MOUSE:TNFA

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Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Tnf ( synonyms: Tnfa, Tnfsf2 )
Protein Name(s)	Tumor necrosis factor Cachectin TNF-alpha Tumor necrosis factor ligand superfamily member 2 TNF-a Tumor necrosis factor, membrane form Tumor necrosis factor, soluble form
External Links
UniProt Identifier	TNFA_MOUSE
UniProt Accessions	P06804, O35853, Q62326, Q91VF3,
EMBL	M20155, M11731, M13049, X02611, M38296, Y00467, U06950, D84196, D84199, U68414, AF109719, AB039224, AB039225, AB039226, AB039227, AB039228, AB039229, AB039230, AB039231, AB039232,
PIR	A22908,
RefSeq	NP_038721.1,
PDB	2TNF,
Ensembl	ENSMUST00000025263, ENSMUST00000167924,
Pfam	PF00229,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0000060	protein import into nucleus, translocation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	PMID:9305915^[1]	IDA: Inferred from Direct Assay		P
	GO:0000187	activation of MAPK activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0001666	response to hypoxia	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0001775	cell activation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0001819	positive regulation of cytokine production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0001891	phagocytic cup	PMID:16282525^[2]	IDA: Inferred from Direct Assay		C
	GO:0001932	regulation of protein phosphorylation	PMID:15169905^[3]	IDA: Inferred from Direct Assay		P
	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0002020	protease binding	PMID:12135759^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q05910	F
	GO:0002037	negative regulation of L-glutamate transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0002439	chronic inflammatory response to antigenic stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0002740	negative regulation of cytokine secretion involved in immune response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0002876	positive regulation of chronic inflammatory response to antigenic stimulus	PMID:9834074^[5]	IGI: Inferred from Genetic Interaction	MGI:MGI:104797	P
	GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin	PMID:9834074^[5]	IGI: Inferred from Genetic Interaction	MGI:MGI:104797	P
	GO:0003009	skeletal muscle contraction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0005125	cytokine activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0202	F
	GO:0005125	cytokine activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	F
	GO:0005125	cytokine activity	PMID:11588035^[6]	IDA: Inferred from Direct Assay		F
	GO:0005125	cytokine activity	PMID:11894098^[7]	IDA: Inferred from Direct Assay		F
	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002959	F
	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006052	F
	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006053	F
	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	F
	GO:0005164	tumor necrosis factor receptor binding	PMID:11588035^[6]	IDA: Inferred from Direct Assay		F
	GO:0005164	tumor necrosis factor receptor binding	PMID:1645445^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P25118	F
	GO:0005164	tumor necrosis factor receptor binding	PMID:1645445^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P25119	F
	GO:0005164	tumor necrosis factor receptor binding	PMID:8171322^[9]	TAS: Traceable Author Statement		F
	GO:0005164	tumor necrosis factor receptor binding	PMID:8387893^[10]	TAS: Traceable Author Statement		F
	GO:0005164	tumor necrosis factor receptor binding	PMID:8395024^[11]	TAS: Traceable Author Statement		F
	GO:0005164	tumor necrosis factor receptor binding	PMID:9223320^[12]	TAS: Traceable Author Statement		F
	GO:0005164	tumor necrosis factor receptor binding	PMID:9256477^[13]	TAS: Traceable Author Statement		F
	GO:0005164	tumor necrosis factor receptor binding	PMID:9368616^[14]	TAS: Traceable Author Statement		F
	GO:0005164	tumor necrosis factor receptor binding	PMID:9565643^[15]	TAS: Traceable Author Statement		F
	GO:0005515	protein binding	PMID:16702408^[16]	IPI: Inferred from Physical Interaction	UniProtKB:Q9QWL7	F
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C
	GO:0005615	extracellular space	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0202	C
	GO:0005615	extracellular space	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	C
	GO:0005615	extracellular space	PMID:10545106^[17]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:10549626^[18]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:10899905^[19]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:11168643^[20]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:11728336^[21]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:11894098^[7]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:12855817^[22]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:12872135^[23]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:14764707^[24]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:15220916^[25]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:1577194^[26]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:16239543^[27]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:16275384^[28]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:17693256^[29]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:18261938^[30]	IDA: Inferred from Direct Assay		C
	GO:0005622	intracellular	PMID:19723499^[31]	IDA: Inferred from Direct Assay		C
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0005886	plasma membrane	PMID:15155767^[32]	IDA: Inferred from Direct Assay		C
	GO:0005887	integral to plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	C
	GO:0005887	integral to plasma membrane	PMID:8879212^[33]	TAS: Traceable Author Statement		C
	GO:0006006	glucose metabolic process	PMID:12068289^[34]	IDA: Inferred from Direct Assay		P
	GO:0006915	apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0006915	apoptosis	PMID:17242187^[35]	IGI: Inferred from Genetic Interaction	MGI:MGI:97583	P
	GO:0006916	anti-apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0006917	induction of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0006917	induction of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0006917	induction of apoptosis	PMID:8208546^[36]	IDA: Inferred from Direct Assay		P
	GO:0006919	activation of caspase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0006927	transformed cell apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0006927	transformed cell apoptosis	PMID:7636227^[37]	TAS: Traceable Author Statement		P
	GO:0006927	transformed cell apoptosis	PMID:8171322^[9]	TAS: Traceable Author Statement		P
	GO:0006927	transformed cell apoptosis	PMID:9368616^[14]	TAS: Traceable Author Statement		P
	GO:0006952	defense response	PMID:8395024^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861040	P
	GO:0006952	defense response	PMID:9223320^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1860250	P
