MOUSE:TENR

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Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Tnr
Protein Name(s)	Tenascin-R TN-R Janusin Neural recognition molecule J1-160/180 Restrictin
External Links
UniProt	Q8BYI9
EMBL	AK039390 BC132392 BC138043 AJ005844
IPI	IPI00227126 IPI00553593
RefSeq	NP_071707.2
UniGene	Mm.44701
ProteinModelPortal	Q8BYI9
SMR	Q8BYI9
IntAct	Q8BYI9
STRING	Q8BYI9
PhosphoSite	Q8BYI9
PRIDE	Q8BYI9
Ensembl	ENSMUST00000040797 ENSMUST00000111669
GeneID	21960
KEGG	mmu:21960
NMPDR	fig\|10090.3.peg.1308
CTD	7143
MGI	MGI:99516
eggNOG	roNOG07418
GeneTree	ENSGT00580000081396
HOGENOM	HBG714000
HOVERGEN	HBG008949
InParanoid	Q8BYI9
OrthoDB	EOG42FSGP
NextBio	301652
ArrayExpress	Q8BYI9
Bgee	Q8BYI9
CleanEx	MM_TNR
Genevestigator	Q8BYI9
GO	GO:0009986 GO:0045121 GO:0072534 GO:0005578 GO:0046625 GO:0008306 GO:0030198 GO:0035641 GO:0060291 GO:0048692 GO:0022408 GO:0050805 GO:0050885 GO:0007158 GO:0051968 GO:0007165 GO:0050808 GO:0022029
InterPro	IPR006210 IPR013032 IPR013111 IPR002181 IPR014716 IPR014715 IPR003961 IPR013783
Gene3D	G3DSA:3.90.215.10 G3DSA:4.10.530.10 G3DSA:2.60.40.10
KO	K06252
Pfam	PF07974 PF00147 PF00041
SMART	SM00181 SM00186 SM00060
SUPFAM	SSF56496 SSF49265
PROSITE	PS00022 PS01186 PS50026 PS00514 PS51406 PS50853

