MOUSE:SYNJ2

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Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Synj2 ( synonyms: Kiaa0348 )
Protein Name(s)	Synaptojanin-2 Synaptic inositol-1,4,5-trisphosphate 5-phosphatase 2
External Links
UniProt Identifier	SYNJ2_MOUSE
UniProt Accessions	Q9D2G5, O35404, O88399, O88400, O88401, O88402, O88403, O88404,
EMBL	AF041857, AF041858, AF041859, AF041860, AF041861, AF041862, AK129122, AK019694, BC058749, BC060214, AF026123,
PIR	JW0105, PW0050, PW0051,
RefSeq	NP_001106822.1, NP_001106823.1, NP_001106824.1, NP_035653.2,
Ensembl	ENSMUST00000061091, ENSMUST00000080283, ENSMUST00000115784, ENSMUST00000115789,
Pfam	PF08952, PF03372, PF02383,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000166	nucleotide binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012677	F
	GO:0003676	nucleic acid binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000504	F
	GO:0003723	RNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015047	F
	GO:0003723	RNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0694	F
	GO:0004437	inositol or phosphatidylinositol phosphatase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000300	F
	GO:0004437	inositol or phosphatidylinositol phosphatase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000062564	F
	GO:0004437	inositol or phosphatidylinositol phosphatase activity	PMID:9636665^[1]	TAS: Traceable Author Statement		F
	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015047	F
	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:3.1.3.36	F
	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	PMID:9442075^[2]	IDA: Inferred from Direct Assay		F
	GO:0004445	inositol-polyphosphate 5-phosphatase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000062564	F
	GO:0005626	insoluble fraction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000062564	C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000062564	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005881	cytoplasmic microtubule	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000062564	C
	GO:0007420	brain development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000062564	P
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016020	membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0162	C
	GO:0016311	dephosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015047	P
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F
	GO:0017124	SH3 domain binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000062564	F
	GO:0030165	PDZ domain binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000062564	F
	GO:0031315	extrinsic to mitochondrial outer membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000062564	C
	GO:0032587	ruffle membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000062564	C
	GO:0042578	phosphoric ester hydrolase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002013	F
	GO:0043679	axon terminus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000062564	C
	GO:0046855	inositol phosphate dephosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000062564	P
	GO:0046856	phosphatidylinositol dephosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000062564	P
	GO:0048312	intracellular distribution of mitochondria	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000062564	P
	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000062564	C
	GO:0090102	cochlea development	PMID:21423608^[3]	IMP: Inferred from Mutant Phenotype		P	Fig 1. A gradual loss of inner and outer hair cells was detected in 8 and 12 week old mutant mice, starting in the basal turn of the cochlea and spreading towards the apical region, leading to a collapse of the Organ of Corti. At the same time there was a reduction in the number of spiral ganglia cells and the remaining cells showed increased vacuolation.	complete
	GO:0000166	nucleotide binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012677	F
	GO:0003676	nucleic acid binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000504	F
	GO:0003723	RNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015047	F
	GO:0003723	RNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0694	F
	GO:0004437	inositol or phosphatidylinositol phosphatase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000300	F
	GO:0004437	inositol or phosphatidylinositol phosphatase activity	PMID:9636665^[1]	TAS: Traceable Author Statement		F
	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015047	F
	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:3.1.3.36	F
	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	PMID:9442075^[2]	IDA: Inferred from Direct Assay		F
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016020	membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0162	C
	GO:0016311	dephosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015047	P
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F
	GO:0042578	phosphoric ester hydrolase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002013	F
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Seet LF et al. (1998) Molecular cloning of multiple isoforms of synaptojanin 2 and assignment of the gene to mouse chromosome 17A2-3.1. Biochem Biophys Res Commun 247: 116-22 PubMed GONUTS page
↑ ^2.0 ^2.1 Khvotchev M & Südhof TC (1998) Developmentally regulated alternative splicing in a novel synaptojanin. J Biol Chem 273: 2306-11 PubMed GONUTS page
↑ Manji SS et al. (2011) A mutation in synaptojanin 2 causes progressive hearing loss in the ENU-mutagenised mouse strain Mozart. PLoS One 6: e17607 PubMed GONUTS page

[PMID:9636665-0] 1.0 ^1.1 Seet LF et al. (1998) Molecular cloning of multiple isoforms of synaptojanin 2 and assignment of the gene to mouse chromosome 17A2-3.1. Biochem Biophys Res Commun 247: 116-22 PubMed GONUTS page

[PMID:9442075-1] 2.0 ^2.1 Khvotchev M & Südhof TC (1998) Developmentally regulated alternative splicing in a novel synaptojanin. J Biol Chem 273: 2306-11 PubMed GONUTS page

[PMID:21423608-2] Manji SS et al. (2011) A mutation in synaptojanin 2 causes progressive hearing loss in the ENU-mutagenised mouse strain Mozart. PLoS One 6: e17607 PubMed GONUTS page

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MOUSE:SYNJ2

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