	GO:0006954	inflammatory response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0006954	inflammatory response	PMID:8171322^[9]	TAS: Traceable Author Statement		P
	GO:0006954	inflammatory response	PMID:8387893^[10]	TAS: Traceable Author Statement		P
	GO:0006955	immune response	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002959	P
	GO:0006955	immune response	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006052	P
	GO:0006955	immune response	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006053	P
	GO:0006959	humoral immune response	PMID:8879212^[33]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2149024	P
	GO:0007165	signal transduction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0007254	JNK cascade	PMID:17015619^[38]	IGI: Inferred from Genetic Interaction	MGI:MGI:1341850	P
	GO:0007275	multicellular organismal development	PMID:9368616^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1860953	P
	GO:0008283	cell proliferation	PMID:7636227^[37]	TAS: Traceable Author Statement		P
	GO:0008284	positive regulation of cell proliferation	PMID:8171322^[9]	TAS: Traceable Author Statement		P
	GO:0008285	negative regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0008624	induction of apoptosis by extracellular signals	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0008624	induction of apoptosis by extracellular signals	PMID:15629131^[39]	IDA: Inferred from Direct Assay		P
	GO:0008625	induction of apoptosis via death domain receptors	PMID:12431371^[40]	IGI: Inferred from Genetic Interaction	MGI:MGI:1096330	P
	GO:0009612	response to mechanical stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0009615	response to virus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0009887	organ morphogenesis	PMID:8879212^[33]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2149024	P
	GO:0009897	external side of plasma membrane	PMID:16282525^[2]	IDA: Inferred from Direct Assay		C
	GO:0009986	cell surface	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	C
	GO:0010552	positive regulation of gene-specific transcription from RNA polymerase II promoter	PMID:18025219^[41]	IGI: Inferred from Genetic Interaction	MGI:MGI:107656	P
	GO:0010843	promoter binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	F
	GO:0014823	response to activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002959	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006052	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006053	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0016021	integral to membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	C
	GO:0016563	transcription activator activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	F
	GO:0016564	transcription repressor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	F
	GO:0019722	calcium-mediated signaling	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0030141	stored secretory granule	PMID:8879212^[33]	TAS: Traceable Author Statement		C
	GO:0030198	extracellular matrix organization	PMID:15381731^[42]	IDA: Inferred from Direct Assay		P
	GO:0030730	sequestering of triglyceride	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0031622	positive regulation of fever generation	PMID:19940926^[43]	IDA: Inferred from Direct Assay		P
	GO:0032582	negative regulation of gene-specific transcription	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0032715	negative regulation of interleukin-6 production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0032722	positive regulation of chemokine production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0032729	positive regulation of interferon-gamma production	PMID:9834074^[5]	IGI: Inferred from Genetic Interaction	MGI:MGI:104797	P
	GO:0032755	positive regulation of interleukin-6 production	PMID:11894098^[7]	IDA: Inferred from Direct Assay		P
	GO:0032800	receptor biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0033209	tumor necrosis factor-mediated signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0033209	tumor necrosis factor-mediated signaling pathway	PMID:3898078^[44]	IDA: Inferred from Direct Assay		P
	GO:0034116	positive regulation of heterotypic cell-cell adhesion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0042127	regulation of cell proliferation	PMID:11799106^[45]	IDA: Inferred from Direct Assay		P
	GO:0042346	positive regulation of NF-kappaB import into nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0042493	response to drug	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0042742	defense response to bacterium	PMID:10899905^[19]	IDA: Inferred from Direct Assay		P
	GO:0042802	identical protein binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	F
	GO:0043066	negative regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0043122	regulation of I-kappaB kinase/NF-kappaB cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	PMID:12867038^[46]	IDA: Inferred from Direct Assay		P
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	PMID:16260493^[47]	IDA: Inferred from Direct Assay		P
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	PMID:16260493^[47]	IGI: Inferred from Genetic Interaction	MGI:MGI:1346877	P
	GO:0043193	positive regulation of gene-specific transcription	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0043525	positive regulation of neuron apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0044130	negative regulation of growth of symbiont in host	PMID:9834074^[5]	IGI: Inferred from Genetic Interaction	MGI:MGI:104797	P
	GO:0045071	negative regulation of viral genome replication	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0045080	positive regulation of chemokine biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0045121	membrane raft	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	C
	GO:0045121	membrane raft	PMID:17010968^[48]	IDA: Inferred from Direct Assay		C
	GO:0045123	cellular extravasation	PMID:10528208^[49]	IDA: Inferred from Direct Assay		P
	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0045670	regulation of osteoclast differentiation	PMID:12490655^[50]	IDA: Inferred from Direct Assay		P
	GO:0045840	positive regulation of mitosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:12761567^[51]	IDA: Inferred from Direct Assay		P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:9305915^[1]	IDA: Inferred from Direct Assay		P
	GO:0045994	positive regulation of translational initiation by iron	PMID:11588035^[6]	IDA: Inferred from Direct Assay		P
	GO:0046325	negative regulation of glucose import	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0046325	negative regulation of glucose import	PMID:12068289^[34]	IDA: Inferred from Direct Assay		P
	GO:0046330	positive regulation of JNK cascade	PMID:16260493^[47]	IDA: Inferred from Direct Assay		P
	GO:0046330	positive regulation of JNK cascade	PMID:16260493^[47]	IGI: Inferred from Genetic Interaction	MGI:MGI:1346877	P
	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0050708	regulation of protein secretion	PMID:19293336^[52]	IDA: Inferred from Direct Assay		P
