MOUSE:RELN

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Species (Taxon ID)	Mus musculus (Mouse). ([1])
Gene Name(s)	Reln (synonyms: Rl)
Protein Name(s)	Reelin Reeler protein
External Links
EMBL	U24703 AC113028 AC116404 AC119906 AC121878 D63520 AK017094
IPI	IPI00121421 IPI00230330 IPI01008135
PIR	S58870
RefSeq	NP_035391.2
UniGene	Mm.425236
PDB	2DDU 2E26 3A7Q
PDBsum	2DDU 2E26 3A7Q
ProteinModelPortal	Q60841
STRING	Q60841
PhosphoSite	Q60841
PRIDE	Q60841
Ensembl	ENSMUST00000062372 ENSMUST00000115152 ENSMUST00000161356
GeneID	19699
KEGG	mmu:19699
UCSC	uc008wpi.1
CTD	5649
MGI	MGI:103022
HOGENOM	HBG358144
HOVERGEN	HBG023117
InParanoid	Q60841
OrthoDB	EOG4GB757
NextBio	297056
ArrayExpress	Q60841
Bgee	Q60841
CleanEx	MM_RELN
Genevestigator	Q60841
GermOnline	ENSMUSG00000042453
GO	GO:0005737 GO:0030425 GO:0005615 GO:0005578 GO:0046872 GO:0004712 GO:0008236 GO:0007411 GO:0007155 GO:0021800 GO:0016358 GO:0010001 GO:0001764 GO:0018108 GO:0045860 GO:0051057 GO:0048265 GO:0021511 GO:0021517
InterPro	IPR002860 IPR006210 IPR013032 IPR000742 IPR013111 IPR011040 IPR002861
Gene3D	G3DSA:2.120.10.10
Pfam	PF02012 PF07974 PF02014
SMART	SM00181
SUPFAM	SSF50939
PROSITE	PS00022 PS01186 PS50026 PS51019

