MOUSE:RGS2

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Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Rgs2
Protein Name(s)	Regulator of G-protein signaling 2 RGS2
External Links
UniProt Identifier	RGS2_MOUSE
UniProt Accessions	O08849, Q544S7, Q91WX1, Q9JL24,
EMBL	U67187, AF215668, AF432916, AK031603, AK077922, AK162276, BC023001,
RefSeq	NP_033087.2,
Ensembl	ENSMUST00000127206,
Pfam	PF00615,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0005634	nucleus		TAS: Traceable Author Statement		C	Source: MGI
	GO:0005096	GTPase activator activity		TAS: Traceable Author Statement		F	Source: MGI
	GO:0004871	signal transducer activity		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0050873	brown fat cell differentiation		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0007049	cell cycle		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0007186	G-protein coupled receptor protein signalin...		TAS: Traceable Author Statement		P	Source: MGI
	GO:0009968	negative regulation of signal transduction		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0007283	spermatogenesis		IEP: Inferred from Expression Pattern		P	Source: BHF-UCL
	GO:0004871	signal transducer activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000342	F
	GO:0005096	GTPase activator activity	GO_REF:0000033	ISS: Inferred from Sequence or Structural Similarity	PANTHER:PTHR10845	F
	GO:0005096	GTPase activator activity	PMID:11342430^[1]	TAS: Traceable Author Statement		F
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	PMID:11342430^[1]	TAS: Traceable Author Statement		C
	GO:0005730	nucleolus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0188	C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005737	cytoplasm	GO_REF:0000033	ISS: Inferred from Sequence or Structural Similarity	PANTHER:PTHR10845	C
	GO:0005829	cytosol	PMID:19127022^[2]	IMP: Inferred from Mutant Phenotype		C
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0005886	plasma membrane	GO_REF:0000033	ISS: Inferred from Sequence or Structural Similarity	PANTHER:PTHR10845	C
	GO:0005886	plasma membrane	PMID:19127022^[2]	IMP: Inferred from Mutant Phenotype		C
	GO:0006417	regulation of translation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0810	P
	GO:0007049	cell cycle	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0131	P
	GO:0007165	signal transduction	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000342	P
	GO:0007186	G-protein coupled receptor protein signaling pathway	PMID:11342430^[1]	TAS: Traceable Author Statement		P
	GO:0007283	spermatogenesis	PMID:14581517^[3]	IEP: Inferred from Expression Pattern		P
	GO:0009898	internal side of plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000005156	C
	GO:0009898	internal side of plasma membrane	PMID:21291891^[4]	IDA: Inferred from Direct Assay		C
	GO:0009968	negative regulation of signal transduction	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0734	P
	GO:0010519	negative regulation of phospholipase activity	PMID:19127022^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0010614	negative regulation of cardiac muscle hypertrophy	PMID:19127022^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0043407	negative regulation of MAP kinase activity	PMID:19127022^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0043547	positive regulation of GTPase activity	GO_REF:0000033	ISS: Inferred from Sequence or Structural Similarity	PANTHER:PTHR10845	P
	GO:0043547	positive regulation of GTPase activity	PMID:11342430^[1]	TAS: Traceable Author Statement		P
	GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway	PMID:19127022^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0050873	brown fat cell differentiation	PMID:18492766^[5]	IDA: Inferred from Direct Assay		P
	GO:0055119	relaxation of cardiac muscle	PMID:19127022^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0060452	positive regulation of cardiac muscle contraction	PMID:19127022^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0060452	positive regulation of cardiac muscle contraction	PMID:21291891^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0071877	regulation of adrenergic receptor signaling pathway	PMID:21291891^[4]	IMP: Inferred from Mutant Phenotype		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Nagata Y et al. (2001) A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes. Blood 97: 3051-60 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Takimoto E et al. (2009) Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice. J Clin Invest 119: 408-20 PubMed GONUTS page
↑ Pang AL et al. (2003) Identification of differentially expressed genes in mouse spermatogenesis. J Androl 24: 899-911 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Chakir K et al. (2011) RGS2 is a primary terminator of β₂-adrenergic receptor-mediated G(i) signaling. J Mol Cell Cardiol 50: 1000-7 PubMed GONUTS page
↑ Wu Y & Smas CM (2008) Wdnm1-like, a new adipokine with a role in MMP-2 activation. Am J Physiol Endocrinol Metab 295: E205-15 PubMed GONUTS page

[PMID:11342430-0] 1.0 ^1.1 ^1.2 ^1.3 Nagata Y et al. (2001) A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes. Blood 97: 3051-60 PubMed GONUTS page

[PMID:19127022-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Takimoto E et al. (2009) Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice. J Clin Invest 119: 408-20 PubMed GONUTS page

[PMID:14581517-2] Pang AL et al. (2003) Identification of differentially expressed genes in mouse spermatogenesis. J Androl 24: 899-911 PubMed GONUTS page

[PMID:21291891-3] 4.0 ^4.1 ^4.2 Chakir K et al. (2011) RGS2 is a primary terminator of β₂-adrenergic receptor-mediated G(i) signaling. J Mol Cell Cardiol 50: 1000-7 PubMed GONUTS page

[PMID:18492766-4] Wu Y & Smas CM (2008) Wdnm1-like, a new adipokine with a role in MMP-2 activation. Am J Physiol Endocrinol Metab 295: E205-15 PubMed GONUTS page

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MOUSE:RGS2

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