	GO:0050715	positive regulation of cytokine secretion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0050796	regulation of insulin secretion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0050806	positive regulation of synaptic transmission	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0050830	defense response to Gram-positive bacterium	PMID:9834074^[5]	IGI: Inferred from Genetic Interaction	MGI:MGI:104797	P
	GO:0050900	leukocyte migration	PMID:15034066^[53]	IDA: Inferred from Direct Assay		P
	GO:0050901	leukocyte tethering or rolling	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0050995	negative regulation of lipid catabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0051023	regulation of immunoglobulin secretion	PMID:12958312^[54]	IDA: Inferred from Direct Assay		P
	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0051222	positive regulation of protein transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0051384	response to glucocorticoid stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0051798	positive regulation of hair follicle development	PMID:16702408^[16]	IMP: Inferred from Mutant Phenotype		P
	GO:0055037	recycling endosome	PMID:16282525^[2]	IDA: Inferred from Direct Assay		C
	GO:0060555	induction of necroptosis by extracellular signals	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0060557	positive regulation of vitamin D biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0060559	positive regulation of calcidiol 1-monooxygenase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	PMID:11241200^[55]	IDA: Inferred from Direct Assay		P
	GO:0060693	regulation of branching involved in salivary gland morphogenesis	PMID:11241200^[55]	IDA: Inferred from Direct Assay		P
	GO:0061048	negative regulation of branching involved in lung morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0070265	necrotic cell death	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0000060	protein import into nucleus, translocation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	PMID:9305915^[1]	IDA: Inferred from Direct Assay		P
	GO:0000185	activation of MAPKKK activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0000187	activation of MAPK activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0001666	response to hypoxia	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0001775	cell activation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0001819	positive regulation of cytokine production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0001891	phagocytic cup	PMID:16282525^[2]	IDA: Inferred from Direct Assay		C
	GO:0001932	regulation of protein phosphorylation	PMID:15169905^[3]	IDA: Inferred from Direct Assay		P
	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0002020	protease binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	F
	GO:0002020	protease binding	PMID:12135759^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q05910	F
	GO:0002037	negative regulation of L-glutamate transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0002439	chronic inflammatory response to antigenic stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0002740	negative regulation of cytokine secretion involved in immune response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0002876	positive regulation of chronic inflammatory response to antigenic stimulus	PMID:9834074^[5]	IGI: Inferred from Genetic Interaction	MGI:MGI:104797	P
	GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin	PMID:9834074^[5]	IGI: Inferred from Genetic Interaction	MGI:MGI:104797	P
	GO:0003009	skeletal muscle contraction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0005125	cytokine activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0202	F
	GO:0005125	cytokine activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	F
	GO:0005125	cytokine activity	PMID:11588035^[6]	IDA: Inferred from Direct Assay		F
	GO:0005125	cytokine activity	PMID:11894098^[7]	IDA: Inferred from Direct Assay		F
	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002959	F
	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006052	F
	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006053	F
	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	F
	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	F
	GO:0005164	tumor necrosis factor receptor binding	PMID:11588035^[6]	IDA: Inferred from Direct Assay		F
	GO:0005164	tumor necrosis factor receptor binding	PMID:1645445^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P25118	F
	GO:0005164	tumor necrosis factor receptor binding	PMID:1645445^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P25119	F
	GO:0005164	tumor necrosis factor receptor binding	PMID:8171322^[9]	TAS: Traceable Author Statement		F
	GO:0005164	tumor necrosis factor receptor binding	PMID:8387893^[10]	TAS: Traceable Author Statement		F
	GO:0005164	tumor necrosis factor receptor binding	PMID:8395024^[11]	TAS: Traceable Author Statement		F
	GO:0005164	tumor necrosis factor receptor binding	PMID:9223320^[12]	TAS: Traceable Author Statement		F
	GO:0005164	tumor necrosis factor receptor binding	PMID:9256477^[13]	TAS: Traceable Author Statement		F
	GO:0005164	tumor necrosis factor receptor binding	PMID:9368616^[14]	TAS: Traceable Author Statement		F
	GO:0005164	tumor necrosis factor receptor binding	PMID:9565643^[15]	TAS: Traceable Author Statement		F
	GO:0005515	protein binding	PMID:16702408^[16]	IPI: Inferred from Physical Interaction	UniProtKB:Q9QWL7	F
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C
	GO:0005615	extracellular space	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0202	C
	GO:0005615	extracellular space	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	C
	GO:0005615	extracellular space	PMID:10545106^[17]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:10549626^[18]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:10899905^[19]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:11168643^[20]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:11728336^[21]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:11894098^[7]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:12855817^[22]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:12872135^[23]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:14764707^[24]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:15220916^[25]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:1577194^[26]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:16239543^[27]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:16275384^[28]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:17693256^[29]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:18261938^[30]	IDA: Inferred from Direct Assay		C
	GO:0005622	intracellular	PMID:19723499^[31]	IDA: Inferred from Direct Assay		C
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	C
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0005886	plasma membrane	PMID:15155767^[32]	IDA: Inferred from Direct Assay		C
