MOUSE:SYUA

From GONUTS

Jump to: navigation, search

Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Snca ( synonyms: Syn )
Protein Name(s)	Alpha-synuclein Non-A beta component of AD amyloid Non-A4 component of amyloid precursor NACP
External Links
UniProt Identifier	SYUA_MOUSE
UniProt Accessions	O55042, Q3U130, Q9CXF8, Q9EQC3, Q9QUR3,
EMBL	AF044672, AF033261, AF179273, AF179272, AF179268, AF179269, AF179270, AF179271, AF163865, AK014472, AK156316, BC046764, AF277451,
RefSeq	NP_001035916.1, NP_033247.1,
Ensembl	ENSMUST00000114268, ENSMUST00000163779,
Pfam	PF01387,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0005829	cytosol		IDA: Inferred from Direct Assay		C	Source: UniProtKB
	GO:0005634	nucleus		IDA: Inferred from Direct Assay		C	Source: UniProtKB
	GO:0005886	plasma membrane		IDA: Inferred from Direct Assay		C	Source: MGI
	GO:0019717	synaptosome		IDA: Inferred from Direct Assay		C	Source: MGI
	GO:0050544	arachidonic acid binding		IDA: Inferred from Direct Assay		F	Source: MGI
	GO:0042393	histone binding		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0042802	identical protein binding		IDA: Inferred from Direct Assay		F	Source: MGI
	GO:0008344	adult locomotory behavior		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0034599	cellular response to oxidative stress		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0042416	dopamine biosynthetic process		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0006631	fatty acid metabolic process		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0060291	long-term synaptic potentiation		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0001774	microglial cell activation		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0042775	mitochondrial ATP synthesis coupled electro...		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0007006	mitochondrial membrane organization		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0043524	negative regulation of neuron apoptosis		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0006638	neutral lipid metabolic process		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0006644	phospholipid metabolic process		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0001956	positive regulation of neurotransmitter sec...		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0050812	regulation of acyl-CoA biosynthetic process		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0014059	regulation of dopamine secretion		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0060079	regulation of excitatory postsynaptic membr...		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0014048	regulation of glutamate secretion		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0040012	regulation of locomotion		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0048169	regulation of long-term neuronal synaptic p...		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0043030	regulation of macrophage activation		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0042493	response to drug		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0001963	synaptic transmission, dopaminergic		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0048488	synaptic vesicle endocytosis		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB
	GO:0000287	magnesium ion binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	F
	GO:0001774	microglial cell activation	PMID:17035541^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2389489	P
	GO:0001921	positive regulation of receptor recycling	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	P
	GO:0001956	positive regulation of neurotransmitter secretion	PMID:15510220^[2]	IDA: Inferred from Direct Assay		P
	GO:0001963	synaptic transmission, dopaminergic	PMID:10707987^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1888382	P
	GO:0001963	synaptic transmission, dopaminergic	PMID:12388586^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2389489	P
	GO:0005509	calcium ion binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	F
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	C
	GO:0005634	nucleus	PMID:16959795^[5]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002460	C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005737	cytoplasm	PMID:17475220^[6]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	PMID:20457918^[7]	IDA: Inferred from Direct Assay		C
	GO:0005739	mitochondrion	PMID:16260631^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2389489	C
	GO:0005829	cytosol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	C
	GO:0005829	cytosol	PMID:18980610^[9]	IDA: Inferred from Direct Assay		C
	GO:0005856	cytoskeleton	PMID:17077307^[10]	IDA: Inferred from Direct Assay		C
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	C
	GO:0005886	plasma membrane	PMID:17475220^[6]	IDA: Inferred from Direct Assay		C
	GO:0005938	cell cortex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	C
	GO:0006631	fatty acid metabolic process	PMID:14507911^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1888382	P
	GO:0006631	fatty acid metabolic process	PMID:17250686^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2389489	P
	GO:0006638	neutral lipid metabolic process	PMID:17250686^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2389489	P
	GO:0006644	phospholipid metabolic process	PMID:15938614^[13]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2389489	P
	GO:0006644	phospholipid metabolic process	PMID:16260631^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2389489	P
	GO:0006644	phospholipid metabolic process	PMID:16734431^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2389489	P
	GO:0006916	anti-apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	P
	GO:0006919	activation of caspase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	P
