MOUSE:PRDX2

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Species (Taxon ID)	Mus musculus (Mouse). (taxon:10090)
Gene Name(s)	Prdx2 ( synonyms: Tdpx1, Tpx )
Protein Name(s)	Peroxiredoxin-2 Thiol-specific antioxidant protein TSA Thioredoxin peroxidase 1 Thioredoxin-dependent peroxide reductase 1
External Links
UniProt Identifier	PRDX2_MOUSE
UniProt Accessions	Q61171, O88376, Q60796, Q9CWJ4, Q9DB49,
EMBL	U51679, X82067, U20611, AF032722, AF032718, AF032719, AF032720, AF032721, AK005225, AK008433, AK010653, AK088280, BC002034, BC081454,
RefSeq	NP_035693.3,
Ensembl	ENSMUST00000005292, ENSMUST00000109733, ENSMUST00000109734, ENSMUST00000164807,
Pfam	PF10417, PF00578,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005739	mitochondrion		IDA: Inferred from Direct Assay		C	Source: MGI
	GO:0005515	protein binding		IPI: Inferred from Physical Interaction		F	Source: MGI
	GO:0008430	selenium binding		TAS: Traceable Author Statement		F	Source: MGI
	GO:0008379	thioredoxin peroxidase activity		TAS: Traceable Author Statement		F	Source: MGI
	GO:0000187	activation of MAPK activity		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0006916	anti-apoptosis		IDA: Inferred from Direct Assay		P	Source: MGI
	GO:0045454	cell redox homeostasis		IEA: Inferred from Electronic Annotation		P	Source: InterPro
	GO:0048872	homeostasis of number of cells		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0042744	hydrogen peroxide catabolic process		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0032088	negative regulation of NF-kappaB transcription factor activity		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0010671	negative regulation of oxygen and reactive oxygen species metabolic process		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0045581	negative regulation of T cell differentiation		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0055114	oxidation reduction		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0010310	regulation of hydrogen peroxide metabolic process		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0002536	respiratory burst involved in inflammatory response		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0032496	response to lipopolysaccharide		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0042098	T cell proliferation		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0048538	thymus development		IMP: Inferred from Mutant Phenotype		P	Source: MGI
	GO:0006979	response to oxidative stress	PMID:20978343^[1]	IMP: Inferred from Mutant Phenotype		P	Figure 7B. Prdx2 overexpression significantly decreased FeCl3-induced superoxide anion generation when compared with WT VSMCs.	complete
	GO:0010671	negative regulation of oxygen and reactive oxygen species metabolic process	PMID:20978343^[1]	IMP: Inferred from Mutant Phenotype		P	FeCl3 treatment induced more ROS generation in the vessel walls of prdx2–/– mice than in prdx2 WT mice (Figure 7C).	complete
	GO:0016209	antioxidant activity	PMID:20978343^[1]	IMP: Inferred from Mutant Phenotype		F	Prdx2 overexpression significantly decreased FeCl3-induced superoxide anion generation when compared with WT VSMCs (Figure 7B).	complete
	GO:0000187	activation of MAPK activity	PMID:17325201^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2668456	P
	GO:0002536	respiratory burst involved in inflammatory response	PMID:17325201^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2668456	P
	GO:0004601	peroxidase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0575	F
	GO:0004601	peroxidase activity	PMID:9115640^[3]	TAS: Traceable Author Statement		F
	GO:0005515	protein binding	PMID:17141802^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q91WA1	F
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005739	mitochondrion	PMID:18614015^[5]	IDA: Inferred from Direct Assay		C
	GO:0006916	anti-apoptosis	PMID:15259009^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2668456	P
	GO:0006916	anti-apoptosis	PMID:9115640^[3]	IDA: Inferred from Direct Assay		P
	GO:0006979	response to oxidative stress	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000301522	P
	GO:0006979	response to oxidative stress	PMID:9115640^[3]	TAS: Traceable Author Statement		P
	GO:0008379	thioredoxin peroxidase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000301522	F
	GO:0008379	thioredoxin peroxidase activity	PMID:9714804^[7]	TAS: Traceable Author Statement		F
	GO:0008430	selenium binding	PMID:9792801^[8]	TAS: Traceable Author Statement		F
	GO:0010310	regulation of hydrogen peroxide metabolic process	PMID:17325201^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2668456	P
	GO:0016209	antioxidant activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000866	F
	GO:0016209	antioxidant activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0049	F
	GO:0016209	antioxidant activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000301522	F
	GO:0016491	oxidoreductase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000866	F
	GO:0016491	oxidoreductase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	F
	GO:0019430	removal of superoxide radicals	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000301522	P
	GO:0019430	removal of superoxide radicals	PMID:20978343^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0030194	positive regulation of blood coagulation	PMID:20978343^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway	PMID:17325201^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2668456	P
	GO:0032088	negative regulation of NF-kappaB transcription factor activity	PMID:17325201^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2668456	P
	GO:0032496	response to lipopolysaccharide	PMID:17325201^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2668456	P
	GO:0034599	cellular response to oxidative stress	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000301522	P
	GO:0042098	T cell proliferation	PMID:15259009^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2668456	P
	GO:0042743	hydrogen peroxide metabolic process	PMID:15259009^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2668456	P
	GO:0042744	hydrogen peroxide catabolic process	PMID:15902258^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2668456	P
	GO:0042981	regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSP00000301522	P
	GO:0045581	negative regulation of T cell differentiation	PMID:16290204^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2668456	P
	GO:0048538	thymus development	PMID:15259009^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2668456	P
	GO:0048872	homeostasis of number of cells	PMID:15259009^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2668456	P
	GO:0051920	peroxiredoxin activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019479	F
	GO:0051920	peroxiredoxin activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:1.11.1.15	F
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000866	P
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR019479	P
	GO:0055114	oxidation-reduction process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	P
	GO:2000378	negative regulation of reactive oxygen species metabolic process	PMID:17325201^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2668456	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Li W et al. (2010) CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs. J Clin Invest 120: 3996-4006 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Yang CS et al. (2007) Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock. J Exp Med 204: 583-94 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Ichimiya S et al. (1997) Murine thioredoxin peroxidase delays neuronal apoptosis and is expressed in areas of the brain most susceptible to hypoxic and ischemic injury. DNA Cell Biol 16: 311-21 PubMed GONUTS page
↑ Gotter AL et al. (2007) Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors. J Mol Biol 366: 36-52 PubMed GONUTS page
↑ Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134: 112-23 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Moon EY et al. (2004) Reactive oxygen species induced by the deletion of peroxiredoxin II (PrxII) increases the number of thymocytes resulting in the enlargement of PrxII-null thymus. Eur J Immunol 34: 2119-28 PubMed GONUTS page
↑ Lim MJ et al. (1998) The type II peroxiredoxin gene family of the mouse: molecular structure, expression and evolution. Gene 216: 197-205 PubMed GONUTS page
↑ Gladyshev VN et al. (1998) Contrasting patterns of regulation of the antioxidant selenoproteins, thioredoxin reductase, and glutathione peroxidase, in cancer cells. Biochem Biophys Res Commun 251: 488-93 PubMed GONUTS page
↑ Choi MH et al. (2005) Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II. Nature 435: 347-53 PubMed GONUTS page
↑ Moon EY et al. (2006) T lymphocytes and dendritic cells are activated by the deletion of peroxiredoxin II (Prx II) gene. Immunol Lett 102: 184-90 PubMed GONUTS page

