MOUSE:PROX1

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Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Prox1
Protein Name(s)	Prospero homeobox protein 1 Homeobox prospero-like protein PROX1 PROX-1
External Links
UniProt Identifier	PROX1_MOUSE
UniProt Accessions	P48437, O88478, Q3UPV1, Q543D8,
EMBL	AF061576, AK052889, AK143179, BC051411,
PIR	JE0269,
RefSeq	NP_032963.1,
Ensembl	ENSMUST00000010319,
Pfam	PF05044,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0005737	cytoplasm		IDA: Inferred from Direct Assay		C	Source: BHF-UCL
	GO:0005634	nucleus		IDA: Inferred from Direct Assay		C	Source: BHF-UCL
	GO:0003705	RNA polymerase II transcription factor acti...		IDA: Inferred from Direct Assay		F	Source: BHF-UCL
	GO:0060414	aorta smooth muscle tissue morphogenesis		IMP: Inferred from Mutant Phenotype		P	Source: BHF-UCL
	GO:0055009	atrial cardiac muscle tissue morphogenesis		IMP: Inferred from Mutant Phenotype		P	Source: BHF-UCL
	GO:0001709	cell fate determination		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0060059	embryonic retina morphogenesis in camera-ty...		IEP: Inferred from Expression Pattern		P	Source: BHF-UCL
	GO:0060214	endocardium formation		IMP: Inferred from Mutant Phenotype		P	Source: BHF-UCL
	GO:0070365	hepatocyte differentiation		IEP: Inferred from Expression Pattern		P	Source: BHF-UCL
	GO:0070309	lens fiber cell morphogenesis		IMP: Inferred from Mutant Phenotype		P	Source: BHF-UCL
	GO:0008285	negative regulation of cell proliferation		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0046619	optic placode formation involved in camera-...		IEP: Inferred from Expression Pattern		P	Source: BHF-UCL
	GO:0060421	positive regulation of heart growth		IMP: Inferred from Mutant Phenotype		P	Source: BHF-UCL
	GO:0060298	positive regulation of sarcomere organization		IMP: Inferred from Mutant Phenotype		P	Source: BHF-UCL
	GO:0030240	skeletal muscle thin filament assembly		IMP: Inferred from Mutant Phenotype		P	Source: BHF-UCL
	GO:0006350	transcription		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0048845	venous blood vessel morphogenesis		IMP: Inferred from Mutant Phenotype		P	Source: BHF-UCL
	GO:0055010	ventricular cardiac muscle tissue morphogen...		IMP: Inferred from Mutant Phenotype		P	Source: BHF-UCL
	GO:0055005	ventricular cardiac myofibril development		IMP: Inferred from Mutant Phenotype		P	Source: BHF-UCL
	GO:0060412	ventricular septum morphogenesis		IMP: Inferred from Mutant Phenotype		P	Source: BHF-UCL
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000420283	P
	GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	PMID:16291864^[1]	IDA: Inferred from Direct Assay		F
	GO:0001709	cell fate determination	PMID:12692551^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386336	P
	GO:0001822	kidney development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000420283	P
	GO:0001889	liver development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000420283	P
	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000420283	P
	GO:0001945	lymph vessel development	PMID:16170315^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2450311	P
	GO:0001945	lymph vessel development	PMID:16170315^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3609548	P
	GO:0001946	lymphangiogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000420283	P
	GO:0002088	lens development in camera-type eye	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000420283	P
	GO:0002089	lens morphogenesis in camera-type eye	PMID:10080188^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007738	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0371	F
	GO:0003677	DNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000420283	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:19091769^[5]	NAS: Non-traceable Author Statement		F
	GO:0003705	sequence-specific enhancer binding RNA polymerase II transcription factor activity	PMID:19091769^[5]	IDA: Inferred from Direct Assay		F
	GO:0003714	transcription corepressor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000420283	F
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007738	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000420283	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:11850194^[6]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:19091769^[5]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000420283	C
	GO:0005737	cytoplasm	PMID:11850194^[6]	IDA: Inferred from Direct Assay		C
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006351	transcription, DNA-dependent	PMID:19091769^[5]	NAS: Non-traceable Author Statement		P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007738	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0006355	regulation of transcription, DNA-dependent	PMID:19091769^[5]	NAS: Non-traceable Author Statement		P
	GO:0006366	transcription from RNA polymerase II promoter	PMID:16291864^[1]	IDA: Inferred from Direct Assay		P
	GO:0007275	multicellular organismal development	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR007738	P
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P
	GO:0007420	brain development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000420283	P
	GO:0008284	positive regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000420283	P
	GO:0008284	positive regulation of cell proliferation	PMID:12692551^[2]	IMP: Inferred from Mutant Phenotype		P
	GO:0008285	negative regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000420283	P
	GO:0008285	negative regulation of cell proliferation	PMID:12692551^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386336	P
	GO:0010468	regulation of gene expression	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000420283	P
	GO:0010468	regulation of gene expression	PMID:10080188^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0010595	positive regulation of endothelial cell migration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000420283	P
	GO:0016922	ligand-dependent nuclear receptor binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000420283	F
	GO:0030240	skeletal muscle thin filament assembly	PMID:19091769^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0030324	lung development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000420283	P
	GO:0031016	pancreas development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000420283	P
	GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000420283	P
	GO:0045071	negative regulation of viral genome replication	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000420283	P
	GO:0045446	endothelial cell differentiation	PMID:11927535^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2386336	P
	GO:0045737	positive regulation of cyclin-dependent protein kinase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000420283	P
	GO:0045750	positive regulation of S phase of mitotic cell cycle	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000420283	P
	GO:0045787	positive regulation of cell cycle	PMID:10080188^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0045892	negative regulation of transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000420283	P
	GO:0045893	positive regulation of transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000420283	P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:16291864^[1]	IDA: Inferred from Direct Assay		P
	GO:0046619	optic placode formation involved in camera-type eye formation	PMID:11850194^[6]	IEP: Inferred from Expression Pattern		P
	GO:0048845	venous blood vessel morphogenesis	PMID:19091769^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0050692	DBD domain binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000420283	F
	GO:0050693	LBD domain binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000420283	F
	GO:0055005	ventricular cardiac myofibril development	PMID:19091769^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0055009	atrial cardiac muscle tissue morphogenesis	PMID:19091769^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0055010	ventricular cardiac muscle tissue morphogenesis	PMID:19091769^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0060059	embryonic retina morphogenesis in camera-type eye	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000420283	P
	GO:0060059	embryonic retina morphogenesis in camera-type eye	PMID:12692551^[2]	IEP: Inferred from Expression Pattern		P
	GO:0060214	endocardium formation	PMID:19091769^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0060298	positive regulation of sarcomere organization	PMID:19091769^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0060412	ventricular septum morphogenesis	PMID:19091769^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0060414	aorta smooth muscle tissue morphogenesis	PMID:19091769^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0060421	positive regulation of heart growth	PMID:19091769^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0060836	lymphatic endothelial cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000420283	P
	GO:0060849	regulation of transcription involved in lymphatic endothelial cell fate commitment	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000420283	P
	GO:0070309	lens fiber cell morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000420283	P
	GO:0070309	lens fiber cell morphogenesis	PMID:10080188^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0070365	hepatocyte differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000420283	P
	GO:0070365	hepatocyte differentiation	PMID:15232737^[8]	IEP: Inferred from Expression Pattern		P
	GO:0070858	negative regulation of bile acid biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000420283	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Shin JW et al. (2006) Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis. Mol Biol Cell 17: 576-84 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Dyer MA et al. (2003) Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina. Nat Genet 34: 53-8 PubMed GONUTS page
↑ ^3.0 ^3.1 Harvey NL et al. (2005) Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity. Nat Genet 37: 1072-81 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Wigle JT et al. (1999) Prox1 function is crucial for mouse lens-fibre elongation. Nat Genet 21: 318-22 PubMed GONUTS page
↑ ^5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 ^5.12 ^5.13 ^5.14 Risebro CA et al. (2009) Prox1 maintains muscle structure and growth in the developing heart. Development 136: 495-505 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Duncan MK et al. (2002) Prox1 is differentially localized during lens development. Mech Dev 112: 195-8 PubMed GONUTS page
↑ Wigle JT et al. (2002) An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype. EMBO J 21: 1505-13 PubMed GONUTS page
↑ Dudas J et al. (2004) The homeobox transcription factor Prox1 is highly conserved in embryonic hepatoblasts and in adult and transformed hepatocytes, but is absent from bile duct epithelium. Anat Embryol (Berl) 208: 359-66 PubMed GONUTS page

