P
	GO:0032496	response to lipopolysaccharide	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000003998	P
	GO:0033554	cellular response to stress	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000003998	P
	GO:0043065	positive regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000356694	P
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000356694	P
	GO:0043525	positive regulation of neuron apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000003998	P
	GO:0045121	membrane raft	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000003998	C
	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000003998	P
	GO:0046666	retinal cell programmed cell death	PMID:14517994^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856384	P
	GO:0048388	endosomal lumen acidification	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000003998	P
	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000003998	C
	GO:0060554	induction of necroptosis of activated-T cells	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000356694	P
	GO:0060555	induction of necroptosis by extracellular signals	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000356694	P
	GO:0070265	necrotic cell death	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000356694	P
	GO:0070848	response to growth factor stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000003998	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Lin YC et al. (2010) FasL gene-deficient mice display a limited disruption in spermatogenesis and inhibition of mono-(2-ethylhexyl) phthalate-induced germ cell apoptosis. Toxicol Sci 114: 335-45 PubMed GONUTS page
↑ Piazzolla D et al. (2005) Raf-1 sets the threshold of Fas sensitivity by modulating Rok-alpha signaling. J Cell Biol 171: 1013-22 PubMed GONUTS page
↑ Hiatt K et al. (2004) Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells. Am J Pathol 164: 1471-9 PubMed GONUTS page
↑ Hsu LJ et al. (2005) Cloning and characterization of a small-size peptide Zfra that regulates the cytotoxic function of tumor necrosis factor by interacting with JNK1. Biochem Biophys Res Commun 327: 415-23 PubMed GONUTS page
↑ Takahashi T et al. (1994) Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76: 969-76 PubMed GONUTS page
↑ Marie JC et al. (2006) Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity 25: 441-54 PubMed GONUTS page
↑ Péquignot MO et al. (2003) Major role of BAX in apoptosis during retinal development and in establishment of a functional postnatal retina. Dev Dyn 228: 231-8 PubMed GONUTS page

[PMID:20100735-0] 1.0 ^1.1 Lin YC et al. (2010) FasL gene-deficient mice display a limited disruption in spermatogenesis and inhibition of mono-(2-ethylhexyl) phthalate-induced germ cell apoptosis. Toxicol Sci 114: 335-45 PubMed GONUTS page

[PMID:16365167-1] Piazzolla D et al. (2005) Raf-1 sets the threshold of Fas sensitivity by modulating Rok-alpha signaling. J Cell Biol 171: 1013-22 PubMed GONUTS page

[PMID:15039234-2] Hiatt K et al. (2004) Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells. Am J Pathol 164: 1471-9 PubMed GONUTS page

[PMID:15629131-3] Hsu LJ et al. (2005) Cloning and characterization of a small-size peptide Zfra that regulates the cytotoxic function of tumor necrosis factor by interacting with JNK1. Biochem Biophys Res Commun 327: 415-23 PubMed GONUTS page

[PMID:7511063-4] Takahashi T et al. (1994) Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76: 969-76 PubMed GONUTS page

[PMID:16973387-5] Marie JC et al. (2006) Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity 25: 441-54 PubMed GONUTS page

[PMID:14517994-6] Péquignot MO et al. (2003) Major role of BAX in apoptosis during retinal development and in establishment of a functional postnatal retina. Dev Dyn 228: 231-8 PubMed GONUTS page

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MOUSE:TNFL6

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