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000904	cell morphogenesis involved in differentiation	PMID:12925587^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856398	P	Seeded From UniProt
	GO:0001764	neuron migration	PMID:12223565^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856398	P	Seeded From UniProt
	GO:0001764	neuron migration	PMID:12724835^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856398	P	Seeded From UniProt
	GO:0001764	neuron migration	PMID:14980731^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856398	P	Seeded From UniProt
	GO:0001764	neuron migration	PMID:15703280^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856416	P	Seeded From UniProt
	GO:0001764	neuron migration	PMID:20711475^[6]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0004712	protein serine/threonine/tyrosine kinase activity	PMID:17330141^[7]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C	Seeded From UniProt
	GO:0005578	proteinaceous extracellular matrix	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0272	C	Seeded From UniProt
	GO:0005578	proteinaceous extracellular matrix	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0111	C	Seeded From UniProt
	GO:0005578	proteinaceous extracellular matrix	PMID:11900467^[8]	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005615	extracellular space	PMID:12526740^[9]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005615	extracellular space	PMID:12724835^[3]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005737	cytoplasm	PMID:15525772^[10]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0006508	proteolysis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0645	P	Seeded From UniProt
	GO:0007155	cell adhesion	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0130	P	Seeded From UniProt
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P	Seeded From UniProt
	GO:0007411	axon guidance	PMID:16324103^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856398	P	Seeded From UniProt
	GO:0007417	central nervous system development	PMID:11900467^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856398	P	Seeded From UniProt
	GO:0007420	brain development	PMID:12223565^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856398	P	Seeded From UniProt
	GO:0008233	peptidase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0645	F	Seeded From UniProt
	GO:0008236	serine-type peptidase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0720	F	Seeded From UniProt
	GO:0010001	glial cell differentiation	PMID:12925587^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856398	P	Seeded From UniProt
	GO:0016358	dendrite development	PMID:14715136^[12]	IGI: Inferred from Genetic Interaction	MGI:MGI:108554	P	Seeded From UniProt
	GO:0016358	dendrite development	PMID:14715136^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856398	P	Seeded From UniProt
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F	Seeded From UniProt
	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:12526740^[9]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0021511	spinal cord patterning	PMID:16580148^[13]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856398	P	Seeded From UniProt
	GO:0021517	ventral spinal cord development	PMID:20711475^[6]	IEP: Inferred from Expression Pattern		P	Seeded From UniProt
	GO:0021800	cerebral cortex tangential migration	PMID:16901480^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856398	P	Seeded From UniProt
	GO:0030425	dendrite	PMID:15677725^[15]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0045860	positive regulation of protein kinase activity	PMID:12526740^[9]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F	Seeded From UniProt
	GO:0048265	response to pain	PMID:16580148^[13]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1856398	P	Seeded From UniProt
	GO:0051057	positive regulation of small GTPase mediated signal transduction	PMID:15062102^[16]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0061003	positive regulation of dendritic spine morphogenesis	PMID:21664258^[17]	IMP: Inferred from Mutant Phenotype		P	Heterozygous reelin (reeler) mice, figure 1C, D show decrease in dendritic spine density compared to wild type mice.	complete
	GO:0035418	protein localization to synapse	PMID:21664258^[17]	IMP: Inferred from Mutant Phenotype		P	Decrease in PSD-95 protein in PSD fraction in heterozygous reelin (reeler) mice, figure 2A. Also figure2C shows reduced PSD-95 postsynaptic levels in mutant mice compared to wild type.	complete
	GO:0097119	postsynaptic density protein 95 clustering	PMID:21664258^[17]	IMP: Inferred from Mutant Phenotype		P	Decrease in PSD-95 protein in PSD fraction in heterozygous reelin (reeler) mice, figure 2A. Also figure2C shows reduced PSD-95 postsynaptic levels in mutant mice compared to wild type.	complete
	GO:0097114	N-methyl-D-aspartate receptor clustering	PMID:21664258^[17]	IMP: Inferred from Mutant Phenotype		P	Figure 3A and C show decrease levels of NR2A and NR2B subunits of NMDA receptors in PSD fraction of heterozygous reelin (reeler) mice compared to wild type. The low level of the NMDA receptors are not due to low protein levels therefore the receptors did not cluster at the postsynaptic membrane (figure 3B).	complete
	GO:0097120	receptor localization to synapse	PMID:21664258^[17]	IMP: Inferred from Mutant Phenotype		P	Figure 3A and C show decrease levels of NR2A and NR2B subunits of NMDA receptors in PSD fraction of heterozygous reelin (reeler) mice compared to wild type. The low level of the NMDA receptors are not due to low protein levels therefore the receptors did not cluster at the postsynaptic membrane (figure 3B).	complete