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0005102	receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002181	F	Seeded From UniProt
	GO:0005102	receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014715	F	Seeded From UniProt
	GO:0005102	receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014716	F	Seeded From UniProt
	GO:0005178	integrin binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000003407	F	Seeded From UniProt
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C	Seeded From UniProt
	GO:0005578	proteinaceous extracellular matrix	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0272	C	Seeded From UniProt
	GO:0005578	proteinaceous extracellular matrix	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000003407	C	Seeded From UniProt
	GO:0005578	proteinaceous extracellular matrix	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0111	C	Seeded From UniProt
	GO:0005578	proteinaceous extracellular matrix	PMID:19141078^[1]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005578	proteinaceous extracellular matrix	PMID:7530142^[2]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0007155	cell adhesion	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0130	P	Seeded From UniProt
	GO:0007158	neuron cell-cell adhesion	PMID:15034584^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2154583	P	Seeded From UniProt
	GO:0007162	negative regulation of cell adhesion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000003407	P	Seeded From UniProt
	GO:0007165	signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002181	P	Seeded From UniProt
	GO:0007165	signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014715	P	Seeded From UniProt
	GO:0007165	signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014716	P	Seeded From UniProt
	GO:0008306	associative learning	PMID:12882316^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2154583	P	Seeded From UniProt
	GO:0009986	cell surface	PMID:12056833^[5]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0010977	negative regulation of neuron projection development	PMID:9405406^[6]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0022029	telencephalon cell migration	PMID:15034584^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2154583	P	Seeded From UniProt
	GO:0022408	negative regulation of cell-cell adhesion	PMID:15034584^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2154583	P	Seeded From UniProt
	GO:0022408	negative regulation of cell-cell adhesion	PMID:16831557^[7]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0030198	extracellular matrix organization	PMID:10341229^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2154583	P	Seeded From UniProt
	GO:0030198	extracellular matrix organization	PMID:11077416^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2154583	P	Seeded From UniProt
	GO:0030198	extracellular matrix organization	PMID:16870730^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2154583	P	Seeded From UniProt
	GO:0030517	negative regulation of axon extension	PMID:16831557^[7]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0035641	locomotory exploration behavior	PMID:14529817^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2154583	P	Seeded From UniProt
	GO:0045121	membrane raft	PMID:12056833^[5]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0046625	sphingolipid binding	PMID:12056833^[5]	TAS: Traceable Author Statement		F	Seeded From UniProt
	GO:0048692	negative regulation of axon extension involved in regeneration	PMID:16870730^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2154583	P	Seeded From UniProt
	GO:0050804	regulation of synaptic transmission	PMID:11377840^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2154583	P	Seeded From UniProt
	GO:0050805	negative regulation of synaptic transmission	PMID:15033179^[13]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2154583	P	Seeded From UniProt
	GO:0050808	synapse organization	PMID:16262627^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2154583	P	Seeded From UniProt
	GO:0050885	neuromuscular process controlling balance	PMID:12882316^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2154583	P	Seeded From UniProt
	GO:0051968	positive regulation of synaptic transmission, glutamatergic	PMID:11161481^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2154583	P	Seeded From UniProt
	GO:0051971	positive regulation of transmission of nerve impulse	PMID:10341229^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2154583	P	Seeded From UniProt
	GO:0060291	long-term synaptic potentiation	PMID:11161481^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2154583	P	Seeded From UniProt
	GO:0060291	long-term synaptic potentiation	PMID:17537973^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2154583	P	Seeded From UniProt
	GO:0072534	perineuronal net	PMID:10341229^[8]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Bekku Y et al. (2009) Brevican distinctively assembles extracellular components at the large diameter nodes of Ranvier in the CNS. J Neurochem 108: 1266-76 PubMed GONUTS page
↑ Schachner M et al. (1994) The perplexing multifunctionality of janusin, a tenascin-related molecule. Perspect Dev Neurobiol 2: 33-41 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Saghatelyan A et al. (2004) Tenascin-R mediates activity-dependent recruitment of neuroblasts in the adult mouse forebrain. Nat Neurosci 7: 347-56 PubMed GONUTS page
↑ ^4.0 ^4.1 Montag-Sallaz M & Montag D (2003) Severe cognitive and motor coordination deficits in tenascin-R-deficient mice. Genes Brain Behav 2: 20-31 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Kappler J et al. (2002) Tenascins are associated with lipid rafts isolated from mouse brain. Biochem Biophys Res Commun 294: 742-7 PubMed GONUTS page
↑ Xiao ZC et al. (1997) Isolation of a tenascin-R binding protein from mouse brain membranes. A phosphacan-related chondroitin sulfate proteoglycan. J Biol Chem 272: 32092-101 PubMed GONUTS page
↑ ^7.0 ^7.1 Pesheva P et al. (2006) Early coevolution of adhesive but not antiadhesive tenascin-R ligand-receptor pairs in vertebrates: a phylogenetic study. Mol Cell Neurosci 32: 366-86 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Weber P et al. (1999) Mice deficient for tenascin-R display alterations of the extracellular matrix and decreased axonal conduction velocities in the CNS. J Neurosci 19: 4245-62 PubMed GONUTS page
↑ Brückner G et al. (2000) Postnatal development of perineuronal nets in wild-type mice and in a mutant deficient in tenascin-R. J Comp Neurol 428: 616-29 PubMed GONUTS page
↑ ^10.0 ^10.1 Apostolova I et al. (2006) Tenascin-R restricts posttraumatic remodeling of motoneuron innervation and functional recovery after spinal cord injury in adult mice. J Neurosci 26: 7849-59 PubMed GONUTS page
↑ Freitag S et al. (2003) Behavioral alterations in mice deficient for the extracellular matrix glycoprotein tenascin-R. Behav Brain Res 145: 189-207 PubMed GONUTS page
↑ Bukalo O et al. (2001) Modification of extracellular matrix by enzymatic removal of chondroitin sulfate and by lack of tenascin-R differentially affects several forms of synaptic plasticity in the hippocampus. Neuroscience 104: 359-69 PubMed GONUTS page
↑ Gurevicius K et al. (2004) Enhanced cortical and hippocampal neuronal excitability in mice deficient in the extracellular matrix glycoprotein tenascin-R. Mol Cell Neurosci 25: 515-23 PubMed GONUTS page
↑ Syková E et al. (2005) Reduced extracellular space in the brain of tenascin-R- and HNK-1-sulphotransferase deficient mice. Eur J Neurosci 22: 1873-80 PubMed GONUTS page
↑ ^15.0 ^15.1 Saghatelyan AK et al. (2001) Reduced perisomatic inhibition, increased excitatory transmission, and impaired long-term potentiation in mice deficient for the extracellular matrix glycoprotein tenascin-R. Mol Cell Neurosci 17: 226-40 PubMed GONUTS page
↑ Bukalo O et al. (2007) Hippocampal metaplasticity induced by deficiency in the extracellular matrix glycoprotein tenascin-R. J Neurosci 27: 6019-28 PubMed GONUTS page