	GO:0007006	mitochondrial membrane organization	PMID:16260631^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2389489	P
	GO:0008198	ferrous iron binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	F
	GO:0008270	zinc ion binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	F
	GO:0008344	adult locomotory behavior	PMID:18333965^[15]	IGI: Inferred from Genetic Interaction	MGI:MGI:1298397	P
	GO:0010040	response to iron(II) ion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	P
	GO:0010517	regulation of phospholipase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	P
	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	P
	GO:0014048	regulation of glutamate secretion	PMID:17689254^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2154692	P
	GO:0014059	regulation of dopamine secretion	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002460	P
	GO:0014059	regulation of dopamine secretion	PMID:18333965^[15]	IGI: Inferred from Genetic Interaction	MGI:MGI:1298397	P
	GO:0015629	actin cytoskeleton	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	C
	GO:0016044	cellular membrane organization	PMID:14507911^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1888382	P
	GO:0019717	synaptosome	PMID:10964942^[17]	IDA: Inferred from Direct Assay		C
	GO:0019894	kinesin binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	F
	GO:0030424	axon	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	C
	GO:0030426	growth cone	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	C
	GO:0030544	Hsp70 protein binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	F
	GO:0031092	platelet alpha granule membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	C
	GO:0031115	negative regulation of microtubule polymerization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	P
	GO:0031623	receptor internalization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	P
	GO:0032026	response to magnesium ion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	P
	GO:0032410	negative regulation of transporter activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	P
	GO:0032496	response to lipopolysaccharide	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	P
	GO:0032769	negative regulation of monooxygenase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	P
	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:21127069^[18]	IMP: Inferred from Mutant Phenotype		P
	GO:0034341	response to interferon-gamma	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	P
	GO:0034599	cellular response to oxidative stress	PMID:16298531^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1888382	P
	GO:0035067	negative regulation of histone acetylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	P
	GO:0040012	regulation of locomotion	PMID:10707987^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1888382	P
	GO:0042393	histone binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	F
	GO:0042393	histone binding	PMID:16959795^[5]	IDA: Inferred from Direct Assay		F
	GO:0042416	dopamine biosynthetic process	PMID:10707987^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1888382	P
	GO:0042417	dopamine metabolic process	PMID:15465911^[20]	IGI: Inferred from Genetic Interaction	MGI:MGI:1889011	P
	GO:0042493	response to drug	PMID:10707987^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1888382	P
	GO:0042775	mitochondrial ATP synthesis coupled electron transport	PMID:16260631^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2389489	P
	GO:0042802	identical protein binding	PMID:10978144^[21]	IDA: Inferred from Direct Assay		F
	GO:0043014	alpha-tubulin binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	F
	GO:0043027	caspase inhibitor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	F
	GO:0043030	regulation of macrophage activation	PMID:17035541^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2389489	P
	GO:0043154	negative regulation of caspase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	P
	GO:0043205	fibril	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	C
	GO:0043524	negative regulation of neuron apoptosis	PMID:16269331^[22]	IGI: Inferred from Genetic Interaction	MGI:MGI:892995	P
	GO:0045502	dynein binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	F
	GO:0045807	positive regulation of endocytosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	P
	GO:0045920	negative regulation of exocytosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	P
	GO:0046928	regulation of neurotransmitter secretion	PMID:10707987^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1888382	P
	GO:0046928	regulation of neurotransmitter secretion	PMID:12388586^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2389489	P
	GO:0046928	regulation of neurotransmitter secretion	PMID:15510220^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2429773	P
	GO:0046928	regulation of neurotransmitter secretion	PMID:18333965^[15]	IGI: Inferred from Genetic Interaction	MGI:MGI:1298397	P
	GO:0048156	tau protein binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	F
	GO:0048168	regulation of neuronal synaptic plasticity	PMID:17610578^[23]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2429773	P
	GO:0048169	regulation of long-term neuronal synaptic plasticity	PMID:15510220^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2429773	P
	GO:0048488	synaptic vesicle endocytosis	PMID:18980610^[9]	IMP: Inferred from Mutant Phenotype		P
	GO:0048489	synaptic vesicle transport	PMID:12388586^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2389489	P
	GO:0050544	arachidonic acid binding	PMID:16734431^[14]	IDA: Inferred from Direct Assay		F
	GO:0050806	positive regulation of synaptic transmission	PMID:15579163^[24]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1888382	P
	GO:0050812	regulation of acyl-CoA biosynthetic process	PMID:16636270^[25]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2389489	P