	GO:0005887	integral to plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	C
	GO:0005887	integral to plasma membrane	PMID:8879212^[33]	TAS: Traceable Author Statement		C
	GO:0006006	glucose metabolic process	PMID:12068289^[34]	IDA: Inferred from Direct Assay		P
	GO:0006915	apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0006915	apoptosis	PMID:17242187^[35]	IGI: Inferred from Genetic Interaction	MGI:MGI:97583	P
	GO:0006916	anti-apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0006917	induction of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0006917	induction of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0006917	induction of apoptosis	PMID:8208546^[36]	IDA: Inferred from Direct Assay		P
	GO:0006919	activation of caspase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0006927	transformed cell apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0006927	transformed cell apoptosis	PMID:7636227^[37]	TAS: Traceable Author Statement		P
	GO:0006927	transformed cell apoptosis	PMID:8171322^[9]	TAS: Traceable Author Statement		P
	GO:0006927	transformed cell apoptosis	PMID:9368616^[14]	TAS: Traceable Author Statement		P
	GO:0006952	defense response	PMID:8395024^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861040	P
	GO:0006952	defense response	PMID:9223320^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1860250	P
	GO:0006954	inflammatory response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0006954	inflammatory response	PMID:8171322^[9]	TAS: Traceable Author Statement		P
	GO:0006954	inflammatory response	PMID:8387893^[10]	TAS: Traceable Author Statement		P
	GO:0006955	immune response	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002959	P
	GO:0006955	immune response	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006052	P
	GO:0006955	immune response	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006053	P
	GO:0006959	humoral immune response	PMID:8879212^[33]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2149024	P
	GO:0007165	signal transduction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0007254	JNK cascade	PMID:17015619^[38]	IGI: Inferred from Genetic Interaction	MGI:MGI:1341850	P
	GO:0007275	multicellular organismal development	PMID:9368616^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1860953	P
	GO:0008283	cell proliferation	PMID:7636227^[37]	TAS: Traceable Author Statement		P
	GO:0008284	positive regulation of cell proliferation	PMID:8171322^[9]	TAS: Traceable Author Statement		P
	GO:0008285	negative regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0008624	induction of apoptosis by extracellular signals	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0008624	induction of apoptosis by extracellular signals	PMID:15629131^[39]	IDA: Inferred from Direct Assay		P
	GO:0008625	induction of apoptosis via death domain receptors	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0008625	induction of apoptosis via death domain receptors	PMID:12431371^[40]	IGI: Inferred from Genetic Interaction	MGI:MGI:1096330	P
	GO:0009612	response to mechanical stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0009615	response to virus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0009887	organ morphogenesis	PMID:8879212^[33]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2149024	P
	GO:0009897	external side of plasma membrane	PMID:16282525^[2]	IDA: Inferred from Direct Assay		C
	GO:0009986	cell surface	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	C
	GO:0014823	response to activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002959	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006052	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006053	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0016021	integral to membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	C
	GO:0019722	calcium-mediated signaling	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0030141	stored secretory granule	PMID:8879212^[33]	TAS: Traceable Author Statement		C
	GO:0030198	extracellular matrix organization	PMID:15381731^[42]	IDA: Inferred from Direct Assay		P
	GO:0030730	sequestering of triglyceride	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0031334	positive regulation of protein complex assembly	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0031622	positive regulation of fever generation	PMID:19940926^[43]	IDA: Inferred from Direct Assay		P
	GO:0032715	negative regulation of interleukin-6 production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0032722	positive regulation of chemokine production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0032729	positive regulation of interferon-gamma production	PMID:9834074^[5]	IGI: Inferred from Genetic Interaction	MGI:MGI:104797	P
	GO:0032755	positive regulation of interleukin-6 production	PMID:11894098^[7]	IDA: Inferred from Direct Assay		P
	GO:0032800	receptor biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0033209	tumor necrosis factor-mediated signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0033209	tumor necrosis factor-mediated signaling pathway	PMID:3898078^[44]	IDA: Inferred from Direct Assay		P
	GO:0034116	positive regulation of heterotypic cell-cell adhesion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0042127	regulation of cell proliferation	PMID:11799106^[45]	IDA: Inferred from Direct Assay		P
	GO:0042346	positive regulation of NF-kappaB import into nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0042493	response to drug	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0042742	defense response to bacterium	PMID:10899905^[19]	IDA: Inferred from Direct Assay		P
	GO:0042802	identical protein binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	F
	GO:0043066	negative regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0043122	regulation of I-kappaB kinase/NF-kappaB cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	PMID:12867038^[46]	IDA: Inferred from Direct Assay		P
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	PMID:16260493^[47]	IDA: Inferred from Direct Assay		P
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	PMID:16260493^[47]	IGI: Inferred from Genetic Interaction	MGI:MGI:1346877	P
	GO:0043243	positive regulation of protein complex disassembly	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0043406	positive regulation of MAP kinase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0043525	positive regulation of neuron apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0044130	negative regulation of growth of symbiont in host	PMID:9834074^[5]	IGI: Inferred from Genetic Interaction	MGI:MGI:104797	P
	GO:0045071	negative regulation of viral genome replication	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0045080	positive regulation of chemokine biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0045121	membrane raft	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	C
