MOUSE:SMO

From GONUTS

Jump to: navigation, search

Species (Taxon ID)	Mus musculus (Mouse). ([1])
Gene Name(s)	Smo (synonyms: Smoh)
Protein Name(s)	Smoothened homolog SMO
External Links
EMBL	AC069469
IPI	IPI00341032
PIR	JC5539
RefSeq	NP_795970.3
UniGene	Mm.29279
ProteinModelPortal	P56726
STRING	P56726
PhosphoSite	P56726
PRIDE	P56726
Ensembl	ENSMUST00000001812
GeneID	319757
MGI	MGI:108075
eggNOG	roNOG05761
HOGENOM	HBG714469
HOVERGEN	HBG000352
InParanoid	P56726
OrthoDB	EOG4Q2DDX
ArrayExpress	P56726
Bgee	P56726
CleanEx	MM_SMO
Genevestigator	P56726
GermOnline	ENSMUSG00000001761
GO	GO:0005737 GO:0016021 GO:0043025 GO:0005886 GO:0072372 GO:0008144 GO:0004930 GO:0030165 GO:0042813 GO:0017147 GO:0021984 GO:0048846 GO:0060070 GO:0010002 GO:0001708 GO:0021953 GO:0021696 GO:0060830 GO:0060248 GO:0003140 GO:0021904 GO:0031076 GO:0048557 GO:0048702 GO:0048703 GO:0060684 GO:0031017 GO:0021561 GO:0021508 GO:0048853 GO:0008406 GO:0031069 GO:0001947 GO:0001701 GO:0060644 GO:0072285 GO:0007494 GO:0035264 GO:0042693 GO:0043066 GO:0043392 GO:0030857 GO:0051799 GO:0000122 GO:0001755 GO:0048663 GO:0031102 GO:0042475 GO:0001649 GO:0032474 GO:0090190 GO:0050679 GO:0007228 GO:0002053 GO:0002052 GO:0045880 GO:0045944 GO:0034504 GO:0050821 GO:2000826 GO:2000036 GO:0048752 GO:0021938 GO:0021910 GO:0061053 GO:0007283 GO:0001570 GO:0007371
InterPro	IPR000539 IPR015526 IPR020067 IPR017981
Gene3D	G3DSA:1.10.2000.10
PANTHER	PTHR11309
Pfam	PF01534 PF01392
PRINTS	PR00489
SMART	SM00063
SUPFAM	SSF63501
PROSITE	PS50038 PS50261

