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MOUSE:STXB1
Contents |
| Species (Taxon ID) | Mus musculus (Mouse). ([1]) | |
| Gene Name(s) | Stxbp1 | |
| Protein Name(s) | Syntaxin-binding protein 1
Protein unc-18 homolog 1 Unc18-1 Protein unc-18 homolog A Unc-18A | |
| External Links | ||
| EMBL | D45903 AB012697 AF326545 AF326563 AL845471 AL845471 AL845471 BC031728 | |
| IPI | IPI00415402 IPI00415403 | |
| RefSeq | NP_001107041.1 NP_033321.2 | |
| UniGene | Mm.278865 | |
| ProteinModelPortal | O08599 | |
| SMR | O08599 | |
| DIP | DIP-31951N | |
| IntAct | O08599 | |
| STRING | O08599 | |
| PhosphoSite | O08599 | |
| PRIDE | O08599 | |
| Ensembl | ENSMUST00000050000 ENSMUST00000077458 ENSMUST00000113222 | |
| GeneID | 20910 | |
| KEGG | mmu:20910 | |
| UCSC | uc008jha.2 uc008jhb.2 | |
| CTD | 6812 | |
| MGI | MGI:107363 | |
| eggNOG | roNOG12948 | |
| GeneTree | ENSGT00390000005206 | |
| HOVERGEN | HBG052710 | |
| OMA | TEVCPEE | |
| OrthoDB | EOG4K6G3W | |
| PhylomeDB | O08599 | |
| Reactome | REACT_112621 | |
| NextBio | 299797 | |
| ArrayExpress | O08599 | |
| Bgee | O08599 | |
| CleanEx | MM_STXBP1 | |
| Genevestigator | O08599 | |
| GermOnline | ENSMUSG00000026797 | |
| GO | GO:0005739 GO:0005886 GO:0017075 GO:0007412 GO:0060292 GO:0043524 GO:0032229 GO:0007274 GO:0007269 GO:0015031 GO:0016188 GO:0006904 | |
| InterPro | IPR001619 | |
| KO | K15292 | |
| PANTHER | PTHR11679 | |
| Pfam | PF00995 | |
| SUPFAM | SSF56815 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005739 |
mitochondrion |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005886 |
plasma membrane |
Reactome:REACT_20509 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0006810 |
transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006887 |
exocytosis |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2183278 |
P |
Seeded From UniProt |
|||
| GO:0006904 |
vesicle docking involved in exocytosis |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006904 |
vesicle docking involved in exocytosis |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2183278 |
P |
Seeded From UniProt |
|||
| GO:0007269 |
neurotransmitter secretion |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2183278 |
P |
Seeded From UniProt |
|||
| GO:0007274 |
neuromuscular synaptic transmission |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2183278 |
P |
Seeded From UniProt |
|||
| GO:0007412 |
axon target recognition |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2183278 |
P |
Seeded From UniProt |
|||
| GO:0015031 |
protein transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0016188 |
synaptic vesicle maturation |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2183278 |
P |
Seeded From UniProt |
|||
| GO:0016192 |
vesicle-mediated transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0017075 |
syntaxin-1 binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0032229 |
negative regulation of synaptic transmission, GABAergic |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0043524 |
negative regulation of neuron apoptosis |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2183278 |
P |
Seeded From UniProt |
|||
| GO:0060292 |
long term synaptic depression |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2183278 |
P |
Seeded From UniProt |
|||
| GO:0060292 |
long term synaptic depression |
IMP: Inferred from Mutant Phenotype |
P |
figure 1 2 3 |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115: 629-40 PubMed GONUTS page
- ↑ 2.0 2.1 Voets T et al. (2001) Munc18-1 promotes large dense-core vesicle docking. Neuron 31: 581-91 PubMed GONUTS page
- ↑ 3.0 3.1 Heeroma JH et al. (2004) Trophic support delays but does not prevent cell-intrinsic degeneration of neurons deficient for munc18-1. Eur J Neurosci 20: 623-34 PubMed GONUTS page
- ↑ 4.0 4.1 Toonen RF et al. (2006) Munc18-1 expression levels control synapse recovery by regulating readily releasable pool size. Proc Natl Acad Sci U S A 103: 18332-7 PubMed GONUTS page
- ↑ Korteweg N et al. (2004) Development of the mouse hypothalamo-neurohypophysial system in the munc18-1 null mutant that lacks regulated secretion. Eur J Neurosci 19: 2944-52 PubMed GONUTS page
- ↑ Bouwman J et al. (2004) Quantification of synapse formation and maintenance in vivo in the absence of synaptic release. Neuroscience 126: 115-26 PubMed GONUTS page
- ↑ Katagiri H et al. (1995) A novel isoform of syntaxin-binding protein homologous to yeast Sec1 expressed ubiquitously in mammalian cells. J Biol Chem 270: 4963-6 PubMed GONUTS page
- ↑ Ho A et al. (2006) Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family. J Neurosci 26: 13089-101 PubMed GONUTS page
- ↑ Collins MO et al. (2005) Proteomic analysis of in vivo phosphorylated synaptic proteins. J Biol Chem 280: 5972-82 PubMed GONUTS page