	GO:0045121	membrane raft	PMID:17010968^[48]	IDA: Inferred from Direct Assay		C
	GO:0045123	cellular extravasation	PMID:10528208^[49]	IDA: Inferred from Direct Assay		P
	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0045670	regulation of osteoclast differentiation	PMID:12490655^[50]	IDA: Inferred from Direct Assay		P
	GO:0045672	positive regulation of osteoclast differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0045840	positive regulation of mitosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0045892	negative regulation of transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0045893	positive regulation of transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:12761567^[51]	IDA: Inferred from Direct Assay		P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:18025219^[41]	IGI: Inferred from Genetic Interaction	MGI:MGI:107656	P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:9305915^[1]	IDA: Inferred from Direct Assay		P
	GO:0045994	positive regulation of translational initiation by iron	PMID:11588035^[6]	IDA: Inferred from Direct Assay		P
	GO:0046325	negative regulation of glucose import	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0046325	negative regulation of glucose import	PMID:12068289^[34]	IDA: Inferred from Direct Assay		P
	GO:0046330	positive regulation of JNK cascade	PMID:16260493^[47]	IDA: Inferred from Direct Assay		P
	GO:0046330	positive regulation of JNK cascade	PMID:16260493^[47]	IGI: Inferred from Genetic Interaction	MGI:MGI:1346877	P
	GO:0046330	positive regulation of JNK cascade	PMID:20080598^[56]	IDA: Inferred from Direct Assay		P
	GO:0048566	embryonic digestive tract development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0050708	regulation of protein secretion	PMID:19293336^[52]	IDA: Inferred from Direct Assay		P
	GO:0050715	positive regulation of cytokine secretion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0050796	regulation of insulin secretion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0050806	positive regulation of synaptic transmission	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0050830	defense response to Gram-positive bacterium	PMID:9834074^[5]	IGI: Inferred from Genetic Interaction	MGI:MGI:104797	P
	GO:0050900	leukocyte migration	PMID:15034066^[53]	IDA: Inferred from Direct Assay		P
	GO:0050901	leukocyte tethering or rolling	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0050995	negative regulation of lipid catabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0051023	regulation of immunoglobulin secretion	PMID:12958312^[54]	IDA: Inferred from Direct Assay		P
	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0051222	positive regulation of protein transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0051222	positive regulation of protein transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001110	P
	GO:0051384	response to glucocorticoid stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0051533	positive regulation of NFAT protein import into nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0051798	positive regulation of hair follicle development	PMID:16702408^[16]	IMP: Inferred from Mutant Phenotype		P
	GO:0051897	positive regulation of protein kinase B signaling cascade	PMID:20080598^[56]	IDA: Inferred from Direct Assay		P
	GO:0055037	recycling endosome	PMID:16282525^[2]	IDA: Inferred from Direct Assay		C
	GO:0060555	induction of necroptosis by extracellular signals	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0060557	positive regulation of vitamin D biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0060559	positive regulation of calcidiol 1-monooxygenase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	PMID:11241200^[55]	IDA: Inferred from Direct Assay		P
	GO:0060693	regulation of branching involved in salivary gland morphogenesis	PMID:11241200^[55]	IDA: Inferred from Direct Assay		P
	GO:0061048	negative regulation of branching involved in lung morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0070265	necrotic cell death	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0071230	cellular response to amino acid stimulus	PMID:20548288^[57]	IDA: Inferred from Direct Assay		P
	GO:0071316	cellular response to nicotine	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
	GO:0071803	positive regulation of podosome assembly	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000398698	P
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Hadri KE et al. (1997) Differential regulation by tumor necrosis factor-alpha of beta1-, beta2-, and beta3-adrenoreceptor gene expression in 3T3-F442A adipocytes. J Biol Chem 272: 24514-21 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Murray RZ et al. (2005) A role for the phagosome in cytokine secretion. Science 310: 1492-5 PubMed GONUTS page
↑ ^3.0 ^3.1 Ueki K et al. (2004) Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Mol Cell Biol 24: 5434-46 PubMed GONUTS page
↑ ^4.0 ^4.1 Amour A et al. (2002) The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs. FEBS Lett 524: 154-8 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 ^5.9 Hultgren O et al. (1998) TNF/lymphotoxin-alpha double-mutant mice resist septic arthritis but display increased mortality in response to Staphylococcus aureus. J Immunol 161: 5937-42 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Carballo E & Blackshear PJ (2001) Roles of tumor necrosis factor-alpha receptor subtypes in the pathogenesis of the tristetraprolin-deficiency syndrome. Blood 98: 2389-95 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Kobayashi K et al. (2002) RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature 416: 194-9 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Goodwin RG et al. (1991) Molecular cloning and expression of the type 1 and type 2 murine receptors for tumor necrosis factor. Mol Cell Biol 11: 3020-6 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 De Togni P et al. (1994) Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science 264: 703-7 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Pfeffer K et al. (1993) Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell 73: 457-67 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Rothe J et al. (1993) Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes. Nature 364: 798-802 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Marino MW et al. (1997) Characterization of tumor necrosis factor-deficient mice. Proc Natl Acad Sci U S A 94: 8093-8 PubMed GONUTS page
↑ ^13.0 ^13.1 Alimzhanov MB et al. (1997) Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice. Proc Natl Acad Sci U S A 94: 9302-7 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 Körner H et al. (1997) Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue. Eur J Immunol 27: 2600-9 PubMed GONUTS page
