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MOUSE:SUFU

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Contents

Species (Taxon ID) Mus musculus (Mouse). ([1])
Gene Name(s) Sufu
Protein Name(s) Suppressor of fused homolog
External Links
EMBL AF134893
AJ131692
AJ308625
AJ308626
AJ308627
AJ308628
AJ308629
AJ308630
AJ308632
AJ308634
AJ308635
AJ308633
AJ308631
AK015885
AK047603
BC048168
BC056997
IPI IPI00124718
IPI00137696
IPI00466980
IPI00554964
RefSeq NP_001020562.1
NP_056567.2
UniGene Mm.41210
ProteinModelPortal Q9Z0P7
SMR Q9Z0P7
IntAct Q9Z0P7
STRING Q9Z0P7
PhosphoSite Q9Z0P7
PRIDE Q9Z0P7
Ensembl ENSMUST00000039922
ENSMUST00000111866
ENSMUST00000111867
GeneID 24069
KEGG mmu:24069
UCSC uc008htn.1
uc008hto.1
uc008htq.1
CTD 51684
MGI MGI:1345643
GeneTree ENSGT00390000009747
HOVERGEN HBG061539
OMA RHGRHFT
OrthoDB EOG49S666
PhylomeDB Q9Z0P7
NextBio 304049
ArrayExpress Q9Z0P7
Bgee Q9Z0P7
CleanEx MM_SUFU
Genevestigator Q9Z0P7
GermOnline ENSMUSG00000025231
GO GO:0005929
GO:0005737
GO:0005634
GO:0008013
GO:0001947
GO:0045879
GO:0000122
GO:0001843
GO:0043588
GO:0021513
InterPro IPR007768
IPR024314
IPR020941
IPR016591
PANTHER PTHR10928
Pfam PF05076
PF12470
PIRSF PIRSF011844

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000122

negative regulation of transcription from RNA polymerase II promoter

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000358918

P

Seeded From UniProt

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

PMID:10531011[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

PMID:16459298[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

GO:0001843

neural tube closure

PMID:16155214[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3512046

P

Seeded From UniProt

GO:0001947

heart looping

PMID:16155214[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3512046

P

Seeded From UniProt

GO:0005515

protein binding

PMID:10531011[1]

IPI: Inferred from Physical Interaction

UniProtKB:P10071

F

Seeded From UniProt

GO:0005515

protein binding

PMID:10531011[1]

IPI: Inferred from Physical Interaction

UniProtKB:P47806

F

Seeded From UniProt

GO:0005515

protein binding

PMID:10531011[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q8K0K3

F

Seeded From UniProt

GO:0005515

protein binding

PMID:10920228[4]

IPI: Inferred from Physical Interaction

UniProtKB:P47806

F

Seeded From UniProt

GO:0005515

protein binding

PMID:10920228[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q61602

F

Seeded From UniProt

GO:0005515

protein binding

PMID:11252182[5]

IPI: Inferred from Physical Interaction

UniProtKB:P19538

F

Seeded From UniProt

GO:0005515

protein binding

PMID:11252182[5]

IPI: Inferred from Physical Interaction

UniProtKB:P23647

F

Seeded From UniProt

GO:0005515

protein binding

PMID:14611647[6]

IPI: Inferred from Physical Interaction

UniProtKB:O55128

F

Seeded From UniProt

GO:0005515

protein binding

PMID:14611647[6]

IPI: Inferred from Physical Interaction

UniProtKB:O88907

F

Seeded From UniProt

GO:0005515

protein binding

PMID:14611647[6]

IPI: Inferred from Physical Interaction

UniProtKB:P16110

F

Seeded From UniProt

GO:0005515

protein binding

PMID:14611647[6]

IPI: Inferred from Physical Interaction

UniProtKB:P50636

F

Seeded From UniProt

GO:0005515

protein binding

PMID:17182001[7]

IPI: Inferred from Physical Interaction

UniProtKB:Q9WV60

F

Seeded From UniProt

GO:0005515

protein binding

PMID:19286674[8]

IPI: Inferred from Physical Interaction

RefSeq:NP_001074594

F

Seeded From UniProt

GO:0005515

protein binding

PMID:19592253[9]