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	PMID:19304890^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176256	P	Seeded From UniProt
	GO:0001503	ossification	PMID:11748145^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176256	P	Seeded From UniProt
	GO:0001503	ossification	PMID:11748145^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176264	P	Seeded From UniProt
	GO:0001570	vasculogenesis	PMID:15294868^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176255	P	Seeded From UniProt
	GO:0001570	vasculogenesis	PMID:17881493^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176255	P	Seeded From UniProt
	GO:0001649	osteoblast differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000011356	P	Seeded From UniProt
	GO:0001649	osteoblast differentiation	PMID:14973297^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176256	P	Seeded From UniProt
	GO:0001701	in utero embryonic development	PMID:17881493^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176255	P	Seeded From UniProt
	GO:0001708	cell fate specification	PMID:18590716^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176255	P	Seeded From UniProt
	GO:0001755	neural crest cell migration	PMID:16687132^[7]	IGI: Inferred from Genetic Interaction	MGI:MGI:101791	P	Seeded From UniProt
	GO:0001947	heart looping	PMID:11517919^[8]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0002052	positive regulation of neuroblast proliferation	PMID:16543460^[9]	IGI: Inferred from Genetic Interaction	MGI:MGI:88274	P	Seeded From UniProt
	GO:0002053	positive regulation of mesenchymal cell proliferation	PMID:19304890^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176256	P	Seeded From UniProt
	GO:0003007	heart morphogenesis	PMID:16687132^[7]	IGI: Inferred from Genetic Interaction	MGI:MGI:101791	P	Seeded From UniProt
	GO:0003140	determination of left/right asymmetry in lateral mesoderm	PMID:11517919^[8]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0003323	type B pancreatic cell development	PMID:20185815^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176256	P	Seeded From UniProt
	GO:0003323	type B pancreatic cell development	PMID:20185815^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2684317	P	Seeded From UniProt
	GO:0004871	signal transducer activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0807	F	Seeded From UniProt
	GO:0004872	receptor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0675	F	Seeded From UniProt
	GO:0004888	transmembrane signaling receptor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017981	F	Seeded From UniProt
	GO:0004930	G-protein coupled receptor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0297	F	Seeded From UniProt
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000011356	C	Seeded From UniProt
	GO:0005737	cytoplasm	GO_REF:0000033		PANTHER:PTHR11309	C	Seeded From UniProt
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000011356	C	Seeded From UniProt
	GO:0005886	plasma membrane	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q99835	C	Seeded From UniProt
	GO:0005886	plasma membrane	GO_REF:0000033		PANTHER:PTHR11309	C	Seeded From UniProt
	GO:0005929	cilium	PMID:16229832^[11]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0007165	signal transduction	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0807	P	Seeded From UniProt
	GO:0007166	cell surface receptor linked signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000539	P	Seeded From UniProt
	GO:0007166	cell surface receptor linked signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017981	P	Seeded From UniProt
	GO:0007186	G-protein coupled receptor signaling pathway	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0297	P	Seeded From UniProt
	GO:0007224	smoothened signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000249373	P	Seeded From UniProt
	GO:0007224	smoothened signaling pathway	PMID:11517919^[8]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0007224	smoothened signaling pathway	PMID:15107405^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176256	P	Seeded From UniProt
	GO:0007224	smoothened signaling pathway	PMID:16136078^[13]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0007224	smoothened signaling pathway	PMID:17199044^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934268	P	Seeded From UniProt
	GO:0007224	smoothened signaling pathway	PMID:17199044^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2445832	P	Seeded From UniProt
	GO:0007224	smoothened signaling pathway	PMID:20185815^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176256	P	Seeded From UniProt
	GO:0007224	smoothened signaling pathway	PMID:20185815^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2684317	P	Seeded From UniProt
	GO:0007224	smoothened signaling pathway	PMID:21177415^[15]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0007228	positive regulation of hh target transcription factor activity	PMID:11517919^[8]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P	Seeded From UniProt
	GO:0007283	spermatogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000011356	P	Seeded From UniProt
	GO:0007283	spermatogenesis	GO_REF:0000033		PANTHER:PTHR11309	P	Seeded From UniProt
	GO:0007368	determination of left/right symmetry	PMID:12421714^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176255	P	Seeded From UniProt
	GO:0007368	determination of left/right symmetry	PMID:15755804^[17]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2137553	P	Seeded From UniProt
	GO:0007371	ventral midline determination	PMID:11517919^[8]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0007389	pattern specification process	PMID:15107405^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176256	P	Seeded From UniProt
