MOUSE:SHH

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Species (Taxon ID)	Mus musculus (Mouse). ([1])
Gene Name(s)	Shh (synonyms: Hhg1)
Protein Name(s)	Sonic hedgehog protein SHH HHG-1 Sonic hedgehog protein N-product Sonic hedgehog protein C-product
External Links
EMBL	X76290 AK077688 BC063087
IPI	IPI00123314
PIR	A49425
RefSeq	NP_033196.1
UniGene	Mm.57202
PDB	1VHH 2WFX 2WG4 3D1M 3N1R
PDBsum	1VHH 2WFX 2WG4 3D1M 3N1R
ProteinModelPortal	Q62226
SMR	Q62226
DIP	DIP-48537N
STRING	Q62226
MEROPS	C46.002
PhosphoSite	Q62226
PRIDE	Q62226
Ensembl	ENSMUST00000002708
GeneID	20423
KEGG	mmu:20423
UCSC	uc008wua.2
CTD	6469
MGI	MGI:98297
eggNOG	roNOG09706
HOGENOM	HBG403179
HOVERGEN	HBG005480
InParanoid	Q62226
OMA	APHNDSA
OrthoDB	EOG46WZ8G
PhylomeDB	Q62226
NextBio	298432
ArrayExpress	Q62226
Bgee	Q62226
CleanEx	MM_SHH
Genevestigator	Q62226
GermOnline	ENSMUSG00000002633
GO	GO:0009986 GO:0031012 GO:0005615 GO:0005624 GO:0045121 GO:0005634 GO:0005886 GO:0005509 GO:0001948 GO:0005539 GO:0043237 GO:0005113 GO:0008233 GO:0004871 GO:0008270 GO:0008209 GO:0009952 GO:0006915 GO:0060840 GO:0007411 GO:0060020 GO:0007596 GO:0060445 GO:0001658 GO:0060447 GO:0043010 GO:0060070 GO:0043369 GO:0071285 GO:0003140 GO:0021904 GO:0007398 GO:0048557 GO:0042733 GO:0048617 GO:0035115 GO:0035116 GO:0048706 GO:0006897 GO:0060664 GO:0030010 GO:0048859 GO:0031069 GO:0001947 GO:0030902 GO:0007442 GO:0048839 GO:0016539 GO:0045109 GO:0060459 GO:0060174 GO:0060428 GO:0060463 GO:0060484 GO:0002320 GO:0060916 GO:0060783 GO:0072136 GO:0030901 GO:0080125 GO:0045445 GO:0014902 GO:0046639 GO:0090090 GO:0030336 GO:2000357 GO:0032435 GO:0042130 GO:0034244 GO:0000122 GO:2000062 GO:0045060 GO:0001755 GO:0007405 GO:0042475 GO:0014003 GO:0048645 GO:0002076 GO:0060021 GO:0031016 GO:0001569 GO:0046638 GO:0060769 GO:0007228 GO:0033092 GO:2000358 GO:2000729 GO:0002052 GO:0048714 GO:0042307 GO:0014858 GO:0048643 GO:0045880 GO:0051155 GO:0033089 GO:0045944 GO:2000063 GO:0030177 GO:0045059 GO:0060516 GO:0060523 GO:0034504 GO:0006508 GO:0060782 GO:0060685 GO:0060458 GO:0060662 GO:0043588 GO:0021938 GO:0048864 GO:0021978 GO:0048538 GO:0030878 GO:0060439 GO:0060979
InterPro	IPR009045 IPR003586 IPR003587 IPR000320 IPR006141 IPR001657 IPR001767
Gene3D	G3DSA:3.30.1380.10
Pfam	PF01085 PF01079
PIRSF	PIRSF009400
PRINTS	PR00632
SMART	SM00305 SM00306
SUPFAM	SSF55166
PROSITE	PS50817

