MOUSE:SOX11

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Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Sox11 (synonyms: Sox-11)
Protein Name(s)	Transcription factor SOX-11
External Links
UniProt	Q7M6Y2
EMBL	AF009414 AB108675 BK001484 AK165693 AK146514 BC062095 Z18960
IPI	IPI00556698
RefSeq	NP_033260.4
UniGene	Mm.41702 Mm.466344
ProteinModelPortal	Q7M6Y2
SMR	Q7M6Y2
STRING	Q7M6Y2
PhosphoSite	Q7M6Y2
PRIDE	Q7M6Y2
Ensembl	ENSMUST00000079063
GeneID	20666
KEGG	mmu:20666
UCSC	uc007nfn.2
CTD	6664
MGI	MGI:98359
GeneTree	ENSGT00600000084237
HOGENOM	HBG715977
HOVERGEN	HBG005040
InParanoid	Q7M6Y2
OMA	REAMDTE
OrthoDB	EOG4QVCCX
PhylomeDB	Q7M6Y2
NextBio	299129
ArrayExpress	Q7M6Y2
Bgee	Q7M6Y2
CleanEx	MM_SOX11
Genevestigator	Q7M6Y2
GermOnline	ENSMUSG00000063632
GO	GO:0005737 GO:0001158 GO:0001077 GO:0001105 GO:0008135 GO:0003211 GO:0061386 GO:0061303 GO:0048557 GO:0048704 GO:0061029 GO:0014009 GO:0060022 GO:0002089 GO:0060174 GO:0060425 GO:0060548 GO:0060253 GO:0000122 GO:2000678 GO:0014032 GO:0001841 GO:0060563 GO:0003357 GO:0003151 GO:0030513 GO:0035332 GO:0046887 GO:2001111 GO:0050769 GO:0045666 GO:0045778 GO:0045669 GO:2000648 GO:0060023 GO:0061053 GO:0021510 GO:0048485 GO:0060412
InterPro	IPR000910 IPR009071 IPR017386
Gene3D	G3DSA:1.10.30.10
KO	K09268
Pfam	PF00505
PIRSF	PIRSF038098
SMART	SM00398
SUPFAM	SSF47095
PROSITE	PS50118