	GO:0007417	central nervous system development	PMID:12435628^[18]	IGI: Inferred from Genetic Interaction	MGI:MGI:95729	P	Seeded From UniProt
	GO:0007494	midgut development	PMID:11517919^[8]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0008144	drug binding	PMID:21177415^[15]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0008284	positive regulation of cell proliferation	PMID:12403705^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176256	P	Seeded From UniProt
	GO:0008284	positive regulation of cell proliferation	PMID:12403705^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2445832	P	Seeded From UniProt
	GO:0008284	positive regulation of cell proliferation	PMID:19124651^[20]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0008406	gonad development	GO_REF:0000033		PANTHER:PTHR11309	P	Seeded From UniProt
	GO:0009611	response to wounding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000011356	P	Seeded From UniProt
	GO:0009953	dorsal/ventral pattern formation	PMID:15755804^[17]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2137553	P	Seeded From UniProt
	GO:0009953	dorsal/ventral pattern formation	PMID:16571630^[21]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176173	P	Seeded From UniProt
	GO:0009953	dorsal/ventral pattern formation	PMID:16571630^[21]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176256	P	Seeded From UniProt
	GO:0010002	cardioblast differentiation	GO_REF:0000033		PANTHER:PTHR11309	P	Seeded From UniProt
	GO:0010033	response to organic substance	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000011356	P	Seeded From UniProt
	GO:0010468	regulation of gene expression	PMID:18590716^[6]	IGI: Inferred from Genetic Interaction	MGI:MGI:1341070	P	Seeded From UniProt
	GO:0010628	positive regulation of gene expression	PMID:16396903^[22]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0010629	negative regulation of gene expression	PMID:16396903^[22]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000539	C	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017981	C	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0162	C	Seeded From UniProt
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C	Seeded From UniProt
	GO:0017147	Wnt-protein binding	GO_REF:0000033		PANTHER:PTHR11309	F	Seeded From UniProt
	GO:0021508	floor plate formation	GO_REF:0000033		PANTHER:PTHR11309	P	Seeded From UniProt
	GO:0021561	facial nerve development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000011356	P	Seeded From UniProt
	GO:0021561	facial nerve development	GO_REF:0000033		PANTHER:PTHR11309	P	Seeded From UniProt
	GO:0021696	cerebellar cortex morphogenesis	PMID:16571625^[23]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176173	P	Seeded From UniProt
	GO:0021696	cerebellar cortex morphogenesis	PMID:16571625^[23]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176256	P	Seeded From UniProt
	GO:0021904	dorsal/ventral neural tube patterning	PMID:18590716^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176255	P	Seeded From UniProt
	GO:0021910	smoothened signaling pathway involved in ventral spinal cord patterning	PMID:19286674^[24]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176255	P	Seeded From UniProt
	GO:0021938	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation	PMID:16571625^[23]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176173	P	Seeded From UniProt
	GO:0021938	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation	PMID:16571625^[23]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176256	P	Seeded From UniProt
	GO:0021953	central nervous system neuron differentiation	PMID:16571630^[21]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176256	P	Seeded From UniProt
	GO:0021953	central nervous system neuron differentiation	PMID:16571630^[21]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2446434	P	Seeded From UniProt
	GO:0021984	adenohypophysis development	GO_REF:0000033		PANTHER:PTHR11309	P	Seeded From UniProt
	GO:0030165	PDZ domain binding	GO_REF:0000033		PANTHER:PTHR11309	F	Seeded From UniProt
	GO:0030857	negative regulation of epithelial cell differentiation	PMID:17199044^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934268	P	Seeded From UniProt
	GO:0030857	negative regulation of epithelial cell differentiation	PMID:17199044^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2445832	P	Seeded From UniProt
	GO:0031017	exocrine pancreas development	GO_REF:0000033		PANTHER:PTHR11309	P	Seeded From UniProt
	GO:0031069	hair follicle morphogenesis	PMID:17199044^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934268	P	Seeded From UniProt
	GO:0031069	hair follicle morphogenesis	PMID:17199044^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2445832	P	Seeded From UniProt
	GO:0031076	embryonic camera-type eye development	GO_REF:0000033		PANTHER:PTHR11309	P	Seeded From UniProt
	GO:0031102	neuron projection regeneration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000011356	P	Seeded From UniProt
	GO:0031102	neuron projection regeneration	GO_REF:0000033		PANTHER:PTHR11309	P	Seeded From UniProt
	GO:0032474	otolith morphogenesis	GO_REF:0000033		PANTHER:PTHR11309	P	Seeded From UniProt
	GO:0033687	osteoblast proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000011356	P	Seeded From UniProt
	GO:0034504	protein localization to nucleus	PMID:19952108^[25]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0035264	multicellular organism growth	PMID:18590716^[6]	IGI: Inferred from Genetic Interaction	MGI:MGI:1341070	P	Seeded From UniProt
	GO:0035264	multicellular organism growth	PMID:18590716^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176255	P	Seeded From UniProt