↑ ^15.0 ^15.1 Sean Riminton D et al. (1998) Challenging cytokine redundancy: inflammatory cell movement and clinical course of experimental autoimmune encephalomyelitis are normal in lymphotoxin-deficient, but not tumor necrosis factor-deficient, mice. J Exp Med 187: 1517-28 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Tong X & Coulombe PA (2006) Keratin 17 modulates hair follicle cycling in a TNFalpha-dependent fashion. Genes Dev 20: 1353-64 PubMed GONUTS page
↑ ^17.0 ^17.1 Xiao X et al. (1999) HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice. EMBO J 18: 5943-52 PubMed GONUTS page
↑ ^18.0 ^18.1 Takeuchi O et al. (1999) Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11: 443-51 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 Fratazzi C et al. (2000) A macrophage invasion mechanism for mycobacteria implicating the extracellular domain of CD43. J Exp Med 192: 183-92 PubMed GONUTS page
↑ ^20.0 ^20.1 Bune AJ et al. (2001) Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disordered macrophage inflammatory responses and reduced clearance of the pathogen, Staphylococcus aureus. Immunology 102: 103-13 PubMed GONUTS page
↑ ^21.0 ^21.1 Allenspach EJ et al. (2001) ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse. Immunity 15: 739-50 PubMed GONUTS page
↑ ^22.0 ^22.1 Yamamoto M et al. (2003) Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301: 640-3 PubMed GONUTS page
↑ ^23.0 ^23.1 Hoebe K et al. (2003) Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 424: 743-8 PubMed GONUTS page
↑ ^24.0 ^24.1 Sakurai D et al. (2004) Fc epsilon RI gamma-ITAM is differentially required for mast cell function in vivo. J Immunol 172: 2374-81 PubMed GONUTS page
↑ ^25.0 ^25.1 Watanabe T et al. (2004) NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat Immunol 5: 800-8 PubMed GONUTS page
↑ ^26.0 ^26.1 De M et al. (1992) Interleukin-1, interleukin-6, and tumor necrosis factor alpha are produced in the mouse uterus during the estrous cycle and are induced by estrogen and progesterone. Dev Biol 151: 297-305 PubMed GONUTS page
↑ ^27.0 ^27.1 Kielian T et al. (2005) Toll-like receptor 2 modulates the proinflammatory milieu in Staphylococcus aureus-induced brain abscess. Infect Immun 73: 7428-35 PubMed GONUTS page
↑ ^28.0 ^28.1 Lin W et al. (2005) Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. J Allergy Clin Immunol 116: 1106-15 PubMed GONUTS page
↑ ^29.0 ^29.1 Lee NK et al. (2007) Endocrine regulation of energy metabolism by the skeleton. Cell 130: 456-69 PubMed GONUTS page
↑ ^30.0 ^30.1 Kim YG et al. (2008) The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. Immunity 28: 246-57 PubMed GONUTS page
↑ ^31.0 ^31.1 Terauchi M et al. (2009) T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling. Cell Metab 10: 229-40 PubMed GONUTS page
↑ ^32.0 ^32.1 Marchetti L et al. (2004) Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation. Essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-kappa B pathway. J Biol Chem 279: 32869-81 PubMed GONUTS page
↑ ^33.0 ^33.1 ^33.2 ^33.3 ^33.4 ^33.5 ^33.6 ^33.7 Pasparakis M et al. (1996) Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. J Exp Med 184: 1397-411 PubMed GONUTS page
↑ ^34.0 ^34.1 ^34.2 ^34.3 Maeda N et al. (2002) Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 8: 731-7 PubMed GONUTS page
↑ ^35.0 ^35.1 Song L et al. (2007) p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation. Mol Cell Biol 27: 2713-31 PubMed GONUTS page
↑ ^36.0 ^36.1 Fernandez A et al. (1994) Differential sensitivity of normal and Ha-ras-transformed C3H mouse embryo fibroblasts to tumor necrosis factor: induction of bcl-2, c-myc, and manganese superoxide dismutase in resistant cells. Oncogene 9: 2009-17 PubMed GONUTS page
↑ ^37.0 ^37.1 ^37.2 ^37.3 Banks TA et al. (1995) Lymphotoxin-alpha-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness. J Immunol 155: 1685-93 PubMed GONUTS page
↑ ^38.0 ^38.1 Gan B et al. (2006) Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways. J Cell Biol 175: 121-33 PubMed GONUTS page
↑ ^39.0 ^39.1 Hsu LJ et al. (2005) Cloning and characterization of a small-size peptide Zfra that regulates the cytotoxic function of tumor necrosis factor by interacting with JNK1. Biochem Biophys Res Commun 327: 415-23 PubMed GONUTS page
↑ ^40.0 ^40.1 Datta SR et al. (2002) Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Dev Cell 3: 631-43 PubMed GONUTS page
↑ ^41.0 ^41.1 Degrandi D et al. (2007) Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense. J Immunol 179: 7729-40 PubMed GONUTS page
↑ ^42.0 ^42.1 Katakai T et al. (2004) Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes. J Exp Med 200: 783-95 PubMed GONUTS page
↑ ^43.0 ^43.1 Hanada R et al. (2009) Central control of fever and female body temperature by RANKL/RANK. Nature 462: 505-9 PubMed GONUTS page
↑ ^44.0 ^44.1 Pennica D et al. (1985) Cloning and expression in Escherichia coli of the cDNA for murine tumor necrosis factor. Proc Natl Acad Sci U S A 82: 6060-4 PubMed GONUTS page
↑ ^45.0 ^45.1 Chang NS (2002) The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression. J Biol Chem 277: 10323-31 PubMed GONUTS page
↑ ^46.0 ^46.1 Egawa T et al. (2003) Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation. Curr Biol 13: 1252-8 PubMed GONUTS page
↑ ^47.0 ^47.1 ^47.2 ^47.3 ^47.4 ^47.5 ^47.6 ^47.7 Shim JH et al. (2005) TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev 19: 2668-81 PubMed GONUTS page
↑ ^48.0 ^48.1 Tellier E et al. (2006) The shedding activity of ADAM17 is sequestered in lipid rafts. Exp Cell Res 312: 3969-80 PubMed GONUTS page
↑ ^49.0 ^49.1 Ding ZM et al. (1999) Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration. J Immunol 163: 5029-38 PubMed GONUTS page
↑ ^50.0 ^50.1 Toraldo G et al. (2003) IL-7 induces bone loss in vivo by induction of receptor activator of nuclear factor kappa B ligand and tumor necrosis factor alpha from T cells. Proc Natl Acad Sci U S A 100: 125-30 PubMed GONUTS page
↑ ^51.0 ^51.1 Abrantes EF et al. (2003) Identification, structural characterization, and tissue distribution of Tsg-5: a new TNF-stimulated gene. Genes Immun 4: 298-311 PubMed GONUTS page
↑ ^52.0 ^52.1 Fowler JD et al. (2009) Regulated renin release from 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab 296: E1383-91 PubMed GONUTS page
↑ ^53.0 ^53.1 Young RE et al. (2004) Neutrophil elastase (NE)-deficient mice demonstrate a nonredundant role for NE in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in response to zymosan particles in vivo. J Immunol 172: 4493-502 PubMed GONUTS page
↑ ^54.0 ^54.1 Hostager BS et al. (2003) Tumor necrosis factor receptor-associated factor 2 (TRAF2)-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling. J Biol Chem 278: 45382-90 PubMed GONUTS page
↑ ^55.0 ^55.1 ^55.2 ^55.3 Melnick M et al. (2001) Embryonic mouse submandibular salivary gland morphogenesis and the TNF/TNF-R1 signal transduction pathway. Anat Rec 262: 318-30 PubMed GONUTS page
↑ ^56.0 ^56.1 Song H et al. (2010) Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A 107: 1431-6 PubMed GONUTS page
↑ Pogribny IP et al. (2010) Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Lab Invest 90: 1437-46 PubMed GONUTS page