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000322568	P	Seeded From UniProt
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	PMID:19808959^[1]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:18505825^[2]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0001071	nucleic acid binding transcription factor activity	PMID:21527504^[3]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	PMID:18505825^[2]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0001105	RNA polymerase II transcription coactivator activity	PMID:18505825^[2]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0001158	enhancer sequence-specific DNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000322568	F	Seeded From UniProt
	GO:0001158	enhancer sequence-specific DNA binding	PMID:19808959^[1]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0001158	enhancer sequence-specific DNA binding	PMID:21527504^[3]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0001501	skeletal system development	PMID:20596238^[4]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0001822	kidney development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000040127	P	Seeded From UniProt
	GO:0001841	neural tube formation	PMID:20596238^[4]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0002089	lens morphogenesis in camera-type eye	PMID:18423449^[5]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0003151	outflow tract morphogenesis	PMID:15254231^[6]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0003211	cardiac ventricle formation	PMID:20596238^[4]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0003357	noradrenergic neuron differentiation	PMID:20147379^[7]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000910	F	Seeded From UniProt
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F	Seeded From UniProt
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000040127	F	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000322568	C	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C	Seeded From UniProt
	GO:0005634	nucleus	PMID:15456859^[8]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005634	nucleus	PMID:19490090^[9]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005634	nucleus	PMID:21527504^[3]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005730	nucleolus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000322568	C	Seeded From UniProt
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000322568	C	Seeded From UniProt
	GO:0005737	cytoplasm	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P35716	C	Seeded From UniProt
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P	Seeded From UniProt
	GO:0006351	transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000040127	P	Seeded From UniProt
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P	Seeded From UniProt
	GO:0006412	translation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000322568	P	Seeded From UniProt
	GO:0006412	translation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P35716	P	Seeded From UniProt
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P	Seeded From UniProt
	GO:0007399	nervous system development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0524	P	Seeded From UniProt
	GO:0007399	nervous system development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000322568	P	Seeded From UniProt
	GO:0008135	translation factor activity, nucleic acid binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000322568	F	Seeded From UniProt
	GO:0008135	translation factor activity, nucleic acid binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P35716	F	Seeded From UniProt
	GO:0008283	cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000040127	P	Seeded From UniProt
	GO:0008284	positive regulation of cell proliferation	PMID:20596238^[4]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0010628	positive regulation of gene expression	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000322568	P	Seeded From UniProt
	GO:0010628	positive regulation of gene expression	PMID:19808959^[1]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0010629	negative regulation of gene expression	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000322568	P	Seeded From UniProt
	GO:0010629	negative regulation of gene expression	PMID:19808959^[1]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0014003	oligodendrocyte development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000040127	P	Seeded From UniProt
	GO:0014009	glial cell proliferation	PMID:20147379^[7]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0014032	neural crest cell development	PMID:20596238^[4]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000322568	P	Seeded From UniProt
	GO:0021510	spinal cord development	PMID:20646169^[10]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0021782	glial cell development	PMID:20147379^[7]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0021782	glial cell development	PMID:20646169^[10]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0030154	cell differentiation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0221	P	Seeded From UniProt
	GO:0030182	neuron differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000322568	P	Seeded From UniProt
	GO:0030513	positive regulation of BMP signaling pathway	PMID:18423449^[5]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0035332	positive regulation of hippo signaling cascade	PMID:20596238^[4]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0045666	positive regulation of neuron differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000322568	P	Seeded From UniProt
	GO:0045666	positive regulation of neuron differentiation	PMID:19490090^[9]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045666	positive regulation of neuron differentiation	PMID:19808959^[1]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000322568	P	Seeded From UniProt
	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P35716	P	Seeded From UniProt
	GO:0045778	positive regulation of ossification	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000322568	P	Seeded From UniProt
	GO:0045778	positive regulation of ossification	PMID:15254231^[6]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:18423449^[5]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:20147379^[7]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:20596238^[4]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:21527504^[3]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000040127	P	Seeded From UniProt
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:18505825^[2]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0046887	positive regulation of hormone secretion	PMID:21527504^[3]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0048485	sympathetic nervous system development	PMID:20147379^[7]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0048557	embryonic digestive tract morphogenesis	PMID:15254231^[6]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0048704	embryonic skeletal system morphogenesis	PMID:15254231^[6]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0050672	negative regulation of lymphocyte proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000322568	P	Seeded From UniProt
	GO:0050769	positive regulation of neurogenesis	PMID:19490090^[9]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0060022	hard palate development	PMID:15254231^[6]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0060023	soft palate development	PMID:15254231^[6]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0060174	limb bud formation	PMID:20596238^[4]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0060253	negative regulation of glial cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000322568	P	Seeded From UniProt
	GO:0060253	negative regulation of glial cell proliferation	PMID:19808959^[1]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0060412	ventricular septum morphogenesis	PMID:15254231^[6]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0060425	lung morphogenesis	PMID:15254231^[6]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0060548	negative regulation of cell death	PMID:20596238^[4]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0060548	negative regulation of cell death	PMID:20646169^[10]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0060563	neuroepithelial cell differentiation	PMID:20646169^[10]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0061029	eyelid development in camera-type eye	PMID:15254231^[6]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0061053	somite development	PMID:20596238^[4]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0061303	cornea development in camera-type eye	PMID:18423449^[5]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0061386	closure of optic fissure	PMID:18423449^[5]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0072404	signal transduction involved in G1/S transition checkpoint	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000322568	P	Seeded From UniProt
	GO:2000648	positive regulation of stem cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000322568	P	Seeded From UniProt
	GO:2000648	positive regulation of stem cell proliferation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P35716	P	Seeded From UniProt
	GO:2000678	negative regulation of transcription regulatory region DNA binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P0C1G9	P	Seeded From UniProt
	GO:2001111	positive regulation of lens epithelial cell proliferation	PMID:18423449^[5]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
Contributes to	GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	PMID:21117150^[11]	IEP: Inferred from Expression Pattern		F	Figures 1,2,3,4 showing cell division in a gragh	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Hide T et al. (2009) Sox11 prevents tumorigenesis of glioma-initiating cells by inducing neuronal differentiation. Cancer Res 69: 7953-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Hoser M et al. (2008) Sox12 deletion in the mouse reveals nonreciprocal redundancy with the related Sox4 and Sox11 transcription factors. Mol Cell Biol 28: 4675-87 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Kim HD et al. (2011) Class-C SOX transcription factors control GnRH gene expression via the intronic transcriptional enhancer. Mol Endocrinol 25: 1184-96 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 ^4.9 Bhattaram P et al. (2010) Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors. Nat Commun 1: 9 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Wurm A et al. (2008) Anterior segment dysgenesis in the eyes of mice deficient for the high-mobility-group transcription factor Sox11. Exp Eye Res 86: 895-907 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 Sock E et al. (2004) Gene targeting reveals a widespread role for the high-mobility-group transcription factor Sox11 in tissue remodeling. Mol Cell Biol 24: 6635-44 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Potzner MR et al. (2010) Sequential requirement of Sox4 and Sox11 during development of the sympathetic nervous system. Development 137: 775-84 PubMed GONUTS page
↑ Tanaka S et al. (2004) Interplay of SOX and POU factors in regulation of the Nestin gene in neural primordial cells. Mol Cell Biol 24: 8834-46 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Haslinger A et al. (2009) Expression of Sox11 in adult neurogenic niches suggests a stage-specific role in adult neurogenesis. Eur J Neurosci 29: 2103-14 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Thein DC et al. (2010) The closely related transcription factors Sox4 and Sox11 function as survival factors during spinal cord development. J Neurochem 115: 131-41 PubMed GONUTS page
↑ Lin L et al. (2011) Sox11 regulates survival and axonal growth of embryonic sensory neurons. Dev Dyn 240: 52-64 PubMed GONUTS page