	GO:0042475	odontogenesis of dentine-containing tooth	PMID:12403705^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176256	P	Seeded From UniProt
	GO:0042475	odontogenesis of dentine-containing tooth	PMID:12403705^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2445832	P	Seeded From UniProt
	GO:0042475	odontogenesis of dentine-containing tooth	PMID:17199044^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934268	P	Seeded From UniProt
	GO:0042475	odontogenesis of dentine-containing tooth	PMID:17199044^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2445832	P	Seeded From UniProt
	GO:0042693	muscle cell fate commitment	GO_REF:0000033		PANTHER:PTHR11309	P	Seeded From UniProt
	GO:0042813	Wnt-activated receptor activity	GO_REF:0000033		PANTHER:PTHR11309	F	Seeded From UniProt
	GO:0043025	neuronal cell body	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000011356	C	Seeded From UniProt
	GO:0043025	neuronal cell body	GO_REF:0000033		PANTHER:PTHR11309	C	Seeded From UniProt
	GO:0043066	negative regulation of apoptosis	PMID:16571630^[21]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176256	P	Seeded From UniProt
	GO:0043066	negative regulation of apoptosis	PMID:16571630^[21]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2446434	P	Seeded From UniProt
	GO:0043392	negative regulation of DNA binding	PMID:16396903^[22]	IGI: Inferred from Genetic Interaction	MGI:MGI:95729	P	Seeded From UniProt
	GO:0043392	negative regulation of DNA binding	PMID:16396903^[22]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0045880	positive regulation of smoothened signaling pathway	PMID:16459297^[26]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:15906375^[27]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:19304890^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176256	P	Seeded From UniProt
	GO:0048468	cell development	PMID:12403705^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176256	P	Seeded From UniProt
	GO:0048468	cell development	PMID:12403705^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2445832	P	Seeded From UniProt
	GO:0048557	embryonic digestive tract morphogenesis	GO_REF:0000033		PANTHER:PTHR11309	P	Seeded From UniProt
	GO:0048565	digestive tract development	PMID:19619492^[28]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176255	P	Seeded From UniProt
	GO:0048589	developmental growth	PMID:16571630^[21]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176256	P	Seeded From UniProt
	GO:0048589	developmental growth	PMID:16571630^[21]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2446434	P	Seeded From UniProt
	GO:0048663	neuron fate commitment	GO_REF:0000033		PANTHER:PTHR11309	P	Seeded From UniProt
	GO:0048702	embryonic neurocranium morphogenesis	GO_REF:0000033		PANTHER:PTHR11309	P	Seeded From UniProt
	GO:0048703	embryonic viscerocranium morphogenesis	GO_REF:0000033		PANTHER:PTHR11309	P	Seeded From UniProt
	GO:0048752	semicircular canal morphogenesis	GO_REF:0000033		PANTHER:PTHR11309	P	Seeded From UniProt
	GO:0048846	axon extension involved in axon guidance	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000011356	P	Seeded From UniProt
	GO:0048846	axon extension involved in axon guidance	GO_REF:0000033		PANTHER:PTHR11309	P	Seeded From UniProt
	GO:0048853	forebrain morphogenesis	PMID:11517919^[8]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0050679	positive regulation of epithelial cell proliferation	PMID:19304890^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176256	P	Seeded From UniProt
	GO:0050821	protein stabilization	PMID:19124651^[20]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0051799	negative regulation of hair follicle development	PMID:17199044^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934268	P	Seeded From UniProt
	GO:0051799	negative regulation of hair follicle development	PMID:17199044^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2445832	P	Seeded From UniProt
	GO:0060070	canonical Wnt receptor signaling pathway	GO_REF:0000033		PANTHER:PTHR11309	P	Seeded From UniProt
	GO:0060248	detection of cell density by contact stimulus involved in contact inhibition	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000249373	P	Seeded From UniProt
	GO:0060248	detection of cell density by contact stimulus involved in contact inhibition	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q99835	P	Seeded From UniProt
	GO:0060644	mammary gland epithelial cell differentiation	PMID:17199044^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934268	P	Seeded From UniProt
	GO:0060644	mammary gland epithelial cell differentiation	PMID:17199044^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2445832	P	Seeded From UniProt
	GO:0060684	epithelial-mesenchymal cell signaling	PMID:19304890^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176256	P	Seeded From UniProt
	GO:0060830	ciliary receptor clustering involved in smoothened signaling pathway	GO_REF:0000033		PANTHER:PTHR11309	P	Seeded From UniProt
	GO:0061053	somite development	PMID:11517919^[8]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0061113	pancreas morphogenesis	PMID:20185815^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176256	P	Seeded From UniProt
	GO:0061113	pancreas morphogenesis	PMID:20185815^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2684317	P	Seeded From UniProt
	GO:0072001	renal system development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000249373	P	Seeded From UniProt