	GO:0014068	positive regulation of phosphatidylinositol 3-kinase cascade	PMID:21664258^[17]	IDA: Inferred from Direct Assay		P	Figure 4B recombinant reelin in wild type mice resulted in increase Akt phosphorylation which is dependent of SFK (scr-family kinase) and PI3K pathways.	complete
	GO:0061098	positive regulation of protein tyrosine kinase activity	PMID:21852430^[18]	IMP: Inferred from Mutant Phenotype		P	Figure 2: wild type mice injected with reelin in hippocampus increase Dab1 phosphorylation by inducing Src family tyrosin kinases. A possible new GO term can be 'regulation of Src family tyrosin kinase' as child term for regulation of protein tyrosine kinase activity. Then another child term for 'regulation of Src family tyrosin kinase' can be 'positive regulation of Src family tyrosin kinase'.	complete
	GO:0032793	positive regulation of CREB transcription factor activity	PMID:21852430^[18]	IMP: Inferred from Mutant Phenotype		P	Figure 3: when reelin was injected in the CA1 and CA3 phosphorylation levels of CREB. Therefore there is a increase in active CREB when reelin is injected.	complete
	GO:0061003	positive regulation of dendritic spine morphogenesis	PMID:21852430^[18]	IMP: Inferred from Mutant Phenotype		P	Figure 4: spine density formation determined when reelin is injected. Spine density increased.	complete
	GO:0060291	long-term synaptic potentiation	PMID:21852430^[18]	IMP: Inferred from Mutant Phenotype		P	Figure 6A and B, reelin injected in mice showed enhanced theta-burst stimulation induced LTP. A new child term for long-term synaptic potentiation can be theta-burst long-term synaptic potentiation	complete
	GO:0007612	learning	PMID:21852430^[18]	IMP: Inferred from Mutant Phenotype		P	Hidden platform water maze Figure 8A: reelin injected mice showed less time to find the hidden platform during training days compared to mice not treated with reelin. A new GO term can be spatial learning as a child term of learning.	complete
	GO:0007616	long-term memory	PMID:21852430^[18]	IMP: Inferred from Mutant Phenotype		P	Hidden platform water maze Figure 8C: reelin injected mice showed higher number of target quadrant entries compared to saline injected mice on day 5 therefore this shows that reelin mice show enhanced memory retention of platform location. The reason I show long term memory because part of the definition include “this type of memory is typically dependent on gene transcription regulated by second messenger activation.” Therefore from figure 3 we see an increase in CREB phosphorylation which is involved in memory and learning.	complete
	GO:0008306	associative learning	PMID:21852430^[18]	IMP: Inferred from Mutant Phenotype		P	Examined hippocampal-dependent associative fear conditioned fear and memory but using a standard two shock protocol. Mice were tested for freezing to the context after 1, 24, 72h training, therefore mice injected with reelin showed enhanced context dependent freezing at 24h and 72h (figure 9) compared to control therefore showed enhanced associative learning. A new GO term as a child term for associative learning can be ‘fear associative learning’	complete
	GO:0045475	locomotor rhythm	PMID:21814183^[19]	IMP: Inferred from Mutant Phenotype		P	CAMKII-alpha promoter overexpression of reelin. Open field test, Figure 2C overexpression reelin in mice showed increase locomotor activity in the dark phase of their circadian rhythm compared to wild type.	complete
	GO:0080134	regulation of response to stress	PMID:21814183^[19]	IMP: Inferred from Mutant Phenotype		P	Figure 2G mice with overexpression of reelin showed less anxiety stress behaviour compared to wild type in black and white field task. Mice don’t like bright open area therefore they prefer to spend time in the dark, therefore mice with overexpression of reelin spend more time in the light area than the dark area compared to wild type mice To measure stress response in mice with overexpression of Reelin compared to control, corticosterone was given to wild type in forced swim task. Time spent floating (showing helplessness) than swimming was measured. Wild type mice showed more floating than overexpression reelin mice therefore showing that overexpression reelin mice showed less helplessness than wild type. Indicating less chronic stress response in reelin overexpression mice figure 3A.	complete
	GO:0051968	positive regulation of synaptic transmission, glutamatergic	PMID:21814183^[19]	IMP: Inferred from Mutant Phenotype		P	Glutamatergic transmission was measured by electrophysiological recordings mice hippocampal neurons. NMDA mediated transmission was measured. There was increase in frequency EPSP response in reelin overexpression mice (figure 5a)	complete
	GO:2000463	positive regulation of excitatory postsynaptic membrane potential	PMID:21814183^[19]	IMP: Inferred from Mutant Phenotype		P	Glutamatergic transmission was measured by electrophysiological recordings mice hippocampal neurons. NMDA mediated transmission was measured. There was increase in frequency EPSP response in reelin overexpression mice (figure 5A).	complete
	GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity	PMID:21814183^[19]	IMP: Inferred from Mutant Phenotype		P	Three stimulus trains were used to evoke to examine synaptic activation of NMDA receptors. Wild type showed reduced NMDA receptor mediated fEPSP compared to reelin overexpression mice figure 5B. Possibly as new GO term can be positive regulation of N-methyl-D-aspartate selective glutamate receptor activity.	complete