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	PMID:9769173^[1]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0001525	angiogenesis	PMID:16778080^[2]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0001525	angiogenesis	PMID:17187775^[3]	IGI: Inferred from Genetic Interaction	MGI:MGI:95516	P	Seeded From UniProt
	GO:0001525	angiogenesis	PMID:17187775^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0001569	patterning of blood vessels	PMID:15936751^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0001570	vasculogenesis	PMID:15294868^[5]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0001656	metanephros development	PMID:12399320^[6]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0001658	branching involved in ureteric bud morphogenesis	PMID:16396903^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0001666	response to hypoxia	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000008497	P	Seeded From UniProt
	GO:0001708	cell fate specification	PMID:12231626^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0001708	cell fate specification	PMID:16647304^[9]	IGI: Inferred from Genetic Interaction	MGI:MGI:1926387	P	Seeded From UniProt
	GO:0001708	cell fate specification	PMID:18076286^[10]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0001755	neural crest cell migration	PMID:15936751^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0001822	kidney development	PMID:11172440^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0001841	neural tube formation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000008497	P	Seeded From UniProt
	GO:0001942	hair follicle development	PMID:16054035^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0001944	vasculature development	PMID:17881493^[13]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0001947	heart looping	PMID:10411502^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0001947	heart looping	PMID:10500184^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0001947	heart looping	PMID:11517919^[16]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0001948	glycoprotein binding	PMID:11476578^[17]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0002052	positive regulation of neuroblast proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000008497	P	Seeded From UniProt
	GO:0002052	positive regulation of neuroblast proliferation	PMID:11748155^[18]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0002053	positive regulation of mesenchymal cell proliferation	PMID:9731532^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0002076	osteoblast development	PMID:16880529^[20]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0002320	lymphoid progenitor cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000297261	P	Seeded From UniProt
	GO:0002320	lymphoid progenitor cell differentiation	PMID:14764698^[21]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0003140	determination of left/right asymmetry in lateral mesoderm	PMID:11517919^[16]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0004871	signal transducer activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000297261	F	Seeded From UniProt
	GO:0004871	signal transducer activity	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q15465	F	Seeded From UniProt
	GO:0005113	patched binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000297261	F	Seeded From UniProt
	GO:0005113	patched binding	PMID:10500113^[22]	IPI: Inferred from Physical Interaction	UniProtKB:Q61115	F	Seeded From UniProt
	GO:0005509	calcium ion binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000297261	F	Seeded From UniProt
	GO:0005509	calcium ion binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q15465	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:10500113^[22]	IPI: Inferred from Physical Interaction	UniProtKB:Q61115	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:18081866^[23]	IPI: Inferred from Physical Interaction	UniProtKB:Q9D1G3	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:19561611^[24]	IPI: Inferred from Physical Interaction	UniProtKB:Q96QV1	F	Seeded From UniProt
	GO:0005539	glycosaminoglycan binding	PMID:11476578^[17]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C	Seeded From UniProt
	GO:0005615	extracellular space	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000297261	C	Seeded From UniProt
	GO:0005615	extracellular space	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000008497	C	Seeded From UniProt
	GO:0005615	extracellular space	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0112	C	Seeded From UniProt
	GO:0005615	extracellular space	PMID:10027293^[25]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005615	extracellular space	PMID:7891723^[26]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005624	membrane fraction	PMID:18477453^[27]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005634	nucleus	PMID:11724907^[28]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005783	endoplasmic reticulum	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000008497	C	Seeded From UniProt
	GO:0005794	Golgi apparatus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000008497	C	Seeded From UniProt
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C	Seeded From UniProt
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C	Seeded From UniProt
	GO:0006355	regulation of transcription, DNA-dependent	PMID:11171399^[29]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861186	P	Seeded From UniProt
	GO:0006355	regulation of transcription, DNA-dependent	PMID:11412027^[30]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0006508	proteolysis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001767	P	Seeded From UniProt
	GO:0006508	proteolysis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0645	P	Seeded From UniProt
	GO:0006897	endocytosis	PMID:18477453^[27]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0006915	apoptosis	PMID:19029980^[31]	IGI: Inferred from Genetic Interaction	MGI:MGI:95728	P	Seeded From UniProt
	GO:0007154	cell communication	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001657	P	Seeded From UniProt
	GO:0007165	signal transduction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000297261	P	Seeded From UniProt
	GO:0007165	signal transduction	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q15465	P	Seeded From UniProt
	GO:0007165	signal transduction	PMID:11684660^[32]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0007224	smoothened signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000297261	P	Seeded From UniProt
	GO:0007224	smoothened signaling pathway	PMID:11118883^[33]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0007224	smoothened signaling pathway	PMID:15269168^[34]	IGI: Inferred from Genetic Interaction	MGI:MGI:1916147	P	Seeded From UniProt
	GO:0007224	smoothened signaling pathway	PMID:17043310^[35]	IGI: Inferred from Genetic Interaction	MGI:MGI:108075	P	Seeded From UniProt
	GO:0007224	smoothened signaling pathway	PMID:8906787^[36]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0007228	positive regulation of hh target transcription factor activity	PMID:10340755^[37]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0007228	positive regulation of hh target transcription factor activity	PMID:11517919^[16]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0007228	positive regulation of hh target transcription factor activity	PMID:16611981^[38]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0007228	positive regulation of hh target transcription factor activity	PMID:16880529^[20]	IGI: Inferred from Genetic Interaction	MGI:MGI:95728	P	Seeded From UniProt
	GO:0007267	cell-cell signaling	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000320	P	Seeded From UniProt
	GO:0007267	cell-cell signaling	PMID:15199404^[39]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934268	P	Seeded From UniProt
	GO:0007267	cell-cell signaling	PMID:16492970^[40]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0007275	multicellular organismal development	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000320	P	Seeded From UniProt
	GO:0007275	multicellular organismal development	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001657	P	Seeded From UniProt
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P	Seeded From UniProt
	GO:0007368	determination of left/right symmetry	PMID:10385121^[41]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0007368	determination of left/right symmetry	PMID:10411502^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0007368	determination of left/right symmetry	PMID:10500184^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0007389	pattern specification process	PMID:12231626^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0007389	pattern specification process	PMID:14602680^[42]	IGI: Inferred from Genetic Interaction	MGI:MGI:95729	P	Seeded From UniProt
	GO:0007398	ectoderm development	PMID:11118883^[33]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0007405	neuroblast proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000008497	P	Seeded From UniProt
	GO:0007405	neuroblast proliferation	PMID:15337776^[43]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0007411	axon guidance	PMID:12679031^[44]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0007411	axon guidance	PMID:12756179^[45]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934268	P	Seeded From UniProt
	GO:0007411	axon guidance	PMID:15065125^[46]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934268	P	Seeded From UniProt
	GO:0007417	central nervous system development	PMID:12435628^[47]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0007442	hindgut morphogenesis	PMID:11485934^[48]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0007502	digestive tract mesoderm development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000008497	P	Seeded From UniProt
	GO:0007507	heart development	PMID:10500184^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0007507	heart development	PMID:11172440^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0007507	heart development	PMID:15936751^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0007596	blood coagulation	PMID:8835524^[49]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1860897	P	Seeded From UniProt
	GO:0008209	androgen metabolic process	PMID:15013801^[50]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0008219	cell death	PMID:9731532^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0008233	peptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001767	F	Seeded From UniProt
	GO:0008233	peptidase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0645	F	Seeded From UniProt
	GO:0008270	zinc ion binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000297261	F	Seeded From UniProt
	GO:0008270	zinc ion binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q15465	F	Seeded From UniProt
	GO:0008283	cell proliferation	PMID:19056373^[51]	IGI: Inferred from Genetic Interaction	MGI:MGI:95728	P	Seeded From UniProt
	GO:0008284	positive regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000008497	P	Seeded From UniProt
	GO:0008284	positive regulation of cell proliferation	PMID:11748155^[18]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0008284	positive regulation of cell proliferation	PMID:15183722^[52]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934268	P	Seeded From UniProt
	GO:0008284	positive regulation of cell proliferation	PMID:15183722^[52]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387802	P	Seeded From UniProt
	GO:0008284	positive regulation of cell proliferation	PMID:15496441^[53]	IGI: Inferred from Genetic Interaction	MGI:MGI:95728	P	Seeded From UniProt
	GO:0008284	positive regulation of cell proliferation	PMID:16054035^[12]	IGI: Inferred from Genetic Interaction	MGI:MGI:95728	P	Seeded From UniProt
	GO:0008284	positive regulation of cell proliferation	PMID:16054035^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0008284	positive regulation of cell proliferation	PMID:16236765^[54]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934268	P	Seeded From UniProt
	GO:0008284	positive regulation of cell proliferation	PMID:16236765^[54]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3052661	P	Seeded From UniProt
	GO:0008284	positive regulation of cell proliferation	PMID:16396903^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0009790	embryo development	PMID:16020517^[55]	IGI: Inferred from Genetic Interaction	MGI:MGI:104719	P	Seeded From UniProt
	GO:0009790	embryo development	PMID:17881493^[13]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0009952	anterior/posterior pattern specification	PMID:11118883^[33]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0009952	anterior/posterior pattern specification	PMID:11389830^[56]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387802	P	Seeded From UniProt
	GO:0009953	dorsal/ventral pattern formation	PMID:15269168^[34]	IGI: Inferred from Genetic Interaction	MGI:MGI:1916147	P	Seeded From UniProt
	GO:0009986	cell surface	PMID:15576403^[57]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0010243	response to organic nitrogen	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000008497	P	Seeded From UniProt
	GO:0010463	mesenchymal cell proliferation	PMID:9731532^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0010468	regulation of gene expression	PMID:18799682^[58]	IGI: Inferred from Genetic Interaction	MGI:MGI:95729	P	Seeded From UniProt
