Have any questions? Please email us at ecoliwiki@gmail.com

MOUSE:RET

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Ret
Protein Name(s) Proto-oncogene tyrosine-protein kinase receptor Ret

Proto-oncogene c-Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment

External Links
UniProt P35546
EMBL X67812
AF209436
AY326397
AK051633
BC059012
CCDS CCDS20470.1
CCDS39608.1
PIR I48735
RefSeq NP_001074249.1
NP_033076.2
UniGene Mm.57199
PDB 1UEF
PDBsum 1UEF
ProteinModelPortal P35546
SMR P35546
BioGrid 202865
IntAct P35546
MINT MINT-5313433
BindingDB P35546
ChEMBL CHEMBL2034799
PhosphoSite P35546
MaxQB P35546
PRIDE P35546
Ensembl ENSMUST00000032201
ENSMUST00000088790
GeneID 19713
KEGG mmu:19713
UCSC uc009dlm.1
uc009dln.1
CTD 5979
MGI MGI:97902
eggNOG COG0515
GeneTree ENSGT00760000118923
HOGENOM HOG000010301
HOVERGEN HBG002609
InParanoid P35546
KO K05126
OMA SMENQVS
OrthoDB EOG7NGQ9N
PhylomeDB P35546
TreeFam TF317640
BRENDA 2.7.10.1
EvolutionaryTrace P35546
NextBio 297098
PRO PR:P35546
Proteomes UP000000589
Bgee P35546
CleanEx MM_RET
Genevestigator P35546
GO GO:0010008
GO:0005887
GO:0045121
GO:0043235
GO:0005524
GO:0005509
GO:0004714
GO:0006919
GO:0009653
GO:0071300
GO:0001838
GO:0048484
GO:0007156
GO:0060384
GO:0000165
GO:0033619
GO:0007399
GO:0001755
GO:0007158
GO:0030182
GO:0042551
GO:0018108
GO:0061146
GO:0033630
GO:0030335
GO:0045793
GO:2001241
GO:0072300
GO:0014042
GO:0010976
GO:0045893
GO:0050770
GO:0042493
GO:0048265
GO:0060041
GO:0007169
GO:0035799
GO:0001657
Gene3D 2.60.40.60
InterPro IPR002126
IPR015919
IPR011009
IPR000719
IPR017441
IPR001245
IPR008266
IPR020635
IPR016249
Pfam PF00028
PF07714
PIRSF PIRSF000631
PRINTS PR00109
SMART SM00112
SM00219
SUPFAM SSF49313
SSF56112
PROSITE PS50268
PS00107
PS50011
PS00109

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000165

MAPKKK cascade

PMID:15569713[1]

IGI: Inferred from Genetic Interaction

MGI:MGI:1930016

P

complete

GO:0000166

nucleotide binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

complete

GO:0001657

ureteric bud development

PMID:12195422[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2136894

P

complete

GO:0001755

neural crest cell migration

PMID:15242795[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2449909

P

complete

GO:0001838

embryonic epithelial tube formation

PMID:15569713[1]

IDA: Inferred from Direct Assay

P

complete

GO:0001838

embryonic epithelial tube formation

PMID:15569713[1]

IGI: Inferred from Genetic Interaction

MGI:MGI:1930016

P

complete

GO:0004672

protein kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719

F

complete

GO:0004672

protein kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001245

F

complete

GO:0004713

protein tyrosine kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008266

F

complete

GO:0004713

protein tyrosine kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020635

F

complete

GO:0004713

protein tyrosine kinase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0829

F

complete

GO:0004714

transmembrane receptor protein tyrosine kinase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.7.10.1

F

complete

GO:0004714

transmembrane receptor protein tyrosine kinase activity

PMID:11731455[4]

TAS: Traceable Author Statement

F

complete

GO:0005509

calcium ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002126

F

complete

GO:0005509

calcium ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015919

F

complete

GO:0005515

protein binding

PMID:15204970[5]

IPI: Inferred from Physical Interaction

UniProtKB:O35118

F

complete

GO:0005515

protein binding

PMID:15569713[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q9JJZ3

F

complete

GO:0005515

protein binding

PMID:9452475[6]