[PMID:19808959-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Hide T et al. (2009) Sox11 prevents tumorigenesis of glioma-initiating cells by inducing neuronal differentiation. Cancer Res 69: 7953-9 PubMed GONUTS page

[PMID:18505825-1] 2.0 ^2.1 ^2.2 ^2.3 Hoser M et al. (2008) Sox12 deletion in the mouse reveals nonreciprocal redundancy with the related Sox4 and Sox11 transcription factors. Mol Cell Biol 28: 4675-87 PubMed GONUTS page

[PMID:21527504-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Kim HD et al. (2011) Class-C SOX transcription factors control GnRH gene expression via the intronic transcriptional enhancer. Mol Endocrinol 25: 1184-96 PubMed GONUTS page

[PMID:20596238-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 ^4.9 Bhattaram P et al. (2010) Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors. Nat Commun 1: 9 PubMed GONUTS page

[PMID:18423449-4] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Wurm A et al. (2008) Anterior segment dysgenesis in the eyes of mice deficient for the high-mobility-group transcription factor Sox11. Exp Eye Res 86: 895-907 PubMed GONUTS page

[PMID:15254231-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 Sock E et al. (2004) Gene targeting reveals a widespread role for the high-mobility-group transcription factor Sox11 in tissue remodeling. Mol Cell Biol 24: 6635-44 PubMed GONUTS page

[PMID:20147379-6] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Potzner MR et al. (2010) Sequential requirement of Sox4 and Sox11 during development of the sympathetic nervous system. Development 137: 775-84 PubMed GONUTS page

[PMID:15456859-7] Tanaka S et al. (2004) Interplay of SOX and POU factors in regulation of the Nestin gene in neural primordial cells. Mol Cell Biol 24: 8834-46 PubMed GONUTS page

[PMID:19490090-8] 9.0 ^9.1 ^9.2 Haslinger A et al. (2009) Expression of Sox11 in adult neurogenic niches suggests a stage-specific role in adult neurogenesis. Eur J Neurosci 29: 2103-14 PubMed GONUTS page

[PMID:20646169-9] 10.0 ^10.1 ^10.2 ^10.3 Thein DC et al. (2010) The closely related transcription factors Sox4 and Sox11 function as survival factors during spinal cord development. J Neurochem 115: 131-41 PubMed GONUTS page

[PMID:21117150-10] Lin L et al. (2011) Sox11 regulates survival and axonal growth of embryonic sensory neurons. Dev Dyn 240: 52-64 PubMed GONUTS page

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MOUSE:SOX11

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