MOUSE:RET

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Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Ret
Protein Name(s)	Proto-oncogene tyrosine-protein kinase receptor Ret Proto-oncogene c-Ret
External Links
UniProt Identifier	RET_MOUSE
UniProt Accessions	P35546, Q8BQ34, Q9QXH9,
EMBL	X67812, AF209436, AY326397, AK051633, BC059012,
PIR	I48735,
RefSeq	NP_001074249.1, NP_033076.2,
PDB	1UEF,
Ensembl	ENSMUST00000032201, ENSMUST00000088790,
Pfam	PF00028, PF07714,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0016021	integral to membrane		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-KW
	GO:0005524	ATP binding		IEA: Inferred from Electronic Annotation		F	Source: UniProtKB-KW
	GO:0005509	calcium ion binding		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0005515	protein binding		IPI: Inferred from Physical Interaction		F	Source: MGI
	GO:0004714	transmembrane receptor protein tyrosine kin...		TAS: Traceable Author Statement		F	Source: MGI
	GO:0001838	embryonic epithelial tube formation		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0048484	enteric nervous system development		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0007156	homophilic cell adhesion		IEA: Inferred from Electronic Annotation		P	Source: InterPro
	GO:0000165	MAPKKK cascade		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0001755	neural crest cell migration		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0042551	neuron maturation		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0006468	protein amino acid phosphorylation		IEA: Inferred from Electronic Annotation		P	Source: InterPro
	GO:0007169	transmembrane receptor protein tyrosine kin...		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0001657	ureteric bud development		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0000165	MAPKKK cascade	PMID:15569713^[1]	IGI: Inferred from Genetic Interaction	MGI:MGI:1930016	P
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0001657	ureteric bud development	PMID:12195422^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2136894	P
	GO:0001755	neural crest cell migration	PMID:15242795^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2449909	P
	GO:0001838	embryonic epithelial tube formation	PMID:15569713^[1]	IDA: Inferred from Direct Assay		P
	GO:0001838	embryonic epithelial tube formation	PMID:15569713^[1]	IGI: Inferred from Genetic Interaction	MGI:MGI:1930016	P
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001245	F
	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008266	F
	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020635	F
	GO:0004713	protein tyrosine kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0829	F
	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:2.7.10.1	F
	GO:0004714	transmembrane receptor protein tyrosine kinase activity	PMID:11731455^[4]	TAS: Traceable Author Statement		F
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002126	F
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015919	F
	GO:0005515	protein binding	PMID:15204970^[5]	IPI: Inferred from Physical Interaction	UniProtKB:O35118	F
	GO:0005515	protein binding	PMID:15569713^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q9JJZ3	F
	GO:0005515	protein binding	PMID:9452475^[6]	IPI: Inferred from Physical Interaction	UniProtKB:O35118	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017441	F
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001245	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008266	P
	GO:0007156	homophilic cell adhesion	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002126	P
	GO:0007399	nervous system development	PMID:11069590^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2136894	P
	GO:0009653	anatomical structure morphogenesis	PMID:11731455^[4]	TAS: Traceable Author Statement		P
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002126	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015919	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016020	membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0162	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0016301	kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	F
	GO:0016310	phosphorylation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	P
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F
	GO:0016772	transferase activity, transferring phosphorus-containing groups	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F
	GO:0042551	neuron maturation	PMID:15233745^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2136894	P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:17047028^[9]	IMP: Inferred from Mutant Phenotype		P
	GO:0048484	enteric nervous system development	PMID:9834195^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2136894	P
	GO:0072300	positive regulation of metanephric glomerulus development	PMID:17047028^[9]	IMP: Inferred from Mutant Phenotype		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Schuetz G et al. (2004) The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells. J Cell Biol 167: 945-52 PubMed GONUTS page
↑ Batourina E et al. (2002) Distal ureter morphogenesis depends on epithelial cell remodeling mediated by vitamin A and Ret. Nat Genet 32: 109-15 PubMed GONUTS page
↑ Yan H et al. (2004) Neural cells in the esophagus respond to glial cell line-derived neurotrophic factor and neurturin, and are RET-dependent. Dev Biol 272: 118-33 PubMed GONUTS page
↑ ^4.0 ^4.1 Brophy PD et al. (2001) Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene. Development 128: 4747-56 PubMed GONUTS page
↑ Bolon B et al. (2004) The candidate neuroprotective agent artemin induces autonomic neural dysplasia without preventing peripheral nerve dysfunction. Toxicol Pathol 32: 275-94 PubMed GONUTS page
↑ Worby CA et al. (1998) Identification and characterization of GFRalpha-3, a novel Co-receptor belonging to the glial cell line-derived neurotrophic receptor family. J Biol Chem 273: 3502-8 PubMed GONUTS page
↑ Rossi J et al. (2000) Distinct roles for GFRalpha1 and GFRalpha2 signalling in different cranial parasympathetic ganglia in vivo. Eur J Neurosci 12: 3944-52 PubMed GONUTS page
↑ Burau K et al. (2004) c-ret regulates cholinergic properties in mouse sympathetic neurons: evidence from mutant mice. Eur J Neurosci 20: 353-62 PubMed GONUTS page
↑ ^9.0 ^9.1 Clarke JC et al. (2006) Regulation of c-Ret in the developing kidney is responsive to Pax2 gene dosage. Hum Mol Genet 15: 3420-8 PubMed GONUTS page
↑ Natarajan D et al. (1999) Multipotential progenitors of the mammalian enteric nervous system capable of colonising aganglionic bowel in organ culture. Development 126: 157-68 PubMed GONUTS page