IPI: Inferred from Physical Interaction

UniProtKB:O35118

F

complete

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719

F

complete

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017441

F

complete

GO:0005524

ATP binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

complete

GO:0006468

protein phosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719

P

complete

GO:0006468

protein phosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001245

P

complete

GO:0006468

protein phosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008266

P

complete

GO:0007156

homophilic cell adhesion

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002126

P

complete

GO:0007399

nervous system development

PMID:11069590[7]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2136894

P

complete

GO:0009653

anatomical structure morphogenesis

PMID:11731455[4]

TAS: Traceable Author Statement

P

complete

GO:0016020

membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002126

C

complete

GO:0016020

membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015919

C

complete

GO:0016020

membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

complete

GO:0016020

membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0162

C

complete

GO:0016021

integral to membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

complete

GO:0016301

kinase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0418

F

complete

GO:0016310

phosphorylation

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0418

P

complete

GO:0016740

transferase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0808

F

complete

GO:0016772

transferase activity, transferring phosphorus-containing groups

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011009

F

complete

GO:0042551

neuron maturation

PMID:15233745[8]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2136894

P

complete

GO:0045893

positive regulation of transcription, DNA-dependent

PMID:17047028[9]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0048484

enteric nervous system development

PMID:9834195[10]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2136894

P

complete

GO:0072300

positive regulation of metanephric glomerulus development

PMID:17047028[9]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0033690

positive regulation of osteoblast proliferation

PMID:23969857[11]

IDA: Inferred from Direct Assay

P

Fig. 1B

complete
CACAO 8625

GO:0043066

negative regulation of apoptotic process

PMID:23969857[11]

IDA: Inferred from Direct Assay

P

Fig. 1G

complete
CACAO 8647

GO:0000165

MAPK cascade

PMID:15569713[1]

IGI: Inferred from Genetic Interaction

MGI:MGI:1930016

P

Seeded From UniProt

complete

GO:0000166

nucleotide binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

GO:0001657

ureteric bud development

PMID:12195422[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2136894

P

Seeded From UniProt

complete

GO:0001755

neural crest cell migration

PMID:15242795[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2449909

P

Seeded From UniProt

complete

GO:0001838

embryonic epithelial tube formation

PMID:15569713[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0001838

embryonic epithelial tube formation

PMID:15569713[1]

IGI: Inferred from Genetic Interaction

MGI:MGI:1930016

P

Seeded From UniProt

complete

GO:0004672

protein kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR008266

F

Seeded From UniProt

complete

GO:0004713

protein tyrosine kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020635

F

Seeded From UniProt

complete

GO:0004713

protein tyrosine kinase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0829

F

Seeded From UniProt

complete

GO:0004714

transmembrane receptor protein tyrosine kinase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.7.10.1

F

Seeded From UniProt

complete

GO:0004714

transmembrane receptor protein tyrosine kinase activity

PMID:11731455[4]

TAS: Traceable Author Statement

F

Seeded From UniProt

complete

GO:0005509

calcium ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002126
InterPro:IPR015919

F

Seeded From UniProt

complete

GO:0005509

calcium ion binding

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:P07949

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:15204970[5]

IPI: Inferred from Physical Interaction

UniProtKB:O35118

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:22304922[12]

IPI: Inferred from Physical Interaction

UniProtKB:Q60629

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:9452475[6]

IPI: Inferred from Physical Interaction

UniProtKB:O35118

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR017441

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000347942

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:P07949

C

Seeded From UniProt

complete

GO:0005768

endosome

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0967

C

Seeded From UniProt

complete

GO:0005769

early endosome

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000047793

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000347942

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-1003

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:P07949

C

Seeded From UniProt

complete

GO:0005887

integral component of plasma membrane

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000347942

C

Seeded From UniProt

complete

GO:0005887

integral component of plasma membrane

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:P07949

C

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR008266
InterPro:IPR020635

P

Seeded From UniProt

complete

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000347942

P

Seeded From UniProt

complete

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:P07949

P

Seeded From UniProt

complete

GO:0007155

cell adhesion

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0130

P

Seeded From UniProt

complete

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002126

P

Seeded From UniProt

complete

GO:0007158

neuron cell-cell adhesion

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000347942

P

Seeded From UniProt

complete

GO:0007158

neuron cell-cell adhesion

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:P07949

P

Seeded From UniProt

complete

GO:0007158

neuron cell-cell adhesion

PMID:21357690[13]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

PMID:9576965[14]