	GO:0010468	regulation of gene expression	PMID:18799682^[58]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0010628	positive regulation of gene expression	PMID:11118883^[33]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0010628	positive regulation of gene expression	PMID:16396903^[7]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0010629	negative regulation of gene expression	PMID:16396903^[7]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0014003	oligodendrocyte development	PMID:8660874^[59]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0014706	striated muscle tissue development	PMID:11171399^[29]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861186	P	Seeded From UniProt
	GO:0014858	positive regulation of skeletal muscle cell proliferation	PMID:11171399^[29]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861186	P	Seeded From UniProt
	GO:0014902	myotube differentiation	PMID:11171399^[29]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0014902	myotube differentiation	PMID:11171399^[29]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861186	P	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C	Seeded From UniProt
	GO:0016539	intein-mediated protein splicing	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006141	P	Seeded From UniProt
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F	Seeded From UniProt
	GO:0021513	spinal cord dorsal/ventral patterning	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000008497	P	Seeded From UniProt
	GO:0021513	spinal cord dorsal/ventral patterning	PMID:11748151^[60]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0021521	ventral spinal cord interneuron specification	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000008497	P	Seeded From UniProt
	GO:0021904	dorsal/ventral neural tube patterning	PMID:17442700^[61]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0021904	dorsal/ventral neural tube patterning	PMID:17504941^[62]	IGI: Inferred from Genetic Interaction	MGI:MGI:95655	P	Seeded From UniProt
	GO:0021904	dorsal/ventral neural tube patterning	PMID:18590716^[63]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0021938	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation	PMID:10375501^[64]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0021940	positive regulation of cerebellar granule cell precursor proliferation	PMID:10027293^[25]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0021978	telencephalon regionalization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000008497	P	Seeded From UniProt
	GO:0021978	telencephalon regionalization	PMID:11060228^[65]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0030010	establishment of cell polarity	PMID:16332353^[66]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0030133	transport vesicle	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000008497	C	Seeded From UniProt
	GO:0030162	regulation of proteolysis	PMID:15136151^[67]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0030177	positive regulation of Wnt receptor signaling pathway	PMID:11520664^[68]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0030178	negative regulation of Wnt receptor signaling pathway	PMID:9356179^[69]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0030323	respiratory tube development	PMID:9731532^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0030324	lung development	PMID:15136151^[67]	IGI: Inferred from Genetic Interaction	MGI:MGI:95729	P	Seeded From UniProt
	GO:0030324	lung development	PMID:15136151^[67]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0030324	lung development	PMID:15305287^[70]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934268	P	Seeded From UniProt
	GO:0030324	lung development	PMID:15305287^[70]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2679524	P	Seeded From UniProt
	GO:0030324	lung development	PMID:17187775^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0030324	lung development	PMID:9731532^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0030324	lung development	PMID:9768363^[71]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934261	P	Seeded From UniProt
	GO:0030326	embryonic limb morphogenesis	PMID:11389830^[56]	IGI: Inferred from Genetic Interaction	MGI:MGI:105373	P	Seeded From UniProt
	GO:0030326	embryonic limb morphogenesis	PMID:11389830^[56]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387802	P	Seeded From UniProt
	GO:0030326	embryonic limb morphogenesis	PMID:15315763^[72]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3053959	P	Seeded From UniProt
	GO:0030326	embryonic limb morphogenesis	PMID:15315763^[72]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3053960	P	Seeded From UniProt
	GO:0030336	negative regulation of cell migration	PMID:15337776^[43]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0030539	male genitalia development	PMID:11684660^[32]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0030850	prostate gland development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000008497	P	Seeded From UniProt
	GO:0030850	prostate gland development	PMID:10208740^[73]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0030850	prostate gland development	PMID:15013801^[50]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0030856	regulation of epithelial cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000008497	P	Seeded From UniProt
	GO:0030878	thyroid gland development	PMID:16968815^[74]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861186	P	Seeded From UniProt
	GO:0030900	forebrain development	PMID:16020517^[55]	IGI: Inferred from Genetic Interaction	MGI:MGI:104719	P	Seeded From UniProt
	GO:0030901	midbrain development	PMID:16020517^[55]	IGI: Inferred from Genetic Interaction	MGI:MGI:104719	P	Seeded From UniProt
	GO:0030902	hindbrain development	PMID:15183722^[52]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934268	P	Seeded From UniProt
	GO:0030902	hindbrain development	PMID:15183722^[52]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387802	P	Seeded From UniProt
	GO:0030902	hindbrain development	PMID:15496441^[53]	IGI: Inferred from Genetic Interaction	MGI:MGI:95728	P	Seeded From UniProt
	GO:0031012	extracellular matrix	PMID:11476578^[17]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0031016	pancreas development	PMID:10821773^[75]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934261	P	Seeded From UniProt
	GO:0031016	pancreas development	PMID:11044404^[76]	IGI: Inferred from Genetic Interaction	MGI:MGI:96533	P	Seeded From UniProt
	GO:0031016	pancreas development	PMID:11044404^[76]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934261	P	Seeded From UniProt
	GO:0031069	hair follicle morphogenesis	PMID:11520664^[68]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0031069	hair follicle morphogenesis	PMID:14623238^[77]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0031069	hair follicle morphogenesis	PMID:9768360^[78]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934261	P	Seeded From UniProt
	GO:0032355	response to estradiol stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000008497	P	Seeded From UniProt
	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	PMID:16611981^[38]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0032526	response to retinoic acid	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000008497	P	Seeded From UniProt
	GO:0033077	T cell differentiation in thymus	PMID:19273836^[79]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0033089	positive regulation of T cell differentiation in thymus	PMID:19109233^[80]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0033092	positive regulation of immature T cell proliferation in thymus	PMID:14764698^[21]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0033092	positive regulation of immature T cell proliferation in thymus	PMID:19273836^[79]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0034244	negative regulation of transcription elongation from RNA polymerase II promoter	PMID:17284610^[81]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0034504	protein localization to nucleus	PMID:19952108^[82]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0035115	embryonic forelimb morphogenesis	PMID:11118883^[33]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0035116	embryonic hindlimb morphogenesis	PMID:11118883^[33]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0042127	regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000008497	P	Seeded From UniProt
	GO:0042127	regulation of cell proliferation	PMID:12756179^[45]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0042130	negative regulation of T cell proliferation	PMID:10981962^[83]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0042177	negative regulation of protein catabolic process	PMID:16611981^[38]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0042307	positive regulation of protein import into nucleus	PMID:17043310^[35]	IGI: Inferred from Genetic Interaction	MGI:MGI:108075	P	Seeded From UniProt
	GO:0042475	odontogenesis of dentine-containing tooth	PMID:11044393^[84]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934268	P	Seeded From UniProt
	GO:0042475	odontogenesis of dentine-containing tooth	PMID:11044393^[84]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2445832	P	Seeded From UniProt
	GO:0042476	odontogenesis	PMID:10781055^[85]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0042733	embryonic digit morphogenesis	PMID:15930098^[86]	IGI: Inferred from Genetic Interaction	MGI:MGI:98715	P	Seeded From UniProt
	GO:0042733	embryonic digit morphogenesis	PMID:17504940^[87]	IGI: Inferred from Genetic Interaction	MGI:MGI:95655	P	Seeded From UniProt
	GO:0042733	embryonic digit morphogenesis	PMID:17504941^[62]	IGI: Inferred from Genetic Interaction	MGI:MGI:95655	P	Seeded From UniProt
	GO:0043010	camera-type eye development	PMID:12195432^[88]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0043010	camera-type eye development	PMID:12756179^[45]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934268	P	Seeded From UniProt
	GO:0043010	camera-type eye development	PMID:16236765^[54]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934268	P	Seeded From UniProt
	GO:0043010	camera-type eye development	PMID:16236765^[54]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3052661	P	Seeded From UniProt
	GO:0043010	camera-type eye development	PMID:18582859^[89]	IGI: Inferred from Genetic Interaction	MGI:MGI:95729	P	Seeded From UniProt
	GO:0043066	negative regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000008497	P	Seeded From UniProt
	GO:0043237	laminin-1 binding	PMID:15056720^[90]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0043369	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000297261	P	Seeded From UniProt
	GO:0043369	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment	PMID:17227833^[91]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0043587	tongue morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000008497	P	Seeded From UniProt
	GO:0043588	skin development	PMID:10331973^[92]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0045059	positive thymic T cell selection	PMID:17227833^[91]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0045060	negative thymic T cell selection	PMID:17227833^[91]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0045109	intermediate filament organization	PMID:11171399^[29]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861186	P	Seeded From UniProt
	GO:0045121	membrane raft	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000008497	C	Seeded From UniProt
	GO:0045121	membrane raft	PMID:15075292^[93]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0045165	cell fate commitment	PMID:17504941^[62]	IGI: Inferred from Genetic Interaction	MGI:MGI:95655	P	Seeded From UniProt
	GO:0045445	myoblast differentiation	PMID:15238161^[94]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045471	response to ethanol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000008497	P	Seeded From UniProt
	GO:0045596	negative regulation of cell differentiation	PMID:15337776^[43]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045596	negative regulation of cell differentiation	PMID:16236765^[54]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934268	P	Seeded From UniProt
	GO:0045596	negative regulation of cell differentiation	PMID:16236765^[54]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3052661	P	Seeded From UniProt
	GO:0045597	positive regulation of cell differentiation	PMID:10357934^[95]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0045666	positive regulation of neuron differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000008497	P	Seeded From UniProt
	GO:0045880	positive regulation of smoothened signaling pathway	PMID:11517919^[16]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0045893	positive regulation of transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000297261	P	Seeded From UniProt
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:12399320^[6]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:9356179^[69]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:10340755^[37]	IGI: Inferred from Genetic Interaction	MGI:MGI:97168	P	Seeded From UniProt
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:10340755^[37]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:11493558^[96]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:16880529^[20]	IGI: Inferred from Genetic Interaction	MGI:MGI:95728	P	Seeded From UniProt