	GO:0072285	mesenchymal to epithelial transition involved in metanephric renal vesicle formation	PMID:16396903^[22]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0072372	primary cilium	PMID:16136078^[13]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	PMID:16396903^[22]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:2000036	regulation of stem cell maintenance	PMID:17199044^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934268	P	Seeded From UniProt
	GO:2000036	regulation of stem cell maintenance	PMID:17199044^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2445832	P	Seeded From UniProt
	GO:2000826	regulation of heart morphogenesis	PMID:11517919^[8]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0051236	establishment of RNA localization	PMID:21209331^[29]	IMP: Inferred from Mutant Phenotype		P	Fig S7B shows Mouse Smo (by comparison to the mutant phenotype) regulates the localisation of the expression of Shh , Nkx2.2, Nkx6.1 and ventralises Pax6	complete
	GO:0021910	smoothened signaling pathway involved in ventral spinal cord patterning	PMID:21209331^[29]	IMP: Inferred from Mutant Phenotype		P	Fig S7B shows Mouse Smo (by comparison to the mutant phenotype)positively regulates the ventralisation of Pax6. Smo known to work within Smoothened signalling pathway	complete
	GO:0035085	cilium axoneme	PMID:21209331^[29]	IDA: Inferred from Direct Assay		C	Fig 4A shows ciliary localisation in WT in absense of anatagonist	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Lan Y & Jiang R (2009) Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth. Development 136: 1387-96 PubMed GONUTS page
↑ ^2.0 ^2.1 Long F et al. (2001) Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development 128: 5099-108 PubMed GONUTS page
↑ Vokes SA et al. (2004) Hedgehog signaling is essential for endothelial tube formation during vasculogenesis. Development 131: 4371-80 PubMed GONUTS page
↑ ^4.0 ^4.1 Astorga J & Carlsson P (2007) Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4. Development 134: 3753-61 PubMed GONUTS page
↑ Long F et al. (2004) Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development 131: 1309-18 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Cho A et al. (2008) FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism. Dev Biol 321: 27-39 PubMed GONUTS page
↑ ^7.0 ^7.1 Lin L et al. (2006) Isl1 is upstream of sonic hedgehog in a pathway required for cardiac morphogenesis. Dev Biol 295: 756-63 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 ^8.8 Zhang XM et al. (2001) Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell 106: 781-92 PubMed GONUTS page
↑ Lien WH et al. (2006) alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway. Science 311: 1609-12 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 Lau J & Hebrok M (2010) Hedgehog signaling in pancreas epithelium regulates embryonic organ formation and adult beta-cell function. Diabetes 59: 1211-21 PubMed GONUTS page
↑ May SR et al. (2005) Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli. Dev Biol 287: 378-89 PubMed GONUTS page
↑ ^12.0 ^12.1 Jeong J et al. (2004) Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes Dev 18: 937-51 PubMed GONUTS page
↑ ^13.0 ^13.1 Corbit KC et al. (2005) Vertebrate Smoothened functions at the primary cilium. Nature 437: 1018-21 PubMed GONUTS page
↑ ^14.00 ^14.01 ^14.02 ^14.03 ^14.04 ^14.05 ^14.06 ^14.07 ^14.08 ^14.09 ^14.10 ^14.11 ^14.12 ^14.13 Gritli-Linde A et al. (2007) Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling. Dev Cell 12: 99-112 PubMed GONUTS page
↑ ^15.0 ^15.1 Roudaut H et al. (2011) Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist. Mol Pharmacol 79: 453-60 PubMed GONUTS page
↑ Kawakami T et al. (2002) Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling. Development 129: 5753-65 PubMed GONUTS page
↑ ^17.0 ^17.1 García-García MJ et al. (2005) Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc Natl Acad Sci U S A 102: 5913-9 PubMed GONUTS page
↑ Wijgerde M et al. (2002) A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev 16: 2849-64 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 Gritli-Linde A et al. (2002) Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization. Development 129: 5323-37 PubMed GONUTS page
↑ ^20.0 ^20.1 Wall DS et al. (2009) Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity. J Cell Biol 184: 101-12 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 ^21.4 ^21.5 ^21.6 ^21.7 Blaess S et al. (2006) Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region. Development 133: 1799-809 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 ^22.4 ^22.5 Hu MC et al. (2006) GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis. Development 133: 569-78 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 Corrales JD et al. (2006) The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation. Development 133: 1811-21 PubMed GONUTS page
↑ Norman RX et al. (2009) Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling. Hum Mol Genet 18: 1740-54 PubMed GONUTS page
↑ Fernandez-L A et al. (2009) YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation. Genes Dev 23: 2729-41 PubMed GONUTS page
↑ Varjosalo M et al. (2006) Divergence of hedgehog signal transduction mechanism between Drosophila and mammals. Dev Cell 10: 177-86 PubMed GONUTS page
↑ Lipinski RJ et al. (2005) Sonic hedgehog signaling regulates the expression of insulin-like growth factor binding protein-6 during fetal prostate development. Dev Dyn 233: 829-36 PubMed GONUTS page
↑ Spence JR et al. (2009) Sox17 regulates organ lineage segregation of ventral foregut progenitor cells. Dev Cell 17: 62-74 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 Qin J et al. (2011) Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc Natl Acad Sci U S A 108: 1456-61 PubMed GONUTS page