[PMID:15569713-0] 1.0 ^1.1 ^1.2 ^1.3 Schuetz G et al. (2004) The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells. J Cell Biol 167: 945-52 PubMed GONUTS page

[PMID:12195422-1] Batourina E et al. (2002) Distal ureter morphogenesis depends on epithelial cell remodeling mediated by vitamin A and Ret. Nat Genet 32: 109-15 PubMed GONUTS page

[PMID:15242795-2] Yan H et al. (2004) Neural cells in the esophagus respond to glial cell line-derived neurotrophic factor and neurturin, and are RET-dependent. Dev Biol 272: 118-33 PubMed GONUTS page

[PMID:11731455-3] 4.0 ^4.1 Brophy PD et al. (2001) Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene. Development 128: 4747-56 PubMed GONUTS page

[PMID:15204970-4] Bolon B et al. (2004) The candidate neuroprotective agent artemin induces autonomic neural dysplasia without preventing peripheral nerve dysfunction. Toxicol Pathol 32: 275-94 PubMed GONUTS page

[PMID:9452475-5] Worby CA et al. (1998) Identification and characterization of GFRalpha-3, a novel Co-receptor belonging to the glial cell line-derived neurotrophic receptor family. J Biol Chem 273: 3502-8 PubMed GONUTS page

[PMID:11069590-6] Rossi J et al. (2000) Distinct roles for GFRalpha1 and GFRalpha2 signalling in different cranial parasympathetic ganglia in vivo. Eur J Neurosci 12: 3944-52 PubMed GONUTS page

[PMID:15233745-7] Burau K et al. (2004) c-ret regulates cholinergic properties in mouse sympathetic neurons: evidence from mutant mice. Eur J Neurosci 20: 353-62 PubMed GONUTS page

[PMID:17047028-8] 9.0 ^9.1 Clarke JC et al. (2006) Regulation of c-Ret in the developing kidney is responsive to Pax2 gene dosage. Hum Mol Genet 15: 3420-8 PubMed GONUTS page

[PMID:9834195-9] Natarajan D et al. (1999) Multipotential progenitors of the mammalian enteric nervous system capable of colonising aganglionic bowel in organ culture. Development 126: 157-68 PubMed GONUTS page

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MOUSE:RET

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