MOUSE:TIE2

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Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Tek ( synonyms: Hyk, Tie-2, Tie2 )
Protein Name(s)	Angiopoietin-1 receptor HYK STK1 Tunica interna endothelial cell kinase Tyrosine-protein kinase receptor TEK Tyrosine-protein kinase receptor TIE-2 mTIE2 p140 TEK
External Links
UniProt Identifier	TIE2_MOUSE
UniProt Accessions	Q02858,
EMBL	X71426, X67553, D13738, S67051,
PIR	I54237, JH0771, JN0712,
Ensembl	ENSMUST00000071168,
Pfam	PF00041, PF10430, PF07714,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005887	integral to plasma membrane		IEA: Inferred from Electronic Annotation		C	Source: InterPro
	GO:0005524	ATP binding		IEA: Inferred from Electronic Annotation		F	Source: UniProtKB-KW
	GO:0005515	protein binding		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0004714	transmembrane receptor protein tyrosine kin...		IEA: Inferred from Electronic Annotation		F	Source: EC
	GO:0001525	angiogenesis		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0006916	anti-apoptosis		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0016337	cell-cell adhesion		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0007160	cell-matrix adhesion		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0030097	hemopoiesis		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0045785	positive regulation of cell adhesion		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0033138	positive regulation of peptidyl-serine phos...		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0006468	protein amino acid phosphorylation		IEA: Inferred from Electronic Annotation		P	Source: InterPro
	GO:0045765	regulation of angiogenesis		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0030334	regulation of cell migration		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0042127	regulation of cell proliferation		IEA: Inferred from Electronic Annotation		P	Source: InterPro
	GO:0032526	response to retinoic acid		IDA: Inferred from Direct Assay		P	Source: BHF-UCL
	GO:0007169	transmembrane receptor protein tyrosine kin...		IEA: Inferred from Electronic Annotation		P	Source: InterPro
incorrect (CACAO)	GO:0035162	embryonic hemopoiesis	PMID:16219799^[1]	TAS: Traceable Author Statement		P	intro 'Tie2 is dispensable for embryonic hematopoiesis using ES cell mouse chimeras'	complete
incorrect (CACAO)	GO:0007507	heart development	PMID:16219799^[1]	TAS: Traceable Author Statement		P	intro 'Tie2-deficient mice exhibit severe defects in vascular and heart development and die by E9.5'	complete
NOT	GO:0060218	hemopoietic stem cell differentiation	PMID:16219799^[1]	IMP: Inferred from Mutant Phenotype		P	Fig.3A-D; Fig.4G	complete
	GO:0060837	blood vessel endothelial cell differentiation	PMID:16219799^[1]	IMP: Inferred from Mutant Phenotype		P	Fig.4	complete
	GO:0060836	lymphatic endothelial cell differentiation	PMID:16219799^[1]	IMP: Inferred from Mutant Phenotype		P	Fig.4	complete
	GO:0006916	anti-apoptosis	PMID:16219799^[1]	IMP: Inferred from Mutant Phenotype		P	Fig.5	complete
	GO:0010468	regulation of gene expression	PMID:16219799^[1]	IMP: Inferred from Mutant Phenotype		P	Fig.1	complete
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0001525	angiogenesis	PMID:20299672^[2]	TAS: Traceable Author Statement		P
	GO:0001525	angiogenesis	PMID:9846489^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2159357	P
	GO:0001569	patterning of blood vessels	PMID:20299672^[2]	TAS: Traceable Author Statement		P
	GO:0001936	regulation of endothelial cell proliferation	PMID:20406889^[4]	TAS: Traceable Author Statement		P
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001245	F
	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008266	F
	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020635	F
	GO:0004713	protein tyrosine kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0829	F
	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018941	F
	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:2.7.10.1	F
	GO:0004872	receptor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0675	F
	GO:0004872	receptor activity	PMID:8980223^[5]	IPI: Inferred from Physical Interaction	UniProtKB:O08538	F
	GO:0005515	protein binding	PMID:10557082^[6]	IPI: Inferred from Physical Interaction	UniProtKB:B2RU80	F
	GO:0005515	protein binding	PMID:20299672^[2]	TAS: Traceable Author Statement		F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017441	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018941	F
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F
	GO:0005886	plasma membrane	Reactome:REACT_13640	TAS: Traceable Author Statement		C
	GO:0005887	integral to plasma membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018941	C
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001245	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008266	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018941	P
	GO:0006916	anti-apoptosis	PMID:19409199^[7]	IGI: Inferred from Genetic Interaction	MGI:MGI:108448	P
	GO:0007160	cell-matrix adhesion	PMID:9683559^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2159358	P
	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018941	P
	GO:0010595	positive regulation of endothelial cell migration	PMID:20299672^[2]	TAS: Traceable Author Statement		P
	GO:0010595	positive regulation of endothelial cell migration	PMID:20406889^[4]	TAS: Traceable Author Statement		P
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016020	membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0162	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0016301	kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	F
	GO:0016310	phosphorylation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	P
	GO:0016337	cell-cell adhesion	PMID:9683559^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2159358	P
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F
	GO:0016772	transferase activity, transferring phosphorus-containing groups	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F
	GO:0030097	hemopoiesis	PMID:15260986^[9]	IMP: Inferred from Mutant Phenotype		P
	GO:0030097	hemopoiesis	PMID:9846489^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2159357	P
	GO:0030334	regulation of cell migration	PMID:9683559^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2159358	P
	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	PMID:20406889^[4]	TAS: Traceable Author Statement		P
	GO:0032526	response to retinoic acid	PMID:18439490^[10]	IDA: Inferred from Direct Assay		P
	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:19409199^[7]	IGI: Inferred from Genetic Interaction	MGI:MGI:108448	P
	GO:0045765	regulation of angiogenesis	PMID:9683559^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2159358	P
	GO:0045785	positive regulation of cell adhesion	PMID:15260986^[9]	IMP: Inferred from Mutant Phenotype		P
	GO:0048014	Tie receptor signaling pathway	PMID:20299672^[2]	TAS: Traceable Author Statement		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Hamaguchi I et al. (2006) Loss of Tie2 receptor compromises embryonic stem cell-derived endothelial but not hematopoietic cell survival. Blood 107: 1207-13 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Olivey HE & Svensson EC (2010) Epicardial-myocardial signaling directing coronary vasculogenesis. Circ Res 106: 818-32 PubMed GONUTS page
↑ ^3.0 ^3.1 Takakura N et al. (1998) Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis. Immunity 9: 677-86 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Suzuki Y et al. (2010) BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo. J Cell Sci 123: 1684-92 PubMed GONUTS page
↑ Davis S et al. (1996) Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell 87: 1161-9 PubMed GONUTS page
↑ Fachinger G et al. (1999) Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2. Oncogene 18: 5948-53 PubMed GONUTS page
↑ ^7.0 ^7.1 Bai Y et al. (2009) An Ang1-Tie2-PI3K axis in neural progenitor cells initiates survival responses against oxygen and glucose deprivation. Neuroscience 160: 371-81 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Patan S (1998) TIE1 and TIE2 receptor tyrosine kinases inversely regulate embryonic angiogenesis by the mechanism of intussusceptive microvascular growth. Microvasc Res 56: 1-21 PubMed GONUTS page
↑ ^9.0 ^9.1 Arai F et al. (2004) Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 118: 149-61 PubMed GONUTS page
↑ Su D & Gudas LJ (2008) Retinoic acid receptor gamma activates receptor tyrosine kinase Tie1 gene transcription through transcription factor GATA4 in F9 stem cells. Exp Hematol 36: 624-41 PubMed GONUTS page