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:17881493^[13]	IGI: Inferred from Genetic Interaction	MGI:MGI:96533	P	Seeded From UniProt
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:19304890^[97]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934268	P	Seeded From UniProt
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:9006067^[98]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:9585504^[99]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:9585504^[99]	IGI: Inferred from Genetic Interaction	MGI:MGI:104327	P	Seeded From UniProt
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:9731532^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:9769173^[1]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0046534	positive regulation of photoreceptor cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000008497	P	Seeded From UniProt
	GO:0046638	positive regulation of alpha-beta T cell differentiation	PMID:14764698^[21]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0046639	negative regulation of alpha-beta T cell differentiation	PMID:10981962^[83]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0048468	cell development	PMID:15183722^[52]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934268	P	Seeded From UniProt
	GO:0048468	cell development	PMID:15183722^[52]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387802	P	Seeded From UniProt
	GO:0048468	cell development	PMID:16236765^[54]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934268	P	Seeded From UniProt
	GO:0048468	cell development	PMID:16236765^[54]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3052661	P	Seeded From UniProt
	GO:0048538	thymus development	PMID:19109233^[80]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0048546	digestive tract morphogenesis	PMID:9731532^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0048557	embryonic digestive tract morphogenesis	PMID:10821773^[75]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934261	P	Seeded From UniProt
	GO:0048568	embryonic organ development	PMID:15680353^[100]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0048589	developmental growth	PMID:11044393^[84]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934268	P	Seeded From UniProt
	GO:0048589	developmental growth	PMID:11044393^[84]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2445832	P	Seeded From UniProt
	GO:0048598	embryonic morphogenesis	PMID:16492970^[40]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0048598	embryonic morphogenesis	PMID:17881493^[13]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0048617	embryonic foregut morphogenesis	PMID:9731532^[19]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0048617	embryonic foregut morphogenesis	PMID:9731532^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0048643	positive regulation of skeletal muscle tissue development	PMID:11171399^[29]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0048643	positive regulation of skeletal muscle tissue development	PMID:11171399^[29]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861186	P	Seeded From UniProt
	GO:0048645	organ formation	PMID:15013801^[50]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0048646	anatomical structure formation involved in morphogenesis	PMID:9768363^[71]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934261	P	Seeded From UniProt
	GO:0048663	neuron fate commitment	PMID:16221724^[101]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934268	P	Seeded From UniProt
	GO:0048678	response to axon injury	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000008497	P	Seeded From UniProt
	GO:0048706	embryonic skeletal system development	PMID:17504941^[62]	IGI: Inferred from Genetic Interaction	MGI:MGI:95655	P	Seeded From UniProt
	GO:0048709	oligodendrocyte differentiation	PMID:11171336^[102]	IGI: Inferred from Genetic Interaction	MGI:MGI:108067	P	Seeded From UniProt
	GO:0048709	oligodendrocyte differentiation	PMID:11493571^[103]	IGI: Inferred from Genetic Interaction	MGI:MGI:108067	P	Seeded From UniProt
	GO:0048709	oligodendrocyte differentiation	PMID:15880651^[104]	IGI: Inferred from Genetic Interaction	MGI:MGI:95729	P	Seeded From UniProt
	GO:0048714	positive regulation of oligodendrocyte differentiation	PMID:11171336^[102]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0048754	branching morphogenesis of a tube	PMID:15042696^[105]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0048754	branching morphogenesis of a tube	PMID:15305287^[70]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934268	P	Seeded From UniProt
	GO:0048754	branching morphogenesis of a tube	PMID:15305287^[70]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2679524	P	Seeded From UniProt
	GO:0048754	branching morphogenesis of a tube	PMID:9768363^[71]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934261	P	Seeded From UniProt
	GO:0048808	male genitalia morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000008497	P	Seeded From UniProt
	GO:0048839	inner ear development	PMID:17395647^[106]	IGI: Inferred from Genetic Interaction	MGI:MGI:95729	P	Seeded From UniProt
	GO:0048839	inner ear development	PMID:17395647^[106]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934261	P	Seeded From UniProt
	GO:0048856	anatomical structure development	PMID:11485934^[48]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0048859	formation of anatomical boundary	PMID:9731532^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0048864	stem cell development	PMID:12843296^[107]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0051146	striated muscle cell differentiation	PMID:15238161^[94]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0051146	striated muscle cell differentiation	PMID:15238161^[94]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0051155	positive regulation of striated muscle cell differentiation	PMID:11171399^[29]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0051155	positive regulation of striated muscle cell differentiation	PMID:11171399^[29]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861186	P	Seeded From UniProt
	GO:0060020	Bergmann glial cell differentiation	PMID:10375501^[64]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0060021	palate development	PMID:19304890^[97]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934268	P	Seeded From UniProt
	GO:0060021	palate development	PMID:19304890^[97]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2176256	P	Seeded From UniProt
	GO:0060070	canonical Wnt receptor signaling pathway	PMID:17284610^[81]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0060173	limb development	PMID:19223390^[108]	IGI: Inferred from Genetic Interaction	MGI:MGI:1329045	P	Seeded From UniProt
	GO:0060173	limb development	PMID:19223390^[108]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0060174	limb bud formation	PMID:11118883^[33]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0060406	positive regulation of penile erection	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000008497	P	Seeded From UniProt
	GO:0060425	lung morphogenesis	PMID:10500184^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0060428	lung epithelium development	PMID:9731532^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0060438	trachea development	PMID:9731532^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0060439	trachea morphogenesis	PMID:9731532^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0060441	epithelial tube branching involved in lung morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000008497	P	Seeded From UniProt
	GO:0060441	epithelial tube branching involved in lung morphogenesis	PMID:10500184^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0060441	epithelial tube branching involved in lung morphogenesis	PMID:9731532^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0060442	branching involved in prostate gland morphogenesis	PMID:10208740^[73]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0060445	branching involved in salivary gland morphogenesis	PMID:15042696^[105]	IGI: Inferred from Genetic Interaction	MGI:MGI:99604	P	Seeded From UniProt
	GO:0060445	branching involved in salivary gland morphogenesis	PMID:15042696^[105]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0060447	bud outgrowth involved in lung branching	PMID:9731532^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0060458	right lung development	PMID:10500184^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0060459	left lung development	PMID:10500184^[15]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0060463	lung lobe morphogenesis	PMID:9731532^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0060484	lung-associated mesenchyme development	PMID:9731532^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0060516	primary prostatic bud elongation	PMID:10208740^[73]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0060523	prostate epithelial cord elongation	PMID:15013801^[50]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0060662	salivary gland cavitation	PMID:16332353^[66]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	PMID:15042696^[105]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0060684	epithelial-mesenchymal cell signaling	PMID:19304890^[97]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1934268	P	Seeded From UniProt
	GO:0060685	regulation of prostatic bud formation	PMID:12221011^[109]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0060685	regulation of prostatic bud formation	PMID:18393306^[110]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0060738	epithelial-mesenchymal signaling involved in prostate gland development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000297261	P	Seeded From UniProt
	GO:0060738	epithelial-mesenchymal signaling involved in prostate gland development	PMID:15987773^[111]	IGI: Inferred from Genetic Interaction	MGI:MGI:1347472	P	Seeded From UniProt
	GO:0060768	regulation of epithelial cell proliferation involved in prostate gland development	PMID:12221011^[109]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0060769	positive regulation of epithelial cell proliferation involved in prostate gland development	PMID:12221011^[109]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0060782	regulation of mesenchymal cell proliferation involved in prostate gland development	PMID:12221011^[109]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0060783	mesenchymal smoothened signaling pathway involved in prostate gland development	PMID:12221011^[109]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0060840	artery development	PMID:16968815^[74]	IGI: Inferred from Genetic Interaction	MGI:MGI:95729	P	Seeded From UniProt
	GO:0060840	artery development	PMID:16968815^[74]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861186	P	Seeded From UniProt
	GO:0060916	mesenchymal cell proliferation involved in lung development	PMID:9006067^[98]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0060979	vasculogenesis involved in coronary vascular morphogenesis	PMID:20299672^[112]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0061053	somite development	PMID:11517919^[16]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0061056	sclerotome development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000297261	P	Seeded From UniProt
	GO:0070447	positive regulation of oligodendrocyte progenitor proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000008497	P	Seeded From UniProt
	GO:0071285	cellular response to lithium ion	PMID:17284610^[81]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0072001	renal system development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000297261	P	Seeded From UniProt
	GO:0072136	metanephric mesenchymal cell proliferation involved in metanephros development	PMID:12399320^[6]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0080125	multicellular structure septum development	PMID:9731532^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857796	P	Seeded From UniProt
	GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	PMID:17284610^[81]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:2000062	negative regulation of ureter smooth muscle cell differentiation	PMID:12399320^[6]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:2000063	positive regulation of ureter smooth muscle cell differentiation	PMID:12399320^[6]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:2000357	negative regulation of kidney smooth muscle cell differentiation	PMID:12399320^[6]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:2000358	positive regulation of kidney smooth muscle cell differentiation	PMID:12399320^[6]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:2000729	positive regulation of mesenchymal cell proliferation involved in ureter development	PMID:12399320^[6]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0016787	hydrolase activity	PMID:10500113^[22]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0060513	prostatic bud formation	PMID:15013801^[50]	IGI: Inferred from Genetic Interaction	MGI:MGI:88064	P	Seeded From UniProt
	GO:0051236	establishment of RNA localization	PMID:21209331^[113]	IMP: Inferred from Mutant Phenotype		P	Fig 2B shows abnormal patterning of Pax7, FoxA2, Nkx2.2, Hb9 with Shh morphant	complete
	GO:0021904	dorsal/ventral neural tube patterning	PMID:21209331^[113]	IMP: Inferred from Mutant Phenotype		P	Fig 2B shows abnormal ventralising neural tube expression patterning with morphant compared to WT	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

