MOUSE:TBPL2

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Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Tbpl2 ( synonyms: Tbp2, Trf3 )
Protein Name(s)	TATA box-binding protein-like protein 2 TBP-like protein 2 TATA box-binding protein-related factor 3 TBP-related factor 3
External Links
UniProt Identifier	TBPL2_MOUSE
UniProt Accessions	Q6SJ95, A2AQK6, Q498A1,
EMBL	AY457924, BK005773, AL844838, AL844838, BC100305, BC119160,
RefSeq	NP_951014.1,
IntAct	Q6SJ95,
Ensembl	ENSMUST00000080453, ENSMUST00000153338,
Pfam	PF00352,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000247219	C
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:17109819^[1]	IDA: Inferred from Direct Assay		P
	GO:0005634	nucleus	PMID:17109819^[1]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0006367	transcription initiation from RNA polymerase II promoter	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000814	P
	GO:0003677	DNA binding	PMID:17109819^[1]	IDA: Inferred from Direct Assay		F
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000814	P
	GO:0006350	transcription	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0005634	nucleus	PMID:17641088^[2]	IDA: Inferred from Direct Assay		C
	GO:0003702	RNA polymerase II transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000814	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:17109819^[1]	IDA: Inferred from Direct Assay		F
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012294	F
	GO:0005488	binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012295	F
	GO:0045449	regulation of transcription	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005515	protein binding	PMID:17704303^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q5HZG4	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000814	F
	GO:0006351	transcription, DNA-dependent	PMID:17109819^[1]	IDA: Inferred from Direct Assay		P
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000247219	C
	GO:0005737	cytoplasm	PMID:17109819^[1]	IDA: Inferred from Direct Assay		C
	GO:0005515	protein binding	PMID:19759265^[4]	EXP: Inferred from Experiment		F	Figure 1. Tbp2-deficient females do not ovulate upon hormonal stimulation. Control and Tbp2-deficient 4-6 - wk-old females were induced for superovulation with intraperitoneal injection of PMSG followed by administration of hCG 48 h later.	complete
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000814	F
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012294	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003677	DNA binding	PMID:17109819^[1]	IDA: Inferred from Direct Assay		F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:17109819^[1]	IDA: Inferred from Direct Assay		F
	GO:0005488	binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012295	F
	GO:0005515	protein binding	PMID:17704303^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q5HZG4	F
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000247219	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:17109819^[1]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:17641088^[2]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000247219	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005737	cytoplasm	PMID:17109819^[1]	IDA: Inferred from Direct Assay		C
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006351	transcription, DNA-dependent	PMID:17109819^[1]	IDA: Inferred from Direct Assay		P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000814	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0006367	transcription initiation from RNA polymerase II promoter	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000814	P
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:17109819^[1]	IDA: Inferred from Direct Assay		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Tanaka Y et al. (2007) Transcriptional repression of the mouse wee1 gene by TBP-related factor 2. Biochem Biophys Res Commun 352: 21-8 PubMed GONUTS page
↑ ^2.0 ^2.1 Gazdag E et al. (2007) Analysis of TATA-binding protein 2 (TBP2) and TBP expression suggests different roles for the two proteins in regulation of gene expression during oogenesis and early mouse development. Reproduction 134: 51-62 PubMed GONUTS page
↑ ^3.0 ^3.1 Deato MD & Tjian R (2007) Switching of the core transcription machinery during myogenesis. Genes Dev 21: 2137-49 PubMed GONUTS page
↑ Gazdag E et al. (2009) TBP2 is essential for germ cell development by regulating transcription and chromatin condensation in the oocyte. Genes Dev 23: 2210-23 PubMed GONUTS page

[PMID:17109819-0] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Tanaka Y et al. (2007) Transcriptional repression of the mouse wee1 gene by TBP-related factor 2. Biochem Biophys Res Commun 352: 21-8 PubMed GONUTS page

[PMID:17641088-1] 2.0 ^2.1 Gazdag E et al. (2007) Analysis of TATA-binding protein 2 (TBP2) and TBP expression suggests different roles for the two proteins in regulation of gene expression during oogenesis and early mouse development. Reproduction 134: 51-62 PubMed GONUTS page

[PMID:17704303-2] 3.0 ^3.1 Deato MD & Tjian R (2007) Switching of the core transcription machinery during myogenesis. Genes Dev 21: 2137-49 PubMed GONUTS page

[PMID:19759265-3] Gazdag E et al. (2009) TBP2 is essential for germ cell development by regulating transcription and chromatin condensation in the oocyte. Genes Dev 23: 2210-23 PubMed GONUTS page

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MOUSE:TBPL2

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