[PMID:9305915-0] 1.0 ^1.1 ^1.2 ^1.3 Hadri KE et al. (1997) Differential regulation by tumor necrosis factor-alpha of beta1-, beta2-, and beta3-adrenoreceptor gene expression in 3T3-F442A adipocytes. J Biol Chem 272: 24514-21 PubMed GONUTS page

[PMID:16282525-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Murray RZ et al. (2005) A role for the phagosome in cytokine secretion. Science 310: 1492-5 PubMed GONUTS page

[PMID:15169905-2] 3.0 ^3.1 Ueki K et al. (2004) Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Mol Cell Biol 24: 5434-46 PubMed GONUTS page

[PMID:12135759-3] 4.0 ^4.1 Amour A et al. (2002) The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs. FEBS Lett 524: 154-8 PubMed GONUTS page

[PMID:9834074-4] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 ^5.9 Hultgren O et al. (1998) TNF/lymphotoxin-alpha double-mutant mice resist septic arthritis but display increased mortality in response to Staphylococcus aureus. J Immunol 161: 5937-42 PubMed GONUTS page

[PMID:11588035-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Carballo E & Blackshear PJ (2001) Roles of tumor necrosis factor-alpha receptor subtypes in the pathogenesis of the tristetraprolin-deficiency syndrome. Blood 98: 2389-95 PubMed GONUTS page

[PMID:11894098-6] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Kobayashi K et al. (2002) RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature 416: 194-9 PubMed GONUTS page

[PMID:1645445-7] 8.0 ^8.1 ^8.2 ^8.3 Goodwin RG et al. (1991) Molecular cloning and expression of the type 1 and type 2 murine receptors for tumor necrosis factor. Mol Cell Biol 11: 3020-6 PubMed GONUTS page

[PMID:8171322-8] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 De Togni P et al. (1994) Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science 264: 703-7 PubMed GONUTS page

[PMID:8387893-9] 10.0 ^10.1 ^10.2 ^10.3 Pfeffer K et al. (1993) Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell 73: 457-67 PubMed GONUTS page

[PMID:8395024-10] 11.0 ^11.1 ^11.2 ^11.3 Rothe J et al. (1993) Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes. Nature 364: 798-802 PubMed GONUTS page

[PMID:9223320-11] 12.0 ^12.1 ^12.2 ^12.3 Marino MW et al. (1997) Characterization of tumor necrosis factor-deficient mice. Proc Natl Acad Sci U S A 94: 8093-8 PubMed GONUTS page

[PMID:9256477-12] 13.0 ^13.1 Alimzhanov MB et al. (1997) Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice. Proc Natl Acad Sci U S A 94: 9302-7 PubMed GONUTS page

[PMID:9368616-13] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 Körner H et al. (1997) Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue. Eur J Immunol 27: 2600-9 PubMed GONUTS page

[PMID:9565643-14] 15.0 ^15.1 Sean Riminton D et al. (1998) Challenging cytokine redundancy: inflammatory cell movement and clinical course of experimental autoimmune encephalomyelitis are normal in lymphotoxin-deficient, but not tumor necrosis factor-deficient, mice. J Exp Med 187: 1517-28 PubMed GONUTS page

[PMID:16702408-15] 16.0 ^16.1 ^16.2 ^16.3 Tong X & Coulombe PA (2006) Keratin 17 modulates hair follicle cycling in a TNFalpha-dependent fashion. Genes Dev 20: 1353-64 PubMed GONUTS page

[PMID:10545106-16] 17.0 ^17.1 Xiao X et al. (1999) HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice. EMBO J 18: 5943-52 PubMed GONUTS page

[PMID:10549626-17] 18.0 ^18.1 Takeuchi O et al. (1999) Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11: 443-51 PubMed GONUTS page

[PMID:10899905-18] 19.0 ^19.1 ^19.2 ^19.3 Fratazzi C et al. (2000) A macrophage invasion mechanism for mycobacteria implicating the extracellular domain of CD43. J Exp Med 192: 183-92 PubMed GONUTS page

[PMID:11168643-19] 20.0 ^20.1 Bune AJ et al. (2001) Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disordered macrophage inflammatory responses and reduced clearance of the pathogen, Staphylococcus aureus. Immunology 102: 103-13 PubMed GONUTS page

[PMID:11728336-20] 21.0 ^21.1 Allenspach EJ et al. (2001) ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse. Immunity 15: 739-50 PubMed GONUTS page

[PMID:12855817-21] 22.0 ^22.1 Yamamoto M et al. (2003) Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301: 640-3 PubMed GONUTS page

[PMID:12872135-22] 23.0 ^23.1 Hoebe K et al. (2003) Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 424: 743-8 PubMed GONUTS page

[PMID:14764707-23] 24.0 ^24.1 Sakurai D et al. (2004) Fc epsilon RI gamma-ITAM is differentially required for mast cell function in vivo. J Immunol 172: 2374-81 PubMed GONUTS page

[PMID:15220916-24] 25.0 ^25.1 Watanabe T et al. (2004) NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat Immunol 5: 800-8 PubMed GONUTS page

[PMID:1577194-25] 26.0 ^26.1 De M et al. (1992) Interleukin-1, interleukin-6, and tumor necrosis factor alpha are produced in the mouse uterus during the estrous cycle and are induced by estrogen and progesterone. Dev Biol 151: 297-305 PubMed GONUTS page

[PMID:16239543-26] 27.0 ^27.1 Kielian T et al. (2005) Toll-like receptor 2 modulates the proinflammatory milieu in Staphylococcus aureus-induced brain abscess. Infect Immun 73: 7428-35 PubMed GONUTS page

[PMID:16275384-27] 28.0 ^28.1 Lin W et al. (2005) Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. J Allergy Clin Immunol 116: 1106-15 PubMed GONUTS page

[PMID:17693256-28] 29.0 ^29.1 Lee NK et al. (2007) Endocrine regulation of energy metabolism by the skeleton. Cell 130: 456-69 PubMed GONUTS page