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↑ ^109.0 ^109.1 ^109.2 ^109.3 ^109.4 Lamm ML et al. (2002) Sonic hedgehog activates mesenchymal Gli1 expression during prostate ductal bud formation. Dev Biol 249: 349-66 PubMed GONUTS page
↑ Vezina CM et al. (2008) Retinoic acid induces prostatic bud formation. Dev Dyn 237: 1321-33 PubMed GONUTS page
↑ Gao N et al. (2005) Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation. Development 132: 3431-43 PubMed GONUTS page
↑ Olivey HE & Svensson EC (2010) Epicardial-myocardial signaling directing coronary vasculogenesis. Circ Res 106: 818-32 PubMed GONUTS page
↑ ^113.0 ^113.1 Qin J et al. (2011) Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc Natl Acad Sci U S A 108: 1456-61 PubMed GONUTS page

[PMID:9769173-0] 1.0 ^1.1 Dassule HR & McMahon AP (1998) Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth. Dev Biol 202: 215-27 PubMed GONUTS page

[PMID:16778080-1] Lavine KJ et al. (2006) Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development. Genes Dev 20: 1651-66 PubMed GONUTS page

[PMID:17187775-2] 3.0 ^3.1 ^3.2 van Tuyl M et al. (2007) Angiogenic factors stimulate tubular branching morphogenesis of sonic hedgehog-deficient lungs. Dev Biol 303: 514-26 PubMed GONUTS page

[PMID:15936751-3] 4.0 ^4.1 ^4.2 Washington Smoak I et al. (2005) Sonic hedgehog is required for cardiac outflow tract and neural crest cell development. Dev Biol 283: 357-72 PubMed GONUTS page

[PMID:15294868-4] Vokes SA et al. (2004) Hedgehog signaling is essential for endothelial tube formation during vasculogenesis. Development 131: 4371-80 PubMed GONUTS page