	GO:0050812	regulation of acyl-CoA biosynthetic process	PMID:16734431^[14]	IDA: Inferred from Direct Assay		P
	GO:0051219	phosphoprotein binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	F
	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	P
	GO:0051585	negative regulation of dopamine uptake	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	P
	GO:0051612	negative regulation of serotonin uptake	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	P
	GO:0051622	negative regulation of norepinephrine uptake	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	P
	GO:0060079	regulation of excitatory postsynaptic membrane potential	PMID:17610578^[23]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2429773	P
	GO:0060291	long-term synaptic potentiation	PMID:17689254^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2154692	P
	GO:0060732	positive regulation of inositol phosphate biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	P
	GO:0070495	negative regulation of thrombin receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	P
	GO:0070555	response to interleukin-1	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	P
	GO:0071902	positive regulation of protein serine/threonine kinase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000378437	P
NOT	GO:0043523	regulation of neuron apoptosis	PMID:15380020^[26]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2429773	P
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Austin SA et al. (2006) Alpha-synuclein expression modulates microglial activation phenotype. J Neurosci 26: 10558-63 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Liu S et al. (2004) alpha-Synuclein produces a long-lasting increase in neurotransmitter release. EMBO J 23: 4506-16 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Abeliovich A et al. (2000) Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 25: 239-52 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Cabin DE et al. (2002) Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein. J Neurosci 22: 8797-807 PubMed GONUTS page
↑ ^5.0 ^5.1 Kontopoulos E et al. (2006) Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity. Hum Mol Genet 15: 3012-23 PubMed GONUTS page
↑ ^6.0 ^6.1 Nakai M et al. (2007) Expression of alpha-synuclein, a presynaptic protein implicated in Parkinson's disease, in erythropoietic lineage. Biochem Biophys Res Commun 358: 104-10 PubMed GONUTS page
↑ Tong Y et al. (2010) Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Proc Natl Acad Sci U S A 107: 9879-84 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Ellis CE et al. (2005) Mitochondrial lipid abnormality and electron transport chain impairment in mice lacking alpha-synuclein. Mol Cell Biol 25: 10190-201 PubMed GONUTS page
↑ ^9.0 ^9.1 Ben Gedalya T et al. (2009) Alpha-synuclein and polyunsaturated fatty acids promote clathrin-mediated endocytosis and synaptic vesicle recycling. Traffic 10: 218-34 PubMed GONUTS page
↑ Duka T et al. (2006) Alpha-synuclein induces hyperphosphorylation of Tau in the MPTP model of parkinsonism. FASEB J 20: 2302-12 PubMed GONUTS page
↑ ^11.0 ^11.1 Sharon R et al. (2003) Altered fatty acid composition of dopaminergic neurons expressing alpha-synuclein and human brains with alpha-synucleinopathies. J Biol Chem 278: 49874-81 PubMed GONUTS page
↑ ^12.0 ^12.1 Barceló-Coblijn G et al. (2007) Brain neutral lipids mass is increased in alpha-synuclein gene-ablated mice. J Neurochem 101: 132-41 PubMed GONUTS page
↑ Golovko MY et al. (2005) Alpha-synuclein gene deletion decreases brain palmitate uptake and alters the palmitate metabolism in the absence of alpha-synuclein palmitate binding. Biochemistry 44: 8251-9 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Golovko MY et al. (2006) Acyl-CoA synthetase activity links wild-type but not mutant alpha-synuclein to brain arachidonate metabolism. Biochemistry 45: 6956-66 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Senior SL et al. (2008) Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synuclein. Eur J Neurosci 27: 947-57 PubMed GONUTS page
↑ ^16.0 ^16.1 Gureviciene I et al. (2007) Role of alpha-synuclein in synaptic glutamate release. Neurobiol Dis 28: 83-9 PubMed GONUTS page
↑ Kahle PJ et al. (2000) Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain. J Neurosci 20: 6365-73 PubMed GONUTS page
↑ Qureshi HY & Paudel HK (2011) Parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and alpha-synuclein mutations promote Tau protein phosphorylation at Ser262 and destabilize microtubule cytoskeleton in vitro. J Biol Chem 286: 5055-68 PubMed GONUTS page
↑ Klivenyi P et al. (2006) Mice lacking alpha-synuclein are resistant to mitochondrial toxins. Neurobiol Dis 21: 541-8 PubMed GONUTS page
↑ Chandra S et al. (2004) Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions. Proc Natl Acad Sci U S A 101: 14966-71 PubMed GONUTS page
↑ Rochet JC et al. (2000) Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein. Biochemistry 39: 10619-26 PubMed GONUTS page
↑ Chandra S et al. (2005) Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell 123: 383-96 PubMed GONUTS page
↑ ^23.0 ^23.1 Liu S et al. (2007) Alpha-synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMKII. Eur J Neurosci 25: 3583-96 PubMed GONUTS page
↑ Martín ED et al. (2004) Stressor-related impairment of synaptic transmission in hippocampal slices from alpha-synuclein knockout mice. Eur J Neurosci 20: 3085-91 PubMed GONUTS page
↑ Stanic AK et al. (2006) Immune dysregulation accelerates atherosclerosis and modulates plaque composition in systemic lupus erythematosus. Proc Natl Acad Sci U S A 103: 7018-23 PubMed GONUTS page
↑ Stefanis L et al. (2004) Lack of alpha-synuclein does not alter apoptosis of neonatal catecholaminergic neurons. Eur J Neurosci 20: 1969-72 PubMed GONUTS page