[PMID:16291864-0] 1.0 ^1.1 ^1.2 Shin JW et al. (2006) Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis. Mol Biol Cell 17: 576-84 PubMed GONUTS page

[PMID:12692551-1] 2.0 ^2.1 ^2.2 ^2.3 Dyer MA et al. (2003) Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina. Nat Genet 34: 53-8 PubMed GONUTS page

[PMID:16170315-2] 3.0 ^3.1 Harvey NL et al. (2005) Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity. Nat Genet 37: 1072-81 PubMed GONUTS page

[PMID:10080188-3] 4.0 ^4.1 ^4.2 ^4.3 Wigle JT et al. (1999) Prox1 function is crucial for mouse lens-fibre elongation. Nat Genet 21: 318-22 PubMed GONUTS page

[PMID:19091769-4] 5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 ^5.12 ^5.13 ^5.14 Risebro CA et al. (2009) Prox1 maintains muscle structure and growth in the developing heart. Development 136: 495-505 PubMed GONUTS page

[PMID:11850194-5] 6.0 ^6.1 ^6.2 Duncan MK et al. (2002) Prox1 is differentially localized during lens development. Mech Dev 112: 195-8 PubMed GONUTS page

[PMID:11927535-6] Wigle JT et al. (2002) An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype. EMBO J 21: 1505-13 PubMed GONUTS page

[PMID:15232737-7] Dudas J et al. (2004) The homeobox transcription factor Prox1 is highly conserved in embryonic hepatoblasts and in adult and transformed hepatocytes, but is absent from bile duct epithelium. Anat Embryol (Berl) 208: 359-66 PubMed GONUTS page

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MOUSE:PROX1

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