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MOUSE:S27A4

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Slc27a4 (synonyms: Acsvl4, Fatp4)
Protein Name(s) Long-chain fatty acid transport protein 4

FATP-4 Fatty acid transport protein 4 Solute carrier family 27 member 4

External Links
UniProt Q91VE0
EMBL AJ251113
AJ276492
AK036919
AK155388
AK170377
CT010312
BC023114
AF072759
CCDS CCDS15858.1
RefSeq NP_036119.1
UniGene Mm.330113
ProteinModelPortal Q91VE0
BioGrid 205025
STRING 10090.ENSMUSP00000078971
SwissLipids SLP:000001141
TCDB 4.C.1.1.1
iPTMnet Q91VE0
PhosphoSitePlus Q91VE0
MaxQB Q91VE0
PaxDb Q91VE0
PeptideAtlas Q91VE0
PRIDE Q91VE0
Ensembl ENSMUST00000080065
GeneID 26569
KEGG mmu:26569
UCSC uc008jaf.1
CTD 10999
MGI MGI:1347347
eggNOG KOG1179
ENOG410XQ8T
GeneTree ENSGT00550000074420
HOGENOM HOG000044189
HOVERGEN HBG005642
InParanoid Q91VE0
KO K08745
OMA LTALWAY
OrthoDB EOG091G0B76
PhylomeDB Q91VE0
TreeFam TF313430
BRENDA 6.2.1.3
Reactome R-MMU-804914
PRO PR:Q91VE0
Proteomes UP000000589
Bgee ENSMUSG00000059316
Genevisible Q91VE0
GO GO:0031526
GO:0005783
GO:0005789
GO:0016021
GO:0016020
GO:0005902
GO:0005886
GO:0004467
GO:0000166
GO:0031957
GO:0006631
GO:0044539
GO:0001676
GO:0015909
GO:0001579
GO:0007584
GO:0043588
GO:0042760
GO:0000038
CDD cd05939
InterPro IPR025110
IPR020845
IPR000873
IPR030304
IPR022272
PANTHER PTHR43107:SF11
Pfam PF00501
PF13193
PROSITE PS00455

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0062003

negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity

PMID:23407971[1]

ECO:0000314

P

“As shown in Fig. 2C, synthesis of 11cROL in the cells decreased as FATP4 expression levels increased.”

UNIPROT name: S27A4 Organism: Mouse

complete
CACAO 13072

involved_in

GO:0044539

long-chain fatty acid import into cell

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002875544
UniProtKB:Q6P1M0

P

Seeded From UniProt

complete

involved_in

GO:0042760

very long-chain fatty acid catabolic process

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1347347
PANTHER:PTN002875544

P

Seeded From UniProt

complete

involved_in

GO:0007584

response to nutrient

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002875544
RGD:1307383

P

Seeded From UniProt

complete

part_of

GO:0005902

microvillus

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1347347
PANTHER:PTN002875544

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1347098
MGI:MGI:1347347
PANTHER:PTN000645414
RGD:620927
UniProtKB:Q6PCB7

C

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002875544
UniProtKB:Q6P1M0

C

Seeded From UniProt

complete

enables

GO:0005324

long-chain fatty acid transporter activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001945407
SGD:S000000245

F

Seeded From UniProt

complete

enables

GO:0004467

long-chain fatty acid-CoA ligase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1347098
MGI:MGI:1347099
MGI:MGI:1347347
PANTHER:PTN001945407
RGD:71103
UniProtKB:O14975
UniProtKB:O53551
UniProtKB:Q6P1M0

F

Seeded From UniProt

complete

involved_in

GO:0001579

medium-chain fatty acid transport

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1347347
PANTHER:PTN002875544

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0044539

long-chain fatty acid import into cell

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q6P1M0

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043588

skin development

PMID:17401141[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2445864

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043588

skin development

PMID:16354193[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2177426,MGI:MGI:2667329

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043588

skin development

PMID:12821645[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2667328

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042760

very long-chain fatty acid catabolic process

PMID:17522045[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0031957

very long-chain fatty acid-CoA ligase activity

PMID:15653672[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2667328

F

occurs_in:(EMAPA:16894)|occurs_in:(EMAPA:32874)|occurs_in:(EMAPA:17525)

Seeded From UniProt

complete

enables

GO:0031957

very long-chain fatty acid-CoA ligase activity

PMID:18258213[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0031957

very long-chain fatty acid-CoA ligase activity

PMID:17522045[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0031957

very long-chain fatty acid-CoA ligase activity

PMID:15653672[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0031526

brush border membrane

PMID:14512415[9]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:16058)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0015909

long-chain fatty acid transport

PMID:14512415[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2684501

P

  • occurs_in:(EMAPA:32874)
  • occurs_in:(CL:0000584)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0015909

long-chain fatty acid transport

PMID:10518211[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • occurs_in:(EMAPA:32764)
  • occurs_in:(CL:0000584)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006631

fatty acid metabolic process

PMID:18843142[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2445864

P

occurs_in:(EMAPA:35440)

Seeded From UniProt

complete

part_of

GO:0005902

microvillus

PMID:10518211[10]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:32764)

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:15496455[12]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q6P1M0