	GO:2000463	positive regulation of excitatory postsynaptic membrane potential	PMID:17229826^[20]	IMP: Inferred from Mutant Phenotype		P	Mouse CA1 pyramidal neurons used to record spontaneous miniature activities and whole cell response. Cells treated with Reelin increased spontaneous mEPSC amplitude which was blocked by a antagonist (figure 1A-C) Figure 6F shows a reduced amplitude of AMPA receptor mediated mEPSC when not treated with reelin. Therefore treatment with reelin rescues mutant reelin (reeler) mice.	complete
	GO:0051968	positive regulation of synaptic transmission, glutamatergic	PMID:17229826^[20]	IMP: Inferred from Mutant Phenotype		P	Mouse CA1 pyramidal neurons used to record spontaneous miniature activities and whole cell response. Cells treated with reelin increased spontaneous mEPSC amplitude which was not seen when blocked by a antagonist (figure 1A-C). In addition figure 2B shows current ratio of AMPA/NMDA. Cells treated with reelin showed high ratio compared to cell not treated with Reelin.	complete
	GO:2000969	positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	PMID:17229826^[20]	IMP: Inferred from Mutant Phenotype		P	Mouse CA1 pyramidal neurons used to record spontaneous miniature activities and whole cell response. Cells treated with reelin increased spontaneous mEPSC amplitude which was not seen when blocked by a antagonist (figure 1A-C). In addition figure 2B shows current ratio of AMPA/NMDA. Cells treated with eeelin showed high ratio compared to cell not treated with reelin. Therefore enhances AMPA receptor function.	complete
	GO:0097113	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor clustering	PMID:17229826^[20]	IMP: Inferred from Mutant Phenotype		P	Figure 3 (A-C) cells treated with reelin showed increase levels of surface GluR1 compared to control.	complete
	GO:0097114	N-methyl-D-aspartate receptor clustering	PMID:17229826^[20]	IDA: Inferred from Direct Assay		P	Figure 3 (A-C) cells treated with reelin showed increase levels of surface NR2A compared to control.	complete
	GO:0090129	positive regulation of synapse maturation	PMID:17229826^[20]	IMP: Inferred from Mutant Phenotype		P	Figure 5A used antagonist to block Reelin activity, which increase the failure rate of functional synapse in CA1 hippocampus region of mice.	complete
	GO:0010976	positive regulation of neuron projection development	PMID:17229826^[20]	IMP: Inferred from Mutant Phenotype		P	In mice with mutation in the reelin gene there was stunted neurite growth but when treated with reelin the growth was corrected, figure 6A-C.	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Hartfuss E et al. (2003) Reelin signaling directly affects radial glia morphology and biochemical maturation. Development 130: 4597-609 PubMed GONUTS page
↑ ^2.0 ^2.1 Jensen P et al. (2002) Dissection of the cellular and molecular events that position cerebellar Purkinje cells: a study of the math1 null-mutant mouse. J Neurosci 22: 8110-6 PubMed GONUTS page
↑ ^3.0 ^3.1 Nishikawa S et al. (2003) Lack of Reelin causes malpositioning of nigral dopaminergic neurons: evidence from comparison of normal and Reln(rl) mutant mice. J Comp Neurol 461: 166-73 PubMed GONUTS page
↑ Hevner RF et al. (2004) Postnatal shifts of interneuron position in the neocortex of normal and reeler mice: evidence for inward radial migration. Neuroscience 124: 605-18 PubMed GONUTS page
↑ Rossel M et al. (2005) Reelin signaling is necessary for a specific step in the migration of hindbrain efferent neurons. Development 132: 1175-85 PubMed GONUTS page
↑ ^6.0 ^6.1 Palmesino E et al. (2010) Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling. PLoS Biol 8: e1000446 PubMed GONUTS page
↑ Zhang G et al. (2007) The Pafah1b complex interacts with the reelin receptor VLDLR. PLoS One 2: e252 PubMed GONUTS page
↑ ^8.0 ^8.1 Phelps PE et al. (2002) Evidence for a cell-specific action of Reelin in the spinal cord. Dev Biol 244: 180-98 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Bock HH & Herz J (2003) Reelin activates SRC family tyrosine kinases in neurons. Curr Biol 13: 18-26 PubMed GONUTS page
↑ Meyer G et al. (2004) Developmental roles of p73 in Cajal-Retzius cells and cortical patterning. J Neurosci 24: 9878-87 PubMed GONUTS page
↑ Li HP et al. (2005) Aberrant trajectory of thalamocortical axons associated with abnormal localization of neurocan immunoreactivity in the cerebral neocortex of reeler mutant mice. Eur J Neurosci 22: 2689-96 PubMed GONUTS page
↑ ^12.0 ^12.1 Niu S et al. (2004) Reelin promotes hippocampal dendrite development through the VLDLR/ApoER2-Dab1 pathway. Neuron 41: 71-84 PubMed GONUTS page
↑ ^13.0 ^13.1 Villeda SA et al. (2006) Absence of Reelin results in altered nociception and aberrant neuronal positioning in the dorsal spinal cord. Neuroscience 139: 1385-96 PubMed GONUTS page
↑ Britanova O et al. (2006) A novel mode of tangential migration of cortical projection neurons. Dev Biol 298: 299-311 PubMed GONUTS page
↑ Yoshihara S et al. (2005) Arx homeobox gene is essential for development of mouse olfactory system. Development 132: 751-62 PubMed GONUTS page
↑ Ballif BA et al. (2004) Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons. Curr Biol 14: 606-10 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 Ventruti A et al. (2011) Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain. Neuroscience 189: 32-42 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 Rogers JT et al. (2011) Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine density. Learn Mem 18: 558-64 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 Teixeira CM et al. (2011) Overexpression of Reelin prevents the manifestation of behavioral phenotypes related to schizophrenia and bipolar disorder. Neuropsychopharmacology 36: 2395-405 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 ^20.4 ^20.5 ^20.6 Qiu S & Weeber EJ (2007) Reelin signaling facilitates maturation of CA1 glutamatergic synapses. J Neurophysiol 97: 2312-21 PubMed GONUTS page