[PMID:20978343-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Li W et al. (2010) CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs. J Clin Invest 120: 3996-4006 PubMed GONUTS page

[PMID:17325201-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Yang CS et al. (2007) Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock. J Exp Med 204: 583-94 PubMed GONUTS page

[PMID:9115640-2] 3.0 ^3.1 ^3.2 Ichimiya S et al. (1997) Murine thioredoxin peroxidase delays neuronal apoptosis and is expressed in areas of the brain most susceptible to hypoxic and ischemic injury. DNA Cell Biol 16: 311-21 PubMed GONUTS page

[PMID:17141802-3] Gotter AL et al. (2007) Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors. J Mol Biol 366: 36-52 PubMed GONUTS page

[PMID:18614015-4] Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134: 112-23 PubMed GONUTS page

[PMID:15259009-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Moon EY et al. (2004) Reactive oxygen species induced by the deletion of peroxiredoxin II (PrxII) increases the number of thymocytes resulting in the enlargement of PrxII-null thymus. Eur J Immunol 34: 2119-28 PubMed GONUTS page

[PMID:9714804-6] Lim MJ et al. (1998) The type II peroxiredoxin gene family of the mouse: molecular structure, expression and evolution. Gene 216: 197-205 PubMed GONUTS page

[PMID:9792801-7] Gladyshev VN et al. (1998) Contrasting patterns of regulation of the antioxidant selenoproteins, thioredoxin reductase, and glutathione peroxidase, in cancer cells. Biochem Biophys Res Commun 251: 488-93 PubMed GONUTS page

[PMID:15902258-8] Choi MH et al. (2005) Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II. Nature 435: 347-53 PubMed GONUTS page

[PMID:16290204-9] Moon EY et al. (2006) T lymphocytes and dendritic cells are activated by the deletion of peroxiredoxin II (Prx II) gene. Immunol Lett 102: 184-90 PubMed GONUTS page

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MOUSE:PRDX2

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