[PMID:19304890-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Lan Y & Jiang R (2009) Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth. Development 136: 1387-96 PubMed GONUTS page

[PMID:11748145-1] 2.0 ^2.1 Long F et al. (2001) Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development 128: 5099-108 PubMed GONUTS page

[PMID:15294868-2] Vokes SA et al. (2004) Hedgehog signaling is essential for endothelial tube formation during vasculogenesis. Development 131: 4371-80 PubMed GONUTS page

[PMID:17881493-3] 4.0 ^4.1 Astorga J & Carlsson P (2007) Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4. Development 134: 3753-61 PubMed GONUTS page

[PMID:14973297-4] Long F et al. (2004) Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development 131: 1309-18 PubMed GONUTS page

[PMID:18590716-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Cho A et al. (2008) FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism. Dev Biol 321: 27-39 PubMed GONUTS page

[PMID:16687132-6] 7.0 ^7.1 Lin L et al. (2006) Isl1 is upstream of sonic hedgehog in a pathway required for cardiac morphogenesis. Dev Biol 295: 756-63 PubMed GONUTS page

[PMID:11517919-7] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 ^8.8 Zhang XM et al. (2001) Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell 106: 781-92 PubMed GONUTS page

[PMID:16543460-8] Lien WH et al. (2006) alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway. Science 311: 1609-12 PubMed GONUTS page