[PMID:17035541-0] 1.0 ^1.1 Austin SA et al. (2006) Alpha-synuclein expression modulates microglial activation phenotype. J Neurosci 26: 10558-63 PubMed GONUTS page

[PMID:15510220-1] 2.0 ^2.1 ^2.2 Liu S et al. (2004) alpha-Synuclein produces a long-lasting increase in neurotransmitter release. EMBO J 23: 4506-16 PubMed GONUTS page

[PMID:10707987-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Abeliovich A et al. (2000) Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 25: 239-52 PubMed GONUTS page

[PMID:12388586-3] 4.0 ^4.1 ^4.2 Cabin DE et al. (2002) Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein. J Neurosci 22: 8797-807 PubMed GONUTS page

[PMID:16959795-4] 5.0 ^5.1 Kontopoulos E et al. (2006) Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity. Hum Mol Genet 15: 3012-23 PubMed GONUTS page

[PMID:17475220-5] 6.0 ^6.1 Nakai M et al. (2007) Expression of alpha-synuclein, a presynaptic protein implicated in Parkinson's disease, in erythropoietic lineage. Biochem Biophys Res Commun 358: 104-10 PubMed GONUTS page

[PMID:20457918-6] Tong Y et al. (2010) Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Proc Natl Acad Sci U S A 107: 9879-84 PubMed GONUTS page

[PMID:16260631-7] 8.0 ^8.1 ^8.2 ^8.3 Ellis CE et al. (2005) Mitochondrial lipid abnormality and electron transport chain impairment in mice lacking alpha-synuclein. Mol Cell Biol 25: 10190-201 PubMed GONUTS page

