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MOUSE:SIRT1
Contents |
| Species (Taxon ID) | Mus musculus (Mouse). ([1]) | |
| Gene Name(s) | Sirt1 (synonyms: Sir2l1) | |
| Protein Name(s) | NAD-dependent deacetylase sirtuin-1
SIR2-like protein 1 SIR2alpha Sir2 mSIR2a | |
| External Links | ||
| EMBL | AF214646 BC006584 | |
| IPI | IPI00134988 | |
| RefSeq | NP_062786.1 | |
| UniGene | Mm.351459 | |
| ProteinModelPortal | Q923E4 | |
| SMR | Q923E4 | |
| DIP | DIP-47052N | |
| IntAct | Q923E4 | |
| STRING | Q923E4 | |
| PhosphoSite | Q923E4 | |
| PRIDE | Q923E4 | |
| Ensembl | ENSMUST00000020257 ENSMUST00000120239 | |
| GeneID | 93759 | |
| KEGG | mmu:93759 | |
| NMPDR | fig|10090.3.peg.13798 | |
| CTD | 23411 | |
| MGI | MGI:2135607 | |
| GeneTree | ENSGT00550000074996 | |
| HOGENOM | HBG403109 | |
| HOVERGEN | HBG054192 | |
| InParanoid | Q923E4 | |
| OMA | GEPLRKR | |
| OrthoDB | EOG4RNB8G | |
| PhylomeDB | Q923E4 | |
| NextBio | 351639 | |
| ArrayExpress | Q923E4 | |
| Bgee | Q923E4 | |
| Genevestigator | Q923E4 | |
| GermOnline | ENSMUSG00000020063 | |
| GO | GO:0005719 GO:0005720 GO:0005637 GO:0016605 GO:0070403 GO:0046969 GO:0002039 GO:0003714 GO:0008270 GO:0006915 GO:0009267 GO:0007517 GO:0045599 GO:0001542 GO:0045768 GO:0045739 GO:0042981 GO:0032071 GO:0034339 GO:0006364 GO:0007283 GO:0006351 GO:0006642 GO:0050872 | |
| InterPro | IPR003000 | |
| PANTHER | PTHR11085 | |
| Pfam | PF02146 | |
| PROSITE | PS50305 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001542 |
ovulation from ovarian follicle |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2448246 |
P |
Seeded From UniProt |
|||
| GO:0002039 |
p53 binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0003714 |
transcription corepressor activity |
IMP: Inferred from Mutant Phenotype |
|
F |
Seeded From UniProt |
|||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005637 |
nuclear inner membrane |
ISS: Inferred from Sequence or Structural Similarity |
C |
Seeded From UniProt |
||||
| GO:0005654 |
nucleoplasm |
ISS: Inferred from Sequence or Structural Similarity |
C |
Seeded From UniProt |
||||
| GO:0005719 |
nuclear euchromatin |
ISS: Inferred from Sequence or Structural Similarity |
C |
Seeded From UniProt |
||||
| GO:0005720 |
nuclear heterochromatin |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0006351 |
transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006364 |
rRNA processing |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006476 |
protein deacetylation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006476 |
protein deacetylation |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0006642 |
triglyceride mobilization |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0006915 |
apoptosis |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007275 |
multicellular organismal development |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007283 |
spermatogenesis |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2448246 |
P |
Seeded From UniProt |
|||
| GO:0007517 |
muscle organ development |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0008270 |
zinc ion binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0009267 |
cellular response to starvation |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0016575 |
histone deacetylation |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0016575 |
histone deacetylation |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0016575 |
histone deacetylation |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0016605 |
PML body |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0465 |
C |
Seeded From UniProt |
|||
| GO:0016787 |
hydrolase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0017136 |
NAD-dependent histone deacetylase activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0019213 |
deacetylase activity |
IMP: Inferred from Mutant Phenotype |
|
F |
Seeded From UniProt |
|||
| GO:0019899 |
enzyme binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0019899 |
enzyme binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0019904 |
protein domain specific binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0030154 |
cell differentiation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0032071 |
regulation of endodeoxyribonuclease activity |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0033558 |
protein deacetylase activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0034339 |
regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0034979 |
NAD-dependent protein deacetylase activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0042981 |
regulation of apoptosis |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0045599 |
negative regulation of fat cell differentiation |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0045739 |
positive regulation of DNA repair |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0045768 |
positive regulation of anti-apoptosis |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0046872 |
metal ion binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0046969 |
NAD-dependent histone deacetylase activity (H3-K9 specific) |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0050872 |
white fat cell differentiation |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0070403 |
NAD+ binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0080134 |
regulation of response to stress |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0045768 |
positive regulation of anti-apoptosis |
IDA: Inferred from Direct Assay |
P |
Figure 3 |
complete | |||
| GO:0007587 |
sugar utilization |
IEP: Inferred from Expression Pattern |
1 |
Figure 3 |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 McBurney MW et al. (2003) The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol 23: 38-54 PubMed GONUTS page
- ↑ 2.0 2.1 Luo J et al. (2001) Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107: 137-48 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Picard F et al. (2004) Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 429: 771-6 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Vaquero A et al. (2007) SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation. Nature 450: 440-4 PubMed GONUTS page
- ↑ Asher G et al. (2008) SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell 134: 317-28 PubMed GONUTS page
- ↑ 6.0 6.1 Revollo JR et al. (2004) The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells. J Biol Chem 279: 50754-63 PubMed GONUTS page
- ↑ 7.0 7.1 Vaziri H et al. (2001) hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107: 149-59 PubMed GONUTS page
- ↑ 8.0 8.1 Imai S et al. (2000) Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403: 795-800 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Kornberg MD et al. (2010) GAPDH mediates nitrosylation of nuclear proteins. Nat Cell Biol 12: 1094-100 PubMed GONUTS page
- ↑ 10.0 10.1 Zhou Y et al. (2009) Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing. Nat Cell Biol 11: 1010-6 PubMed GONUTS page
- ↑ Lafontaine-Lacasse M et al. (2011) Hexosamines stimulate apoptosis by altering SIRT1 action and levels in rodent pancreatic β-cells. J Endocrinol 208: 41-9 PubMed GONUTS page
- ↑ Vetterli L et al. (2011) Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism. J Biol Chem 286: 6049-60 PubMed GONUTS page