IGI: Inferred from Genetic Interaction

MGI:MGI:108417
MGI:MGI:1195462

P

Seeded From UniProt

complete

GO:0007399

nervous system development

PMID:11069590[7]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2136894

P

Seeded From UniProt

complete

GO:0009653

anatomical structure morphogenesis

PMID:11731455[4]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0010008

endosome membrane

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000347942

C

Seeded From UniProt

complete

GO:0010008

endosome membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0100

C

Seeded From UniProt

complete

GO:0010008

endosome membrane

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:P07949

C

Seeded From UniProt

complete

GO:0010628

positive regulation of gene expression

PMID:22897442[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0010628

positive regulation of gene expression

PMID:22897442[15]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3819163

P

Seeded From UniProt

complete

GO:0010976

positive regulation of neuron projection development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000347942

P

Seeded From UniProt

complete

GO:0010976

positive regulation of neuron projection development

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:P07949

P

Seeded From UniProt

complete

GO:0014042

positive regulation of neuron maturation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000047793

P

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002126
InterPro:IPR015919

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

GO:0016301

kinase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

GO:0016310

phosphorylation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

GO:0016740

transferase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

GO:0018108

peptidyl-tyrosine phosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020635

P

Seeded From UniProt

complete

GO:0018108

peptidyl-tyrosine phosphorylation

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.7.10.1

P

Seeded From UniProt

complete

GO:0018108

peptidyl-tyrosine phosphorylation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0829

P

Seeded From UniProt

complete

GO:0018108

peptidyl-tyrosine phosphorylation

PMID:11731455[4]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0030155

regulation of cell adhesion

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000347942

P

Seeded From UniProt

complete

GO:0030155

regulation of cell adhesion

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:P07949

P

Seeded From UniProt

complete

GO:0030182

neuron differentiation

PMID:17553423[16]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2386570
MGI:MGI:4413350

P

Seeded From UniProt

complete

GO:0030335

positive regulation of cell migration

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000347942

P

Seeded From UniProt

complete

GO:0030335

positive regulation of cell migration

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:P07949

P

Seeded From UniProt

complete

GO:0030424

axon

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000047793

C

Seeded From UniProt

complete

GO:0030425

dendrite

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000047793

C

Seeded From UniProt

complete

GO:0033619

membrane protein proteolysis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000347942

P

Seeded From UniProt

complete

GO:0033619

membrane protein proteolysis

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:P07949

P

Seeded From UniProt

complete

GO:0033630

positive regulation of cell adhesion mediated by integrin

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000347942

P

Seeded From UniProt

complete

GO:0033630

positive regulation of cell adhesion mediated by integrin

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:P07949

P

Seeded From UniProt

complete

GO:0035799

ureter maturation

PMID:21521737[17]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2136894

P

Seeded From UniProt

complete

GO:0042493

response to drug

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000047793

P

Seeded From UniProt

complete

GO:0042551

neuron maturation

PMID:15233745[8]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2136894

P

Seeded From UniProt

complete

GO:0043025

neuronal cell body

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000047793

C

Seeded From UniProt

complete

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000347942

C

Seeded From UniProt

complete

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:P07949

C

Seeded From UniProt

complete

GO:0043235

receptor complex

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000347942

C

Seeded From UniProt

complete

GO:0043235

receptor complex

PMID:23382219[18]

ISO: Inferred from Sequence Orthology

UniProtKB:P07949

C

Seeded From UniProt

complete

GO:0045121

membrane raft

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000047793

C

Seeded From UniProt

complete

GO:0045793

positive regulation of cell size

PMID:17553423[16]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2386570
MGI:MGI:4413350

P

Seeded From UniProt

complete

GO:0045893

positive regulation of transcription, DNA-templated

PMID:17047028[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048265

response to pain

PMID:20237269[19]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048484

enteric nervous system development

PMID:9834195[10]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2136894

P

Seeded From UniProt

complete

GO:0050770

regulation of axonogenesis

PMID:17553423[16]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2386570
MGI:MGI:4413350