[PMID:12925587-0] 1.0 ^1.1 Hartfuss E et al. (2003) Reelin signaling directly affects radial glia morphology and biochemical maturation. Development 130: 4597-609 PubMed GONUTS page

[PMID:12223565-1] 2.0 ^2.1 Jensen P et al. (2002) Dissection of the cellular and molecular events that position cerebellar Purkinje cells: a study of the math1 null-mutant mouse. J Neurosci 22: 8110-6 PubMed GONUTS page

[PMID:12724835-2] 3.0 ^3.1 Nishikawa S et al. (2003) Lack of Reelin causes malpositioning of nigral dopaminergic neurons: evidence from comparison of normal and Reln(rl) mutant mice. J Comp Neurol 461: 166-73 PubMed GONUTS page

[PMID:14980731-3] Hevner RF et al. (2004) Postnatal shifts of interneuron position in the neocortex of normal and reeler mice: evidence for inward radial migration. Neuroscience 124: 605-18 PubMed GONUTS page

[PMID:15703280-4] Rossel M et al. (2005) Reelin signaling is necessary for a specific step in the migration of hindbrain efferent neurons. Development 132: 1175-85 PubMed GONUTS page

[PMID:20711475-5] 6.0 ^6.1 Palmesino E et al. (2010) Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling. PLoS Biol 8: e1000446 PubMed GONUTS page

[PMID:17330141-6] Zhang G et al. (2007) The Pafah1b complex interacts with the reelin receptor VLDLR. PLoS One 2: e252 PubMed GONUTS page

[PMID:11900467-7] 8.0 ^8.1 Phelps PE et al. (2002) Evidence for a cell-specific action of Reelin in the spinal cord. Dev Biol 244: 180-98 PubMed GONUTS page

[PMID:12526740-8] 9.0 ^9.1 ^9.2 Bock HH & Herz J (2003) Reelin activates SRC family tyrosine kinases in neurons. Curr Biol 13: 18-26 PubMed GONUTS page

[PMID:15525772-9] Meyer G et al. (2004) Developmental roles of p73 in Cajal-Retzius cells and cortical patterning. J Neurosci 24: 9878-87 PubMed GONUTS page

[PMID:16324103-10] Li HP et al. (2005) Aberrant trajectory of thalamocortical axons associated with abnormal localization of neurocan immunoreactivity in the cerebral neocortex of reeler mutant mice. Eur J Neurosci 22: 2689-96 PubMed GONUTS page

[PMID:14715136-11] 12.0 ^12.1 Niu S et al. (2004) Reelin promotes hippocampal dendrite development through the VLDLR/ApoER2-Dab1 pathway. Neuron 41: 71-84 PubMed GONUTS page

[PMID:16580148-12] 13.0 ^13.1 Villeda SA et al. (2006) Absence of Reelin results in altered nociception and aberrant neuronal positioning in the dorsal spinal cord. Neuroscience 139: 1385-96 PubMed GONUTS page

[PMID:16901480-13] Britanova O et al. (2006) A novel mode of tangential migration of cortical projection neurons. Dev Biol 298: 299-311 PubMed GONUTS page

[PMID:15677725-14] Yoshihara S et al. (2005) Arx homeobox gene is essential for development of mouse olfactory system. Development 132: 751-62 PubMed GONUTS page

[PMID:15062102-15] Ballif BA et al. (2004) Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons. Curr Biol 14: 606-10 PubMed GONUTS page

[PMID:21664258-16] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 Ventruti A et al. (2011) Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain. Neuroscience 189: 32-42 PubMed GONUTS page

[PMID:21852430-17] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 Rogers JT et al. (2011) Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine density. Learn Mem 18: 558-64 PubMed GONUTS page

[PMID:21814183-18] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 Teixeira CM et al. (2011) Overexpression of Reelin prevents the manifestation of behavioral phenotypes related to schizophrenia and bipolar disorder. Neuropsychopharmacology 36: 2395-405 PubMed GONUTS page

[PMID:17229826-19] 20.0 ^20.1 ^20.2 ^20.3 ^20.4 ^20.5 ^20.6 Qiu S & Weeber EJ (2007) Reelin signaling facilitates maturation of CA1 glutamatergic synapses. J Neurophysiol 97: 2312-21 PubMed GONUTS page

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MOUSE:RELN

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