[PMID:18980610-8] 9.0 ^9.1 Ben Gedalya T et al. (2009) Alpha-synuclein and polyunsaturated fatty acids promote clathrin-mediated endocytosis and synaptic vesicle recycling. Traffic 10: 218-34 PubMed GONUTS page

[PMID:17077307-9] Duka T et al. (2006) Alpha-synuclein induces hyperphosphorylation of Tau in the MPTP model of parkinsonism. FASEB J 20: 2302-12 PubMed GONUTS page

[PMID:14507911-10] 11.0 ^11.1 Sharon R et al. (2003) Altered fatty acid composition of dopaminergic neurons expressing alpha-synuclein and human brains with alpha-synucleinopathies. J Biol Chem 278: 49874-81 PubMed GONUTS page

[PMID:17250686-11] 12.0 ^12.1 Barceló-Coblijn G et al. (2007) Brain neutral lipids mass is increased in alpha-synuclein gene-ablated mice. J Neurochem 101: 132-41 PubMed GONUTS page

[PMID:15938614-12] Golovko MY et al. (2005) Alpha-synuclein gene deletion decreases brain palmitate uptake and alters the palmitate metabolism in the absence of alpha-synuclein palmitate binding. Biochemistry 44: 8251-9 PubMed GONUTS page

[PMID:16734431-13] 14.0 ^14.1 ^14.2 Golovko MY et al. (2006) Acyl-CoA synthetase activity links wild-type but not mutant alpha-synuclein to brain arachidonate metabolism. Biochemistry 45: 6956-66 PubMed GONUTS page

[PMID:18333965-14] 15.0 ^15.1 ^15.2 Senior SL et al. (2008) Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synuclein. Eur J Neurosci 27: 947-57 PubMed GONUTS page

[PMID:17689254-15] 16.0 ^16.1 Gureviciene I et al. (2007) Role of alpha-synuclein in synaptic glutamate release. Neurobiol Dis 28: 83-9 PubMed GONUTS page

[PMID:10964942-16] Kahle PJ et al. (2000) Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain. J Neurosci 20: 6365-73 PubMed GONUTS page

[PMID:21127069-17] Qureshi HY & Paudel HK (2011) Parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and alpha-synuclein mutations promote Tau protein phosphorylation at Ser262 and destabilize microtubule cytoskeleton in vitro. J Biol Chem 286: 5055-68 PubMed GONUTS page

[PMID:16298531-18] Klivenyi P et al. (2006) Mice lacking alpha-synuclein are resistant to mitochondrial toxins. Neurobiol Dis 21: 541-8 PubMed GONUTS page

[PMID:15465911-19] Chandra S et al. (2004) Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions. Proc Natl Acad Sci U S A 101: 14966-71 PubMed GONUTS page

[PMID:10978144-20] Rochet JC et al. (2000) Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein. Biochemistry 39: 10619-26 PubMed GONUTS page

[PMID:16269331-21] Chandra S et al. (2005) Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell 123: 383-96 PubMed GONUTS page

[PMID:17610578-22] 23.0 ^23.1 Liu S et al. (2007) Alpha-synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMKII. Eur J Neurosci 25: 3583-96 PubMed GONUTS page

[PMID:15579163-23] Martín ED et al. (2004) Stressor-related impairment of synaptic transmission in hippocampal slices from alpha-synuclein knockout mice. Eur J Neurosci 20: 3085-91 PubMed GONUTS page

[PMID:16636270-24] Stanic AK et al. (2006) Immune dysregulation accelerates atherosclerosis and modulates plaque composition in systemic lupus erythematosus. Proc Natl Acad Sci U S A 103: 7018-23 PubMed GONUTS page

[PMID:15380020-25] Stefanis L et al. (2004) Lack of alpha-synuclein does not alter apoptosis of neonatal catecholaminergic neurons. Eur J Neurosci 20: 1969-72 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

[26]

MOUSE:SYUA

Contents

Annotations

Notes

References

a

c

d

e

f

g

h

i

k

l

m

n

p

p cont.

r

s

t

v

z

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Cacao

Journal Clubs

page contributors

Toolbox