[PMID:16219799-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Hamaguchi I et al. (2006) Loss of Tie2 receptor compromises embryonic stem cell-derived endothelial but not hematopoietic cell survival. Blood 107: 1207-13 PubMed GONUTS page

[PMID:20299672-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Olivey HE & Svensson EC (2010) Epicardial-myocardial signaling directing coronary vasculogenesis. Circ Res 106: 818-32 PubMed GONUTS page

[PMID:9846489-2] 3.0 ^3.1 Takakura N et al. (1998) Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis. Immunity 9: 677-86 PubMed GONUTS page

[PMID:20406889-3] 4.0 ^4.1 ^4.2 Suzuki Y et al. (2010) BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo. J Cell Sci 123: 1684-92 PubMed GONUTS page

[PMID:8980223-4] Davis S et al. (1996) Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell 87: 1161-9 PubMed GONUTS page

[PMID:10557082-5] Fachinger G et al. (1999) Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2. Oncogene 18: 5948-53 PubMed GONUTS page

[PMID:19409199-6] 7.0 ^7.1 Bai Y et al. (2009) An Ang1-Tie2-PI3K axis in neural progenitor cells initiates survival responses against oxygen and glucose deprivation. Neuroscience 160: 371-81 PubMed GONUTS page

[PMID:9683559-7] 8.0 ^8.1 ^8.2 ^8.3 Patan S (1998) TIE1 and TIE2 receptor tyrosine kinases inversely regulate embryonic angiogenesis by the mechanism of intussusceptive microvascular growth. Microvasc Res 56: 1-21 PubMed GONUTS page

[PMID:15260986-8] 9.0 ^9.1 Arai F et al. (2004) Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 118: 149-61 PubMed GONUTS page

[PMID:18439490-9] Su D & Gudas LJ (2008) Retinoic acid receptor gamma activates receptor tyrosine kinase Tie1 gene transcription through transcription factor GATA4 in F9 stem cells. Exp Hematol 36: 624-41 PubMed GONUTS page

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MOUSE:TIE2

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