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:17062637[13]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:15496455[12]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004467

long-chain fatty acid-CoA ligase activity

PMID:17062637[13]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004467

long-chain fatty acid-CoA ligase activity

PMID:15653672[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004467

long-chain fatty acid-CoA ligase activity

PMID:11404000[14]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004467

long-chain fatty acid-CoA ligase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q6P1M0

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001676

long-chain fatty acid metabolic process

PMID:15653672[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001676

long-chain fatty acid metabolic process

PMID:11404000[14]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001676

long-chain fatty acid metabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q6P1M0

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001579

medium-chain fatty acid transport

PMID:18258213[8]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000000245
SGD:S000005844

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001579

medium-chain fatty acid transport

PMID:17062637[13]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000038

very long-chain fatty acid metabolic process

PMID:17401141[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2445864

P

occurs_in:(EMAPA:17528)|occurs_in:(EMAPA:17525)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000038

very long-chain fatty acid metabolic process

PMID:17522045[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000038

very long-chain fatty acid metabolic process

PMID:15653672[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007584

response to nutrient

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:G3V7V3
ensembl:ENSRNOP00000019500

P

Seeded From UniProt

complete

involved_in

GO:0044539

long-chain fatty acid import into cell

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6P1M0
ensembl:ENSP00000300456

P

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6P1M0
ensembl:ENSP00000300456

C

Seeded From UniProt

complete

enables

GO:0004467

long-chain fatty acid-CoA ligase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6P1M0
ensembl:ENSP00000300456

F

Seeded From UniProt

complete

involved_in

GO:0001676

long-chain fatty acid metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6P1M0
ensembl:ENSP00000300456

P

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000873

F

Seeded From UniProt

complete

enables

GO:0004467

long-chain fatty acid-CoA ligase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030304

F

Seeded From UniProt

complete

involved_in

GO:0015908

fatty acid transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030304

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030304

C

Seeded From UniProt

complete

enables

GO:0031957

very long-chain fatty acid-CoA ligase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030304

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:15464426[15]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004467

long-chain fatty acid-CoA ligase activity

PMID:15464426[15]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001676

long-chain fatty acid metabolic process

PMID:15464426[15]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0006629

lipid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0443

P

Seeded From UniProt

complete

involved_in

GO:0006869

lipid transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0445

P

Seeded From UniProt

complete

involved_in

GO:0006631

fatty acid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0276

P

Seeded From UniProt

complete

enables

GO:0016874

ligase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0436

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0097

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Li, S et al. (2013) Fatty acid transport protein 4 (FATP4) prevents light-induced degeneration of cone and rod photoreceptors by inhibiting RPE65 isomerase. J. Neurosci. 33 3178-89 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. 3.0 3.1 Moulson, CL et al. (2007) Keratinocyte-specific expression of fatty acid transport protein 4 rescues the wrinkle-free phenotype in Slc27a4/Fatp4 mutant mice. J. Biol. Chem. 282 15912-20 PubMed GONUTS page
  4. Herrmann, T et al. (2005) Disturbed epidermal structure in mice with temporally controlled fatp4 deficiency. J. Invest. Dermatol. 125 1228-35 PubMed GONUTS page
  5. Herrmann, T et al. (2003) Mice with targeted disruption of the fatty acid transport protein 4 (Fatp 4, Slc27a4) gene show features of lethal restrictive dermopathy. J. Cell Biol. 161 1105-15 PubMed GONUTS page
  6. 6.0 6.1 6.2 Jia, Z et al. (2007) Fatty acid transport protein 4 is the principal very long chain fatty acyl-CoA synthetase in skin fibroblasts. J. Biol. Chem. 282 20573-83 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 7.4 Hall, AM et al. (2005) Enzymatic properties of purified murine fatty acid transport protein 4 and analysis of acyl-CoA synthetase activities in tissues from FATP4 null mice. J. Biol. Chem. 280 11948-54 PubMed GONUTS page
  8. 8.0 8.1 DiRusso, CC et al. (2008) Functional domains of the fatty acid transport proteins: studies using protein chimeras. Biochim. Biophys. Acta 1781 135-43 PubMed GONUTS page
  9. 9.0 9.1 Gimeno, RE et al. (2003) Targeted deletion of fatty acid transport protein-4 results in early embryonic lethality. J. Biol. Chem. 278 49512-6 PubMed GONUTS page
  10. 10.0 10.1 Stahl, A et al. (1999) Identification of the major intestinal fatty acid transport protein. Mol. Cell 4 299-308 PubMed GONUTS page
  11. Shim, J et al. (2009) Fatty acid transport protein 4 is dispensable for intestinal lipid absorption in mice. J. Lipid Res. 50 491-500 PubMed GONUTS page
  12. 12.0 12.1 Pohl, J et al. (2005) FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts. Mol. Biol. Cell 16 24-31 PubMed GONUTS page
  13. 13.0 13.1 13.2 Milger, K et al. (2006) Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4. J. Cell. Sci. 119 4678-88 PubMed GONUTS page
  14. 14.0 14.1 Herrmann, T et al. (2001) Mouse fatty acid transport protein 4 (FATP4): characterization of the gene and functional assessment as a very long chain acyl-CoA synthetase. Gene 270 31-40 PubMed GONUTS page
  15. 15.0 15.1 15.2 Jia, Z et al. () X-linked adrenoleukodystrophy: role of very long-chain acyl-CoA synthetases. Mol. Genet. Metab. 83 117-27 PubMed GONUTS page