GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
MOUSE:SIX3
Contents |
| Species (Taxon ID) | Mus musculus (Mouse). (taxon:10090) | |
| Gene Name(s) | Six3 | |
| Protein Name(s) |
| |
| External Links | ||
| UniProt Identifier | SIX3_MOUSE | |
| UniProt Accessions | Q62233, P70176, P70177, Q4QQQ3, | |
| EMBL | X90871, D83144, D83145, BC098096, | |
| PIR | S74255, | |
| RefSeq | NP_035511.2, | |
| IntAct | Q62233, | |
| Ensembl | ENSMUST00000162436, ENSMUST00000162989, | |
| Pfam | PF00046, | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
C |
Source: MGI |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Source: IntAct |
||||
| GO:0003705 |
RNA polymerase II transcription factor acti... |
IDA: Inferred from Direct Assay |
F |
Source: MGI |
||||
| GO:0016564 |
transcription repressor activity |
IDA: Inferred from Direct Assay |
F |
Source: MGI |
||||
| GO:0021536 |
diencephalon development |
IGI: Inferred from Genetic Interaction |
P |
Source: MGI |
||||
| GO:0021797 |
forebrain anterior/posterior pattern formation |
IGI: Inferred from Genetic Interaction |
P |
Source: MGI |
||||
| GO:0060235 |
lens induction in camera-type eye |
IMP: Inferred from Mutant Phenotype |
P |
Source: MGI |
||||
| GO:0030178 |
negative regulation of Wnt receptor signali... |
IMP: Inferred from Mutant Phenotype |
P |
Source: MGI |
||||
| GO:0045944 |
positive regulation of transcription from R... |
IDA: Inferred from Direct Assay |
P |
Source: MGI |
||||
| GO:0006606 |
protein import into nucleus |
IDA: Inferred from Direct Assay |
P |
Source: MGI |
||||
| GO:0002088 |
lens development in camera-type eye |
IMP: Inferred from Mutant Phenotype |
P |
Fig 1H,k,l |
complete | |||
| GO:0021537 |
telencephalon development |
IMP: Inferred from Mutant Phenotype |
P |
Source: MGI |
||||
| GO:0010628 |
positive regulation of gene expression |
IMP: Inferred from Mutant Phenotype |
P |
Fig 3c'+D' |
complete | |||
| GO:0035326 |
enhancer binding |
IDA: Inferred from Direct Assay |
F |
Fig 7A |
complete | |||
| GO:0043193 |
positive regulation of gene-specific transcription |
IDA: Inferred from Direct Assay |
P |
Fig 7c |
complete | |||
| GO:0016563 |
transcription activator activity |
IDA: Inferred from Direct Assay |
F |
Fig 7c |
complete | |||
| GO:0046619 |
optic placode formation involved in camera-type eye |
IMP: Inferred from Mutant Phenotype |
P |
Fig 4A',b'+j |
complete | |||
| GO:0001654 |
eye development |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0003677 |
DNA binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0003677 |
DNA binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0003677 |
DNA binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0003677 |
DNA binding |
IDA: Inferred from Direct Assay |
F |
|||||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0003705 |
sequence-specific enhancer binding RNA polymerase II transcription factor activity |
IDA: Inferred from Direct Assay |
F |
|||||
| GO:0003705 |
sequence-specific enhancer binding RNA polymerase II transcription factor activity |
IDA: Inferred from Direct Assay |
F |
|||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0191 |
C |
||||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
C |
|||||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
C |
|||||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
C |
|||||
| GO:0006351 |
transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0006606 |
protein import into nucleus |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0007275 |
multicellular organismal development |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0007420 |
brain development |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2450901 |
P |
||||
| GO:0021536 |
diencephalon development |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98953 |
P |
||||
| GO:0021537 |
telencephalon development |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2450901 |
P |
||||
| GO:0021797 |
forebrain anterior/posterior pattern formation |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98953 |
P |
||||
| GO:0021797 |
forebrain anterior/posterior pattern formation |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2450901 |
P |
||||
| GO:0030178 |
negative regulation of Wnt receptor signaling pathway |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2450901 |
P |
||||
| GO:0043010 |
camera-type eye development |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97490 |
P |
||||
| GO:0043565 |
sequence-specific DNA binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0043565 |
sequence-specific DNA binding |
IDA: Inferred from Direct Assay |
F |
|||||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0060235 |
lens induction in camera-type eye |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3693322 |
P |
| |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Liu W et al. (2006) Six3 activation of Pax6 expression is essential for mammalian lens induction and specification. EMBO J 25: 5383-95 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Zhu CC et al. (2002) Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors. Development 129: 2835-49 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Lagutin OV et al. (2003) Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development. Genes Dev 17: 368-79 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Purcell P et al. (2005) Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction. Gene Expr Patterns 6: 110-8 PubMed GONUTS page
- ↑ 5.0 5.1 Kawakami K et al. (1996) Identification and expression of six family genes in mouse retina. FEBS Lett 393: 259-63 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Lavado A et al. (2008) Six3 inactivation causes progressive caudalization and aberrant patterning of the mammalian diencephalon. Development 135: 441-50 PubMed GONUTS page
- ↑ Goudreau G et al. (2002) Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype. Proc Natl Acad Sci U S A 99: 8719-24 PubMed GONUTS page