[PMID:18261938-29] 30.0 ^30.1 Kim YG et al. (2008) The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. Immunity 28: 246-57 PubMed GONUTS page

[PMID:19723499-30] 31.0 ^31.1 Terauchi M et al. (2009) T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling. Cell Metab 10: 229-40 PubMed GONUTS page

[PMID:15155767-31] 32.0 ^32.1 Marchetti L et al. (2004) Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation. Essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-kappa B pathway. J Biol Chem 279: 32869-81 PubMed GONUTS page

[PMID:8879212-32] 33.0 ^33.1 ^33.2 ^33.3 ^33.4 ^33.5 ^33.6 ^33.7 Pasparakis M et al. (1996) Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. J Exp Med 184: 1397-411 PubMed GONUTS page

[PMID:12068289-33] 34.0 ^34.1 ^34.2 ^34.3 Maeda N et al. (2002) Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 8: 731-7 PubMed GONUTS page

[PMID:17242187-34] 35.0 ^35.1 Song L et al. (2007) p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation. Mol Cell Biol 27: 2713-31 PubMed GONUTS page

[PMID:8208546-35] 36.0 ^36.1 Fernandez A et al. (1994) Differential sensitivity of normal and Ha-ras-transformed C3H mouse embryo fibroblasts to tumor necrosis factor: induction of bcl-2, c-myc, and manganese superoxide dismutase in resistant cells. Oncogene 9: 2009-17 PubMed GONUTS page

[PMID:7636227-36] 37.0 ^37.1 ^37.2 ^37.3 Banks TA et al. (1995) Lymphotoxin-alpha-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness. J Immunol 155: 1685-93 PubMed GONUTS page

[PMID:17015619-37] 38.0 ^38.1 Gan B et al. (2006) Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways. J Cell Biol 175: 121-33 PubMed GONUTS page

[PMID:15629131-38] 39.0 ^39.1 Hsu LJ et al. (2005) Cloning and characterization of a small-size peptide Zfra that regulates the cytotoxic function of tumor necrosis factor by interacting with JNK1. Biochem Biophys Res Commun 327: 415-23 PubMed GONUTS page

[PMID:12431371-39] 40.0 ^40.1 Datta SR et al. (2002) Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Dev Cell 3: 631-43 PubMed GONUTS page

[PMID:18025219-40] 41.0 ^41.1 Degrandi D et al. (2007) Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense. J Immunol 179: 7729-40 PubMed GONUTS page

[PMID:15381731-41] 42.0 ^42.1 Katakai T et al. (2004) Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes. J Exp Med 200: 783-95 PubMed GONUTS page

[PMID:19940926-42] 43.0 ^43.1 Hanada R et al. (2009) Central control of fever and female body temperature by RANKL/RANK. Nature 462: 505-9 PubMed GONUTS page

[PMID:3898078-43] 44.0 ^44.1 Pennica D et al. (1985) Cloning and expression in Escherichia coli of the cDNA for murine tumor necrosis factor. Proc Natl Acad Sci U S A 82: 6060-4 PubMed GONUTS page

[PMID:11799106-44] 45.0 ^45.1 Chang NS (2002) The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression. J Biol Chem 277: 10323-31 PubMed GONUTS page

[PMID:12867038-45] 46.0 ^46.1 Egawa T et al. (2003) Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation. Curr Biol 13: 1252-8 PubMed GONUTS page

[PMID:16260493-46] 47.0 ^47.1 ^47.2 ^47.3 ^47.4 ^47.5 ^47.6 ^47.7 Shim JH et al. (2005) TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev 19: 2668-81 PubMed GONUTS page

[PMID:17010968-47] 48.0 ^48.1 Tellier E et al. (2006) The shedding activity of ADAM17 is sequestered in lipid rafts. Exp Cell Res 312: 3969-80 PubMed GONUTS page

[PMID:10528208-48] 49.0 ^49.1 Ding ZM et al. (1999) Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration. J Immunol 163: 5029-38 PubMed GONUTS page

[PMID:12490655-49] 50.0 ^50.1 Toraldo G et al. (2003) IL-7 induces bone loss in vivo by induction of receptor activator of nuclear factor kappa B ligand and tumor necrosis factor alpha from T cells. Proc Natl Acad Sci U S A 100: 125-30 PubMed GONUTS page

[PMID:12761567-50] 51.0 ^51.1 Abrantes EF et al. (2003) Identification, structural characterization, and tissue distribution of Tsg-5: a new TNF-stimulated gene. Genes Immun 4: 298-311 PubMed GONUTS page

[PMID:19293336-51] 52.0 ^52.1 Fowler JD et al. (2009) Regulated renin release from 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab 296: E1383-91 PubMed GONUTS page

[PMID:15034066-52] 53.0 ^53.1 Young RE et al. (2004) Neutrophil elastase (NE)-deficient mice demonstrate a nonredundant role for NE in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in response to zymosan particles in vivo. J Immunol 172: 4493-502 PubMed GONUTS page

[PMID:12958312-53] 54.0 ^54.1 Hostager BS et al. (2003) Tumor necrosis factor receptor-associated factor 2 (TRAF2)-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling. J Biol Chem 278: 45382-90 PubMed GONUTS page

[PMID:11241200-54] 55.0 ^55.1 ^55.2 ^55.3 Melnick M et al. (2001) Embryonic mouse submandibular salivary gland morphogenesis and the TNF/TNF-R1 signal transduction pathway. Anat Rec 262: 318-30 PubMed GONUTS page

[PMID:20080598-55] 56.0 ^56.1 Song H et al. (2010) Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A 107: 1431-6 PubMed GONUTS page

[PMID:20548288-56] Pogribny IP et al. (2010) Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Lab Invest 90: 1437-46 PubMed GONUTS page

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MOUSE:TNFA

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