[PMID:12399320-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Yu J et al. (2002) Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Development 129: 5301-12 PubMed GONUTS page

[PMID:16396903-6] 7.0 ^7.1 ^7.2 ^7.3 Hu MC et al. (2006) GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis. Development 133: 569-78 PubMed GONUTS page

[PMID:12231626-7] 8.0 ^8.1 Riccomagno MM et al. (2002) Specification of the mammalian cochlea is dependent on Sonic hedgehog. Genes Dev 16: 2365-78 PubMed GONUTS page

[PMID:16647304-8] Tenzen T et al. (2006) The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice. Dev Cell 10: 647-56 PubMed GONUTS page

[PMID:18076286-9] Kittappa R et al. (2007) The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age. PLoS Biol 5: e325 PubMed GONUTS page

[PMID:11172440-10] 11.0 ^11.1 Kim PC et al. (2001) Murine models of VACTERL syndrome: Role of sonic hedgehog signaling pathway. J Pediatr Surg 36: 381-4 PubMed GONUTS page

[PMID:16054035-11] 12.0 ^12.1 ^12.2 Mill P et al. (2005) Shh controls epithelial proliferation via independent pathways that converge on N-Myc. Dev Cell 9: 293-303 PubMed GONUTS page

[PMID:17881493-12] 13.0 ^13.1 ^13.2 ^13.3 Astorga J & Carlsson P (2007) Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4. Development 134: 3753-61 PubMed GONUTS page

[PMID:10411502-13] 14.0 ^14.1 Meyers EN & Martin GR (1999) Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHH. Science 285: 403-6 PubMed GONUTS page

[PMID:10500184-14] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 Tsukui T et al. (1999) Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1. Proc Natl Acad Sci U S A 96: 11376-81 PubMed GONUTS page

[PMID:11517919-15] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 Zhang XM et al. (2001) Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell 106: 781-92 PubMed GONUTS page

[PMID:11476578-16] 17.0 ^17.1 ^17.2 Gritli-Linde A et al. (2001) The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides. Dev Biol 236: 364-86 PubMed GONUTS page

[PMID:11748155-17] 18.0 ^18.1 Dahmane N et al. (2001) The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis. Development 128: 5201-12 PubMed GONUTS page

[PMID:9731532-18] 19.00 ^19.01 ^19.02 ^19.03 ^19.04 ^19.05 ^19.06 ^19.07 ^19.08 ^19.09 ^19.10 ^19.11 ^19.12 ^19.13 ^19.14 ^19.15 ^19.16 ^19.17 Litingtung Y et al. (1998) Sonic hedgehog is essential to foregut development. Nat Genet 20: 58-61 PubMed GONUTS page

[PMID:16880529-19] 20.0 ^20.1 ^20.2 Zhao M et al. (2006) The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling. Mol Cell Biol 26: 6197-208 PubMed GONUTS page

[PMID:14764698-20] 21.0 ^21.1 ^21.2 Shah DK et al. (2004) Reduced thymocyte development in sonic hedgehog knockout embryos. J Immunol 172: 2296-306 PubMed GONUTS page

[PMID:10500113-21] 22.0 ^22.1 ^22.2 Fuse N et al. (1999) Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched. Proc Natl Acad Sci U S A 96: 10992-9 PubMed GONUTS page

[PMID:18081866-22] Abe Y et al. (2008) Mammalian Gup1, a homolog of Saccharomyces cerevisiae glycerol uptake/transporter 1, acts as a negative regulator for N-terminal palmitoylation of Sonic hedgehog. FEBS J 275: 318-31 PubMed GONUTS page

[PMID:19561611-23] Bishop B et al. (2009) Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP. Nat Struct Mol Biol 16: 698-703 PubMed GONUTS page

[PMID:10027293-24] 25.0 ^25.1 Wechsler-Reya RJ & Scott MP (1999) Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron 22: 103-14 PubMed GONUTS page

[PMID:7891723-25] Bumcrot DA et al. (1995) Proteolytic processing yields two secreted forms of sonic hedgehog. Mol Cell Biol 15: 2294-303 PubMed GONUTS page

[PMID:18477453-26] 27.0 ^27.1 Capurro MI et al. (2008) Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding. Dev Cell 14: 700-11 PubMed GONUTS page

[PMID:11724907-27] Miller LA et al. (2001) Immunolocalization of sonic hedgehog (Shh) in developing mouse lung. J Histochem Cytochem 49: 1593-604 PubMed GONUTS page

[PMID:11171399-28] 29.0 ^29.1 ^29.2 ^29.3 ^29.4 ^29.5 ^29.6 ^29.7 ^29.8 ^29.9 Krüger M et al. (2001) Sonic hedgehog is a survival factor for hypaxial muscles during mouse development. Development 128: 743-52 PubMed GONUTS page

[PMID:11412027-29] Garg V et al. (2001) Tbx1, a DiGeorge syndrome candidate gene, is regulated by sonic hedgehog during pharyngeal arch development. Dev Biol 235: 62-73 PubMed GONUTS page

[PMID:19029980-30] Nasr R et al. (2008) Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation. Nat Med 14: 1333-42 PubMed GONUTS page

[PMID:11684660-31] 32.0 ^32.1 Haraguchi R et al. (2001) Unique functions of Sonic hedgehog signaling during external genitalia development. Development 128: 4241-50 PubMed GONUTS page

[PMID:11118883-32] 33.0 ^33.1 ^33.2 ^33.3 ^33.4 ^33.5 ^33.6 Kraus P et al. (2001) Some distal limb structures develop in mice lacking Sonic hedgehog signaling. Mech Dev 100: 45-58 PubMed GONUTS page

[PMID:15269168-33] 34.0 ^34.1 Tian H et al. (2004) Dose dependency of Disp1 and genetic interaction between Disp1 and other hedgehog signaling components in the mouse. Development 131: 4021-33 PubMed GONUTS page

[PMID:17043310-34] 35.0 ^35.1 Kim JW & Lemke G (2006) Hedgehog-regulated localization of Vax2 controls eye development. Genes Dev 20: 2833-47 PubMed GONUTS page

[PMID:8906787-35] Stone DM et al. (1996) The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 384: 129-34 PubMed GONUTS page

[PMID:10340755-36] 37.0 ^37.1 ^37.2 Zhang Y et al. (1999) Msx1 is required for the induction of Patched by Sonic hedgehog in the mammalian tooth germ. Dev Dyn 215: 45-53 PubMed GONUTS page

[PMID:16611981-37] 38.0 ^38.1 ^38.2 Pan Y et al. (2006) Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. Mol Cell Biol 26: 3365-77 PubMed GONUTS page

[PMID:15199404-38] Rice R et al. (2004) Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate. J Clin Invest 113: 1692-700 PubMed GONUTS page

[PMID:16492970-39] 40.0 ^40.1 Yamagishi C et al. (2006) Sonic hedgehog is essential for first pharyngeal arch development. Pediatr Res 59: 349-54 PubMed GONUTS page