[PMID:19141078-0] Bekku Y et al. (2009) Brevican distinctively assembles extracellular components at the large diameter nodes of Ranvier in the CNS. J Neurochem 108: 1266-76 PubMed GONUTS page

[PMID:7530142-1] Schachner M et al. (1994) The perplexing multifunctionality of janusin, a tenascin-related molecule. Perspect Dev Neurobiol 2: 33-41 PubMed GONUTS page

[PMID:15034584-2] 3.0 ^3.1 ^3.2 Saghatelyan A et al. (2004) Tenascin-R mediates activity-dependent recruitment of neuroblasts in the adult mouse forebrain. Nat Neurosci 7: 347-56 PubMed GONUTS page

[PMID:12882316-3] 4.0 ^4.1 Montag-Sallaz M & Montag D (2003) Severe cognitive and motor coordination deficits in tenascin-R-deficient mice. Genes Brain Behav 2: 20-31 PubMed GONUTS page

[PMID:12056833-4] 5.0 ^5.1 ^5.2 Kappler J et al. (2002) Tenascins are associated with lipid rafts isolated from mouse brain. Biochem Biophys Res Commun 294: 742-7 PubMed GONUTS page

[PMID:9405406-5] Xiao ZC et al. (1997) Isolation of a tenascin-R binding protein from mouse brain membranes. A phosphacan-related chondroitin sulfate proteoglycan. J Biol Chem 272: 32092-101 PubMed GONUTS page

[PMID:16831557-6] 7.0 ^7.1 Pesheva P et al. (2006) Early coevolution of adhesive but not antiadhesive tenascin-R ligand-receptor pairs in vertebrates: a phylogenetic study. Mol Cell Neurosci 32: 366-86 PubMed GONUTS page

[PMID:10341229-7] 8.0 ^8.1 ^8.2 Weber P et al. (1999) Mice deficient for tenascin-R display alterations of the extracellular matrix and decreased axonal conduction velocities in the CNS. J Neurosci 19: 4245-62 PubMed GONUTS page

[PMID:11077416-8] Brückner G et al. (2000) Postnatal development of perineuronal nets in wild-type mice and in a mutant deficient in tenascin-R. J Comp Neurol 428: 616-29 PubMed GONUTS page

[PMID:16870730-9] 10.0 ^10.1 Apostolova I et al. (2006) Tenascin-R restricts posttraumatic remodeling of motoneuron innervation and functional recovery after spinal cord injury in adult mice. J Neurosci 26: 7849-59 PubMed GONUTS page

[PMID:14529817-10] Freitag S et al. (2003) Behavioral alterations in mice deficient for the extracellular matrix glycoprotein tenascin-R. Behav Brain Res 145: 189-207 PubMed GONUTS page

[PMID:11377840-11] Bukalo O et al. (2001) Modification of extracellular matrix by enzymatic removal of chondroitin sulfate and by lack of tenascin-R differentially affects several forms of synaptic plasticity in the hippocampus. Neuroscience 104: 359-69 PubMed GONUTS page

[PMID:15033179-12] Gurevicius K et al. (2004) Enhanced cortical and hippocampal neuronal excitability in mice deficient in the extracellular matrix glycoprotein tenascin-R. Mol Cell Neurosci 25: 515-23 PubMed GONUTS page

[PMID:16262627-13] Syková E et al. (2005) Reduced extracellular space in the brain of tenascin-R- and HNK-1-sulphotransferase deficient mice. Eur J Neurosci 22: 1873-80 PubMed GONUTS page

[PMID:11161481-14] 15.0 ^15.1 Saghatelyan AK et al. (2001) Reduced perisomatic inhibition, increased excitatory transmission, and impaired long-term potentiation in mice deficient for the extracellular matrix glycoprotein tenascin-R. Mol Cell Neurosci 17: 226-40 PubMed GONUTS page

[PMID:17537973-15] Bukalo O et al. (2007) Hippocampal metaplasticity induced by deficiency in the extracellular matrix glycoprotein tenascin-R. J Neurosci 27: 6019-28 PubMed GONUTS page

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MOUSE:TENR

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