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MOUSE:PTHR

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Pthlh (synonyms: Pthrp)
Protein Name(s) Parathyroid hormone-related protein

PTH-rP PTHrP Parathyroid hormone-like protein PLP Osteostatin

External Links
UniProt P22858
EMBL M60057
M60058
M60056
BC058187
CCDS CCDS39717.1
PIR JN0103
UniGene Mm.28440
ProteinModelPortal P22858
SMR P22858
STRING 10090.ENSMUSP00000051433
PhosphoSite P22858
PaxDb P22858
PRIDE P22858
MGI MGI:97800
eggNOG ENOG410IW2I
ENOG41126XH
HOGENOM HOG000115765
HOVERGEN HBG003236
InParanoid P22858
PhylomeDB P22858
PRO PR:P22858
Proteomes UP000000589
CleanEx MM_PTHLH
GO GO:0005737
GO:0005615
GO:0005794
GO:0005622
GO:0005654
GO:0005179
GO:0051428
GO:0007189
GO:0001958
GO:0007492
GO:0030855
GO:0048286
GO:0060649
GO:0032331
GO:0043433
GO:0060659
GO:0002076
GO:0030819
GO:0008284
GO:0016485
GO:0010468
GO:0001501
GO:0043129
InterPro IPR003626
IPR001415
PANTHER PTHR17223
Pfam PF01279
SMART SM00087
PROSITE PS00335

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005634

nucleus

PMID:26859332[1]

ECO:0000314

C

Fig 1 A

"The nuclear localization of C terminus PTHrP was detected using antibody against PTHrP(112–131) only in EMSCs from WT and p27-/- mice(Figure 1A)"

complete
CACAO 11367

enables

GO:0051428

peptide hormone receptor binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P12272

F

Seeded From UniProt

complete

enables

GO:0051428

peptide hormone receptor binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000425409
UniProtKB:P12272

F

Seeded From UniProt

complete

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000425409
RGD:3441
UniProtKB:P12272

P

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000425409
RGD:3441

F

Seeded From UniProt

complete

involved_in

GO:0002076

osteoblast development

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97800
PANTHER:PTN000425409

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0061182

negative regulation of chondrocyte development

PMID:9008714[3]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12272

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060659

nipple sheath formation

PMID:9477327[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2154515

P

results_in_formation_of:(EMAPA:17759)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060649

mammary gland bud elongation

PMID:9477327[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2154515

P

occurs_in:(EMAPA:17759)

Seeded From UniProt

complete

enables

GO:0051428

peptide hormone receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12272

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048286

lung alveolus development

PMID:15162506[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2154515

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043433

negative regulation of DNA-binding transcription factor activity

PMID:17328886[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043129

surfactant homeostasis

PMID:15162506[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2154515

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032331

negative regulation of chondrocyte differentiation

PMID:17328886[6]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95728

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032331

negative regulation of chondrocyte differentiation

PMID:8895385[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2154515

P

regulates_o_results_in_acquisition_of_features_of:(CL:0000138)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032331

negative regulation of chondrocyte differentiation

PMID:17328886[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032331

negative regulation of chondrocyte differentiation

PMID:9008714[3]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12272

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030855

epithelial cell differentiation

PMID:15162506[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2154515

P

  • occurs_in:(EMAPA:16728)
  • results_in_acquisition_of_features_of:(CL:0000082)

Seeded From UniProt

complete

NOT|acts_upstream_of_or_within

GO:0030282

bone mineralization

PMID:11606467[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2154515

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0016485

protein processing

PMID:17328886[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010468

regulation of gene expression

PMID:9008714[3]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12272

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008284

positive regulation of cell population proliferation

PMID:17328886[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007492

endoderm development

PMID:9921650[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3441

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12272

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12272

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12272

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12272

C

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3441

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002076

osteoblast development

PMID:9832460[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2154515

P

  • occurs_in:(EMAPA:19142)
  • results_in_development_of:(CL:0000062)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001958

endochondral ossification

PMID:8895385[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2154515

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001501

skeletal system development

PMID:8314082[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2154515

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001501

skeletal system development

PMID:11606467[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2154515

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001501

skeletal system development

PMID:9008714[3]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P12272

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001415
InterPro:IPR003626

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001415
InterPro:IPR003626

C

Seeded From UniProt

complete

involved_in

GO:0055074

calcium ion homeostasis

PMID:19968565[12]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

  • occurs_in:(EMAPA:35770)
  • occurs_in:(EMAPA:36771)

Seeded From UniProt

complete

involved_in

GO:0055062

phosphate ion homeostasis

PMID:19968565[12]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

  • occurs_in:(EMAPA:35770)
  • occurs_in:(EMAPA:36771)

Seeded From UniProt

complete

involved_in

GO:0010960

magnesium ion homeostasis

PMID:19968565[12]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

  • occurs_in:(EMAPA:35770)
  • occurs_in:(EMAPA:36771)

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:11606467[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

PMID:11606467[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0372

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Sun, W et al. (2016) PTHrP Nuclear Localization and Carboxyl Terminus Sequences Modulate Dental and Mandibular Development in Part via the Action of p27. Endocrinology 157 1372-84 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Amling, M et al. (1997) Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development. J. Cell Biol. 136 205-13 PubMed GONUTS page
  4. 4.0 4.1 Wysolmerski, JJ et al. (1998) Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development. Development 125 1285-94 PubMed GONUTS page
  5. 5.0 5.1 5.2 Rubin, LP et al. (2004) Arrested pulmonary alveolar cytodifferentiation and defective surfactant synthesis in mice missing the gene for parathyroid hormone-related protein. Dev. Dyn. 230 278-89 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 Mau, E et al. (2007) PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms. Dev. Biol. 305 28-39 PubMed GONUTS page
  7. 7.0 7.1 Lee, K et al. (1996) Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development. Endocrinology 137 5109-18 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 Kovacs, CS et al. (2001) PTH regulates fetal blood calcium and skeletal mineralization independently of PTHrP. Endocrinology 142 4983-93 PubMed GONUTS page
  9. Roelen, BA et al. (1998) Identification of two distinct functions for TGF-beta in early mouse development. Differentiation 64 19-31 PubMed GONUTS page
  10. Lanske, B et al. (1998) The parathyroid hormone (PTH)/PTH-related peptide receptor mediates actions of both ligands in murine bone. Endocrinology 139 5194-204 PubMed GONUTS page
  11. Karaplis, AC et al. (1994) Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes Dev. 8 277-89 PubMed GONUTS page
  12. 12.0 12.1 12.2 Simmonds, CS et al. (2010) Parathyroid hormone regulates fetal-placental mineral homeostasis. J. Bone Miner. Res. 25 594-605 PubMed GONUTS page