[PMID:20185815-9] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 Lau J & Hebrok M (2010) Hedgehog signaling in pancreas epithelium regulates embryonic organ formation and adult beta-cell function. Diabetes 59: 1211-21 PubMed GONUTS page

[PMID:16229832-10] May SR et al. (2005) Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli. Dev Biol 287: 378-89 PubMed GONUTS page

[PMID:15107405-11] 12.0 ^12.1 Jeong J et al. (2004) Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes Dev 18: 937-51 PubMed GONUTS page

[PMID:16136078-12] 13.0 ^13.1 Corbit KC et al. (2005) Vertebrate Smoothened functions at the primary cilium. Nature 437: 1018-21 PubMed GONUTS page

[PMID:17199044-13] 14.00 ^14.01 ^14.02 ^14.03 ^14.04 ^14.05 ^14.06 ^14.07 ^14.08 ^14.09 ^14.10 ^14.11 ^14.12 ^14.13 Gritli-Linde A et al. (2007) Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling. Dev Cell 12: 99-112 PubMed GONUTS page

[PMID:21177415-14] 15.0 ^15.1 Roudaut H et al. (2011) Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist. Mol Pharmacol 79: 453-60 PubMed GONUTS page

[PMID:12421714-15] Kawakami T et al. (2002) Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling. Development 129: 5753-65 PubMed GONUTS page

[PMID:15755804-16] 17.0 ^17.1 García-García MJ et al. (2005) Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc Natl Acad Sci U S A 102: 5913-9 PubMed GONUTS page

[PMID:12435628-17] Wijgerde M et al. (2002) A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev 16: 2849-64 PubMed GONUTS page

[PMID:12403705-18] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 Gritli-Linde A et al. (2002) Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization. Development 129: 5323-37 PubMed GONUTS page

[PMID:19124651-19] 20.0 ^20.1 Wall DS et al. (2009) Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity. J Cell Biol 184: 101-12 PubMed GONUTS page

[PMID:16571630-20] 21.0 ^21.1 ^21.2 ^21.3 ^21.4 ^21.5 ^21.6 ^21.7 Blaess S et al. (2006) Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region. Development 133: 1799-809 PubMed GONUTS page

[PMID:16396903-21] 22.0 ^22.1 ^22.2 ^22.3 ^22.4 ^22.5 Hu MC et al. (2006) GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis. Development 133: 569-78 PubMed GONUTS page

[PMID:16571625-22] 23.0 ^23.1 ^23.2 ^23.3 Corrales JD et al. (2006) The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation. Development 133: 1811-21 PubMed GONUTS page

[PMID:19286674-23] Norman RX et al. (2009) Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling. Hum Mol Genet 18: 1740-54 PubMed GONUTS page

[PMID:19952108-24] Fernandez-L A et al. (2009) YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation. Genes Dev 23: 2729-41 PubMed GONUTS page

[PMID:16459297-25] Varjosalo M et al. (2006) Divergence of hedgehog signal transduction mechanism between Drosophila and mammals. Dev Cell 10: 177-86 PubMed GONUTS page

[PMID:15906375-26] Lipinski RJ et al. (2005) Sonic hedgehog signaling regulates the expression of insulin-like growth factor binding protein-6 during fetal prostate development. Dev Dyn 233: 829-36 PubMed GONUTS page

[PMID:19619492-27] Spence JR et al. (2009) Sox17 regulates organ lineage segregation of ventral foregut progenitor cells. Dev Cell 17: 62-74 PubMed GONUTS page

[PMID:21209331-28] 29.0 ^29.1 ^29.2 Qin J et al. (2011) Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc Natl Acad Sci U S A 108: 1456-61 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

[26]

[27]

[28]

[29]

MOUSE:SMO

Contents

Annotations

Notes

References

a

c

d

e

f

g

g cont.

h

i

m

n

o

p

p cont.

r

s

t

v

w

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Cacao

Journal Clubs

page contributors

Toolbox