[PMID:10385121-40] Izraeli S et al. (1999) The SIL gene is required for mouse embryonic axial development and left-right specification. Nature 399: 691-4 PubMed GONUTS page

[PMID:14602680-41] Buttitta L et al. (2003) Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction. Development 130: 6233-43 PubMed GONUTS page

[PMID:15337776-42] 43.0 ^43.1 ^43.2 Fu M et al. (2004) Sonic hedgehog regulates the proliferation, differentiation, and migration of enteric neural crest cells in gut. J Cell Biol 166: 673-84 PubMed GONUTS page

[PMID:12679031-43] Charron F et al. (2003) The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. Cell 113: 11-23 PubMed GONUTS page

[PMID:12756179-44] 45.0 ^45.1 ^45.2 Dakubo GD et al. (2003) Retinal ganglion cell-derived sonic hedgehog signaling is required for optic disc and stalk neuroepithelial cell development. Development 130: 2967-80 PubMed GONUTS page

[PMID:15065125-45] Balmer CW & LaMantia AS (2004) Loss of Gli3 and Shh function disrupts olfactory axon trajectories. J Comp Neurol 472: 292-307 PubMed GONUTS page

[PMID:12435628-46] Wijgerde M et al. (2002) A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev 16: 2849-64 PubMed GONUTS page

[PMID:11485934-47] 48.0 ^48.1 Mo R et al. (2001) Anorectal malformations caused by defects in sonic hedgehog signaling. Am J Pathol 159: 765-74 PubMed GONUTS page

[PMID:8835524-48] Rusiniak ME et al. (1996) Molecular markers near the mouse brachymorphic (bm) gene, which affects connective tissues and bleeding time. Mamm Genome 7: 98-102 PubMed GONUTS page

[PMID:15013801-49] 50.0 ^50.1 ^50.2 ^50.3 ^50.4 Berman DM et al. (2004) Roles for Hedgehog signaling in androgen production and prostate ductal morphogenesis. Dev Biol 267: 387-98 PubMed GONUTS page

[PMID:19056373-50] Pan Y et al. (2009) Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development. Dev Biol 326: 177-89 PubMed GONUTS page

[PMID:15183722-51] 52.0 ^52.1 ^52.2 ^52.3 ^52.4 ^52.5 Lewis PM et al. (2004) Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum. Dev Biol 270: 393-410 PubMed GONUTS page

[PMID:15496441-52] 53.0 ^53.1 Corrales JD et al. (2004) Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development. Development 131: 5581-90 PubMed GONUTS page

[PMID:16236765-53] 54.0 ^54.1 ^54.2 ^54.3 ^54.4 ^54.5 ^54.6 ^54.7 Wang Y et al. (2005) Retinal ganglion cell-derived sonic hedgehog locally controls proliferation and the timing of RGC development in the embryonic mouse retina. Development 132: 5103-13 PubMed GONUTS page

[PMID:16020517-54] 55.0 ^55.1 ^55.2 Grobe K et al. (2005) Cerebral hypoplasia and craniofacial defects in mice lacking heparan sulfate Ndst1 gene function. Development 132: 3777-86 PubMed GONUTS page

[PMID:11389830-55] 56.0 ^56.1 ^56.2 Lewis PM et al. (2001) Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Cell 105: 599-612 PubMed GONUTS page

[PMID:15576403-56] Jeong J & McMahon AP (2005) Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1. Development 132: 143-54 PubMed GONUTS page

[PMID:18799682-57] 58.0 ^58.1 Tucker ES et al. (2008) Molecular specification and patterning of progenitor cells in the lateral and medial ganglionic eminences. J Neurosci 28: 9504-18 PubMed GONUTS page

[PMID:8660874-58] Pringle NP et al. (1996) Determination of neuroepithelial cell fate: induction of the oligodendrocyte lineage by ventral midline cells and sonic hedgehog. Dev Biol 177: 30-42 PubMed GONUTS page

[PMID:11748151-59] Bai CB & Joyner AL (2001) Gli1 can rescue the in vivo function of Gli2. Development 128: 5161-72 PubMed GONUTS page

[PMID:17442700-60] Vokes SA et al. (2007) Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning. Development 134: 1977-89 PubMed GONUTS page

[PMID:17504941-61] 62.0 ^62.1 ^62.2 ^62.3 Allen BL et al. (2007) The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development. Genes Dev 21: 1244-57 PubMed GONUTS page

[PMID:18590716-62] Cho A et al. (2008) FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism. Dev Biol 321: 27-39 PubMed GONUTS page

[PMID:10375501-63] 64.0 ^64.1 Dahmane N & Ruiz i Altaba A (1999) Sonic hedgehog regulates the growth and patterning of the cerebellum. Development 126: 3089-100 PubMed GONUTS page

[PMID:11060228-64] Corbin JG et al. (2000) The Gsh2 homeodomain gene controls multiple aspects of telencephalic development. Development 127: 5007-20 PubMed GONUTS page

[PMID:16332353-65] 66.0 ^66.1 Hashizume A & Hieda Y (2006) Hedgehog peptide promotes cell polarization and lumen formation in developing mouse submandibular gland. Biochem Biophys Res Commun 339: 996-1000 PubMed GONUTS page

[PMID:15136151-66] 67.0 ^67.1 ^67.2 Li Y et al. (2004) Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation during mouse lung organogenesis. Dev Biol 270: 214-31 PubMed GONUTS page

[PMID:11520664-67] 68.0 ^68.1 Reddy S et al. (2001) Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis. Mech Dev 107: 69-82 PubMed GONUTS page

[PMID:9356179-68] 69.0 ^69.1 Fan CM et al. (1997) A role for WNT proteins in induction of dermomyotome. Dev Biol 191: 160-5 PubMed GONUTS page

[PMID:15305287-69] 70.0 ^70.1 ^70.2 ^70.3 Miller LA et al. (2004) Role of Sonic hedgehog in patterning of tracheal-bronchial cartilage and the peripheral lung. Dev Dyn 231: 57-71 PubMed GONUTS page

[PMID:9768363-70] 71.0 ^71.1 ^71.2 Pepicelli CV et al. (1998) Sonic hedgehog regulates branching morphogenesis in the mammalian lung. Curr Biol 8: 1083-6 PubMed GONUTS page

[PMID:15315763-71] 72.0 ^72.1 Harfe BD et al. (2004) Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell 118: 517-28 PubMed GONUTS page

[PMID:10208740-72] 73.0 ^73.1 ^73.2 Podlasek CA et al. (1999) Prostate development requires Sonic hedgehog expressed by the urogenital sinus epithelium. Dev Biol 209: 28-39 PubMed GONUTS page

[PMID:16968815-73] 74.0 ^74.1 ^74.2 Alt B et al. (2006) Arteries define the position of the thyroid gland during its developmental relocalisation. Development 133: 3797-804 PubMed GONUTS page

[PMID:10821773-74] 75.0 ^75.1 Ramalho-Santos M et al. (2000) Hedgehog signals regulate multiple aspects of gastrointestinal development. Development 127: 2763-72 PubMed GONUTS page

[PMID:11044404-75] 76.0 ^76.1 Hebrok M et al. (2000) Regulation of pancreas development by hedgehog signaling. Development 127: 4905-13 PubMed GONUTS page