IPI: Inferred from Physical Interaction

UniProtKB:Q2M1P5

F

Seeded From UniProt

GO:0005515

protein binding

PMID:20360384[10]

IPI: Inferred from Physical Interaction

UniProtKB:Q61602

F

Seeded From UniProt

GO:0005515

protein binding

PMID:21816948[11]

IPI: Inferred from Physical Interaction

UniProtKB:Q8VDL9

F

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0539

C

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000358918

C

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0191

C

Seeded From UniProt

GO:0005634

nucleus

PMID:16254602[12]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005737

cytoplasm

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded From UniProt

GO:0005737

cytoplasm

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000358918

C

Seeded From UniProt

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded From UniProt

GO:0005737

cytoplasm

PMID:10531011[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005737

cytoplasm

PMID:16316410[13]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005737

cytoplasm

PMID:20360384[10]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005929

cilium

PMID:16254602[12]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0007368

determination of left/right symmetry

PMID:16155214[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3512046

P

Seeded From UniProt

GO:0008013

beta-catenin binding

PMID:11477086[14]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

GO:0008134

transcription factor binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000358918

F

Seeded From UniProt

GO:0021513

spinal cord dorsal/ventral patterning

PMID:16459298[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3619046

P

Seeded From UniProt

GO:0042802

identical protein binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000358918

F

Seeded From UniProt

GO:0043588

skin development

PMID:16459298[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3619046

P

Seeded From UniProt

GO:0045879

negative regulation of smoothened signaling pathway

PMID:10531011[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

GO:0045879

negative regulation of smoothened signaling pathway

PMID:16459298[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3619046

P

Seeded From UniProt

GO:0035085

cilium axoneme

PMID:21209331[15]

IDA: Inferred from Direct Assay

C

Fig 4A shows ciliary localisation in WT

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Ding Q et al. (1999) Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1. Curr Biol 9: 1119-22 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Svärd J et al. (2006) Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway. Dev Cell 10: 187-97 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Cooper AF et al. (2005) Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused. Development 132: 4407-17 PubMed GONUTS page
  4. ↑ 4.0 4.1 Simon-Chazottes D et al. (2000) Genomic organization, chromosomal assignment, and expression analysis of the mouse suppressor of fused gene (Sufu) coding a Gli protein partner. Mamm Genome 11: 614-21 PubMed GONUTS page
  5. ↑ 5.0 5.1 Delattre M et al. (1999) The Suppressor of fused gene, involved in Hedgehog signal transduction in Drosophila, is conserved in mammals. Dev Genes Evol 209: 294-300 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 Paces-Fessy M et al. (2004) The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins. Biochem J 378: 353-62 PubMed GONUTS page
  7. ↑ Takenaka K et al. (2007) GSK3beta positively regulates Hedgehog signaling through Sufu in mammalian cells. Biochem Biophys Res Commun 353: 501-8 PubMed GONUTS page
  8. ↑ Norman RX et al. (2009) Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling. Hum Mol Genet 18: 1740-54 PubMed GONUTS page
  9. ↑ Endoh-Yamagami S et al. (2009) The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development. Curr Biol 19: 1320-6 PubMed GONUTS page
  10. ↑ 10.0 10.1 Humke EW et al. (2010) The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. Genes Dev 24: 670-82 PubMed GONUTS page
  11. ↑ Li B et al. (2011) Increased hedgehog signaling in postnatal kidney results in aberrant activation of nephron developmental programs. Hum Mol Genet 20: 4155-66 PubMed GONUTS page
  12. ↑ 12.0 12.1 Haycraft CJ et al. (2005) Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet 1: e53 PubMed GONUTS page
  13. ↑ Barnfield PC et al. (2005) Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms. Differentiation 73: 397-405 PubMed GONUTS page
  14. ↑ Meng X et al. (2001) Suppressor of fused negatively regulates beta-catenin signaling. J Biol Chem 276: 40113-9 PubMed GONUTS page
  15. ↑ Qin J et al. (2011) Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc Natl Acad Sci U S A 108: 1456-61 PubMed GONUTS page
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