P

Seeded From UniProt

complete

GO:0060041

retina development in camera-type eye

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000047793

P

Seeded From UniProt

complete

GO:0060384

innervation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000047793

P

Seeded From UniProt

complete

GO:0061146

Peyer's patch morphogenesis

PMID:17322904[20]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0071300

cellular response to retinoic acid

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000347942

P

Seeded From UniProt

complete

GO:0071300

cellular response to retinoic acid

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:P07949

P

Seeded From UniProt

complete

GO:0072300

positive regulation of metanephric glomerulus development

PMID:17047028[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:2001241

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000347942

P

Seeded From UniProt

complete

GO:2001241

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:P07949

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Schuetz, G et al. (2004) The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells. J. Cell Biol. 167 945-52 PubMed GONUTS page
  2. 2.0 2.1 Batourina, E et al. (2002) Distal ureter morphogenesis depends on epithelial cell remodeling mediated by vitamin A and Ret. Nat. Genet. 32 109-15 PubMed GONUTS page
  3. 3.0 3.1 Yan, H et al. (2004) Neural cells in the esophagus respond to glial cell line-derived neurotrophic factor and neurturin, and are RET-dependent. Dev. Biol. 272 118-33 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 Brophy, PD et al. (2001) Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene. Development 128 4747-56 PubMed GONUTS page
  5. 5.0 5.1 Bolon, B et al. () The candidate neuroprotective agent artemin induces autonomic neural dysplasia without preventing peripheral nerve dysfunction. Toxicol Pathol 32 275-94 PubMed GONUTS page
  6. 6.0 6.1 Worby, CA et al. (1998) Identification and characterization of GFRalpha-3, a novel Co-receptor belonging to the glial cell line-derived neurotrophic receptor family. J. Biol. Chem. 273 3502-8 PubMed GONUTS page
  7. 7.0 7.1 Rossi, J et al. (2000) Distinct roles for GFRalpha1 and GFRalpha2 signalling in different cranial parasympathetic ganglia in vivo. Eur. J. Neurosci. 12 3944-52 PubMed GONUTS page
  8. 8.0 8.1 Burau, K et al. (2004) c-ret regulates cholinergic properties in mouse sympathetic neurons: evidence from mutant mice. Eur. J. Neurosci. 20 353-62 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 Clarke, JC et al. (2006) Regulation of c-Ret in the developing kidney is responsive to Pax2 gene dosage. Hum. Mol. Genet. 15 3420-8 PubMed GONUTS page
  10. 10.0 10.1 Natarajan, D et al. (1999) Multipotential progenitors of the mammalian enteric nervous system capable of colonising aganglionic bowel in organ culture. Development 126 157-68 PubMed GONUTS page
  11. 11.0 11.1 Khedgikar, V et al. (2013) Withaferin A: a proteasomal inhibitor promotes healing after injury and exerts anabolic effect on osteoporotic bone. Cell Death Dis 4 e778 PubMed GONUTS page
  12. Bonanomi, D et al. (2012) Ret is a multifunctional coreceptor that integrates diffusible- and contact-axon guidance signals. Cell 148 568-82 PubMed GONUTS page
  13. Cabrera, JR et al. (2011) RET modulates cell adhesion via its cleavage by caspase in sympathetic neurons. J. Biol. Chem. 286 14628-38 PubMed GONUTS page
  14. Baloh, RH et al. (1998) GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family. Proc. Natl. Acad. Sci. U.S.A. 95 5801-6 PubMed GONUTS page
  15. 15.0 15.1 Evangelisti, C et al. (2012) Apolipoprotein B is a new target of the GDNF/RET and ET-3/EDNRB signalling pathways. Neurogastroenterol. Motil. 24 e497-508 PubMed GONUTS page
  16. 16.0 16.1 16.2 Luo, W et al. (2007) A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron 54 739-54 PubMed GONUTS page
  17. Chia, I et al. (2011) Nephric duct insertion is a crucial step in urinary tract maturation that is regulated by a Gata3-Raldh2-Ret molecular network in mice. Development 138 2089-97 PubMed GONUTS page
  18. Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page
  19. Golden, JP et al. (2010) RET signaling is required for survival and normal function of nonpeptidergic nociceptors. J. Neurosci. 30 3983-94 PubMed GONUTS page
  20. Veiga-Fernandes, H et al. (2007) Tyrosine kinase receptor RET is a key regulator of Peyer's patch organogenesis. Nature 446 547-51 PubMed GONUTS page