[PMID:14623238-76] Michno K et al. (2003) Shh expression is required for embryonic hair follicle but not mammary gland development. Dev Biol 264: 153-65 PubMed GONUTS page

[PMID:9768360-77] St-Jacques B et al. (1998) Sonic hedgehog signaling is essential for hair development. Curr Biol 8: 1058-68 PubMed GONUTS page

[PMID:19273836-78] 79.0 ^79.1 Rowbotham NJ et al. (2009) Sonic hedgehog negatively regulates pre-TCR-induced differentiation by a Gli2-dependent mechanism. Blood 113: 5144-56 PubMed GONUTS page

[PMID:19109233-79] 80.0 ^80.1 Outram SV et al. (2009) Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation. Blood 113: 2217-28 PubMed GONUTS page

[PMID:17284610-80] 81.0 ^81.1 ^81.2 ^81.3 Iwatsuki K et al. (2007) Wnt signaling interacts with Shh to regulate taste papilla development. Proc Natl Acad Sci U S A 104: 2253-8 PubMed GONUTS page

[PMID:19952108-81] Fernandez-L A et al. (2009) YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation. Genes Dev 23: 2729-41 PubMed GONUTS page

[PMID:10981962-82] 83.0 ^83.1 Outram SV et al. (2000) Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte. Immunity 13: 187-97 PubMed GONUTS page

[PMID:11044393-83] 84.0 ^84.1 ^84.2 ^84.3 Dassule HR et al. (2000) Sonic hedgehog regulates growth and morphogenesis of the tooth. Development 127: 4775-85 PubMed GONUTS page

[PMID:10781055-84] Sarkar L et al. (2000) Wnt/Shh interactions regulate ectodermal boundary formation during mammalian tooth development. Proc Natl Acad Sci U S A 97: 4520-4 PubMed GONUTS page

[PMID:15930098-85] Liu A et al. (2005) Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development 132: 3103-11 PubMed GONUTS page

[PMID:17504940-86] Martinelli DC & Fan CM (2007) Gas1 extends the range of Hedgehog action by facilitating its signaling. Genes Dev 21: 1231-43 PubMed GONUTS page

[PMID:12195432-87] Wang YP et al. (2002) Development of normal retinal organization depends on Sonic hedgehog signaling from ganglion cells. Nat Neurosci 5: 831-2 PubMed GONUTS page

[PMID:18582859-88] Dakubo GD et al. (2008) Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye. Dev Biol 320: 242-55 PubMed GONUTS page

[PMID:15056720-89] Blaess S et al. (2004) Beta1-integrins are critical for cerebellar granule cell precursor proliferation. J Neurosci 24: 3402-12 PubMed GONUTS page

[PMID:17227833-90] 91.0 ^91.1 ^91.2 Rowbotham NJ et al. (2007) Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation. Blood 109: 3757-66 PubMed GONUTS page

[PMID:10331973-91] Karlsson L et al. (1999) Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle. Development 126: 2611-21 PubMed GONUTS page

[PMID:15075292-92] Chen MH et al. (2004) Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. Genes Dev 18: 641-59 PubMed GONUTS page

[PMID:15238161-93] 94.0 ^94.1 ^94.2 Li X et al. (2004) Hedgehog can drive terminal differentiation of amniote slow skeletal muscle. BMC Dev Biol 4: 9 PubMed GONUTS page

[PMID:10357934-94] Wallace VA & Raff MC (1999) A role for Sonic hedgehog in axon-to-astrocyte signalling in the rodent optic nerve. Development 126: 2901-9 PubMed GONUTS page

[PMID:11493558-95] Mahlapuu M et al. (2001) Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations. Development 128: 2397-406 PubMed GONUTS page

[PMID:19304890-96] 97.0 ^97.1 ^97.2 ^97.3 Lan Y & Jiang R (2009) Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth. Development 136: 1387-96 PubMed GONUTS page

[PMID:9006067-97] 98.0 ^98.1 Bellusci S et al. (1997) Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis. Development 124: 53-63 PubMed GONUTS page

[PMID:9585504-98] 99.0 ^99.1 McMahon JA et al. (1998) Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev 12: 1438-52 PubMed GONUTS page

[PMID:15680353-99] Moore-Scott BA & Manley NR (2005) Differential expression of Sonic hedgehog along the anterior-posterior axis regulates patterning of pharyngeal pouch endoderm and pharyngeal endoderm-derived organs. Dev Biol 278: 323-35 PubMed GONUTS page

[PMID:16221724-100] Xu Q et al. (2005) Sonic hedgehog maintains the identity of cortical interneuron progenitors in the ventral telencephalon. Development 132: 4987-98 PubMed GONUTS page

[PMID:11171336-101] 102.0 ^102.1 Nery S et al. (2001) Sonic hedgehog contributes to oligodendrocyte specification in the mammalian forebrain. Development 128: 527-40 PubMed GONUTS page

[PMID:11493571-102] Tekki-Kessaris N et al. (2001) Hedgehog-dependent oligodendrocyte lineage specification in the telencephalon. Development 128: 2545-54 PubMed GONUTS page

[PMID:15880651-103] Oh S et al. (2005) Specific requirements of sonic hedgehog signaling during oligodendrocyte development. Dev Dyn 234: 489-96 PubMed GONUTS page

[PMID:15042696-104] 105.0 ^105.1 ^105.2 ^105.3 Jaskoll T et al. (2004) Sonic hedgehog signaling plays an essential role during embryonic salivary gland epithelial branching morphogenesis. Dev Dyn 229: 722-32 PubMed GONUTS page

[PMID:17395647-105] 106.0 ^106.1 Bok J et al. (2007) Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear. Development 134: 1713-22 PubMed GONUTS page

[PMID:12843296-106] Viti J et al. (2003) Wnt regulation of progenitor maturation in the cortex depends on Shh or fibroblast growth factor 2. J Neurosci 23: 5919-27 PubMed GONUTS page

[PMID:19223390-107] 108.0 ^108.1 Patterson VL et al. (2009) Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway. Hum Mol Genet 18: 1719-39 PubMed GONUTS page

[PMID:12221011-108] 109.0 ^109.1 ^109.2 ^109.3 ^109.4 Lamm ML et al. (2002) Sonic hedgehog activates mesenchymal Gli1 expression during prostate ductal bud formation. Dev Biol 249: 349-66 PubMed GONUTS page

[PMID:18393306-109] Vezina CM et al. (2008) Retinoic acid induces prostatic bud formation. Dev Dyn 237: 1321-33 PubMed GONUTS page

[PMID:15987773-110] Gao N et al. (2005) Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation. Development 132: 3431-43 PubMed GONUTS page

[PMID:20299672-111] Olivey HE & Svensson EC (2010) Epicardial-myocardial signaling directing coronary vasculogenesis. Circ Res 106: 818-32 PubMed GONUTS page

[PMID:21209331-112] 113.0 ^113.1 Qin J et al. (2011) Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc Natl Acad Sci U S A 108: 1456-61 PubMed GONUTS page

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MOUSE:SHH

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